Xiaohong Li

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Elevated immune response in the brain of autistic patients
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, USA
    J Neuroimmunol 207:111-6. 2009
  2. doi Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 76:54-62. 2009
  3. doi PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA
    Dev Biol 356:475-85. 2011
  4. ncbi Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Biochim Biophys Acta 1782:1-9. 2008
  5. doi Analysis of inflammatory cytokines in the tears of dry eye patients
    Morgan L Massingale
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cornea 28:1023-7. 2009
  6. pmc The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome
    Hongen Wei
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York, United States of America
    PLoS ONE 7:e36981. 2012
  7. doi Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA
    Biochim Biophys Acta 1822:831-42. 2012
  8. ncbi Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney
    Xiaohong Li
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Soc Nephrol 16:3543-52. 2005
  9. ncbi Disruption of polycystin-1 function interferes with branching morphogenesis of the ureteric bud in developing mouse kidneys
    Katalin Polgar
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Dev Biol 286:16-30. 2005
  10. pmc Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects
    Hongen Wei
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York 10314, USA
    Am J Pathol 179:66-74. 2011

Research Grants

Collaborators

  • Patricia D Wilson
  • Hongen Wei
  • Yi Wei
  • Kun Yang
  • Abha Chauhan
  • Penny A Asbell
  • Kathryn K Chadman
  • Marius Sudol
  • Fei Liu
  • Cheng Xin Gong
  • GABRIELE LUCA GUSELLA
  • ERIC NEILSON
  • Xiaohua Wu
  • Daniel P McCloskey
  • Neil Bhowmick
  • Rebecca Chan
  • Mazhar Malik
  • Ashfaq M Sheikh
  • Guang Wen
  • Dongmei Chen
  • Morgan L Massingale
  • Feng Chun Yang
  • Jin Yuan
  • Shi Chen
  • Fujiang Cao
  • Zujaja Tauqeer
  • Amenah Nagori
  • W Ted Brown
  • William T Brown
  • Maithreyi Vallabhajosyula
  • Jincheng Yan
  • Xinli Zhu
  • VERONICA R PLACENCIO
  • Yan Li
  • Yangxin Li
  • Todd D Nebesio
  • Selina A Estwick
  • Travis Clegg
  • Samantha J Wilson
  • Lorenzo Battini
  • Christopher R Burrow
  • Deborah P Hyink
  • Katalin Polgar
  • G E Woodard
  • Geoffrey E Woodard
  • Haiyu Zhang
  • George Merz
  • Frank Schirripa
  • Ailan Yin
  • Michael Schirripa
  • Warren Spivack
  • Michael D Fenko
  • Ved Chauhan
  • J Mario Wolosin
  • Seth Epstein
  • Robert J Matusik
  • Ali Reza Sharif-Afshar
  • Reuben Kapur
  • Consolate Uwamariya
  • Yingze Zhang
  • Reuben Karpur
  • Yan Jin
  • Alexander G Robling
  • Michael M Shen
  • Wenguo Cui
  • Hongxia Huang
  • Simon W Hayward
  • Yanzhu Yang
  • Wenyu Ming
  • Shuguang Lin
  • Xiyong Yu
  • Saidan Zhang
  • Yao Hua Song
  • Cynthia M Hingtgen
  • David A Ingram
  • D Wade Clapp
  • Waleed Khalaf
  • Trent Morgan
  • Jeff Travers
  • Luis F Parada
  • Weining Lu
  • Jing Zhou
  • Salvador Macip
  • Sarah Burgin
  • Kurt Amsler
  • Elena Fedorova
  • Katie Thornton
  • J A Rosado
  • John Brown
  • Juan A Rosado

Detail Information

Publications34

  1. pmc Elevated immune response in the brain of autistic patients
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, USA
    J Neuroimmunol 207:111-6. 2009
    ..Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD...
  2. doi Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 76:54-62. 2009
    ..These studies suggest that Polycystin-1 and Pin-1 may mediate the function of PRKX in kidney development...
  3. doi PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA
    Dev Biol 356:475-85. 2011
    ..The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could contribute to the stimulating role of PRKX in angiogenesis...
  4. ncbi Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Biochim Biophys Acta 1782:1-9. 2008
    ..These results suggest that PRKX can restore normal function to PKD1-deficient kidneys and have implications for the development of preventative therapy for ADPKD...
  5. doi Analysis of inflammatory cytokines in the tears of dry eye patients
    Morgan L Massingale
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cornea 28:1023-7. 2009
    ..To determine the levels of 8 important cytokines and 1 chemokine in tears of patients with dry eye disease...
  6. pmc The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome
    Hongen Wei
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York, United States of America
    PLoS ONE 7:e36981. 2012
    ..These findings suggest that memantine may exert its therapeutic capacity through a stimulatory effect on dendritic spine maturation and excitatory synapse formation, as well as promoting adhesion of CGCs...
  7. doi Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA
    Biochim Biophys Acta 1822:831-42. 2012
    ..These findings suggest that IL-6 elevation in the brain could mediate autistic-like behaviors, possibly through the imbalances of neural circuitry and impairments of synaptic plasticity...
  8. ncbi Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney
    Xiaohong Li
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Soc Nephrol 16:3543-52. 2005
    ..These results suggest that PRKX stimulates epithelial branching morphogenesis by activating cell migration and support a role for this kinase in the regulation of nephrogenesis and of collecting system development in the fetal kidney...
  9. ncbi Disruption of polycystin-1 function interferes with branching morphogenesis of the ureteric bud in developing mouse kidneys
    Katalin Polgar
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Dev Biol 286:16-30. 2005
    ....
  10. pmc Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects
    Hongen Wei
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, New York 10314, USA
    Am J Pathol 179:66-74. 2011
    ....
  11. doi Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development
    Kun Yang
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY, 10314, USA
    Brain Struct Funct 218:669-82. 2013
    ..Together, these results suggest that the up-regulation of the Raf/ERK signaling pathway may contribute to the pathogenesis of autism through both its impairment of cortical neuron development and causing neural circuit imbalances...
  12. pmc Alteration of astrocytes and Wnt/β-catenin signaling in the frontal cortex of autistic subjects
    Fujiang Cao
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island New York, NY 10314, USA
    J Neuroinflammation 9:223. 2012
    ..However, there is yet no direct evidence showing how astrocytes develop in the brain of autistic individuals...
  13. pmc PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis
    Xiaohong Li
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 99:9260-5. 2002
    ....
  14. ncbi Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia
    Samantha J Wilson
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochim Biophys Acta 1762:647-55. 2006
    ..These studies implicate HER2(neu/ErbB2) as an effector of apical EGFR complex mispolarization and that its inhibition should be considered a candidate for clinical therapy of ADPKD...
  15. pmc IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, USA
    J Neuroinflammation 8:52. 2011
    ..Recent evidence shows that IL-6 has a crucial role in the development and plasticity of CNS...
  16. doi BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects
    Ashfaq M Sheikh
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, New York 10314, USA
    J Neurosci Res 88:2641-7. 2010
    ..These results suggest that down-regulation of the BDNF-Akt-Bcl2 antiapoptotic signaling pathway in the autistic brain could be one of the underlying mechanisms responsible for the pathogenesis of autism...
  17. ncbi Analysis of inflammatory cytokines in the tears of dry eye patients
    Morgan L Massingale
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, USA
    Cornea 28:1023-7. 2009
    ..To determine the levels of 8 important cytokines and 1 chemokine in tears of patients with dry eye disease...
  18. pmc NF-κB signaling in the brain of autistic subjects
    Mazhar Malik
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Mediators Inflamm 2011:785265. 2011
    ..Our findings suggest that the NF-κB signaling pathway is not disregulated in the brain of autistic subjects and thus may not be significantly involved in the processes of abnormal inflammatory responses suggested in autistic brain...
  19. doi A novel approach for characterization of cathepsin D protease and its effect on tau and β-amyloid proteins
    Mazhar Malik
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island New York, NY 10314, USA
    Neurochem Res 36:754-60. 2011
    ..Our findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease. Our findings also indicate that cathepsin D could be a new approach to treating Alzheimer's disease...
  20. doi Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects
    Mazhar Malik
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Immunobiology 216:80-5. 2011
    ....
  21. ncbi Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance
    Lorenzo Battini
    Division of Renal Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Soc Nephrol 17:3049-58. 2006
    ..Furthermore, these findings indicate that reduction of PC1 expression levels, rather than the loss of heterozygosity, may be sufficient to induce cystogenesis...
  22. doi sPLA2-IIa is an inflammatory mediator when the ocular surface is compromised
    Dongmei Chen
    Department of Ophthalmology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Eye Res 88:880-8. 2009
    ..These findings indicate that sPLA2-IIa may play an important role in chronic ocular surface inflammation, especially when the ocular surface is compromised...
  23. doi Genes associated with autism spectrum disorder
    Xiaohong Li
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, United States
    Brain Res Bull 88:543-52. 2012
    ....
  24. doi Phosphorylation, protein kinases and ADPKD
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY, USA
    Biochim Biophys Acta 1812:1219-24. 2011
    ..The two proteins form a functional complex and prevent cyst formation, but the precise mechanism(s) involved remains unknown. This article is part of a Special Issue entitled: Polycystic Kidney Disease...
  25. pmc Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity
    VERONICA R PLACENCIO
    Departments of Cancer Biology, Urologic Surgery, and Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 68:4709-18. 2008
    ..These studies reveal a novel TGF-beta, androgen, and Wnt paracrine signaling axis that enables prostatic regression of the distal ducts after androgen ablation while supporting proximal duct survival...
  26. ncbi [The cloning and functional analysis of Sinorhizobium fredii 042BS regulatory modulation genes]
    Haiyu Zhang
    Department of Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Wei Sheng Wu Xue Bao 42:33-9. 2002
    ..leguminosarum bv. viciae LPR5054 to study the function of the nodD1. The results showed that nodD1 of 042B can be induced by genistein and luteolin secreted by the seedlings of soybean and alfalfa respectively...
  27. ncbi Receptor subtypes for vasonatrin peptide in renal glomeruli and arteries
    Geoffrey E Woodard
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Building 10, Rm 8C 208, 10 Center Drive, MSC 1752 Bethesda, MD 20892, USA
    Regul Pept 129:183-9. 2005
    ..Finally, we have found that VNP increases cGMP production in rat renal glomeruli, suggesting that this peptide functionally binds to NPR-A...
  28. ncbi Characteristics of the renal C-type natriuretic peptide receptor in hypertrophied and developing rat kidney
    G E Woodard
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1752, USA
    J Mol Endocrinol 35:519-30. 2005
    ..The enhanced inhibitory role of natriuretic peptides on cAMP synthesis in hypertrophied and developing kidney may influence glomerular function in the rat kidney and suggests a role for the 67 kDa NPR-C-like protein in growth...
  29. ncbi Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1
    Jincheng Yan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:936-48. 2008
    ..Collectively, these data demonstrate that Rac1 critically contributes to increased osteoclast function induced by haploinsufficiency of Nf1 and implicate Rac1 as a rational therapeutic target for osteoporosis...
  30. ncbi Renal atrial natriuretic peptide receptors binding properties and function are resistant to DOCA-salt-induced hypertension in rats
    Xiaohong Li
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Rm 8C 208, 10 Center Drive, MSC 1752, Bethesda, MD 20892 1752, USA
    Regul Pept 137:114-20. 2006
    ..These findings indicate that NPR-A and NPR-C binding properties and NPR-C-mediated inhibition of cAMP generation remain unaltered in DOCA-treated rats...
  31. pmc Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling
    Feng Chun Yang
    Department of Pediatrics, and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:2421-37. 2006
    ..Genetic or pharmacological inhibition of c-abl reverses fibroblast proliferation and collagen synthesis to wild-type levels. These studies identify a novel molecular target to inhibit neurofibroma formation...
  32. doi Electrospun fibrous mats with high porosity as potential scaffolds for skin tissue engineering
    Xinli Zhu
    Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People s Republic of China
    Biomacromolecules 9:1795-801. 2008
    ..It is supposed that highly porous electrospun fibrous scaffolds could be constructed by this elaboration and may be used for skin tissue engineering...
  33. ncbi Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy
    Todd D Nebesio
    Department of Pediatrics, Herman B Wells Center for Pediatric Cancer Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Glia 55:527-36. 2007
    ....
  34. ncbi Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells
    Yangxin Li
    Laboratory of Heart Failure and Stem Cell, Texas Heart Institute, Houston, TX 77030, USA
    Biochem Biophys Res Commun 356:780-4. 2007
    ..These findings provide a new paradigm for biological effects of IGF-1 on MSC and have implications for the development of novel stem cell therapeutic strategies...

Research Grants1

  1. Role of Serine/Threonine Protein Kinase in ADPKD
    Xiaohong Li; Fiscal Year: 2003
    ..abstract_text> ..