Hanna Ksiezak-Reding

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols
    Hanna Ksiezak-Reding
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 33:1427-39. 2012
  2. ncbi request reprint Tau protein expression in adult bovine oligodendrocytes: functional and pathological significance
    Hanna Ksiezak-Reding
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Neurochem Res 28:1385-92. 2003
  3. ncbi request reprint Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro
    Hanna Ksiezak-Reding
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Biochim Biophys Acta 1639:159-68. 2003
  4. ncbi request reprint Characterization of paired helical filaments by scanning transmission electron microscopy
    Hanna Ksiezak-Reding
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Microsc Res Tech 67:126-40. 2005
  5. ncbi request reprint Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles
    Makio Takahashi
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine and the James J Peters Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    J Neuropathol Exp Neurol 65:1157-69. 2006
  6. pmc Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies
    Giulio Maria Pasinetti
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurochem 114:1557-68. 2010
  7. pmc Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes
    Ismael Santa-Maria
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:20522-33. 2012
  8. pmc GSPE interferes with tau aggregation in vivo: implication for treating tauopathy
    Ismael Santa-Maria
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 33:2072-81. 2012
  9. doi request reprint Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 22:653-61. 2010
  10. ncbi request reprint Morphological and biochemical correlations of abnormal tau filaments in progressive supranuclear palsy
    Makio Takahashi
    Department of Pathology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA
    J Neuropathol Exp Neurol 61:33-45. 2002

Collaborators

Detail Information

Publications14

  1. doi request reprint Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols
    Hanna Ksiezak-Reding
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 33:1427-39. 2012
    ..Collectively, our results suggest that GSPE has a significant potential for therapeutic development by neutralizing phospho-epitopes and disrupting fibrillary conformation leading to disintegration of PHFs...
  2. ncbi request reprint Tau protein expression in adult bovine oligodendrocytes: functional and pathological significance
    Hanna Ksiezak-Reding
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Neurochem Res 28:1385-92. 2003
    ..We propose that the tau isoform profile and phosphorylation status contribute to the vulnerability of OLGs in degenerative diseases linked to overexpression of exon 10...
  3. ncbi request reprint Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro
    Hanna Ksiezak-Reding
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Biochim Biophys Acta 1639:159-68. 2003
    ..Our data suggest that phosphorylation of tau by Akt may play specific role(s) in Akt-mediated anti-apoptotic signaling, particularly relevant to AD and other neurodegenerations...
  4. ncbi request reprint Characterization of paired helical filaments by scanning transmission electron microscopy
    Hanna Ksiezak-Reding
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Microsc Res Tech 67:126-40. 2005
    ..Others goals are to describe the biochemical and ultrastructural complexity of authentic PHFs, to assess similarities between authentic and synthetic PHFs, and to discuss recent advances in PHF modeling...
  5. ncbi request reprint Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles
    Makio Takahashi
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine and the James J Peters Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    J Neuropathol Exp Neurol 65:1157-69. 2006
    ..Our studies indicate that GRK2 is a novel component of neuronal and glial fibrillary tau deposits with no preference in tau isoform binding. GRK2 may play a role in hyperphosphorylation of tau in tauopathies...
  6. pmc Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies
    Giulio Maria Pasinetti
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurochem 114:1557-68. 2010
    ..In this mini-review article, we discuss the biochemical characterization of GSPE in our laboratory and its potential preventative and therapeutic role in model systems of abnormal tau processing pertinent to PSP and related tauopathies...
  7. pmc Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes
    Ismael Santa-Maria
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:20522-33. 2012
    ..The evidence that cells can internalize PHFs, leading to formation of aggresome-like bodies, opens new therapeutic avenues to prevent propagation and spreading of tau pathology...
  8. pmc GSPE interferes with tau aggregation in vivo: implication for treating tauopathy
    Ismael Santa-Maria
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 33:2072-81. 2012
    ..Our studies support further evaluation of GSPE for preventing and/or treating of tauopathies in humans...
  9. doi request reprint Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 22:653-61. 2010
    ....
  10. ncbi request reprint Morphological and biochemical correlations of abnormal tau filaments in progressive supranuclear palsy
    Makio Takahashi
    Department of Pathology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA
    J Neuropathol Exp Neurol 61:33-45. 2002
    ..Neuronal and glial inclusions also vary in the biochemical profile of tau protein. These differences may depend on the metabolism of tau in the diseased oligodendrocytes, astrocytes, and neurons...
  11. ncbi request reprint Expression of tau reduces secretion of Abeta without altering the amyloid precursor protein content in CHOsw cells
    Zhong Zhao
    Neuroinflammation Research Laboratories, Department of Psychiatry of the Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FEBS Lett 579:2119-24. 2005
    ..This was accompanied by a reduction in the gamma-secretase and an increase in the insulin degrading enzyme activities. Our results suggest that tau may play an inhibitory role in the amyloidogenic activity of APP...
  12. ncbi request reprint Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications
    Giulio Maria Pasinetti
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Interdiscip Top Gerontol 35:159-75. 2007
    ....
  13. ncbi request reprint Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York, NY 10468, USA
    Schizophr Res 84:1-14. 2006
    ..Our studies suggest that aberrant IR function may be important in the pathophysiology of schizophrenia...
  14. ncbi request reprint Phosphorylation of tau by fyn: implications for Alzheimer's disease
    Gloria Lee
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 24:2304-12. 2004
    ..We also found evidence suggesting that differentially phosphorylated tau existed within degenerating neurons. Our data add new support for a role for fyn in the neurodegenerative process...