Affiliation: Mount Sinai School of Medicine
Papatsenko D, Darr H, Kulakovskiy I, Waghray A, Makeev V, MacArthur B, et al
. Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal. Stem Cell Reports. 2015;5:207-20 pubmed publisher
..Analyses of such incoherent feedforward loops with feedback (iFFL-FB) suggest a dynamic model for the maintenance of mESC pluripotency and self-renewal. ..
Papatsenko D, Lemischka I. Emerging Modeling Concepts and Solutions in Stem Cell Research. Curr Top Dev Biol. 2016;116:709-21 pubmed publisher
Lee D, Su J, Kim H, Chang B, Papatsenko D, Zhao R, et al
. Modeling familial cancer with induced pluripotent stem cells. Cell. 2015;161:240-54 pubmed publisher
..In summary, these findings demonstrate the feasibility of studying inherited human cancer syndromes with iPSCs. ..
Waghray A, Saiz N, Jayaprakash A, Freire A, Papatsenko D, Pereira C, et al
. Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm. Stem Cell Reports. 2015;5:97-110 pubmed publisher
..In conclusion, we identify a signaling-TF axis that controls the exit of mESCs from a self-renewing pluripotent state toward mesoderm differentiation. ..
Gingold J, Coakley E, Su J, Lee D, Lau Z, Zhou H, et al
. Distribution Analyzer, a methodology for identifying and clustering outlier conditions from single-cell distributions, and its application to a Nanog reporter RNAi screen. BMC Bioinformatics. 2015;16:225 pubmed publisher
..We find several outliers from a mouse ESC RNAi screen that we confirm to be pluripotency regulators. Many of these outliers would have been missed by other analysis methods. ..
Gingold J, Fidalgo M, Guallar D, Lau Z, Sun Z, Zhou H, et al
. A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Mol Cell. 2014;56:140-52 pubmed publisher
..Our study thus uncovers the interplay between Nanog and mesenchymal factors Snai1 and Snai2 in the transcriptional regulation of pluripotency-associated genes and miRNAs during the Nanog-driven reprogramming process. ..