Steven R Levine
Affiliation: Mount Sinai School of Medicine
- Pathophysiology and therapeutic targets for ischemic strokeSteven R Levine
Stroke Program, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
Clin Cardiol 27:II12-24. 2004..An understanding of the pathophysiology of stroke and TIA can help identify appropriate therapeutic targets...
- Hypercoagulable states and stroke: a selective reviewSteven R Levine
Stroke Program, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
CNS Spectr 10:567-78. 2005..Treatment of a first stroke with a documented hypercoagulable state is typically long-term or indefinite duration warfarin, although there is a paucity of clinical trial data supporting this clinical approach...
- Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic strokeSteven R Levine
Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029 6574, USA
JAMA 291:576-84. 2004..The presence of antiphospholipid antibodies (aPL) has been associated with vascular occlusive events. However, the role of aPL in predicting ischemic events, particularly recurrent ischemic stroke, is controversial...
- Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosisScott E Kasner
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Circulation 113:555-63. 2006..A prespecified aim of WASID was to identify patients at highest risk for stroke in the territory of the stenotic artery who would be the target group for a subsequent trial comparing intracranial stenting with medical therapy...
- Patent foramen ovale, cardiac valve thickening, and antiphospholipid antibodies as risk factors for subsequent vascular events: the PICSS-APASS studyKumar Rajamani
Department of Neurology, Wayne State University, Detroit, MI 48201, USA
Stroke 40:2337-42. 2009..PFO is associated with cryptogenic ischemic stroke. Also, the presence of aPL is associated with ischemic cerebrovascular disease...
- Dosing errors did not have a major impact on outcome in the NINDS t-PA stroke studySteven R Messe
Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Stroke Cerebrovasc Dis 20:236-40. 2011....
- A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic strokeBrett Cucchiara
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Stroke Cerebrovasc Dis 17:331-3. 2008..Ability to predict risk of postthrombolysis intracerebral hemorrhage (ICH) is currently limited...
- Improved quality of stroke care for hospitalized Medicare beneficiaries in MichiganBradley S Jacobs
Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
Stroke 36:1227-31. 2005..We investigated whether these and other measures improved after a quality improvement initiative...
- Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosisMarc I Chimowitz
Department of Neurology, School of Medicine, Emory University, Atlanta, USA
N Engl J Med 352:1305-16. 2005..Atherosclerotic intracranial arterial stenosis is an important cause of stroke. Warfarin is commonly used in preference to aspirin for this disorder, but these therapies have not been compared in a randomized trial...
- Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II TrialsBrett Cucchiara
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Stroke 40:3067-72. 2009..A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies...
- Virtual TeleStroke support for the emergency department evaluation of acute strokeLee H Schwamm
Department of Neurology, VBK 915, Massachusetts General Hospital, Boston, MA 02114, USA
Acad Emerg Med 11:1193-7. 2004..Telemedicine-enabled acute stroke consultation (TeleStroke) may be useful to determine eligibility for treatment with tissue plasminogen activator (tPA) and provide support to emergency departments without on-site stroke expertise...
- Teleneurology applications: Report of the Telemedicine Work Group of the American Academy of NeurologyLawrence R Wechsler
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neurology 80:670-6. 2013..To review current literature on neurology telemedicine and to discuss its application to patient care, neurology practice, military medicine, and current federal policy...
- Thrombophilias and stroke: diagnosis, treatment, and prognosisMadeline C Fields
Department of Neurology, Stroke Center, The Mount Sinai School of Medicine, New York 10029-6574, USA
J Thromb Thrombolysis 20:113-26. 2005
- Prediction of hospital disposition after thrombolysis for acute ischemic stroke using the National Institutes of Health Stroke ScaleDaniel J Schlegel
Comprehensive Stroke Center, Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, 3W Gates Building, Philadelphia, PA 19104, USA
Arch Neurol 61:1061-4. 2004..However, symptomatic ICH after rt-PA is a catastrophic event that may preclude discharge to home...
- Telestroke 10 years later--'telestroke 2.0'Jeffrey A Switzer
Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Cerebrovasc Dis 28:323-30. 2009..The lack of physicians with specialty stroke training represents a significant challenge to the future of stroke. This deficit limits both quality stroke care and clinical research initiatives...
- Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trialE Clarke Haley
Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
Stroke 41:707-11. 2010..If promise was established, then the trial would continue as a Phase III efficacy trial comparing the selected tenecteplase dose to standard rtPA...
- Emergency physician and stroke specialist beliefs and expectations regarding telestrokeAri Moskowitz
BA, The Mount Sinai School of Medicine, 50 E 98th Street 9K, New York, NY 10029
Stroke 41:805-9. 2010..Differences between barriers perceived by EPs and SSs need to be addressed to enhance acute ischemic stroke treatment...
- Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trialsPooja Khatri
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0525, USA
Stroke 41:2581-6. 2010..We sought to further characterize the patients with minor stroke who were included in the National Institute of Neurological Disorders and Stroke trials...
- Detection of carotid stenosis in African Americans with ischemic heart diseaseKumar Rajamani
Department of Neurology, Wayne State University, Detroit, MI 48201, USA
J Vasc Surg 43:1162-5. 2006..CONCLUSION: African American patients with established IHD have higher rates of extracranial carotid stenosis than community dwelling African American subjects and comparable rates with other populations...
- Do gender and race impact the use of antithrombotic therapy in patients with stroke/TIA?Lynda D Lisabeth
Stroke Program, University of Michigan Health System, Ann Arbor, MI 48109 0489, USA
Neurology 62:2313-5. 2004....
- Amino terminal pro-B-type natriuretic peptide, secondary stroke prevention, and choice of antithrombotic therapyW T Longstreth
Department of Neurology, Harborview Medical Center, Seattle, WA, USA
Stroke 44:714-9. 2013....
- Lessons from adult stroke trialsSteven G Pavlakis
Mount Sinai School of Medicine, New York, New York, USA
Pediatr Neurol 34:446-9. 2006..Because clinical trials, more often than not, fail to give positive (effective treatment) results, it seems reasonable to attempt to learn from others' past experiences before initiating pediatric stroke trials...
- The management of stroke in antiphospholipid syndromeKessarin Panichpisal
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203 2098, USA
Curr Rheumatol Rep 14:99-106. 2012..Alternative and emerging therapies including low molecular weight heparin, new oral anticoagulants (including direct thrombin inhibitors), hydroxychloroquine, statins, and rituximab, are also addressed...
- Neuropsychiatric disorders following vascular brain injuryEran Chemerinski
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 73:1006-14. 2006..Much less is known about the potential impact of psychiatric conditions on recovery after stroke. Controlled trials will be able to adequately determine the effectiveness of treatment for these disorders...
- Effectiveness of stroke education in the emergency department waiting roomYu Feng Yvonne Chan
Department of Emergency Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Stroke Cerebrovasc Dis 19:209-15. 2010..We hypothesized that showing educational videos, providing one-on-one counseling, and distributing literature would result in greater stroke knowledge and positive behavioral modification...
- HandiStroke: a handheld tool for the emergent evaluation of acute stroke patientsJason Shapiro
Stroke Program, Department of Emergency Medicine, Division of Informatics, The Mount Sinai School of Medicine, New York, NY 10029-6574, USA
Acad Emerg Med 10:1325-8. 2003....
- Stroke trials: what have we learned?Ramesh Madhavan
Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
Neurol Res 24:S27-32. 2002..Studies in communities utilizing intravenous tPA for stroke illustrate the need for close adherence to the NINDS study protocol or else the risk of tPA use may exceed the benefits...
- National Stroke Association guidelines for the management of transient ischemic attacksS Claiborne Johnston
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Ann Neurol 60:301-13. 2006..Management varies widely, and most published guidelines have not been updated in several years. We sought to create comprehensive, unbiased, evidence-based guidelines for the management of patients with transient ischemic attacks...
- Postpartum eclampsia complicated by reversible cerebral herniationVictoria Belogolovkin
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai Medical Center, NY 10029 6574, USA
Obstet Gynecol 107:442-5. 2006..We present, to our knowledge, the first reported case of late postpartum eclampsia complicated by posterior reversible encephalopathy syndrome and reversible cerebral herniation...
- Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic strokeDavid Tanne
Stroke Center, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Stroke 37:1798-804. 2006..We investigated in an exploratory, post hoc analysis the relationship between hemostatic markers and clinical outcomes among patients included in the National Institute of Neurological Disorders and Stroke (NINDS) rtPA Stroke Study...
- Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke SurveyDavid Tanne
Stroke Unit, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
Circulation 105:1679-85. 2002..Our aim was to identify, in a large cohort of patients, readily available baseline factors that are associated with thrombolysis-related ICH...
- In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?David M Kent
Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
Stroke 35:1141-6. 2004..We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA)...
- Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke StudyAndrew M Demchuk
Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
Stroke 36:2110-5. 2005..We examined whether ASPECTS could be a treatment modifier by systematically reviewing the CT scans in the NINDS rtPA Stroke Study...
- Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trialsWerner Hacke
Medical University at Heidelberg, Germany
Lancet 363:768-74. 2004..0002). INTERPRETATION: The sooner that rt-PA is given to stroke patients, the greater the benefit, especially if started within 90 min. Our results suggest a potential benefit beyond 3 h, but this potential might come with some risks...
- Acute ischemic stroke in hospitalized medicare patients: evaluation and treatmentCanopy Roychoudhury
Michigan Peer Review Organization, Plymouth, Mich 48170, USA
Stroke 35:e22-3. 2004..This study describes several quality indicators of care in hospitalized stroke patients in Michigan from 1998 to 1999...
- Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke StudyEdward C Jauch
Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0769, USA
Stroke 37:2508-13. 2006..These biochemical markers, myelin basic protein (MBP), neuron-specific enolase (NSE), S100beta, and soluble thrombomodulin, were studied for an association with initial stroke severity, infarct volume, and functional outcome...
- aPL and stroke in young women: more fuel for the stroke risk fireStanley Tuhrim
Stroke 33:2400-1. 2002
- Stroke knowledge and barriers to stroke prevention among African Americans: implications for health communicationCharlotte A Pratt
Resource Center for Cardiovascular Health, Michigan Public Health Institute, USA
J Health Commun 8:369-81. 2003..Stress and poor financial status were most frequently reported as barriers to stroke prevention. These findings have implications for developing more effective strategies for educating African Americans about stroke prevention...
- Smoke without fire: the complex effects of cigarette smoking on thrombolytic therapy for acute ischemic strokeSteven R Levine
Neurology 65:183. 2005
- Safer thrombolysis for acute ischemic stroke: is early recanalization the key?David Tanne
Neurology 71:1300-1. 2008
- Anticardiolipin antibodies and mortality in patients with ischemic stroke: a prospective follow-up studyDavid Tanne
Detroit Medical Center Stroke Center, Wayne State University School of Medicine, Detroit, Mich, USA
Neuroepidemiology 21:93-9. 2002....
- The impact of imbalances in baseline stroke severity on outcome in the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke StudyThomas Kwiatkowski
Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
Ann Emerg Med 45:377-84. 2005..Stroke severity was based on the NIH Stroke Scale. We also compare early mortality (2-week and 30-day) in the tPA and placebo groups...
- Patient page. Clot-busting therapy helps stroke victims--but only if they get treatment in timeMadeline C Fields
Neurology 64:E1-2. 2005
- Stroke:Role of aPL, hemostatic markers, and telestrokeSteven Levine; Fiscal Year: 2006....
- CEREBROVASCULAR RESEARCH TRAINING PROGRAMSteven Levine; Fiscal Year: 2007....