Xiu Min Li

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Novel approaches for the treatment of food allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Curr Opin Allergy Clin Immunol 2:273-8. 2002
  2. ncbi The potential use of Chinese herbal medicines in treating allergic asthma
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 93:S35-44. 2004
  3. ncbi Traditional Chinese medicine for the therapy of allergic disorders
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Curr Opin Otolaryngol Head Neck Surg 14:191-6. 2006
  4. ncbi Beyond allergen avoidance: update on developing therapies for peanut allergy
    Xiu Min Li
    Pediatric Allergy and Immunology, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Curr Opin Allergy Clin Immunol 5:287-92. 2005
  5. ncbi Complementary and alternative medicine in pediatric allergic disorders
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Curr Opin Allergy Clin Immunol 9:161-7. 2009
  6. ncbi Treatment of asthma and food allergy with herbal interventions from traditional chinese medicine
    Xiu Min Li
    Department of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 78:697-716. 2011
  7. ncbi Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis
    Ivan Lopez-Exposito
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Chin Med 6:35. 2011
  8. ncbi Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 170:3289-95. 2003
  9. ncbi Traditional Chinese herbal remedies for asthma and food allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 120:25-31. 2007
  10. ncbi Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma
    Tengfei Zhang
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Phytother Res 24:1047-55. 2010

Research Grants

  1. Effects of Chinese Herbal Medicines on Allergic Asthma
    Xiu Min Li; Fiscal Year: 2003
  2. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2007
  3. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2009
  4. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2010

Collaborators

Detail Information

Publications39

  1. ncbi Novel approaches for the treatment of food allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Curr Opin Allergy Clin Immunol 2:273-8. 2002
    ....
  2. ncbi The potential use of Chinese herbal medicines in treating allergic asthma
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 93:S35-44. 2004
    ....
  3. ncbi Traditional Chinese medicine for the therapy of allergic disorders
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Curr Opin Otolaryngol Head Neck Surg 14:191-6. 2006
    ..This review summarizes the important publications focusing on traditional Chinese medicine therapies for allergic disorders in the year 2005...
  4. ncbi Beyond allergen avoidance: update on developing therapies for peanut allergy
    Xiu Min Li
    Pediatric Allergy and Immunology, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Curr Opin Allergy Clin Immunol 5:287-92. 2005
    ..Attempts to manage peanut allergy by strict avoidance are often unsuccessful. The purpose of this review is to highlight the most promising novel approaches for treating peanut allergy beyond allergen avoidance...
  5. ncbi Complementary and alternative medicine in pediatric allergic disorders
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Curr Opin Allergy Clin Immunol 9:161-7. 2009
    ..This review focuses on traditional Chinese medicine (TCM) herbal products and acupuncture for treating pediatric allergies...
  6. ncbi Treatment of asthma and food allergy with herbal interventions from traditional chinese medicine
    Xiu Min Li
    Department of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 78:697-716. 2011
    ..This review article discusses promising traditional Chinese medicine interventions for asthma, food allergy, and comorbid conditions, and explores their possible mechanisms of action...
  7. ncbi Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis
    Ivan Lopez-Exposito
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Chin Med 6:35. 2011
    ..abstract:..
  8. ncbi Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 170:3289-95. 2003
    ..These results show that immunotherapy with modified PN proteins and HKLM is effective for treating PN allergy in this model, and may be a potential approach for treating PNA...
  9. ncbi Traditional Chinese herbal remedies for asthma and food allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 120:25-31. 2007
    ..This effort may lead to improved therapies and better health care/patient outcomes. This review presents an update on the most promising Chinese herbal remedies for asthma and food allergy...
  10. ncbi Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma
    Tengfei Zhang
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Phytother Res 24:1047-55. 2010
    ..ASHMI abrogation of allergic airway responses is associated with broad effects on asthma pathological mechanisms...
  11. ncbi Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo
    Paula J Busse
    Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 116:1256-63. 2005
    ..TNF-alpha increases the expression of these genes in vitro but has not been investigated in vivo...
  12. ncbi The traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice
    Paula J Busse
    Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann Allergy Asthma Immunol 104:236-46. 2010
    ..We developed a novel traditional Chinese medicine to treat asthma called antiasthma simplified herbal medicine intervention (ASHMI). Herbal products may offer safer adjunctive treatment for older asthmatic patients...
  13. ncbi Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells
    Kamal D Srivastava
    Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 123:443-51. 2009
    ..We previously reported that Food Allergy Herbal Formula (FAHF)-2) protected peanut-allergic mice against anaphylactic reactions as long as 4 weeks posttherapy. This formula is now in clinical trials in the United States...
  14. ncbi Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils
    Ying Song
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 126:1208-17.e3. 2010
    ..The Chinese herbal formula, food allergy herbal formula 2 (FAHF-2), protects against peanut anaphylaxis in mice. However, the mechanisms underlying this effect are not fully elucidated...
  15. ncbi Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula-2 (FAHF-2) on peanut allergy
    Jacob D Kattan
    Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Phytother Res 22:651-9. 2008
    ....
  16. ncbi Clinical safety of Food Allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study
    Sangita P Patil
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 128:1259-1265.e2. 2011
    ..Food Allergy Herbal Formula-2 (FAHF-2) blocks peanut-induced anaphylaxis in a murine model of peanut-induced anaphylaxis. It was found to be safe and well tolerated in an acute phase I study of patients with food allergy...
  17. ncbi Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma
    Paula J Busse
    Division of Clinical Immunology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann Allergy Asthma Immunol 103:295-303. 2009
    ..Anti-TNF-a decreased asthma exacerbations and improved forced expiratory volume in 1 second in these patients. Whether anti-TNF-a reduces mucous cell metaplasia or hyperplasia has not been evaluated...
  18. ncbi Persistent protective effect of heat-killed Escherichia coli producing "engineered," recombinant peanut proteins in a murine model of peanut allergy
    Xiu-Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    J Allergy Clin Immunol 112:159-67. 2003
    ..CONCLUSIONS: Treatment with pr HKE-MP123 can induce long-term "downregulation" of peanut hypersensitivity, which might be secondary to decreased antigen-specific T(H)2 and increased T(H)1 and T regulatory cytokine production...
  19. ncbi The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy
    Kamal D Srivastava
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    J Allergy Clin Immunol 115:171-8. 2005
    ..This result was associated with downregulation of T H 2 responses. FAHF-2 may be a potentially effective and safe therapy for peanut allergy...
  20. ncbi Maternal peanut exposure during pregnancy and lactation reduces peanut allergy risk in offspring
    Ivan Lopez-Exposito
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:1039-46. 2009
    ..However, there is no direct evidence of maternal transmission of PNA susceptibility, and it is unknown whether maternal peanut exposure affects the development of PNA in offspring...
  21. ncbi Efficacy and immunological actions of FAHF-2 in a murine model of multiple food allergies
    Kamal D Srivastava
    Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Ann Allergy Asthma Immunol 108:351-358.e1. 2012
    ..Multiple food allergies (MFA) are common and associated with a higher risk of anaphylaxis. No well-characterized murine model of sensitization to multiple food allergens exists, and no satisfactory therapy for MFA is currently available...
  22. ncbi Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study
    Julie Wang
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 105:75-84. 2010
    ..A new herbal product, called food allergy herbal formula 2 (FAHF-2), has been demonstrated to have a high safety profile and potent long-term efficacy in a murine model of peanut-induced anaphylaxis...
  23. ncbi Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice
    Paula J Busse
    Department of Medicine, Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY, USA
    Clin Exp Allergy 37:1392-403. 2007
    ..The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized...
  24. ncbi Immunomodulatory effect of the antiasthma Chinese herbal formula MSSM-002 on TH2 cells
    Kamal Srivastava
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 113:268-76. 2004
    ..CONCLUSION: MSSM-002, in contrast to the overall suppression of T cells by dexamethasone, exhibits immunomodulatory actions on T(H)2 cells caused, at least partially, by downregulation of GATA-3...
  25. ncbi Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study
    Kristin Kelly-Pieper
    Division of Pediatric Pulmonary Medicine, Columbia University, New York, NY, USA
    J Altern Complement Med 15:735-43. 2009
    ..A novel three-herb antiasthma herbal medicine intervention (ASHMI; Sino-Lion Pharmaceutical Company; Shan Dong China) was demonstrated to be effective and safe in a murine model of asthma and in a preliminary clinical study in China...
  26. ncbi Detection of immunological biomarkers correlated with asthma control and quality of life measurements in sera from chronic asthmatic patients
    Sangita P Patil
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 106:205-13. 2011
    ..Clinical outcomes of patients with asthma are highly variable. Immunological biomarkers associated with asthma control have not been elucidated...
  27. ncbi Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 123:297-306; quiz 307-8. 2009
    ..There is increasing scientific evidence supporting the use of TCM for asthma treatment...
  28. ncbi New approaches for the treatment of anaphylaxis
    Donald Y M Leung
    Division of Pediatric Allergy/Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Novartis Found Symp 257:248-60; discussion 260-4, 276-85. 2004
    ..These studies suggest that treatment of patients with anti-IgE therapy may represent an effective long-term approach for management of food-induced anaphylaxis...
  29. ncbi Chinese herbal therapy for the treatment of food allergy
    Julie Wang
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Curr Allergy Asthma Rep 12:332-8. 2012
    ..Currently, a phase 2 trial examining efficacy of FAHF-2 is on-going. Other TCMs also show a potential for treating food allergies in preclinical studies...
  30. ncbi Alternative and complementary treatment for food allergy
    Julia Ann Wisniewski
    Department of Pediatrics, Division of Allergy and Immunology, University of Virginia, 409 Lane Road, Box 801355, Charlottesville, VA 22908, USA
    Immunol Allergy Clin North Am 32:135-50. 2012
    ..The mechanism of action of several novel approaches to treatment of food allergy is reviewed, but FAHF-2 is the only investigational herbal formulation currently validated for use in human clinical trials...
  31. ncbi Novel approaches to immunotherapy for food allergy
    Xiu-Min Li
    Mount Sinai School of Medicine, New York, New York, USA
    Clin Allergy Immunol 18:663-79. 2004
  32. ncbi sPLA2-IIa amplifies ocular surface inflammation in the experimental dry eye (DE) BALB/c mouse model
    Yi Wei
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Invest Ophthalmol Vis Sci 52:4780-8. 2011
    ..However, its role in ocular surface inflammation remains unclear. An experimentally induced BALB/c mouse dry eye (DE) model was used to elucidate the role of sPLA2-IIa in ocular surface inflammation...
  33. ncbi Use of complementary and alternative medicine by food-allergic patients
    Jimmy Ko
    Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann Allergy Asthma Immunol 97:365-9. 2006
    ..Interest in complementary and alternative medicine (CAM) is increasing. Use of CAM in food-allergic patients has not previously been evaluated...
  34. ncbi Use of herbal remedies and adherence to inhaled corticosteroids among inner-city asthmatic patients
    Angkana Roy
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York, USA
    Ann Allergy Asthma Immunol 104:132-8. 2010
    ..However, it is unclear whether use of the herbal remedies is associated with decreased adherence to inhaled corticosteroids (ICSs), a key component of asthma management...
  35. ncbi Elevated immune response in the brain of autistic patients
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, USA
    J Neuroimmunol 207:111-6. 2009
    ..Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD...
  36. ncbi The effect of oral tolerance on the allergic airway response in younger and aged mice
    Janette M Birmingham
    Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Asthma 50:122-32. 2013
    ..The effect of increased age on the induction of oral tolerance by low-dose antigen feeding and its effect on the response to antigen airway challenge in aged mice have not been well characterized...
  37. ncbi Effects and mechanisms of actions of Chinese herbal medicines for asthma
    Min Li Hong
    Center for Chinese Medicine for Allergy and Asthma, Jaffe Food Allergy Institute, Pediatric Department, Division of Allergy and Immunology, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Chin J Integr Med 17:483-91. 2011
    ..More controlled clinical studies are warranted and some anti-asthma CM may be proved to be effective when used as monotherapy or complementary asthma therapies...
  38. ncbi Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro
    Bolleddula Jayaprakasam
    Departments of Pediatrics, Genetics and Genomics Science, and Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York City, New York 10029, USA
    J Agric Food Chem 57:820-5. 2009
    ..2, 0.92, and 0.21 microg/mL, respectively, demonstrating that Glycyrrhiza flavonoids inhibit eotaxin-1 secretion in vitro...
  39. ncbi Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma
    Ming Chun Wen
    Weifang Asthma Hospital, Shandong, China
    J Allergy Clin Immunol 116:517-24. 2005
    ..Chinese herbal medicine has a long history of human use. A novel herbal formula, anti-asthma herbal medicine intervention (ASHMI), has been shown to be an effective therapy in a murine model of allergic asthma...

Research Grants8

  1. Effects of Chinese Herbal Medicines on Allergic Asthma
    Xiu Min Li; Fiscal Year: 2003
    ..Accomplishing these goals should provide an experimental basis for applying Chinese herbal medicines to the treatment of allergic asthma, and for understanding immunoregulatory mechanisms underlying their effects. ..
  2. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2007
    ..These studies may lead to a novel approach for treating PNA, and other IgE mediated food allergies. ..
  3. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2009
    ....
  4. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2010
    ....