Research Topics
Genomes and Genes
| Pavel KatselSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human plateletsPavel L Katsel
Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Platelets 14:21-33. 2003..This study identified AC-III as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation...- Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology studyPavel Katsel
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029 6575, USA
Schizophr Res 79:157-73. 2005.... 
Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytesPavel Katsel
Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
Schizophr Res 130:238-49. 2011..Thus, OLG function may be perturbed by mutant hDISC1 in a model system that provides new avenues for studying aspects of the pathogenesis of SZ...- Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?Pavel Katsel
Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
Neurochem Res 32:845-56. 2007..This disrupted balance within the sphingolipid metabolism may trigger signaling events promoting neurodegeneration across cortical regions. This potential mechanism may provide a link between lipid metabolism disturbance and AD... 
Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytesPavel Katsel
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
Neuropsychopharmacology 33:2993-3009. 2008..These data suggest that the normal patterns of cell cycle gene and protein expression are disrupted in SZ and that this disruption may contribute to the oligodendroglial deficits observed in SZ...- Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individualsPavel Katsel
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
PLoS ONE 4:e7642. 2009..We sought to characterize transcriptional and protein profiles of dementia in the oldest-old... - Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophreniaVahram Haroutunian
Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
Int J Neuropsychopharmacol 10:565-73. 2007.... - PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementiaWeiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
Arch Neurol 66:352-61. 2009.... - Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampusAfia Akram
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Brain Res 1318:167-77. 2010.... - Transcriptional vulnerability of brain regions in Alzheimer's disease and dementiaVahram Haroutunian
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
Neurobiol Aging 30:561-73. 2009.... - Convergent findings for abnormalities of the NF-κB signaling pathway in schizophreniaPanos Roussos
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
Neuropsychopharmacology 38:533-9. 2013..These findings implicate abnormalities of the NF-κB signaling pathway in SZ and provide evidence for an additional possible mechanism affecting the translocation of NF-κB signaling to the nucleus... - Synaptic protein deficits are associated with dementia irrespective of extreme old ageMichal Schnaider Beeri
Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
Neurobiol Aging 33:1125.e1-8. 2012.... - Association of ApoE and LRP mRNA levels with dementia and AD neuropathologyAfia Akram
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
Neurobiol Aging 33:628.e1-628.e14. 2012.... - The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophreniaVahram Haroutunian
Department of Psychiatry, Rm 4F 33A, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
Am J Psychiatry 163:1834-7. 2006..The authors sought to understand the origins of oligodendrocyte/myelin gene expression abnormalities in the brains of persons with schizophrenia... - Microarray database mining and cell differentiation defects in schizophreniaAurelian Radu
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Adv Exp Med Biol 696:67-74. 2011..These observations constitute an incentive for a new direction of study, aimed at investigating the potential role of OPCs in schizophrenia... - Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophreniaDavid Kerns
J J Peters VA Medical Center, 130 West Kingsbridge Ave, Bronx, New York, NY 10468, USA
Schizophr Res 120:150-8. 2010..These data are consistent with the hypothesis that Ol and myelin deficits in SZ involve a failure of Ol precursors to appropriately exit the cell cycle in order to differentiate and mature into myelinating Ols... - Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophreniaPanos Roussos
Department of Psychiatry, The Mount Sinai School of Medicine, Bronx, NY 10468, USA
Arch Gen Psychiatry 69:7-15. 2012.... - Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophreniaPavel Katsel
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
Neuropsychopharmacology 36:1171-7. 2011..These findings suggest that a subset of astrocytes localized to specific cortical layers is adversely affected in schizophrenia and raise the possibility of glutamatergic dyshomeostasis in selected neuronal populations... - Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?Afia Akram
Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Neurodegener 5:36. 2010..LXR/RXR functions as a sensor of cellular cholesterol concentration and mediates cholesterol efflux by inducing the transcription of key cholesterol shuffling vehicles namely, ATP-binding cassette transporter A1 (ABCA1) and ApoE... - FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4Yuji Kajiwara
Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY, USA
PLoS ONE 4:e5071. 2009..As caspase-4 shows evidence of being a primate-specific gene, current models of AD and other neurodegenerative conditions may be incomplete because of the absence of this gene in the murine genome... - Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease casesLap Ho
Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, New York, NY 10029, USA
Int J Alzheimers Dis 2012:321280. 2012..Outcomes from our study support the development of insulin-sensitizing therapeutic strategies to stimulate downstream IR signaling in nondiabetic AD cases...