Research Topics
Species | Virginia R LitleSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
Laparoscopic Heller myotomy for achalasia: a review of the controversiesVirginia R Litle
Division of Thoracic Surgery, Department of Cardiothoracic Surgery, The Mount Sinai Medical Center, New York, New York 10029 6574, USA
Ann Thorac Surg 85:S743-6. 2008..The optimal length of myotomy as suggested in the literature is also summarized. To complete the goal, peer-reviewed publications were identified in PubMed by search terms achalasia, myotomy, fundoplication, Nissen, Dor, and Toupet...- Gene expression profiles in esophageal adenocarcinoma predict survival after resectionArjun Pennathur
Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Thorac Cardiovasc Surg 145:505-12; discussion 512-3. 2013..The main objective of the present study was to evaluate the gene expression profiles in esophageal adenocarcinoma and determine their association with survival after resection... - Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancerAlexander J Greenstein
Department of General Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
Cancer 112:1239-46. 2008..In the current study, the association between survival and the number of LNs evaluated was examined in patients who underwent resection of lymph node-negative (American Joint Committee on Cancer [AJCC] TNM stage I-IIA) esophageal cancer... - Thoracoscopic lobectomy: report on safety, discharge independence, pain, and chemotherapy toleranceDaniel G Nicastri
Department of Surgery, Mount Sinai Medical Center, New York, NY 10029, USA
J Thorac Cardiovasc Surg 135:642-7. 2008..This series analyzed the safety, pain, analgesic use, and discharge disposition in patients who underwent thoracoscopic lobectomy and segmentectomy at a single institution... 
Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancerLiqiang Xi
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
Nucleic Acids Res 36:6535-47. 2008..Such studies may lead to the development of additional tools for tumor diagnosis, prognosis and therapy...- MicroRNA expression profiles of esophageal cancerAndrew Feber
Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
J Thorac Cardiovasc Surg 135:255-60; discussion 260. 2008..The purpose of our study was to examine microRNA expression in Barrett esophagus and esophageal cancer to identify potential markers for disease progression... - Prognostic significance of the number of lymph node metastases in esophageal cancerAlexander J Greenstein
Department of General Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
J Am Coll Surg 206:239-46. 2008..In this study, we examined whether involvement of a higher number of LNs is associated with worse survival among esophageal cancer patients... - Early G₁ cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinomaAmin Ismail
Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA
Clin Cancer Res 17:4513-22. 2011..However, this event has not been mapped with fine resolution in a large EAC cohort, and its association with clinical endpoints and functional relevance are unclear... - Placental transmogrification of the lung presenting as emphysema and a lung massMark Shapiro
Department of Surgery, Mount Sinai Medical Center, New York, New York, USA
Ann Thorac Surg 87:615-6. 2009..Here we show that untreated placental transmogrification of the lung can lead to severe pulmonary symptoms and surgery is diagnostic and curative... - The esophagus: do sex and gender matter?Virginia R Litle
Division of Thoracic Foregut Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Semin Thorac Cardiovasc Surg 23:131-6. 2011..Although discussions of treatment and outcomes might differ between the sexes and genders, there are no important data to support different care on the basis of sex or gender... - Gastroesophageal reflux disease and idiopathic pulmonary fibrosisYevgenia Y Pashinsky
Division of Gastroenterology, Mount Sinai Medical Center, New York, NY, USA
Mt Sinai J Med 76:24-9. 2009.... - Video-assisted thoracoscopic lobectomy: state of the art and future directionsJason P Shaw
Division of Thoracic Surgery, The Mount Sinai Medical Center, New York, New York 10029, USA
Ann Thorac Surg 85:S705-9. 2008..Several published reports suggest thoracoscopic resection is safe, with the potential advantage of shorter hospital stay, quicker recovery, and comparable oncologic results... 
Minimally invasive resection for esophageal cancerVirginia R Litle
Division of Thoracic and Foregut Surgery, University of Pittsburgh, UPMC Presbyterian, 200 Lothrop Street, Suite C-800, Pittsburgh, PA 15213, USA
Surg Clin North Am 82:711-28. 2002..A multi-institutional prospective trial is planned to evaluate the clinical and oncologic results of MIE for cancer compared with traditional open surgery...- Photodynamic therapy as palliation for esophageal cancer: experience in 215 patientsVirginia R Litle
Division of Thoracic and Foregut Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Ann Thorac Surg 76:1687-92; discussion 1692-3. 2003..The ideal EC patient for PDT palliation has an obstructing endoluminal cancer. Patients living more than 2 months may require reintervention to maintain palliation of malignant dysphagia, and a multimodality treatment approach is common... - Results of laparoscopic repair of giant paraesophageal hernias: 200 consecutive patientsAndrew F Pierre
Division of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Ann Thorac Surg 74:1909-15; discussion 1915-6. 2002..CONCLUSIONS: Laparoscopic repair of GPEH is possible in the majority of patients with acceptable morbidity, a median length of hospital stay of 3 days and excellent intermediate-term results in an experienced center... - Photodynamic therapy for endobronchial metastases from nonbronchogenic primariesVirginia R Litle
Division of Thoracic and Foregut Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Ann Thorac Surg 76:370-5; discussion 375. 2003..Photodynamic therapy was effective in palliating hemoptysis or dyspnea from EBM with an acceptable morbidity, although the 30-day mortality was 22%... - Minimally invasive esophagectomyAlberto De Hoyos
Division of Thoracic and Foregut Surgery and the Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, UPMC Presbyterian, Suite C-800, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Surg Clin North Am 85:631-47. 2005..Prospective trials with longer follow-up will be required to confirm any advantages of MIE over conventional approaches. Open surgical approaches should remain the standard operation for esophagectomy in most institutions... - Minimally invasive esophagectomy: outcomes in 222 patientsJames D Luketich
Division of Thoracic Surgery and Foregut Surgery, University of Pittsburgh Medical Center, Pittsburgh 15213, USA
Ann Surg 238:486-94; discussion 494-5. 2003..4%) and shorter hospital stay (7 days) than most open series. Given these results, we are now developing an intergroup trial (ECOG 2202) to assess MIE in a multicenter setting...
Research Grants
- Micro RNA expression in esophageal adenocarcinomaVirginia Litle; Fiscal Year: 2007..Identification of unique miRNA profiles should be useful in molecular classification of premalignant esophageal lesions and GEJ adenocarcinomas and thus improve the current surgical treatment and outcome from this deadly disease. ..