Arif O Khan

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Buphthalmos in the setting of persistent hyperplastic primary vitreous cataract
    Arif Omar Khan
    Department of Pediatrics, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Am J Ophthalmol 136:945-7. 2003
  2. doi Early-onset severe retinal dystrophy as the initial presentation of IFT140-related skeletal ciliopathy
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:203-5. 2014
  3. doi The ECEL1-related strabismus phenotype is consistent with congenital cranial dysinnervation disorder
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:362-7. 2014
  4. doi Infantile esotropia with cross-fixation, inability to abduct, and underlying horizontal gaze palsy with progressive scoliosis
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:389-91. 2014
  5. doi Congenital glaucoma with acquired peripheral circumferential iris degeneration
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 17:105-7. 2013
  6. doi Results of fibrillin-1 gene analysis in children from inbred families with lens subluxation
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:134-9. 2014
  7. doi Ocular genetic disease in the Middle East
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Curr Opin Ophthalmol 24:369-78. 2013
  8. doi Corneal enlargement without optic disk cupping in children with recessive CYP1B1 mutations
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Electronic address
    J AAPOS 17:643-5. 2013
  9. doi The RPGRIP1-related retinal phenotype in children
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Br J Ophthalmol 97:760-4. 2013
  10. doi Juvenile cataract morphology in 3 siblings not yet diagnosed with cerebrotendinous xanthomatosis
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmology 120:956-60. 2013

Collaborators

Detail Information

Publications99

  1. ncbi Buphthalmos in the setting of persistent hyperplastic primary vitreous cataract
    Arif Omar Khan
    Department of Pediatrics, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Am J Ophthalmol 136:945-7. 2003
    ..To report a case of unilateral persistent hyperplastic primary vitreous cataract presenting with ipsilateral buphthalmos...
  2. doi Early-onset severe retinal dystrophy as the initial presentation of IFT140-related skeletal ciliopathy
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:203-5. 2014
    ..Genetic analysis revealed both to harbor recessive mutations in IFT140, a cilium gene recently associated with the skeletal ciliopathy conorenal syndrome. ..
  3. doi The ECEL1-related strabismus phenotype is consistent with congenital cranial dysinnervation disorder
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:362-7. 2014
    ..To better define the ECEL1-related ophthalmic phenotype, we detail ophthalmic findings in 4 affected siblings from a consanguineous family and review documented ophthalmic findings for other reported mutation-positive cases...
  4. doi Infantile esotropia with cross-fixation, inability to abduct, and underlying horizontal gaze palsy with progressive scoliosis
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:389-91. 2014
    ....
  5. doi Congenital glaucoma with acquired peripheral circumferential iris degeneration
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 17:105-7. 2013
    ..Genetic testing revealed a common homozygous CYP1B1 mutation in one (p.Gly61Glu) and a novel heterozygous FOXC1 deletion in the other (p.Tyr81_Pro95del)...
  6. doi Results of fibrillin-1 gene analysis in children from inbred families with lens subluxation
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Electronic address
    J AAPOS 18:134-9. 2014
    ..We report the results of routine FBN1 sequencing for children from inbred families referred with nontraumatic lens subluxation without cataract or vitreoretinal degeneration...
  7. doi Ocular genetic disease in the Middle East
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Curr Opin Ophthalmol 24:369-78. 2013
    ..These social factors increase the frequency of homozygosity, including homozygosity for gene mutation and thus for recessive ocular disease. This review highlights recent studies of ocular genetic disease in the Middle East...
  8. doi Corneal enlargement without optic disk cupping in children with recessive CYP1B1 mutations
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Electronic address
    J AAPOS 17:643-5. 2013
    ..One child later developed unilateral Haab striae, still in the absence of optic disk cupping. These cases illustrate that CYP1B1-related corneal changes can occur in young children without visible optic nerve head damage. ..
  9. doi The RPGRIP1-related retinal phenotype in children
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Br J Ophthalmol 97:760-4. 2013
    ....
  10. doi Juvenile cataract morphology in 3 siblings not yet diagnosed with cerebrotendinous xanthomatosis
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmology 120:956-60. 2013
    ..This study highlights the morphology of lens opacities in a family with genetically confirmed disease...
  11. doi Familial spherophakia with short stature caused by a novel homozygous ADAMTS17 mutation
    Arif O Khan
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Ophthalmic Genet 33:235-9. 2012
    ..The purpose of this report is to determine the genetic cause of isolated spherophakia with short stature in two siblings from a consanguineous Saudi family...
  12. doi Microcornea with myopic chorioretinal atrophy, telecanthus and posteriorly-rotated ears: a distinct clinical syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 33:196-9. 2012
    ..To characterize a novel and distinct hereditary clinical syndrome of microcornea, myopic chorioretinal atrophy, telecanthus and posteriorly-rotated ears...
  13. doi Clinical characterisation of the CABP4-related retinal phenotype
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
    Br J Ophthalmol 97:262-5. 2013
    ..We expand the number of reported patients with CABP4 mutations and clinically characterise the CABP4-related phenotype...
  14. doi CYP1B1 analysis of unilateral primary newborn glaucoma in Saudi children
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 16:571-2. 2012
    ..None of these children with unilateral primary newborn glaucoma harbored CYP1B1 mutations, suggesting that in this population the pathogenesis of unilateral disease differs from that of bilateral disease...
  15. doi Nummular dystrophic calcification of an Ahmed glaucoma valve in a child
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 16:401-2. 2012
    ....
  16. doi Phenotype-genotype correlation in potential female carriers of X-linked developmental cataract (Nance-Horan syndrome)
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 33:89-95. 2012
    ..To correlate clinical examination with underlying genotype in asymptomatic females who are potential carriers of X-linked developmental cataract (Nance-Horan syndrome)...
  17. doi Double elevator weakening for unilateral congenital superior oblique palsy with ipsilateral superior rectus contracture and lax superior oblique tendon
    Arif O Khan
    King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh, 11462, Saudi Arabia
    J AAPOS 16:301-3. 2012
    ..This procedure seems to be an acceptable initial surgical option for treating congenital superior oblique muscle palsy with ipsilateral contracture of the superior rectus muscle, even when the ipsilateral superior oblique tendon is lax...
  18. doi The distinct ophthalmic phenotype of Knobloch syndrome in children
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
    Br J Ophthalmol 96:890-5. 2012
    ..This report characterises eye findings of the syndrome in children with genetically confirmed disease...
  19. doi Clinical and molecular analysis of children with central pulverulent cataract from the Arabian Peninsula
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
    Br J Ophthalmol 96:650-5. 2012
    ..To clinically and genetically characterise central pulverulent cataract in a consecutive cohort of children from the Arabian Peninsula who were referred for ophthalmic evaluation...
  20. doi The relationship of axial length to cycloplegic refraction and keratometry in amblyopic eyes of hyperopic children
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 16:46-8. 2012
    ..04 × refraction] + 2.98) × (corneal radius)]. The purpose of this study is to determine whether the pathophysiology of amblyopia affects this relationship...
  21. doi 'Cone dystrophy with supranormal rod response' in children
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
    Br J Ophthalmol 96:422-6. 2012
    ..To describe the initial clinical presentation of children with 'cone dystrophy with supranormal rod response,' a distinct retinal disorder from recessive KCNV2 mutations...
  22. doi Germline Mosaicism for KIF21A Mutation (p.R954L) Mimicking Recessive Inheritance for Congenital Fibrosis of the Extraocular Muscles
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia Department of Genetics, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Ophthalmology 117:154-8. 2010
    ..To document the genotype for familial congenital fibrosis of the extraocular muscles (CFEOM) with apparent autosomal recessive inheritance...
  23. ncbi Cycloplegic refractions in children who never wore and who always wore prescribed spectacles for refractive accommodative esotropia: exploring the natural history of this form of strabismus and the effect of treatment on their hyperopia
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Binocul Vis Strabismus Q 24:151-6. 2009
    ..To compare cycloplegic refractions in accommodative esotropes who never and who always wore prescribed spectacles...
  24. pmc Founder heterozygous P23T CRYGD mutation associated with cerulean (and coralliform) cataract in 2 Saudi families
    Arif O Khan
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Vis 15:1407-11. 2009
    ..To assess for gammaD-crystallin (CRYGD) mutation in 2 Saudi patients with cerulean cataract and in a brother of one of the patients who had coralliform cataract...
  25. doi Age at the time of cataract surgery and relative risk for aphakic glaucoma in nontraumatic infantile cataract
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 13:166-9. 2009
    ..To report the relative risk for aphakic glaucoma as a function of age at surgery in infants who underwent cataract surgery before 10 months of age for nontraumatic infantile cataract without microcornea...
  26. ncbi Cycloplegic refractions as a function of age in children with infantile esotropia
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Kingdom of Saudi Arabia
    Binocul Vis Strabismus Q 24:39-42. 2009
    ..To describe cycloplegic refractions as a function of age in children with infantile esotropia...
  27. doi Corneal decompensation in recessive cornea plana
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 30:142-5. 2009
    ..To report corneal decompensation in 3 patients with recessive cornea plana...
  28. doi Comparison of polypropylene and silicone Ahmed valve survival 2 years following implantation in the first 2 years of life
    A O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462 Saudi Arabia
    Br J Ophthalmol 93:791-4. 2009
    ..To compare the 2-year survival rates of polypropylene and silicone Ahmed glaucoma valves (AGVs) implanted during the first 2 years of life...
  29. doi PAX6 analysis of two unrelated families from the Arabian Peninsula with classic hereditary aniridia
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 29:145-8. 2008
    ..The purpose of this study to assess for PAX6 mutation in two unrelated families with classic hereditary aniridia from the Arabian Peninsula...
  30. doi Ophthalmic features of Joubert syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Ophthalmology 115:2286-9. 2008
    ..The objective of the current study is to describe the ophthalmic phenotype in a cohort of patients with Joubert syndrome for whom the diagnosis was made using current diagnostic criteria...
  31. doi Bilateral synergistic convergence associated with homozygous ROB03 mutation (p.Pro771Leu)
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmology 115:2262-5. 2008
    ..To document the phenotype and determine the genotype of a child with synergistic convergence...
  32. ncbi Monocular elevation deficiency with contralateral superior oblique muscle tendon laxity
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Kingdom of Saudi Arabia
    Binocul Vis Strabismus Q 23:159-63. 2008
    ..The purpose of this report is to raise awareness that monocular elevation deficiency can be associated with, and may be secondary to, a floppy (lax) superior oblique muscle tendon in the contralateral fixating eye...
  33. doi Later retinal degeneration following childhood surgical aphakia in a family with recessive CRYAB mutation (p.R56W)
    Arif O Khan
    King Khaled Eye Specialist Hospital, Pediatric Ophthalmology, Riyadh, Saudi Arabia
    Ophthalmic Genet 31:30-6. 2010
    ..R56W mutation in CRYAB, a gene that encodes a heat-shock protein (alphaB-crystallin) in both retina and the lens...
  34. doi Helicoid subretinal fibrosis associated with a novel recessive NR2E3 mutation p.S44X
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Saudi Arabia
    Arch Ophthalmol 128:344-8. 2010
    ..To describe a unique pattern of helicoid subretinal fibrosis associated with a novel recessive NR2E3 mutation and to highlight how examination of the proband's affected relative allowed appropriate genetic testing...
  35. pmc Congenital megalocornea with zonular weakness and childhood lens-related secondary glaucoma - a distinct phenotype caused by recessive LTBP2 mutations
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 17:2570-9. 2011
    ..To clinically and genetically characterize a distinct phenotype of congenital megalocornea (horizontal corneal diameter ≥13 mm) with secondary glaucoma from spherophakia and/or ectopia lentis during childhood in affected Saudi families...
  36. pmc Infantile esotropia could be oligogenic and allelic with Duane retraction syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 17:1997-2002. 2011
    ..To describe phenotyping and linkage analysis results for available members from a consanguineous nuclear family with hereditary congenital strabismus...
  37. doi Prolonged pursuit by optokinetic drum testing in asymptomatic female carriers of novel FRMD7 splice mutation c.1050 +5 G>A
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
    Arch Ophthalmol 129:936-40. 2011
    ..To determine the genotype underlying suspected X-linked infantile nystagmus in a family and to correlate genotype with clinical examination in potential female carriers...
  38. doi The relationships among cycloplegic refraction, keratometry, and axial length in children with refractive accommodative esotropia
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 15:241-4. 2011
    ..To explore the relationships among cycloplegic refraction, keratometry, and axial length in children with refractive accommodative esotropia and to evaluate the feasibility of axial length estimation from the other 2 parameters...
  39. doi Familial juvenile glaucoma with underlying homozygous p.G61E CYP1B1 mutations
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 15:198-9. 2011
    ..G61E CYP1B1 mutations while MYOC mutation was not detected, illustrating that mutations in CYP1B1 rather than mutation in MYOC can underlie familial primary juvenile glaucoma in certain populations...
  40. pmc Potential linkage of different phenotypic forms of childhood strabismus to a recessive susceptibility locus (16p13.12-p12.3)
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 17:971-6. 2011
    ..To perform linkage analysis on an inbred family with members who exhibit different phenotypic forms of childhood strabismus...
  41. doi The optic nerve head in congenital fibrosis of the extraocular muscles
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 32:175-80. 2011
    ..Optic nerve head abnormalities have been reported in some patients with congenital fibrosis of the extraocular muscles (CFEOM). This study prospectively assesses optic nerve head appearance in a consecutive CFEOM cohort...
  42. doi Conditions that can be mistaken as early childhood glaucoma
    Arif O Khan
    Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 32:129-37. 2011
    ..These signs also occur in developmental glaucoma (anterior segment dysgeneses) with infantile onset. However, similar findings can occur in other pediatric conditions which are sometimes are mistaken as early childhood glaucoma...
  43. doi Molecular characterization of newborn glaucoma including a distinct aniridic phenotype
    Arif O Khan
    Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 32:138-42. 2011
    ..To characterize the underlying genetic defect in otherwise healthy Saudi newborns with buphthalmos, including those with iris abnormalities...
  44. pmc Lack of KIF21A mutations in congenital fibrosis of the extraocular muscles type I patients from consanguineous Saudi Arabian families
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Mol Vis 17:218-24. 2011
    ..The objective of this study is to explore this possibility by assessing CFEOM1 patients exclusively from consanguineous families, who are the most likely to have recessive cause for their phenotype if a recessive cause exists...
  45. doi Genetics of primary glaucoma
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Curr Opin Ophthalmol 22:347-55. 2011
    ..To provide an overview of the genetics of the primary open-angle glaucomas with particular attention to congenital, infantile, and juvenile forms...
  46. ncbi Clinical characteristics of bilateral Duane syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 10:198-201. 2006
    ..To describe the clinical characteristics of bilateral Duane syndrome...
  47. ncbi Corneal tattooing for the treatment of debilitating glare in a child with traumatic iris loss
    Arif O Khan
    Department of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Saudi Arabia
    Am J Ophthalmol 139:920-1. 2005
    ..To report the cosmetic and therapeutic use of corneal tattooing for a child with sectoral traumatic corneal scarring and symptomatic glare from sectoral traumatic iris loss...
  48. ncbi Pediatric periodic alternating gaze deviation with midline cerebellar disease
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 11:410-1. 2007
    ..This report details the findings of an affected infant with cerebellar hypoplasia in the context of previously reported cases and supports the idea that the phenomenon typically is caused by cerebellar midline disease...
  49. ncbi Paradoxical head tilt during fixation with the affected eye in unilateral congenital fourth nerve palsy
    Arif O Khan
    Department of Ophthalmology, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Saudi Arabia
    J AAPOS 9:200-1. 2005
  50. ncbi Infected epithelial inclusion cyst mimicking subconjunctival abscess after strabismus surgery
    Arif O Khan
    Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 11:303-4. 2007
    ..We suggest that previous reports of presumed subconjunctival abscess after strabismus surgery also may have been caused by a similar mechanism...
  51. ncbi Two horizontal rectus eye muscle surgery combined with botulinum toxin for the treatment of very large angle esotropia. A pilot study
    Arif O Khan
    Pediatric Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Binocul Vis Strabismus Q 20:15-20. 2005
    ..To evaluate the effectiveness of a proposed new protocol for the primary treatment for very large angle esotropia: two muscle horizontal rectus muscle surgery with simultaneous botulinum toxin A injection in a small pilot study...
  52. ncbi Persistent diplopia following secondary intraocular lens placement in patients with sensory strabismus from uncorrected monocular aphakia
    Arif O Khan
    Division of Paediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Br J Ophthalmol 92:51-3. 2008
    ..To evaluate the incidence of persistent diplopia after secondary posterior chamber intraocular lens (PCIOL) implantation in patients with prolonged uncorrected monocular aphakia with associated sensory strabismus...
  53. ncbi Ptotic lid elevation during contralateral head tilt
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 11:297-9. 2007
    ..1,2) The subject of this report is a novel form in which the patient's ptotic eyelid elevated only during contralateral head tilt when the patient was upright, suggesting a congenital abnormality within the otolith-oculomotor pathway...
  54. ncbi Pediatric ophthalmology and strabismus in the Kingdom of Saudi Arabia
    Arif O Khan
    Department of Pediatric Ophthalmology, King Khaled Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    J AAPOS 8:513-4. 2004
  55. ncbi Ophthalmic features of hypoparathyroidism-retardation-dysmorphism
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 11:288-90. 2007
    ..We describe the ocular features of four Saudi Arabian HRD children referred to our institution for ocular complaints noted by their parents...
  56. ncbi Early diagnosis of the papillorenal syndrome by optic disc morphology
    Arif O Khan
    Department of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J Neuroophthalmol 25:209-11. 2005
    ..We report an infant whose characteristic fundus findings led to the early diagnosis of the papillorenal syndrome before the potential development of renal dysfunction...
  57. ncbi Bilateral Duane syndrome and bilateral aniridia
    Arif O Khan
    Pediatric Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    J AAPOS 10:273-4. 2006
    ..A novel association, that of bilateral Duane syndrome with bilateral aniridia, is the subject of this report...
  58. ncbi Fixation preference for the affected eye in patients with unilateral Duane syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    J AAPOS 10:275-6. 2006
    ..The most frequent associated ophthalmic finding was decreased vision in the unaffected eye from anisometropia and/or amblyopia. An additional associated finding was decompensated intermittent exotropia in 2 patients...
  59. pmc Paediatric secondary intraocular lens estimation from the aphakic refraction alone: comparison with a standard biometric technique
    A O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Br J Ophthalmol 90:1458-60. 2006
    ....
  60. ncbi Severe psychogenic visual loss in a girl with siblings blinded from congenital glaucoma
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
    J AAPOS 10:373-4. 2006
  61. ncbi Recessive cornea plana in the Kingdom of Saudi Arabia
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmology 113:1773-8. 2006
    ....
  62. ncbi Familial blepharophimosis-like syndrome with esotropia, uveal coloboma, and short stature
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 27:79-82. 2006
    ..Thought to be due to a contiguous gene syndrome, the recognizable phenotype of 3q interstitial deletion includes BPES facies and has not been associated with other loci...
  63. ncbi Corneal ectasia and hydrops in a patient with autosomal recessive cornea plana
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 27:99-101. 2006
    ..To report the development of corneal ectasia and hydrops in a patient with autosomal recessive cornea plana...
  64. pmc Retinoscopic (refractive) estimation of axial length in paediatric aphakia: a comparison with ultrasonic measurement
    A O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, 11462, Saudi Arabia
    Br J Ophthalmol 90:987-9. 2006
    ..To compare paediatric axial length values estimated from the aphakic refraction alone with axial length values measured by ultrasound...
  65. ncbi Bilateral congenital stromal cyst of the cornea
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 11:400-1. 2007
    ..We describe a bilateral congenital case in which the cysts occupied posterior excavations of the cornea and the affected infant developed angle-closure glaucoma...
  66. ncbi Osseous choristoma of the lateral canthus
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 11:502-3. 2007
    ..The subject of this report is a unique U-shaped subcutaneous osseous choristoma that did not involve the eye itself but rather conformed to the right lateral canthus in an otherwise normal 2-year-old boy...
  67. doi Heterozygous FOXC1 mutation (M161K) associated with congenital glaucoma and aniridia in an infant and a milder phenotype in her mother
    Arif O Khan
    Pediatric Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 29:67-71. 2008
    ..To report the genetic basis for congenital glaucoma with clinical aniridia in an infant and a milder phenotype in her mother...
  68. doi Correlation of ophthalmic examination with carrier status in females potentially harboring a severe Norrie disease gene mutation
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmology 115:730-3. 2008
    ..To correlate ophthalmic findings with carrier status for a severe Norrie disease (ND) gene mutation (C95F)...
  69. doi Congential fibrosis of the extraocular muscles type I (CFEOM1) on the Arabian Peninsula
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, KSA
    Ophthalmic Genet 29:25-8. 2008
    ..To assess for KIF21A mutation in the first two reported Saudi Arabian families with the classic phenotype of congenital fibrosis of the extraocular muscles type I (CFEOM1)...
  70. doi Infantile corneal myxoma
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 12:207-9. 2008
    ..The current report documents the clinical and histopathologic features of a 4-month-old girl with infantile corneal myxoma...
  71. doi Binocular diplopia following vision restoration in patients with keratoconus and sensory strabismus
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Strabismus 16:19-22. 2008
    ..To report the phenomenon of newly-noted binocular diplopia following vision improvement in patients with sensory strabismus secondary to keratoconus, and to document the effect of strabismus surgery on this diplopia...
  72. ncbi Lens coloboma associated with a ciliary body cyst
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, KSA
    Ophthalmic Genet 28:208-9. 2007
    ..The purpose of this report is to describe the association of lens coloboma with an adjacent cyst in the ciliary body and to suggest that ciliary body cysts may be an under-recognized cause of congenital lens coloboma...
  73. ncbi Ophthalmic features of ataxia telangiectasia-like disorder
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 12:186-9. 2008
    ..The purpose of this article is to describe the ophthalmic features of ATLD...
  74. ncbi A novel KERA mutation associated with autosomal recessive cornea plana
    Arif Khan
    Department of Pediatrics, King Khaled Eye Specialist Hospital P O Box 7191 Riyadh 11462 Saudi Arabia
    Ophthalmic Genet 25:147-52. 2004
    ..To report a novel KERA mutation associated with autosomal recessive cornea plana in members of a nuclear family and to describe their ophthalmic phenotypes...
  75. ncbi Optic nerve dysfunction in a child following low-dose maternal warfarin exposure
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmic Genet 28:183-4. 2007
    ..The current case, however, highlights that optic nerve dysfunction (as well as other signs of warfarin embryopathy) can occur after low-dose maternal warfarin exposure...
  76. ncbi Successful use of topical cysteamine formulated from the oral preparation in a child with keratopathy secondary to cystinosis
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Am J Ophthalmol 138:674-5. 2004
    ..To report the successful use of topical cysteamine formulated from the oral preparation in the treatment of severe photophobia from corneal crystal deposition in cystinosis...
  77. pmc Bilateral inverse globe retraction (Duane's) syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Saudi Arabia
    Indian J Ophthalmol 55:388-9. 2007
    ..A case of true inverse Duane's retraction syndrome, bilateral inverse globe retraction syndrome apparently due to abnormal innervation, is the subject of this clinical report...
  78. ncbi Recessive congenital total cataract with microcornea and heterozygote carrier signs caused by a novel missense CRYAA mutation (R54C)
    Arif O Khan
    Pediatric Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Am J Ophthalmol 144:949-952. 2007
    ..To determine the genetic basis for congenital total white cataract with microcornea in three affected siblings...
  79. doi Allelic heterogeneity in inbred populations: the Saudi experience with Alström syndrome as an illustrative example
    Mohamed A Aldahmesh
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Am J Med Genet A 149:662-5. 2009
    ..While we frequently assume founder effect in inbred populations, this report should serve to remind us of the powerful effect of the consanguinity factor, a common confounding variable among some of those populations...
  80. pmc Synergistic divergence: a distinct ocular motility dysinnervation pattern
    Darren T Oystreck
    Pediatric Ophthalmology Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Invest Ophthalmol Vis Sci 50:5213-6. 2009
    ..To summarize the clinical, neuroradiologic, and genetic observations in a group of patients with unilateral synergistic divergence (SD)...
  81. doi Novel recessive BFSP2 and PITX3 mutations: insights into mutational mechanisms from consanguineous populations
    Mohammed A Aldahmesh
    Department of Genetics, King Faisal Specialist Hospital and Research Center, King Saud University, Riyadh, Saudi Arabia
    Genet Med 13:978-81. 2011
    ..Genes in which both classes of mutations are known to exist are particularly interesting to study because these mutations typically define distinct pathogenic mechanisms at the molecular level...
  82. ncbi A novel missense Norrie disease mutation associated with a severe ocular phenotype
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia
    J Pediatr Ophthalmol Strabismus 41:361-3. 2004
    ..DNA sequencing demonstrated a novel missense mutation (703G>T) that significantly alters predicted protein structure. Less severe retinal developmental disease may be associated with milder mutations in the Norrie disease gene...
  83. pmc Molecular characterization of retinitis pigmentosa in Saudi Arabia
    Mohammed A Aldahmesh
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Vis 15:2464-9. 2009
    ..To catalog mutations that underlie retinitis pigmentosa (RP) in Saudi Arabia using a representative sample...
  84. doi Characterization of CTNS mutations in Arab patients with cystinosis
    Mohammed A Aldahmesh
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Ophthalmic Genet 30:185-9. 2009
    ..Mutations in CTNS, encoding cystinosin, are the only known cause of this autosomal recessive disorder with more than 85 different mutations described so far...
  85. doi Mutational spectrum of SLC4A11 in autosomal recessive CHED in Saudi Arabia
    Mohammed A Aldahmesh
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Invest Ophthalmol Vis Sci 50:4142-5. 2009
    ..To determine the extent of allelic, and possibly locus, heterogeneity in congenital hereditary endothelial dystrophy (CHED, MIM 217700) in patients from a highly consanguineous Saudi population...
  86. ncbi Restrictive strabismus in Parry-Romberg syndrome
    Arif O Khan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J Pediatr Ophthalmol Strabismus 44:51-2. 2007
    ..This suggests that an orbital inflammatory process (causing extraocular muscle fibrosis) is part of this rare and poorly understood syndrome...
  87. ncbi Familial ptotic lid elevation during ipsilateral abduction
    Arif O Khan
    Department of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 8:571-5. 2004
    ..To report and discuss the clinical findings of a 17-member family with 2 siblings who exhibit ptosis and abnormal synkinetic lid elevation associated with ipsilateral abduction...
  88. ncbi Resolution of childhood recurrent corneal phlyctenulosis following eradication of an intestinal parasite
    Mohammad A Al-Amry
    Divisions of Anterior Segment and Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 12:89-90. 2008
    ..Following treatment for the intestinal parasite, the child no longer suffered from recurrent ocular surface inflammation...
  89. ncbi Severe ocular surface disease and glaucoma in a newborn with aniridia
    Sami Al-Shahwan
    Glaucoma Division, King Khaled Eye Specialist Hospital, Riyadh 11462, Kingdom of Saudi Arabia
    J AAPOS 9:499-500. 2005
  90. ncbi Large-segment superior oblique tendon expanders in the management of severe congenital Brown syndrome
    Abdulaziz H Awad
    Department of Medical Education, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 7:274-8. 2003
    ..To report the effectiveness of large-segment superior oblique tendon expanders for severe congenital Brown syndrome...
  91. ncbi Control of intermittent esotropia by head shaking
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 11:206. 2007
    ..1) Head shaking as a compensatory mechanism to maintain ocular alignment in intermittent esotropia is the subject of this case report...
  92. doi Aphakic glaucoma after cataract surgery for isolated nontraumatic pediatric cataract
    Saad Al-Dahmash
    Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia
    Eye Contact Lens 36:177-80. 2010
    ..g., no microcornea) nontraumatic cataract with at least 5 years follow-up...
  93. ncbi Emmetropization after lensectomy and anterior vitrectomy for persistent hyperplastic primary vitreous cataract
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Eye Contact Lens 33:199-200. 2007
    ..To report the case of a 2-year-old boy whose aphakic eye became emmetropic 15 months after lensectomy with anterior vitrectomy for a classic persistent hyperplastic primary vitreous cataract...
  94. ncbi Pediatric endogenous bacterial endophthalmitis: case report and review of the literature
    Imtiaz A Chaudhry
    Department of Oculoplastic Surgery, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    J AAPOS 10:491-3. 2006
  95. doi Bilateral response following unilateral intravitreal bevacizumab injection in a child with uveitic cystoid macular edema
    Hassan Al-Dhibi
    Division of Uveitis, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 13:400-2. 2009
    ..The purpose of this report is to document bilateral reduction of uveitic CME following unilateral intravitreal bevacizumab injection in an 8-year-old girl...
  96. ncbi Management of congenital unilateral proptosis from an orbital epithelial cyst by cyst aspiration
    Adel H Alsuhaibani
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 10:589-91. 2006
    ..The subject of this report is the management of a congenital orbital epithelial cyst by needle aspiration in a newborn with ipsilateral esotropia and severe unilateral proptosis...
  97. doi Two-year survival of Ahmed valve implantation in the first 2 years of life with and without intraoperative mitomycin-C
    Faisal Al-Mobarak
    The King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    Ophthalmology 116:1862-5. 2009
    ..To evaluate the effect of intraoperative mitomycin-C (MMC) on polypropylene Ahmed glaucoma valve (AGV) survival 2 years after implantation during the first 2 years of life...
  98. doi High measured intraocular pressure in children with recessive congenital hereditary endothelial dystrophy
    Arif O Khan
    King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J Pediatr Ophthalmol Strabismus 47:29-33. 2010
    ..To report the phenomenon of high measured intraocular pressure in recessive congenital hereditary endothelial dystrophy...
  99. doi Delayed suprachoroidal hemorrhage after pediatric glaucoma surgery
    Faisal E Ghadhfan
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
    J AAPOS 13:283-6. 2009
    ..The purpose of this study was to identify surgical risk factors for delayed suprachoroidal hemorrhage after glaucoma surgery in children...