Pavel Katsel

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Cycle checkpoint abnormalities during dementia: a plausible association with the loss of protection against oxidative stress in Alzheimer's disease
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 8:e68361. 2013
  2. pmc Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Schizophr Res 130:238-49. 2011
  3. ncbi request reprint Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets
    Pavel L Katsel
    Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Platelets 14:21-33. 2003
  4. pmc Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals
    Pavel Katsel
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 4:e7642. 2009
  5. doi request reprint Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 33:2993-3009. 2008
  6. ncbi request reprint Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Neurochem Res 32:845-56. 2007
  7. ncbi request reprint Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029 6575, USA
    Schizophr Res 79:157-73. 2005
  8. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
  9. ncbi request reprint Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Int J Neuropsychopharmacol 10:565-73. 2007
  10. pmc Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1318:167-77. 2010

Detail Information

Publications22

  1. pmc Cycle checkpoint abnormalities during dementia: a plausible association with the loss of protection against oxidative stress in Alzheimer's disease
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 8:e68361. 2013
    ..Recent studies have reported the role of CCL checkpoint proteins and tumor suppressors, such as ATM and p53 in the control of glycolysis and oxidative metabolism in cancer, but their involvement in AD remains uncertain...
  2. pmc Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Schizophr Res 130:238-49. 2011
    ..Thus, OLG function may be perturbed by mutant hDISC1 in a model system that provides new avenues for studying aspects of the pathogenesis of SZ...
  3. ncbi request reprint Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets
    Pavel L Katsel
    Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Platelets 14:21-33. 2003
    ..This study identified AC-III as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation...
  4. pmc Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals
    Pavel Katsel
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 4:e7642. 2009
    ..We sought to characterize transcriptional and protein profiles of dementia in the oldest-old...
  5. doi request reprint Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 33:2993-3009. 2008
    ..These data suggest that the normal patterns of cell cycle gene and protein expression are disrupted in SZ and that this disruption may contribute to the oligodendroglial deficits observed in SZ...
  6. ncbi request reprint Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Neurochem Res 32:845-56. 2007
    ..This disrupted balance within the sphingolipid metabolism may trigger signaling events promoting neurodegeneration across cortical regions. This potential mechanism may provide a link between lipid metabolism disturbance and AD...
  7. ncbi request reprint Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029 6575, USA
    Schizophr Res 79:157-73. 2005
    ....
  8. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
    ....
  9. ncbi request reprint Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Int J Neuropsychopharmacol 10:565-73. 2007
    ....
  10. pmc Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1318:167-77. 2010
    ....
  11. pmc Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia
    Panos Roussos
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 38:533-9. 2013
    ..These findings implicate abnormalities of the NF-κB signaling pathway in SZ and provide evidence for an additional possible mechanism affecting the translocation of NF-κB signaling to the nucleus...
  12. pmc Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 30:561-73. 2009
    ....
  13. pmc Synaptic protein deficits are associated with dementia irrespective of extreme old age
    Michal Schnaider Beeri
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    Neurobiol Aging 33:1125.e1-8. 2012
    ....
  14. pmc Association of ApoE and LRP mRNA levels with dementia and AD neuropathology
    Afia Akram
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Neurobiol Aging 33:628.e1-628.e14. 2012
    ....
  15. doi request reprint Microarray database mining and cell differentiation defects in schizophrenia
    Aurelian Radu
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Adv Exp Med Biol 696:67-74. 2011
    ..These observations constitute an incentive for a new direction of study, aimed at investigating the potential role of OPCs in schizophrenia...
  16. doi request reprint Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia
    David Kerns
    J J Peters VA Medical Center, 130 West Kingsbridge Ave, Bronx, New York, NY 10468, USA
    Schizophr Res 120:150-8. 2010
    ..These data are consistent with the hypothesis that Ol and myelin deficits in SZ involve a failure of Ol precursors to appropriately exit the cell cycle in order to differentiate and mature into myelinating Ols...
  17. ncbi request reprint The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, Rm 4F 33A, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Psychiatry 163:1834-7. 2006
    ..The authors sought to understand the origins of oligodendrocyte/myelin gene expression abnormalities in the brains of persons with schizophrenia...
  18. doi request reprint Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia
    Panos Roussos
    Department of Psychiatry, The Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Arch Gen Psychiatry 69:7-15. 2012
    ....
  19. pmc Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?
    Afia Akram
    Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Neurodegener 5:36. 2010
    ..LXR/RXR functions as a sensor of cellular cholesterol concentration and mediates cholesterol efflux by inducing the transcription of key cholesterol shuffling vehicles namely, ATP-binding cassette transporter A1 (ABCA1) and ApoE...
  20. pmc Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 36:1171-7. 2011
    ..These findings suggest that a subset of astrocytes localized to specific cortical layers is adversely affected in schizophrenia and raise the possibility of glutamatergic dyshomeostasis in selected neuronal populations...
  21. pmc FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
    Yuji Kajiwara
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY, USA
    PLoS ONE 4:e5071. 2009
    ..As caspase-4 shows evidence of being a primate-specific gene, current models of AD and other neurodegenerative conditions may be incomplete because of the absence of this gene in the murine genome...
  22. pmc Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases
    Lap Ho
    Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, New York, NY 10029, USA
    Int J Alzheimers Dis 2012:321280. 2012
    ..Outcomes from our study support the development of insulin-sensitizing therapeutic strategies to stimulate downstream IR signaling in nondiabetic AD cases...