Steven R Levine

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Hypercoagulable states and stroke: a selective review
    Steven R Levine
    Stroke Program, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    CNS Spectr 10:567-78. 2005
  2. ncbi request reprint Pathophysiology and therapeutic targets for ischemic stroke
    Steven R Levine
    Stroke Program, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Cardiol 27:II12-24. 2004
  3. ncbi request reprint Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke
    Steven R Levine
    Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029 6574, USA
    JAMA 291:576-84. 2004
  4. ncbi request reprint Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Circulation 113:555-63. 2006
  5. pmc Patent foramen ovale, cardiac valve thickening, and antiphospholipid antibodies as risk factors for subsequent vascular events: the PICSS-APASS study
    Kumar Rajamani
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Stroke 40:2337-42. 2009
  6. doi request reprint Dosing errors did not have a major impact on outcome in the NINDS t-PA stroke study
    Steven R Messe
    Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Stroke Cerebrovasc Dis 20:236-40. 2011
  7. doi request reprint A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Stroke Cerebrovasc Dis 17:331-3. 2008
  8. ncbi request reprint Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    Marc I Chimowitz
    Department of Neurology, School of Medicine, Emory University, Atlanta, USA
    N Engl J Med 352:1305-16. 2005
  9. ncbi request reprint Improved quality of stroke care for hospitalized Medicare beneficiaries in Michigan
    Bradley S Jacobs
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Stroke 36:1227-31. 2005
  10. pmc Amino terminal pro-B-type natriuretic peptide, secondary stroke prevention, and choice of antithrombotic therapy
    W T Longstreth
    Department of Neurology, Harborview Medical Center, Seattle, WA, USA
    Stroke 44:714-9. 2013

Research Grants

  1. Stroke:Role of aPL, hemostatic markers, and telestroke
    Steven Levine; Fiscal Year: 2006
  2. CEREBROVASCULAR RESEARCH TRAINING PROGRAM
    Steven Levine; Fiscal Year: 2007

Detail Information

Publications44

  1. ncbi request reprint Hypercoagulable states and stroke: a selective review
    Steven R Levine
    Stroke Program, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    CNS Spectr 10:567-78. 2005
    ..Treatment of a first stroke with a documented hypercoagulable state is typically long-term or indefinite duration warfarin, although there is a paucity of clinical trial data supporting this clinical approach...
  2. ncbi request reprint Pathophysiology and therapeutic targets for ischemic stroke
    Steven R Levine
    Stroke Program, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Cardiol 27:II12-24. 2004
    ..An understanding of the pathophysiology of stroke and TIA can help identify appropriate therapeutic targets...
  3. ncbi request reprint Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke
    Steven R Levine
    Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029 6574, USA
    JAMA 291:576-84. 2004
    ..The presence of antiphospholipid antibodies (aPL) has been associated with vascular occlusive events. However, the role of aPL in predicting ischemic events, particularly recurrent ischemic stroke, is controversial...
  4. ncbi request reprint Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis
    Scott E Kasner
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Circulation 113:555-63. 2006
    ..A prespecified aim of WASID was to identify patients at highest risk for stroke in the territory of the stenotic artery who would be the target group for a subsequent trial comparing intracranial stenting with medical therapy...
  5. pmc Patent foramen ovale, cardiac valve thickening, and antiphospholipid antibodies as risk factors for subsequent vascular events: the PICSS-APASS study
    Kumar Rajamani
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Stroke 40:2337-42. 2009
    ..PFO is associated with cryptogenic ischemic stroke. Also, the presence of aPL is associated with ischemic cerebrovascular disease...
  6. doi request reprint Dosing errors did not have a major impact on outcome in the NINDS t-PA stroke study
    Steven R Messe
    Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Stroke Cerebrovasc Dis 20:236-40. 2011
    ....
  7. doi request reprint A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Stroke Cerebrovasc Dis 17:331-3. 2008
    ..Ability to predict risk of postthrombolysis intracerebral hemorrhage (ICH) is currently limited...
  8. ncbi request reprint Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis
    Marc I Chimowitz
    Department of Neurology, School of Medicine, Emory University, Atlanta, USA
    N Engl J Med 352:1305-16. 2005
    ..Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial...
  9. ncbi request reprint Improved quality of stroke care for hospitalized Medicare beneficiaries in Michigan
    Bradley S Jacobs
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Stroke 36:1227-31. 2005
    ..We investigated whether these and other measures improved after a quality improvement initiative...
  10. pmc Amino terminal pro-B-type natriuretic peptide, secondary stroke prevention, and choice of antithrombotic therapy
    W T Longstreth
    Department of Neurology, Harborview Medical Center, Seattle, WA, USA
    Stroke 44:714-9. 2013
    ....
  11. doi request reprint Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Stroke 40:3067-72. 2009
    ..A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies...
  12. ncbi request reprint Virtual TeleStroke support for the emergency department evaluation of acute stroke
    Lee H Schwamm
    Department of Neurology, VBK 915, Massachusetts General Hospital, Boston, MA 02114, USA
    Acad Emerg Med 11:1193-7. 2004
    ..Telemedicine-enabled acute stroke consultation (TeleStroke) may be useful to determine eligibility for treatment with tissue plasminogen activator (tPA) and provide support to emergency departments without on-site stroke expertise...
  13. pmc Teleneurology applications: Report of the Telemedicine Work Group of the American Academy of Neurology
    Lawrence R Wechsler
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 80:670-6. 2013
    ..To review current literature on neurology telemedicine and to discuss its application to patient care, neurology practice, military medicine, and current federal policy...
  14. ncbi request reprint Prediction of hospital disposition after thrombolysis for acute ischemic stroke using the National Institutes of Health Stroke Scale
    Daniel J Schlegel
    Comprehensive Stroke Center, Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, 3W Gates Building, Philadelphia, PA 19104, USA
    Arch Neurol 61:1061-4. 2004
    ..Early determination of discharge destination after acute stroke may promote earlier rehabilitation and reduce costs by shortening the duration of hospitalization...
  15. ncbi request reprint Thrombophilias and stroke: diagnosis, treatment, and prognosis
    Madeline C Fields
    Department of Neurology, Stroke Center, The Mount Sinai School of Medicine, New York 10029 6574, USA
    J Thromb Thrombolysis 20:113-26. 2005
  16. pmc Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial
    E Clarke Haley
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 41:707-11. 2010
    ..If promise was established, then the trial would continue as a Phase III efficacy trial comparing the selected tenecteplase dose to standard rtPA...
  17. doi request reprint Telestroke 10 years later--'telestroke 2.0'
    Jeffrey A Switzer
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Cerebrovasc Dis 28:323-30. 2009
    ..The lack of physicians with specialty stroke training represents a significant challenge to the future of stroke. This deficit limits both quality stroke care and clinical research initiatives...
  18. pmc Emergency physician and stroke specialist beliefs and expectations regarding telestroke
    Ari Moskowitz
    BA, The Mount Sinai School of Medicine, 50 E 98th Street 9K, New York, NY 10029
    Stroke 41:805-9. 2010
    ..Differences between barriers perceived by EPs and SSs need to be addressed to enhance acute ischemic stroke treatment...
  19. pmc Comparison of short-term outcomes of thrombolysis for in-hospital stroke and out-of-hospital stroke in United States
    Yogesh Moradiya
    Department of Neurology, Stroke Center, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Stroke 44:1903-8. 2013
    ..In-hospital stroke (IHS) differs from out-of-hospital stroke (OHS) in risk factors and outcomes. We compared IHS and OHS treated with thrombolysis from a large national cohort in a cross-sectional study to further clarify these differences...
  20. ncbi request reprint Do gender and race impact the use of antithrombotic therapy in patients with stroke/TIA?
    Lynda D Lisabeth
    Stroke Program, University of Michigan Health System, Ann Arbor, MI 48109 0489, USA
    Neurology 62:2313-5. 2004
    ....
  21. pmc Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials
    Pooja Khatri
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
    Stroke 41:2581-6. 2010
    ..We sought to further characterize the patients with minor stroke who were included in the National Institute of Neurological Disorders and Stroke trials...
  22. ncbi request reprint Detection of carotid stenosis in African Americans with ischemic heart disease
    Kumar Rajamani
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    J Vasc Surg 43:1162-5. 2006
    ..This study was conducted to define the frequency of internal carotid stenosis in African American patients with ischemic heart disease (IHD)...
  23. ncbi request reprint Lessons from adult stroke trials
    Steven G Pavlakis
    Mount Sinai School of Medicine, New York, New York, USA
    Pediatr Neurol 34:446-9. 2006
    ..Because clinical trials, more often than not, fail to give positive (effective treatment) results, it seems reasonable to attempt to learn from others' past experiences before initiating pediatric stroke trials...
  24. doi request reprint The management of stroke in antiphospholipid syndrome
    Kessarin Panichpisal
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
    Curr Rheumatol Rep 14:99-106. 2012
    ..Alternative and emerging therapies including low molecular weight heparin, new oral anticoagulants (including direct thrombin inhibitors), hydroxychloroquine, statins, and rituximab, are also addressed...
  25. doi request reprint Effectiveness of stroke education in the emergency department waiting room
    Yu Feng Yvonne Chan
    Department of Emergency Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Stroke Cerebrovasc Dis 19:209-15. 2010
    ..We hypothesized that showing educational videos, providing one-on-one counseling, and distributing literature would result in greater stroke knowledge and positive behavioral modification...
  26. ncbi request reprint Neuropsychiatric disorders following vascular brain injury
    Eran Chemerinski
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:1006-14. 2006
    ..Much less is known about the potential impact of psychiatric conditions on recovery after stroke. Controlled trials will be able to adequately determine the effectiveness of treatment for these disorders...
  27. ncbi request reprint HandiStroke: a handheld tool for the emergent evaluation of acute stroke patients
    Jason Shapiro
    Stroke Program, Department of Emergency Medicine, Division of Informatics, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Acad Emerg Med 10:1325-8. 2003
    ..There is a need for tools to facilitate the evaluation and decision making in the acute stroke patient to make the correct diagnosis and, when indicated, to properly administer intravenous thrombolytic therapy...
  28. ncbi request reprint National Stroke Association guidelines for the management of transient ischemic attacks
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Ann Neurol 60:301-13. 2006
    ..Management varies widely, and most published guidelines have not been updated in several years. We sought to create comprehensive, unbiased, evidence-based guidelines for the management of patients with transient ischemic attacks...
  29. ncbi request reprint Stroke trials: what have we learned?
    Ramesh Madhavan
    Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
    Neurol Res 24:S27-32. 2002
    ..Studies in communities utilizing intravenous tPA for stroke illustrate the need for close adherence to the NINDS study protocol or else the risk of tPA use may exceed the benefits...
  30. ncbi request reprint Postpartum eclampsia complicated by reversible cerebral herniation
    Victoria Belogolovkin
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai Medical Center, NY 10029 6574, USA
    Obstet Gynecol 107:442-5. 2006
    ..We present, to our knowledge, the first reported case of late postpartum eclampsia complicated by posterior reversible encephalopathy syndrome and reversible cerebral herniation...
  31. ncbi request reprint Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey
    David Tanne
    Stroke Unit, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Circulation 105:1679-85. 2002
    ..Our aim was to identify, in a large cohort of patients, readily available baseline factors that are associated with thrombolysis-related ICH...
  32. ncbi request reprint Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
    Werner Hacke
    Medical University at Heidelberg, Germany
    Lancet 363:768-74. 2004
    ..Quick administration of intravenous recombinant tissue plasminogen activator (rt-PA) after stroke improved outcomes in previous trials. We aimed to analyse combined data for individual patients to confirm the importance of rapid treatment...
  33. ncbi request reprint In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
    Stroke 35:1141-6. 2004
    ..We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA)...
  34. ncbi request reprint Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study
    Edward C Jauch
    Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0769, USA
    Stroke 37:2508-13. 2006
    ..These biochemical markers, myelin basic protein (MBP), neuron-specific enolase (NSE), S100beta, and soluble thrombomodulin, were studied for an association with initial stroke severity, infarct volume, and functional outcome...
  35. ncbi request reprint Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
    Stroke 36:2110-5. 2005
    ..We examined whether ASPECTS could be a treatment modifier by systematically reviewing the CT scans in the NINDS rtPA Stroke Study...
  36. ncbi request reprint Acute ischemic stroke in hospitalized medicare patients: evaluation and treatment
    Canopy Roychoudhury
    Michigan Peer Review Organization, Plymouth, Mich 48170, USA
    Stroke 35:e22-3. 2004
    ..This study describes several quality indicators of care in hospitalized stroke patients in Michigan from 1998 to 1999...
  37. ncbi request reprint Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke
    David Tanne
    Stroke Center, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Stroke 37:1798-804. 2006
    ..We investigated in an exploratory, post hoc analysis the relationship between hemostatic markers and clinical outcomes among patients included in the National Institute of Neurological Disorders and Stroke (NINDS) rtPA Stroke Study...
  38. ncbi request reprint Smoke without fire: the complex effects of cigarette smoking on thrombolytic therapy for acute ischemic stroke
    Steven R Levine
    Neurology 65:183. 2005
  39. ncbi request reprint aPL and stroke in young women: more fuel for the stroke risk fire
    Stanley Tuhrim
    Stroke 33:2400-1. 2002
  40. ncbi request reprint Safer thrombolysis for acute ischemic stroke: is early recanalization the key?
    David Tanne
    Neurology 71:1300-1. 2008
  41. ncbi request reprint Patient page. Clot-busting therapy helps stroke victims--but only if they get treatment in time
    Madeline C Fields
    Neurology 64:E1-2. 2005
  42. ncbi request reprint The impact of imbalances in baseline stroke severity on outcome in the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study
    Thomas Kwiatkowski
    Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Ann Emerg Med 45:377-84. 2005
    ..Stroke severity was based on the NIH Stroke Scale. We also compare early mortality (2-week and 30-day) in the tPA and placebo groups...
  43. ncbi request reprint Anticardiolipin antibodies and mortality in patients with ischemic stroke: a prospective follow-up study
    David Tanne
    Detroit Medical Center Stroke Center, Wayne State University School of Medicine, Detroit, Mich, USA
    Neuroepidemiology 21:93-9. 2002
    ....
  44. ncbi request reprint Stroke knowledge and barriers to stroke prevention among African Americans: implications for health communication
    Charlotte A Pratt
    Resource Center for Cardiovascular Health, Michigan Public Health Institute, USA
    J Health Commun 8:369-81. 2003
    ..Stress and poor financial status were most frequently reported as barriers to stroke prevention. These findings have implications for developing more effective strategies for educating African Americans about stroke prevention...

Research Grants3

  1. Stroke:Role of aPL, hemostatic markers, and telestroke
    Steven Levine; Fiscal Year: 2006
    ....
  2. CEREBROVASCULAR RESEARCH TRAINING PROGRAM
    Steven Levine; Fiscal Year: 2007
    ....