Gareth John

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Investigation of astrocyte - oligodendrocyte interactions in human cultures
    Gareth R John
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 814:401-14. 2012
  2. ncbi request reprint Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis
    Gareth R John
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 24:2837-45. 2004
  3. pmc TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation
    Yueting Zhang
    Corinne Goldsmith Dickinson Center for MS, Mount Sinai School of Medicine, New York, New York 10029, USA
    Glia 58:964-74. 2010
  4. ncbi request reprint Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation
    Gareth R John
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1115-21. 2002
  5. ncbi request reprint IL-1-regulated responses in astrocytes: relevance to injury and recovery
    Gareth R John
    Department of Neurology, Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, New York 10641, USA
    Glia 49:161-76. 2005
  6. ncbi request reprint IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program
    Azeb Tadesse Argaw
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 177:5574-84. 2006
  7. ncbi request reprint Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation
    Yueting Zhang
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 26:12174-85. 2006
  8. pmc Revisiting Notch in remyelination of multiple sclerosis lesions
    Celia F Brosnan
    Department of Pathology, Albert Einstein College of Medicine, New York, NY 10461, USA
    J Clin Invest 119:10-3. 2009
  9. ncbi request reprint The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture
    Mark A Rivieccio
    Sue Golding Graduate Division, Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:3719-26. 2005
  10. ncbi request reprint Cytokines: powerful regulators of glial cell activation
    Gareth R John
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuroscientist 9:10-22. 2003

Research Grants

  1. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
  2. Astrocyte regulation of CNS remyelination
    Gareth R John; Fiscal Year: 2010
  3. Cytokine regulation of glial reactivity
    Gareth John; Fiscal Year: 2007
  4. Reactive astrogliosis regulates blood-brain barrier permeability.
    Gareth R John; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. pmc Investigation of astrocyte - oligodendrocyte interactions in human cultures
    Gareth R John
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 814:401-14. 2012
    ..These approaches are designed to facilitate analysis of mechanisms underlying astrocytic regulation of progenitor survival and myelin repair...
  2. ncbi request reprint Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis
    Gareth R John
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 24:2837-45. 2004
    ....
  3. pmc TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation
    Yueting Zhang
    Corinne Goldsmith Dickinson Center for MS, Mount Sinai School of Medicine, New York, New York 10029, USA
    Glia 58:964-74. 2010
    ....
  4. ncbi request reprint Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation
    Gareth R John
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1115-21. 2002
    ..These data are the first to implicate the Notch pathway in the limited remyelination in MS. Thus, Notch may represent a potential target for therapeutic intervention in this disease...
  5. ncbi request reprint IL-1-regulated responses in astrocytes: relevance to injury and recovery
    Gareth R John
    Department of Neurology, Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, New York 10641, USA
    Glia 49:161-76. 2005
    ..In this report we review data obtained with this technology to provide an overview of the extent of changes induced in astrocytes by the cytokine IL-1...
  6. ncbi request reprint IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program
    Azeb Tadesse Argaw
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 177:5574-84. 2006
    ..These results suggest that IL-1beta contributes to BBB permeability in MS via reactivation of the HIF-VEGF axis. This pathway may represent a potential therapeutic target to restrict lesion formation...
  7. ncbi request reprint Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation
    Yueting Zhang
    Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 26:12174-85. 2006
    ..These data are the first to implicate IL-11 in oligodendrocyte viability, maturation, and myelination. We suggest that this pathway may represent a potential therapeutic target for oligodendrocyte protection and remyelination in MS...
  8. pmc Revisiting Notch in remyelination of multiple sclerosis lesions
    Celia F Brosnan
    Department of Pathology, Albert Einstein College of Medicine, New York, NY 10461, USA
    J Clin Invest 119:10-3. 2009
    ..These data target TIP30 as a new pathogenic factor in MS...
  9. ncbi request reprint The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture
    Mark A Rivieccio
    Sue Golding Graduate Division, Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:3719-26. 2005
    ..These data are the first to show that IL-1beta, in addition to TLRs, can stimulate IRF3, implicating this cytokine as an activator of genes involved in innate antiviral responses in astrocytes...
  10. ncbi request reprint Cytokines: powerful regulators of glial cell activation
    Gareth R John
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuroscientist 9:10-22. 2003
    ..In this review, we focus on current information that has helped to define the role of cytokines in regulating glial cell function as it relates to the properties of microglia and astrocytes...
  11. ncbi request reprint CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis
    Kakuri M Omari
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, F 140, Bronx, NY 10461, USA
    Brain 128:1003-15. 2005
    ....

Research Grants11

  1. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
    ..abstract_text> ..
  2. Astrocyte regulation of CNS remyelination
    Gareth R John; Fiscal Year: 2010
    ....
  3. Cytokine regulation of glial reactivity
    Gareth John; Fiscal Year: 2007
    ....
  4. Reactive astrogliosis regulates blood-brain barrier permeability.
    Gareth R John; Fiscal Year: 2010
    ..In this proposal, using a conditional knockout approach we will determine the roles of HIF-1a, VEGF-A, CLN-5 and OCLN in BBB disruption, with the goal of identifying novel therapeutic targets to restrict lesion formation in MS. ..