ROBERT KRAUSS

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation
    Jong Sun Kang
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    EMBO J 21:114-24. 2002
  2. pmc Regulation of promyogenic signal transduction by cell-cell contact and adhesion
    Robert S Krauss
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Cell Res 316:3042-9. 2010
  3. pmc Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation
    Gyu Un Bae
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biol 29:4130-43. 2009
  4. ncbi request reprint Holoprosencephaly: new models, new insights
    Robert S Krauss
    Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Expert Rev Mol Med 9:1-17. 2007
  5. pmc Regulation of myotube formation by the actin-binding factor drebrin
    Annalisa Mancini
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L, Levy Place, New York, NY 10029, USA
    Skelet Muscle 1:36. 2011
  6. ncbi request reprint Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact
    Robert S Krauss
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 118:2355-62. 2005
  7. pmc Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo
    Giichi Takaesu
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 175:383-8. 2006
  8. pmc A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation
    Jong Sun Kang
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 182:497-507. 2008
  9. ncbi request reprint Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO
    Francesca Cole
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 7:843-54. 2004
  10. pmc Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation
    Jong Sun Kang
    Department of Molecular, Cell, and Developmental Biology, Box 1020, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 100:3989-94. 2003

Collaborators

  • Jong Sun Kang
  • Wei Zhang
  • Gyu Un Bae
  • Francesca Cole
  • Hye Jin Lee
  • Annalisa Mancini
  • Min Lu
  • Youn Joo Yang
  • Karen A Schachter
  • Toyoaki Tenzen
  • Giichi Takaesu
  • Marta Wegorzewska
  • Philip J Mulieri
  • Dario Sirabella
  • Tomoaki Shirao
  • Hiroyuki Yamazaki
  • Marc Tessier-Lavigne
  • Guoying Jiang
  • Bok Geon Kim
  • Ji Eun Oh
  • Mingi Hong
  • Su Jae Lee
  • Ursula Gaio
  • Min Jeong Yi
  • Clement M Lee
  • Benjamin L Allen
  • Andrew P McMahon
  • E Premkumar Reddy
  • Assaf Geyra
  • David A Sassoon

Detail Information

Publications23

  1. pmc BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation
    Jong Sun Kang
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    EMBO J 21:114-24. 2002
    ..CDO and BOC are proposed to be components of a receptor complex that mediates some of the cell-cell interactions between muscle precursors that are required for myogenesis...
  2. pmc Regulation of promyogenic signal transduction by cell-cell contact and adhesion
    Robert S Krauss
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Cell Res 316:3042-9. 2010
    ..Nevertheless, it is possible that the murine adhesion receptors rate-limiting in vivo have not yet been identified or fully assessed...
  3. pmc Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation
    Gyu Un Bae
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biol 29:4130-43. 2009
    ..Abl's promyogenic effect is therefore linked to a multiprotein cell surface complex that regulates differentiation-dependent p38 activation...
  4. ncbi request reprint Holoprosencephaly: new models, new insights
    Robert S Krauss
    Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Expert Rev Mol Med 9:1-17. 2007
    ..Furthermore, these model systems suggest that human HPE arises from a complex interaction between the timing and strength of developmental signalling pathways, genetic variation and exposure to environmental agents...
  5. pmc Regulation of myotube formation by the actin-binding factor drebrin
    Annalisa Mancini
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L, Levy Place, New York, NY 10029, USA
    Skelet Muscle 1:36. 2011
    ..abstract:..
  6. ncbi request reprint Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact
    Robert S Krauss
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 118:2355-62. 2005
    ..Mechanistic studies in vitro indicate that specific cadherins and immunoglobulin superfamily proteins exert some of their effects in an interdependent fashion by signaling from a multiprotein complex found at sites of cell-cell contact...
  7. pmc Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo
    Giichi Takaesu
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 175:383-8. 2006
    ..These results document a novel mechanism of signaling during cell differentiation: the interaction of a MAPK scaffold protein with a cell surface receptor...
  8. pmc A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation
    Jong Sun Kang
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 182:497-507. 2008
    ..Furthermore, interaction with multiple scaffold-type proteins is a distinctive mode of cell surface receptor signaling and provides one mechanism for specificity of p38alpha/beta activation during cell differentiation...
  9. ncbi request reprint Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO
    Francesca Cole
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 7:843-54. 2004
    ..The promyogenic effect of cell-cell contact is therefore linked to the activity of myogenic bHLH factors. Furthermore, the myogenic positive feedback network extends from the cell surface to the nucleus...
  10. pmc Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation
    Jong Sun Kang
    Department of Molecular, Cell, and Developmental Biology, Box 1020, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 100:3989-94. 2003
    ..Thus, some of the cell-cell contact-mediated activities that are required for myogenesis seem to be based on interdependent activities of promyogenic classical cadherins and Ig superfamily members...
  11. ncbi request reprint Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD
    Marta Wegorzewska
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Carcinog 37:1-4. 2003
    ..These observations are consistent with the notion that CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage...
  12. pmc Netrins and neogenin promote myotube formation
    Jong Sun Kang
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 167:493-504. 2004
    ..It is proposed that netrin-3 and neogenin may promote myogenic differentiation by an autocrine mechanism as components of a higher order complex of several promyogenic cell surface proteins...
  13. ncbi request reprint Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 10:657-65. 2006
    ..Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions...
  14. ncbi request reprint Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon
    Francesca Cole
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Biol 13:411-5. 2003
    ....
  15. ncbi request reprint Expression of the boc gene during murine embryogenesis
    Philip J Mulieri
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Dyn 223:379-88. 2002
    ....
  16. pmc Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro
    Gyu Un Bae
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Cell 20:4920-31. 2009
    ..Together, netrin-neogenin signaling is an important extracellular cue in regulation of myogenic differentiation and myofiber size...
  17. pmc Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Box 1020, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 26:3764-72. 2006
    ..These results indicate that CDO promotes neuronal differentiation and support the hypothesis that CDO coordinates differentiation of multiple cell lineages by regulating the activity of tissue-specific bHLH factors...
  18. pmc N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts
    Min Lu
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:4212-7. 2010
    ..Furthermore, they are consistent with a model whereby Cdo serves as a multifunctional coreceptor with mechanistically distinct roles in multiple signaling pathways...
  19. pmc Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164
    Gyu Un Bae
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Biol Chem 283:8301-9. 2008
    ..Taken together, these results suggest that CD164 is a regulator of myoblast motility and that this property contributes to its ability to promote myoblast fusion into myotubes...
  20. doi request reprint Ocular abnormalities in mice lacking the immunoglobulin superfamily member Cdo
    Wei Zhang
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, USA
    FEBS J 276:5998-6010. 2009
    ....
  21. doi request reprint Murine models of holoprosencephaly
    Karen A Schachter
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York 10029, USA
    Curr Top Dev Biol 84:139-70. 2008
    ..Here, we review forebrain development with an emphasis on the pathways known to be defective in HPE and describe the strengths and weaknesses of various murine models of HPE...
  22. ncbi request reprint The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    Toyoaki Tenzen
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Cell 10:647-56. 2006
    ..Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. We propose a model where Cdo and Boc enhance Shh signaling within its target field...
  23. ncbi request reprint Hedgehog signaling: cooking with Gas1
    Jong Sun Kang
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea
    Sci STKE 2007:pe50. 2007
    ..The coordinate regulation of the activity and expression of several different positively and negatively acting Shh binding proteins should result in fine-tuned modulation of graded Shh signaling...

Research Grants23

  1. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2007
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. ..
  2. Role of CD164 in Skeletal Myogenesis
    ROBERT KRAUSS; Fiscal Year: 2007
    ..These experiments will provide information critical to molecular and genetic understanding of CD164's role in myogenesis. This research should therefore shed light on fundamental processes by which skeletal muscles develop. ..
  3. THE ROLE OF CDO IN MYOGENIC DIFFERENTIATION
    ROBERT KRAUSS; Fiscal Year: 2009
    ..This research should shed light on fundamental processes by which skeletal muscles develop and therefore advance potential strategies for improved treatment of skeletal muscle diseases. ..
  4. Interactions between Shh pathway regulators and fetal alcohol exposure in mice
    ROBERT KRAUSS; Fiscal Year: 2009
    ..Studies on this model, and its extension to additional ethanol-associated birth defects, are proposed, with the goal of shedding light on how genetic susceptibility may influence the outcome of fetal alcohol exposure. ..
  5. RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTH
    ROBERT KRAUSS; Fiscal Year: 2002
    ..Such genes represent potential mediators of the transformed phenotype. ..
  6. THE ROLE OF CDO IN MYOGENIC DIFFERENTIATION
    ROBERT KRAUSS; Fiscal Year: 2004
    ..The proposed work will provide information critical to a molecular understanding of CDO's role in myogenesis and should therefore shed light on fundamental processes by which skeletal muscles develop. ..
  7. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  8. Interactions between Shh pathway regulators and fetal alcohol exposure in mice
    Robert S Krauss; Fiscal Year: 2010
    ..Studies on this model, and its extension to additional ethanol-associated birth defects, are proposed, with the goal of shedding light on how genetic susceptibility may influence the outcome of fetal alcohol exposure. ..