Anice C Lowen

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Influenza virus transmission is dependent on relative humidity and temperature
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    PLoS Pathog 3:1470-6. 2007
  2. pmc Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein
    Benjamin G Hale
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 84:6909-22. 2010
  3. pmc The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses
    Natalie Pica
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Virol 85:12825-9. 2011
  4. pmc Blocking interhost transmission of influenza virus by vaccination in the guinea pig model
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Pl, New York, NY 10029 6574, USA
    J Virol 83:2803-18. 2009
  5. ncbi request reprint Transmission of influenza virus via aerosols and fomites in the guinea pig model
    Samira Mubareka
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 199:858-65. 2009
  6. pmc Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 5:e1000252. 2009
  7. pmc Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 84:21-6. 2010
  8. pmc Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 85:1400-2. 2011
  9. pmc A nine-segment influenza a virus carrying subtype H1 and H3 hemagglutinins
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 84:8062-71. 2010
  10. pmc The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model
    Yi Ying Chou
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 85:11235-41. 2011

Detail Information

Publications17

  1. pmc Influenza virus transmission is dependent on relative humidity and temperature
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    PLoS Pathog 3:1470-6. 2007
    ..We provide direct, experimental evidence to support the role of weather conditions in the dynamics of influenza and thereby address a long-standing question fundamental to the understanding of influenza epidemiology and evolution...
  2. pmc Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein
    Benjamin G Hale
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 84:6909-22. 2010
    ..We discuss the impact that a natural future gain of this NS1 function may have on the new pandemic virus in humans...
  3. pmc The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses
    Natalie Pica
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Virol 85:12825-9. 2011
    ..Our data demonstrate the utility of DBA.2 mice for the elucidation of influenza virus pathogenicity determinants and the testing of influenza vaccines...
  4. pmc Blocking interhost transmission of influenza virus by vaccination in the guinea pig model
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Pl, New York, NY 10029 6574, USA
    J Virol 83:2803-18. 2009
    ..In conclusion, we have shown that the guinea pig model can be used to test influenza virus vaccines and that the efficiency of transmission is a valuable readout when vaccine efficacy is evaluated...
  5. ncbi request reprint Transmission of influenza virus via aerosols and fomites in the guinea pig model
    Samira Mubareka
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 199:858-65. 2009
    ..The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission...
  6. pmc Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    PLoS Pathog 5:e1000252. 2009
    ..Thus, our data show that PB2 amino acids 627 and 701 are determinants of mammalian inter-host transmission in diverse virus backgrounds...
  7. pmc Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 84:21-6. 2010
    ..In addition, the use of interferon as an antiviral prophylaxis may be an effective way to limit spread in at-risk populations...
  8. pmc Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 85:1400-2. 2011
    ..Our data indicate that the observed differences in the timings of outbreaks with regard to the seasons are most likely not due to intrinsic differences in transmission between the pandemic H1N1 and seasonal H3N2 influenza viruses...
  9. pmc A nine-segment influenza a virus carrying subtype H1 and H3 hemagglutinins
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 84:8062-71. 2010
    ..Using the described methodology, we show that a ninth segment can also be incorporated by manipulation of the PB2 or PA segment-specific packaging signals. This approach offers a means of generating a bivalent influenza virus vaccine...
  10. pmc The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model
    Yi Ying Chou
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 85:11235-41. 2011
    ....
  11. pmc Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus
    Benjamin G Hale
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Gen Virol 91:1737-42. 2010
    ..Our data suggest that the currently circulating 2009 H1N1 virus is optimized to replicate efficiently without requiring certain NS1 functions...
  12. pmc Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza
    John Steel
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Virol 83:1742-53. 2009
    ....
  13. pmc High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 82:5650-2. 2008
    ..Our data imply that contact or short-range spread predominates in the tropics and offer an explanation for the lack of a well-defined, recurrent influenza season affecting tropical and subtropical regions of the world...
  14. pmc The guinea pig as a transmission model for human influenza viruses
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:9988-92. 2006
    ..Our results demonstrate that influenza virus can pass between guinea pigs by means of droplet spread and thereby establish the suitability of the guinea pig as a model host for influenza virus transmission studies...
  15. pmc Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol
    Nicole M Bouvier
    Department of Microbiology, Box 1124, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 82:10052-8. 2008
    ..The present results suggest that oseltamivir resistance mutations reduce aerosol transmission of influenza virus, which could have implications for public health measures taken in the event of an influenza pandemic...
  16. pmc Effects of receptor binding specificity of avian influenza virus on the human innate immune response
    Irene Ramos
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 85:4421-31. 2011
    ..These data indicate that binding to SAα2,3 by H5N1 HPAIV may be sensed by human cells differently than binding to SAα2,6, inducing an exacerbated innate proinflammatory response in infected individuals...
  17. ncbi request reprint Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    Infect Disord Drug Targets 7:318-28. 2007
    ..Anti-influenza drugs in development which show efficacy in terms of mitigating disease or viral growth should also be tested for their potential to block transmission...