Yongke Lu

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver
    Yongke Lu
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Alcohol 47:353-7. 2013
  2. pmc Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway
    Yongke Lu
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine New York, New York 10029, USA
    Toxicol Sci 128:427-38. 2012
  3. pmc Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicology 252:9-16. 2008
  4. pmc Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice
    Xiaodong Ge
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Hepatology 59:1600-16. 2014
  5. doi request reprint Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice
    Tung Ming Leung
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:1596-609. 2012
  6. pmc Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 47:518-28. 2009
  7. ncbi request reprint Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5
    Yongke Lu
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 44:263-74. 2006
  8. pmc Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 49:1406-16. 2010
  9. doi request reprint Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
  10. pmc Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice
    Elisabetta Mormone
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 142:612-621.e5. 2012

Collaborators

Detail Information

Publications22

  1. pmc Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver
    Yongke Lu
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Alcohol 47:353-7. 2013
    ..Tobacco smoke increases alcoholic steatosis in apoE(-/-) mice. Tobacco smoke contains more than 4000 chemicals, but it is unknown which compounds in tobacco smoke play a major role in increasing alcoholic steatosis...
  2. pmc Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway
    Yongke Lu
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine New York, New York 10029, USA
    Toxicol Sci 128:427-38. 2012
    ..Results obtained from primary hepatocytes, mice gavaged with binge ethanol or fed chronic ethanol, show that Nrf2-regulated ethanol induction of CYP2A5 protects against ethanol-induced steatosis...
  3. pmc Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicology 252:9-16. 2008
    ..In summary, even though ROS-producing CYP2E1/2A5 were not elevated by pyrazole, impaired antioxidant capacity resulting from Nrf2 deficiency appear to be sufficient to promote pyrazole-induced oxidative liver injury...
  4. pmc Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice
    Xiaodong Ge
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Hepatology 59:1600-16. 2014
    ..Conclusion: Natural induction plus forced overexpression of OPN in the liver or treatment with m-OPN protect from early alcohol-induced liver injury by blocking the gut-derived LPS and TNFα effects in the liver...
  5. doi request reprint Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice
    Tung Ming Leung
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:1596-609. 2012
    ....
  6. pmc Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 47:518-28. 2009
    ..These results show that chronic ethanol feeding enhances Fas-induced liver injury by a mechanism associated with induction of CYP2E1, elevated serum TNF-alpha levels, and activation of MAPK...
  7. ncbi request reprint Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5
    Yongke Lu
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 44:263-74. 2006
    ..In conclusion, induction of CYP2E1 plays an important role in the enhancement of LPS liver injury by pyrazole, but some contribution by CYP2A5 cannot be excluded...
  8. pmc Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 49:1406-16. 2010
    ....
  9. doi request reprint Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
    ....
  10. pmc Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice
    Elisabetta Mormone
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 142:612-621.e5. 2012
    ..We propose that fibromodulin contributes to the pathogenesis of fibrosis by regulating the fibrogenic phenotype of hepatic stellate cells (HSCs)...
  11. ncbi request reprint Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice
    Xiaodong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Hepatology 42:400-10. 2005
    ..In conclusion, enhanced hepatotoxicity of Fas was found in mice with elevated levels of CYP2E1. We speculate that overexpression of CYP2E1 might synergize and increase the susceptibility to Fas induced-liver injury...
  12. ncbi request reprint Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1
    Yongke Lu
    The Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Toxicol Sci 89:515-23. 2006
    ..Both in vitro and in vivo results indicate that elevated CYP2E1 enhances cisplatin-induced hepatotoxicity, and the mechanism may involve increased production of ROS and oxidative stress...
  13. doi request reprint Role of oxidative stress in alcohol-induced liver injury
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Toxicol 83:519-48. 2009
    ..Special emphasis is placed on CYP2E1, which is induced by alcohol and is reactive in metabolizing and activating many hepatotoxins, including ethanol, to reactive products, and in generating ROS...
  14. pmc The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 43:1061-75. 2007
    ....
  15. pmc Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress
    Yongke Lu
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 302:G287-95. 2012
    ..Partial Ass ablation prevents pyrazole plus LPS-mediated liver injury by reducing nitrosative stress, TNFα, apoptosis, and neutrophil infiltration...
  16. pmc Ethanol induction of CYP2A5: permissive role for CYP2E1
    Yongke Lu
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Drug Metab Dispos 39:330-6. 2011
    ..The possibility that induction of CYP2E1 is permissive for the induction of CYP2A5 may reflect a new contribution by CYP2E1 to the actions of ethanol...
  17. pmc Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury
    Xiaodong Ge
    Div of Liver Diseases, Dept of Medicine, Mount Sinai School of Medicine, Box 11 23, 1425 Madison Ave, Rm 11 70, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 304:G929-39. 2013
    ..Milk osteopontin could be a simple effective nutritional therapeutic strategy to prevent alcohol hepatotoxicity due, among others, to gut protective, anti-inflammatory, and anti-steatotic actions...
  18. pmc CYP2E1 and oxidative liver injury by alcohol
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 44:723-38. 2008
    ....
  19. pmc Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling
    Raquel Urtasun
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:594-608. 2012
    ..Last, chronic CCl(4) injection and TAA treatment caused more liver fibrosis to WT than to Opn(-/-) mice and the reverse occurred in Opn(HEP) Tg mice...
  20. pmc Ethanol plus the Jo2 Fas agonistic antibody-induced liver injury is attenuated in mice with partial ablation of argininosuccinate synthase
    Yongke Lu
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
    Alcohol Clin Exp Res 38:649-56. 2014
    ..Thus, ASS conditions NO· synthesis by NOS2. Because of the relevance of NOS2 activation for liver injury, we examined the contribution of ASS to NO· generation and how it impacts liver injury...
  21. ncbi request reprint Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole
    Yongke Lu
    Dept of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 289:G308-19. 2005
    ..The enhanced liver necrosis appears to involve an increase in oxidative and nitrosative stress generated by the combination of LPS plus elevated CYP2E1 levels...
  22. pmc CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY, 10029, USA
    Genes Nutr 5:149-67. 2010
    ..This review will summarize studies showing potentiated interactions between these two risk factors in promoting liver injury and the mechanisms involved...