Steven Itzkowitz

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Diagnosis and management of dysplasia in patients with inflammatory bowel diseases
    Steven H Itzkowitz
    The Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 126:1634-48. 2004
  2. ncbi request reprint Polypoid dysplasia in inflammatory bowel disease: removing the bumps in the road
    Steven Itzkowitz
    Mount Sinai School of Medicine, New York City, NY 10029, USA
    Inflamm Bowel Dis 12:919-20. 2006
  3. ncbi request reprint Improved fecal DNA test for colorectal cancer screening
    Steven H Itzkowitz
    Department of Medicine and Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 5:111-7. 2007
  4. ncbi request reprint Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease
    Steven H Itzkowitz
    Division of Gastroenterology, Department of Medicine, The Mount Sinai School of Medicine, New York, New York, USA
    Inflamm Bowel Dis 11:314-21. 2005
  5. ncbi request reprint Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
    Steven H Itzkowitz
    Gastrointestinal Division, Box 1069, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 287:G7-17. 2004
  6. ncbi request reprint Molecular biology of dysplasia and cancer in inflammatory bowel disease
    Steven H Itzkowitz
    The Dr Henry D Janowitz Division of Gastroenterology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Gastroenterol Clin North Am 35:553-71. 2006
  7. ncbi request reprint Colon carcinogenesis in inflammatory bowel disease: applying molecular genetics to clinical practice
    Steven Itzkowitz
    Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Clin Gastroenterol 36:S70-4; discussion S94-6. 2003
  8. ncbi request reprint Cancer prevention in patients with inflammatory bowel disease
    Steven H Itzkowitz
    Dr Henry D Janowitz Division of Gastroenterology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Gastroenterol Clin North Am 31:1133-44. 2002
  9. doi request reprint Progression to colorectal neoplasia in ulcerative colitis: effect of mesalamine
    Thomas Ullman
    Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 6:1225-30; quiz 1177. 2008
  10. ncbi request reprint A randomized controlled trial using patient navigation to increase colonoscopy screening among low-income minorities
    Jennifer Christie
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    J Natl Med Assoc 100:278-84. 2008

Research Grants

  1. TFF3 GENE EXPRESSION IN METASTATIC COLON CANCER
    Steven Itzkowitz; Fiscal Year: 2001
  2. Trefoil Factors in GI Cancer Biology
    Steven Itzkowitz; Fiscal Year: 2007
  3. Trefoil Factors in GI Cancer Biology
    Steven Itzkowitz; Fiscal Year: 2009
  4. Trefoil Factors in GI Cancer Biology
    Steven H Itzkowitz; Fiscal Year: 2010

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Diagnosis and management of dysplasia in patients with inflammatory bowel diseases
    Steven H Itzkowitz
    The Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 126:1634-48. 2004
    ..The clinical application of newer molecular methods to detect neoplasia, particularly gene microarrays and stool DNA testing, also deserve further study...
  2. ncbi request reprint Polypoid dysplasia in inflammatory bowel disease: removing the bumps in the road
    Steven Itzkowitz
    Mount Sinai School of Medicine, New York City, NY 10029, USA
    Inflamm Bowel Dis 12:919-20. 2006
  3. ncbi request reprint Improved fecal DNA test for colorectal cancer screening
    Steven H Itzkowitz
    Department of Medicine and Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 5:111-7. 2007
    ..The present study was conducted to determine the sensitivity and specificity of a second-generation assay (version 2) that uses improved DNA stabilization/isolation techniques and a new promoter methylation marker...
  4. ncbi request reprint Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease
    Steven H Itzkowitz
    Division of Gastroenterology, Department of Medicine, The Mount Sinai School of Medicine, New York, New York, USA
    Inflamm Bowel Dis 11:314-21. 2005
    ..A panel of international experts was assembled to develop consensus recommendations for the performance of surveillance. The findings are presented herein...
  5. ncbi request reprint Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
    Steven H Itzkowitz
    Gastrointestinal Division, Box 1069, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 287:G7-17. 2004
    ..Mice genetically prone to inflammatory bowel disease also develop colorectal cancer especially in the presence of bacterial colonization. These observations offer compelling support for the role of inflammation in colon carcinogenesis...
  6. ncbi request reprint Molecular biology of dysplasia and cancer in inflammatory bowel disease
    Steven H Itzkowitz
    The Dr Henry D Janowitz Division of Gastroenterology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Gastroenterol Clin North Am 35:553-71. 2006
    ..Although none of the molecular alterations to be discussed have yet been integrated into clinical practice, there is potential for molecular diagnostics to enhance the management of patients with long-standing IBD...
  7. ncbi request reprint Colon carcinogenesis in inflammatory bowel disease: applying molecular genetics to clinical practice
    Steven Itzkowitz
    Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Clin Gastroenterol 36:S70-4; discussion S94-6. 2003
    ..It will be important to study whether these markers, or other panels of gene or protein expression, can identify patients at highest risk for developing CRC in future clinical studies...
  8. ncbi request reprint Cancer prevention in patients with inflammatory bowel disease
    Steven H Itzkowitz
    Dr Henry D Janowitz Division of Gastroenterology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Gastroenterol Clin North Am 31:1133-44. 2002
    ..Future research will help to define better the natural history of dysplasia in IBD, and to determine how molecular approaches may be integrated into surveillance programs to reduce CRC risk...
  9. doi request reprint Progression to colorectal neoplasia in ulcerative colitis: effect of mesalamine
    Thomas Ullman
    Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 6:1225-30; quiz 1177. 2008
    ..The aim of this study was to compare rates of progression with advanced neoplasia in patient cohorts with UC taking low and high doses of mesalamine and to determine where in the process of neoplastic progression mesalamine might act...
  10. ncbi request reprint A randomized controlled trial using patient navigation to increase colonoscopy screening among low-income minorities
    Jennifer Christie
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    J Natl Med Assoc 100:278-84. 2008
    ..A PN improves compliance with screening colonoscopy in low-income minorities. Larger studies are needed to evaluate what features of navigation are most effective in facilitating completion of screening colonoscopy...
  11. pmc Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study
    Roopali Bansal Gupta
    Department of Medicine, The University of Texas Southwestern, Dallas, Texas, USA
    Gastroenterology 133:1099-105; quiz 1340-1. 2007
    ..Our aim was to determine whether severity of microscopic inflammation over time is an independent risk factor for neoplastic progression in UC...
  12. doi request reprint A simplified, noninvasive stool DNA test for colorectal cancer detection
    Steven Itzkowitz
    Department of Medicine and Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Gastroenterol 103:2862-70. 2008
    ....
  13. doi request reprint Trefoil factor-3 expression in human colon cancer liver metastasis
    Mark Babyatsky
    The Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1069, New York, NY 10029 6574, USA
    Clin Exp Metastasis 26:143-51. 2009
    ..These results provide further evidence that TFF3 contributes to the malignant behavior of colon cancer cells. These observations may have relevance for designing new diagnostic and treatment approaches to colorectal cancer...
  14. doi request reprint A program to enhance completion of screening colonoscopy among urban minorities
    Lea Ann Chen
    Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 6:443-50. 2008
    ..This study investigated the use of patient navigation within an open-access referral system and its effects on colonoscopy completion rates among urban minorities...
  15. pmc Sociodemographic correlates of stage of adoption for colorectal cancer screening in African Americans
    Jennifer Christie
    Emory University School of Medicine, Department of Medicine, Atlanta, GA 30322, USA
    Ethn Dis 19:323-9. 2009
    ..Endoscopic screening, while effective in reducing both, is greatly underutilized. This research sought to understand sociodemographic factors related to stage of readiness for endoscopic screening...
  16. doi request reprint Dysplasia is more common in the distal than proximal colon in ulcerative colitis surveillance
    Robert Goldstone
    Department of Medicine, Division of Gastroenterology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Inflamm Bowel Dis 18:832-7. 2012
    ..The aim was to determine whether a difference exists in the anatomic distribution of dysplasia discovered in UC patients undergoing colonoscopic surveillance...
  17. pmc An examination of the psychosocial factors influencing colorectal cancer patients' communication of colorectal cancer patient risk with their siblings
    Catalina Lawsin
    Department of Psychology, B 8 215 Baruch College, City University of New York, One Bernard Baruch Way, New York, NY 10010, USA
    Cancer Epidemiol Biomarkers Prev 18:2907-12. 2009
    ....
  18. doi request reprint Chromoendoscopy-targeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial
    James F Marion
    Mount Sinai School of Medicine, New York, New York 10028 0517, USA
    Am J Gastroenterol 103:2342-9. 2008
    ..We prospectively compared dye-spray technique using methylene blue to standard colonoscopic surveillance in detecting dysplasia...
  19. ncbi request reprint Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine
    Sierra Matula
    Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 3:1015-21. 2005
    ..Our aim was to determine the effect of the immunomodulators 6-mercaptopurine (6MP) and azathioprine (AZA) in preventing the development of dysplasia or CRC in UC...
  20. ncbi request reprint Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis
    Thomas Ullman
    Department of Medicine, The Dr Henry D Janowitz Division of Gastroenterology, Box 1069, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Gastroenterology 125:1311-9. 2003
    ....
  21. ncbi request reprint Barriers to colorectal cancer screening: inadequate knowledge by physicians
    Melissa Gennarelli
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA
    Mt Sinai J Med 72:36-44. 2005
    ..The purpose of this study was to assess physicians' knowledge of (a) American Cancer Society (ACS) CRC screening guidelines for average-risk and high-risk patients, and (b) general colorectal cancer facts which support these guidelines...
  22. doi request reprint Progression of low-grade dysplasia in ulcerative colitis: effect of colonic location
    Robert Goldstone
    The Dr Henry D Janowitz Division of Gastroenterology, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastrointest Endosc 74:1087-93. 2011
    ..Emerging evidence suggests that the biology of sporadic colorectal neoplasia may differ between the proximal and distal colon. Whether such a difference exists in colitis-associated colorectal neoplasia is unknown...
  23. pmc Predictors of endoscopy in minority women
    Jennifer Christie
    Division of Gastroenterology, Mount Sinai School of Medicine New York, NY 10029, USA
    J Natl Med Assoc 97:1361-8. 2005
    ..This study evaluates the association between socioeconomic, medical and psychosocial factors and the use of endoscopy in low-income minority women...
  24. ncbi request reprint Trefoil factor family-3 is associated with aggressive behavior of colon cancer cells
    Xianyang Yio
    The Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Clin Exp Metastasis 22:157-65. 2005
    ..The present study was conducted to determine whether TFF3 expression contributes to the malignant behavior of cancer cells in vitro and in vivo...
  25. ncbi request reprint Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways
    Xianyang Yio
    Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 130:1696-706. 2006
    ..Recently, TFF1 mutations have been found in human gastric cancer. The purpose of this study was to determine the functionality of these mutants...
  26. pmc Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: a case-control study
    Inga Peter
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029 USA
    BMC Med Genet 12:63. 2011
    ..We evaluated a set of well-established CD-susceptibility variants to determine if they can explain the increased CD risk in the AJ population...
  27. ncbi request reprint Chemoprevention of colorectal cancer in ulcerative colitis
    Victoria J Croog
    Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Int J Colorectal Dis 18:392-400. 2003
    ..Evidence suggests, but does not prove, that folic acid is chemopreventive in patients with UC. Further studies are needed to fully define the chemoprotective role of these and other agents...
  28. pmc Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 133:1869-81. 2007
    ..The molecular mechanisms linking inflammation and colon carcinogenesis are incompletely understood. We tested the hypothesis that Toll-like receptor 4 (TLR4) is involved in tumorigenesis in the setting of chronic inflammation...
  29. ncbi request reprint Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population
    Thomas F Imperiale
    Department of Medicine, Indiana University, and the Regenstrief Institute, Indianapolis, IN 46202, USA
    N Engl J Med 351:2704-14. 2004
    ..We compared an approach that identifies abnormal DNA in stool samples with the Hemoccult II fecal occult-blood test in average-risk, asymptomatic persons 50 years of age or older...
  30. doi request reprint Clinical and prognostic features of rectal neuroendocrine tumors
    Brett Weinstock
    Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, N Y, USA
    Neuroendocrinology 98:180-7. 2013
    ..Staging according to ENETS/NANETS guidelines should be used in the treatment algorithm rather than size alone. © 2013 S. Karger AG, Basel. ..
  31. pmc Implementation of culturally targeted patient navigation system for screening colonoscopy in a direct referral system
    Lina Jandorf
    Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA, Population Studies and Disparities Research Program, Department of Oncology, School of Medicine, Karmanos Cancer Institute, Wayne State University, 4100 John R, MM03CB Detroit, MI 48201, USA and Mailman School of Public Health, Columbia University, 722 West, 168th Street, New York, NY 10032, USA
    Health Educ Res 28:803-15. 2013
    ..navigators, how CTPN was implemented and provide a preliminary answer to our questions of the study aims: can peer navigators be as effective as professionals and what is the potential impact of patient navigation on screening adherence?..
  32. ncbi request reprint Short-chain fatty acid induces intestinal mucosal injury in newborn rats and down-regulates intestinal trefoil factor gene expression in vivo and in vitro
    Jing Lin
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Pediatr Gastroenterol Nutr 41:607-11. 2005
    ..Intestinal trefoil factor (ITF) is a factor important for the maintenance and repair of the intestinal mucosal barrier. Regulation of ITF gene expression by SCFAs may be involved as one of the mechanisms...
  33. ncbi request reprint Teaching clinical management skills for genetic testing of hereditary nonpolyposis colorectal cancer using a Web-based tutorial
    Kathleen Barnes
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genet Med 5:43-8. 2003
    ..To pilot and evaluate an interactive Web-based continuing medical education tutorial on clinical management of hereditary nonpolyposis colon cancer (HNPCC) and genetic testing...
  34. ncbi request reprint Distress among inflammatory bowel disease patients at high risk for colorectal cancer: a preliminary investigation of the effects of family history of cancer, disease duration, and perceived social support
    Christine Rini
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Psychooncology 17:354-62. 2008
    ..02). Having a DR history of CRC also predicted higher CRC-specific distress, but only among patients diagnosed more recently (p = 0.03). Clinical implications of these findings are discussed along with future research directions...
  35. pmc Diversified microbiota of meconium is affected by maternal diabetes status
    Jianzhong Hu
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
    PLoS ONE 8:e78257. 2013
    ..This study was aimed to assess the diversity of the meconium microbiome and determine if the bacterial community is affected by maternal diabetes status...
  36. ncbi request reprint Intestinal trefoil factor: a marker of poor prognosis in gastric carcinoma
    Takasuke Yamachika
    Gastrointestinal Research Laboratory, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Cancer Res 8:1092-9. 2002
    ..Gastric adenocarcinomas can arise through a process of intestinalization, but no study has yet comprehensively examined the expression of ITF in gastric cancer or correlated ITF expression with clinical outcome in any cancer type...
  37. doi request reprint Prognostic clinicopathologic factors in longitudinally followed patients with metastatic small bowel carcinoid tumors
    Thomas Curran
    Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Pancreas 40:1253-7. 2011
    ..Neuroendocrine tumors demonstrate heterogeneous behavior based on the site of origin and histology. This study aimed to delineate prognostic clinicopathologic features in patients with metastatic midgut carcinoid...
  38. pmc Cancer in inflammatory bowel disease
    Jianlin Xie
    GI Division, Mount Sinai School of Medicine, One Gustave Levy Place, New York City, NY 10029, USA
    World J Gastroenterol 14:378-89. 2008
    ..New endoscopic and molecular screening approaches may further refine our current surveillance guidelines and our understanding of the natural history of dysplasia...
  39. ncbi request reprint The diagnosis and treatment of pouchitis in inflammatory bowel disease
    Adam Cheifetz
    Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Clin Gastroenterol 38:S44-50. 2004
    ..Hopefully, this will also bring more clarity to the heterogeneous population of patients with pouchitis and allow for more focused therapeutic strategies...
  40. ncbi request reprint Awareness of genetic testing for colorectal cancer predisposition among specialists in gastroenterology
    Shivani Batra
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Gastroenterol 97:729-33. 2002
    ....
  41. pmc Use of a patient navigator to increase colorectal cancer screening in an urban neighborhood health clinic
    Lina Jandorf
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Urban Health 82:216-24. 2005
    ..1% vs. 25%, P=.086). Thus, a PN system successfully increases CRC screening rates among a predominantly minority population of low socioeconomic status...
  42. ncbi request reprint Demographic, medical, and psychosocial correlates to CAM use among survivors of colorectal cancer
    Catalina Lawsin
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Support Care Cancer 15:557-64. 2007
    ..This study examined correlates of CAM use among colorectal cancer (CRC) survivors, an understudied population that experiences many physical and psychological difficulties...
  43. ncbi request reprint The molecular and genetic basis of colon cancer
    David H Robbins
    Dr Henry D Janowitz Division of Gastroenterology, Box 1069, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Med Clin North Am 86:1467-95. 2002
    ..It is hoped that such progress will impact on the frequency and mortality of this very common and frequently fatal cancer...
  44. ncbi request reprint Practical advances in stool screening for colorectal cancer
    Jonathan Potack
    The Dr Henry D Janowitz Division of Gastroenterology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Natl Compr Canc Netw 8:81-92. 2010
    ..As the performance characteristics for FIT and stool DNA tests continue to evolve, stool-based testing for CRC is expected to become a more reliable component in the armamentarium for CRC screening...
  45. ncbi request reprint Pathology of mouse models of intestinal cancer: consensus report and recommendations
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Gastroenterology 124:762-77. 2003

Research Grants7

  1. TFF3 GENE EXPRESSION IN METASTATIC COLON CANCER
    Steven Itzkowitz; Fiscal Year: 2001
    ..The use of the TFF3 gene to drive expression of suicide genes offers a novel approach which should result in more targetted, safer gene therapy for metastatic colon cancer. ..
  2. Trefoil Factors in GI Cancer Biology
    Steven Itzkowitz; Fiscal Year: 2007
    ..The results of these studies could provide insights into novel treatment strategies for gastrointestinal malignancies. ..
  3. Trefoil Factors in GI Cancer Biology
    Steven Itzkowitz; Fiscal Year: 2009
    ..The results of these studies could provide insights into novel treatment strategies for gastrointestinal malignancies. ..
  4. Trefoil Factors in GI Cancer Biology
    Steven H Itzkowitz; Fiscal Year: 2010
    ..The results of these studies could provide insights into novel treatment strategies for gastrointestinal malignancies. ..