Research Topics
| M LawSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Detail Information
Publications
Dynamic susceptibility contrast-enhanced perfusion and conventional MR imaging findings for adult patients with cerebral primitive neuroectodermal tumorsMeng Law
Department of Radiology, New York University Medical Center, New York, NY 10016, USA
AJNR Am J Neuroradiol 25:997-1005. 2004....- High cerebral blood volume in human gliomas predicts deletion of chromosome 1p: Preliminary results of molecular studies in gliomas with elevated perfusionMeng Law
Department of Radiology, NYU Medical Center, New York, NY, USA
J Magn Reson Imaging 25:1113-9. 2007..Loss of heterozygosity of chromosomes 1p and 19q confers responsiveness to chemotherapy improving survival in gliomas... - Histogram analysis versus region of interest analysis of dynamic susceptibility contrast perfusion MR imaging data in the grading of cerebral gliomasM Law
Department of Radiology, NYU Medical Center, New York, NY, USA
AJNR Am J Neuroradiol 28:761-6. 2007..We compare the routine ROI method with histogram analysis in the grading of glial neoplasms... 
Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imagingMeng Law
Department of Radiology, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
Radiology 247:490-8. 2008....- Comparing perfusion metrics obtained from a single compartment versus pharmacokinetic modeling methods using dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma gradeM Law
Department of Radiology, NYU Medical Center, New York, NY 10016, USA
AJNR Am J Neuroradiol 27:1975-82. 2006..Parameters derived from 3 different analyses were correlated with histopathologically confirmed grade in gliomas to determine which parameters best predict tumor grade... - Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal-appearing corpus callosum: support for primary hypoperfusion in multiple sclerosisA M Saindane
Department of Radiology, New York University Medical Center, New York, NY, USA
AJNR Am J Neuroradiol 28:767-72. 2007..This study evaluated whether correlating perfusion and diffusion tensor imaging (DTI) metrics in normal-appearing corpus callosum could provide support for an ischemic mechanism for hypoperfusion... - Predicting grade of cerebral glioma using vascular-space occupancy MR imagingH Lu
Department of Radiology, New York University School of Medicine, New York, NY, USA
AJNR Am J Neuroradiol 29:373-8. 2008..We hypothesize that a combined measure of cerebral blood volume and vascular permeability using vascular-space occupancy (VASO) MR imaging, a recently developed imaging technique, is of diagnostic value for predicting tumor grade... - Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging--prediction of patient clinical responseMeng Law
Department of Radiology, New York University Medical Center, MRI Department, Schwartz Building, Basement HCC, 530 First Ave, New York, NY 10016, USA
Radiology 238:658-67. 2006..To determine retrospectively whether relative cerebral blood volume (CBV) measurements can be used to predict clinical response in patients with low-grade gliomas... - 3D time-resolved MR angiography (MRA) of the carotid arteries with time-resolved imaging with stochastic trajectories: comparison with 3D contrast-enhanced Bolus-Chase MRA and 3D time-of-flight MRAR P Lim
Department of Radiology, NYU Langone Medical Center, New York, NY, USA
AJNR Am J Neuroradiol 29:1847-54. 2008.... - Whole-brain N-acetylaspartate spectroscopy and diffusion tensor imaging in patients with newly diagnosed gliomas: a preliminary studyM Inglese
Department of Radiology, New York University School of Medicine, NY 10016, USA
AJNR Am J Neuroradiol 27:2137-40. 2006..975). CONCLUSION: The correlation between the WBNAA and MD in the contralateral NAWM suggests that the microstructural damage possibly related to the presence of infiltrative tumor cells contributes to WBNAA decline in these patients... - Accuracy of the Alberta Stroke Program Early CT Score during the first 3 hours of middle cerebral artery stroke: comparison of noncontrast CT, CT angiography source images, and CT perfusionK Lin
Department of Radiology, New York University Medical Center, New York, NY, USA
AJNR Am J Neuroradiol 29:931-6. 2008..Our aim was to retrospectively compare the accuracy of ASPECTS on noncontrast CT, CT angiography (CTA) source images, and CT perfusion maps of cerebral blood volume (CBV) during the first 3 hours of middle cerebral artery (MCA) stroke... - Perfusion and permeability MR imaging of gliomasM S Shiroishi
Division of Neuroradiology, Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo St, Los Angeles, CA 90033, USA
Technol Cancer Res Treat 10:59-71. 2011..Perfusion and permeability MR imaging are two such techniques that have shown promise in this regard. This review will highlight the underlying principles, applications, and pitfalls of these evolving advanced MRI methods... - Perfusion magnetic resonance imaging predicts patient outcome as an adjunct to histopathology: a second reference standard in the surgical and nonsurgical treatment of low-grade gliomasMeng Law
Department of Radiology, New York University Medical Center, New York, New York 10016, USA
Neurosurgery 58:1099-107; discussion 1099-107. 2006.... - High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imagingMeng Law
Department of Radiology, NYU Medical Center, 560 First Ave, RIM Rm 234, New York, NY 10016, USA
Radiology 222:715-21. 2002.... - Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma gradeMeng Law
Department of Radiology, NYU Medical Center, NY 10016, USA
AJNR Am J Neuroradiol 25:746-55. 2004..rCBV and K(trans) were positively but weakly correlated, suggesting that these parameters demonstrate different tumor characteristics. rCBV is a more significant predictor of high-grade glioma than K(trans)... - Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imagingMeng Law
Department of Radiology, New York University Medical Center, NY, USA
AJNR Am J Neuroradiol 24:1989-98. 2003..Threshold values can be used in a clinical setting to evaluate tumors preoperatively for histologic grade and provide a means for guiding treatment and predicting postoperative patient outcome... - Neuroimaging for the pediatric endocrinologistBradley N Delman
Department of Radiology, Mount Sinai Medical Center, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
Pediatr Endocrinol Rev 5:708-19. 2008..Because of the association of pituitary endocrinopathies with midline anomalies, one should pay careful attention to midline structures included on a sellar survey... - Dynamic contrast-enhanced T2*-weighted MR imaging of gliomatosis cerebriStanley Yang
Department of Radiology, New York University Medical Center, NY, USA
AJNR Am J Neuroradiol 23:350-5. 2002.... - Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cordS M Hesseltine
Department of Radiology, New York University Medical Center, 530 First Avenue, New York, NY 10016, USA
AJNR Am J Neuroradiol 27:1189-93. 2006..7) were demonstrated. CONCLUSION: The NASC in RRMS demonstrates DTI changes. This may prove useful in detecting occult spinal cord pathology, predicting clinical course, and monitoring disease progression and therapeutic effect in MS... - Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matterMeng Law
Departments of Radiology and Neurology, New York University Medical Center, MRI Department, Schwartz Building, Basement HCC, 530 First Avenue, New York, NY 10016, USA
Radiology 231:645-52. 2004.... - Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemic stroke using first-pass dynamic perfusion CT imagingK Lin
Department of Radiology, New York University Medical Center, New York, NY 10029, USA
AJNR Am J Neuroradiol 28:1292-8. 2007.... - Spectroscopic magnetic resonance imaging of a tumefactive demyelinating lesionM Law
MRI Department, Department of Radiology, New York University Medical Center, Schwartz Building, Basement HCC, 530 First Avenue, New York, NY 10016, USA
Neuroradiology 44:986-9. 2002..This case emphasizes the need for caution when confronted with a patient who presents with a differential diagnosis of demyelinating lesion versus neoplasm... 
Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiformeGabriel Pivawer
Department of Radiology, NYU Medical Center, New York, NY 10016, USA
Magn Reson Imaging 25:238-43. 2007..This report will review the utility of advanced imaging for differentiating inflammatory from neoplastic appearing lesions on conventional imaging...- Comparison of region-of-interest analysis with three different histogram analysis methods in the determination of perfusion metrics in patients with brain gliomasRobert Young
Department of Radiology, NYU Medical Center, New York, New York, USA
J Magn Reson Imaging 26:1053-63. 2007..Current region-of-interest (ROI)-based methods for the analysis of dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC MRI) data are operator-dependent... - Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRIHanzhang Lu
Department of Radiology, New York University School of Medicine, New York, NY 10016, USA
NMR Biomed 21:226-32. 2008..5 T and 3 T gave mean +/- SD scBV values of 4.3 +/- 0.7 ml/100 mL tissue (n = 6) and 4.4 +/- 0.7 ml/100 mL tissue (n = 4), respectively, consistent with the expectation that the scBV values would not be field-dependent... - Dynamic contrast-enhanced perfusion MR imaging measurements of endothelial permeability: differentiation between atypical and typical meningiomasStanley Yang
Department of Radiology/Division of Neuroradiology, New York University Medical Center, NY, USA
AJNR Am J Neuroradiol 24:1554-9. 2003..CONCLUSION: DCE pMRI may have a role in the prospective characterization of meningiomas. Specifically, the measurement of K(trans) is of use in distinguishing atypical meningiomas from typical meningiomas... - Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imagingHanzhang Lu
Center of Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
Magn Reson Med 54:1403-11. 2005..In comparison with previous pre/postcontrast difference approaches, VASO MRI provides maximal signal difference between pre- and postcontrast situation and does not require the use of whole blood for signal normalization... - Imaging of the intracranial venous system with a contrast-enhanced volumetric interpolated examinationStephan G Wetzel
Department of Radiology, New York University Medical Center, 530 First Avenue, HCC Basement MRI, New York, NY 10016, USA
Eur Radiol 13:1010-8. 2003..Contrast-enhanced VIBE acquisitions are faster and enable a visualization of the normal intracranial venous system superior to that of 2D TOF MRV... - Preoperative assessment of intracranial tumors with perfusion MR and a volumetric interpolated examination: a comparative study with DSAStephan G Wetzel
Department of Radiology, New York University Medical Center, New York, NY 10016, USA
AJNR Am J Neuroradiol 23:1767-74. 2002..However, the MR protocol provides insufficient visualization of distal cerebral arteries... - Field, coil, and echo-time influence on sensitivity and reproducibility of brain proton MR spectroscopyM Inglese
Department of Radiology, New York University School of Medicine, New York, NY 10016, USA
AJNR Am J Neuroradiol 27:684-8. 2006..5T with a PA coil, making it a cost-effective upgrade for existing scanners. Surprisingly and counterintuitively, despite the lowest SNR, the best reproducibility was obtained at the longest TE (288 ms), regardless of field or coil... - Differentiating intracranial aspergillosis from a high grade glioma using MRI and MR spectroscopic imagingErica Pollack
Department of Radiology, NYU Medical Center, New York, NY 10029, USA
J Neuroimaging 17:361-6. 2007..We also demonstrate the diffusion-weighted imaging (DWI) findings and discuss how MR spectroscopy can be useful in differentiating an aspergilloma from a high-grade glioma... - Dynamic contrast enhanced perfusion MRI in mycosis fungoidesMeng Law
Department of Radiology, Division of Neuroradiology, New York University Medical Center, New York, New York 10016, USA
J Magn Reson Imaging 18:364-7. 2003..Multiple relative cerebral blood volume (rCBV) measurements were made and the minimum rCBV was 0.30 with the maximum rCBV being 1.61. The mean rCBV was 0.81 +/- 0.49 (average of 10 measurements and standard deviation)... - Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in gangliogliomaMeng Law
Department of Radiology, NYU Medical Center, New York, NY, USA
Magn Reson Imaging 22:599-606. 2004..Higher cerebral blood volume measurements can help differentiate gangliogliomas from other low-grade gliomas... - Proton MR spectroscopy of tumefactive demyelinating lesionsAmit M Saindane
Department of Radiology, New York University Medical Center, MRI Center, NY, USA
AJNR Am J Neuroradiol 23:1378-86. 2002..However, overall metabolite profiles of both lesions were similar; this finding emphasizes the need for the cautious interpretation of spectroscopic findings... - Relative cerebral blood volume measurements in intracranial mass lesions: interobserver and intraobserver reproducibility studyStephan G Wetzel
Department of Radiology, New York University School of Medicine, 550 First Ave, NY 10016, USA
Radiology 224:797-803. 2002..Measurement variations between observers correlated significantly (P <.001) with increasing rCBV values. CONCLUSION: In this study, interobserver and intraobserver reproducibility of rCBV measurements were clinically acceptable... - Imaging of lymphoma of the central nervous system, spine, and orbitSofia Haque
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York Presbyterian Hospital Weill Cornell Medical College, New York, NY 10065, USA
Radiol Clin North Am 46:339-61, ix. 2008..Also described are metabolic imaging techniques with nuclear medicine and advanced MR imaging and how they can help improve the understanding of tumor biology... - Brainstem corticospinal tract diffusion tensor imaging in patients with primary posterior fossa neoplasms stratified by tumor type: a study of association with motor weakness and outcomeYvonne W Lui
Department of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10467 2490, USA
Neurosurgery 61:1199-207; discussion 1207-8. 2007..The purpose of this study was to determine whether or not abnormalities of DTI metrics and fiber tractography correlate with neurological deficits and clinical status in patients with primary posterior fossa tumors... - Correlation of volumetric mismatch and mismatch of Alberta Stroke Program Early CT Scores on CT perfusion mapsKe Lin
Department of Radiology, NYU Medical Center Bellevue Hospital, 462 First Avenue, NBV 3W39, New York, NY 10016, USA
Neuroradiology 51:17-23. 2009..We aimed to determine if volumetric mismatch between tissue at risk and tissue destined to infarct on computed tomography perfusion (CTP) can be described by the mismatch of Alberta Stroke Program Early CT Score (ASPECTS)... - Intracranial lesions mimicking neoplasmsClare H Cunliffe
Department of Pathology, Division of Neuropathology, New York University Medical Center, New York, NY, USA
Arch Pathol Lab Med 133:101-23. 2009..We give an overview of such diseases, which represent a potential pitfall for pathologists and other clinicians involved in patient care, and present selected cases from each category... - Magnetic resonance perfusion and permeability imaging in brain tumorsSaulo Lacerda
Department of Radiology, Mount Sinai Medical Center, New York, NY 10029, USA
Neuroimaging Clin N Am 19:527-57. 2009.... - Central nervous system lymphoma characterization by diffusion-weighted imaging and MR spectroscopyT Thomas Zacharia
Neuroradiology, Mount Sinai Medical Center, New York, NY, USA
J Neuroimaging 18:411-7. 2008..The purpose of this study is to characterize the diffusion-weighted imaging (DWI) and MR spectroscopic (MRS) findings in CNS lymphoma... - Conventional and perfusion MR imaging of parafalcine chondrosarcomaNishita Kothary
Department of Radiology, New York University Medical Center, MRI-Basement, Schwartz Building, 530 First Avenue, New York, NY 10016, USA
AJNR Am J Neuroradiol 24:245-8. 2003..We present a rare case of primary chondrosarcoma arising from the falx in a young woman with no history of radiation. The CT, conventional MR imaging, perfusion MR imaging, and digital subtraction angiography findings are described... - Dynamic susceptibility contrast perfusion MR imaging of multiple sclerosis lesions: characterizing hemodynamic impairment and inflammatory activityYulin Ge
Department of Radiology, New York University School of Medicine, NY 10016, USA
AJNR Am J Neuroradiol 26:1539-47. 2005..Non-enhancing lesions showed both low and high perfusion suggesting microvascular abnormalities with hemodynamic impairment and inflammatory reactivity that cannot be seen on conventional MRI... - MR spectroscopy of brain tumorsMeng Law
Department of Radiology, New York University Medical Center, New York, New York 10016, USA
Top Magn Reson Imaging 15:291-313. 2004..This article aims to provide tools to increase our sensitivity and specificity of neurodiagnosis, particularly in combination with other advanced MRI techniques such as perfusion MR imaging... - Prominent perivenular spaces in multiple sclerosis as a sign of perivascular inflammation in primary demyelinationYulin Ge
Department of Radiology, New York University School of Medicine, New York, NY 10016, USA
AJNR Am J Neuroradiol 26:2316-9. 2005..This widening may be an important sign in differentiating primary (ie, in multiple sclerosis) from secondary causes of demyelination... - Differentiating surgical from non-surgical lesions using perfusion MR imaging and proton MR spectroscopic imagingMeng Law
Department of Radiology, NYU Medical Center, MRI Dept, Schwartz Building, Basement HCC, 530 First Avenue, New York, NY 10016, USA
Technol Cancer Res Treat 3:557-65. 2004..The utility of combining clinical findings with multi-parametric information from perfusion and spectroscopic MR imaging in differentiating surgical lesions from those which do not require surgical intervention is discussed... - Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: introduction of the tumor infiltration indexStanley Lu
Department of Radiology, New York University Medical Center, New York, NY, USA
Radiology 232:221-8. 2004..In addition, the TII enables one to distinguish presumed tumor-infiltrated edema from purely vasogenic edema... - Angiogenesis in gliomas: imaging and experimental therapeuticsJean-Pierre Gagner
Microvascular and Molecular Neuro-oncology Laboratory, New York University School of Medicine, USA
Brain Pathol 15:342-63. 2005.... - Preferential occult injury of corpus callosum in multiple sclerosis measured by diffusion tensor imagingYulin Ge
Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
J Magn Reson Imaging 20:1-7. 2004..75, P = 0.001) in patients. CONCLUSION: The water diffusion changes indicate that in the early phase of disease there is a preferential occult injury of CC, which is likely due to the Wallerian degeneration from distant lesions... - Comparing real-world advantages for the clinical neuroradiologist between a high field (3 T), a phased array (1.5 T) vs. a single-channel 1.5-T MR systemDarren B Orbach
Department of Radiology, Division of Neuroradiology, NYU Medical Center, New York, New York, USA
J Magn Reson Imaging 24:16-24. 2006..CONCLUSION: Both quantitatively and qualitatively, the phased-array system provided image quality superior to that of the 1.5-T and 3-T single-channel systems... - The emerging role of multidetector row CT angiography in the diagnosis of cervical arterial dissection: preliminary studyLucas Elijovich
Department of Neurology, NYU Medical Center, New York, NY 10016, USA
Neuroradiology 48:606-12. 2006.... - Angiogenesis in gliomas: biology and molecular pathophysiologyIngeborg Fischer
Microvascular and Molecular Neuro-oncology Laboratory, New York University School of Medicine, USA
Brain Pathol 15:297-310. 2005..Understanding the roles of these regulatory processes in tumor neovascularization, tumor growth and progression, and resistance to therapy will ultimately lead to the development of improved antiangiogenic therapies for GBMs... - Applications of diffusion tensor MR imaging in multiple sclerosisYulin Ge
Department of Radiology, New York University Medical Center, 530 First Avenue, Basement HCC, New York, NY 10016, USA
Ann N Y Acad Sci 1064:202-19. 2005..This review outlines the current state of the art and future direction of DTI and fiber tractography in the study of MS disease...