Lilian M Hsu

Summary

Affiliation: Mount Holyoke College
Country: USA

Publications

  1. ncbi request reprint Promoter clearance and escape in prokaryotes
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, South Hadley, MA 01075, USA
    Biochim Biophys Acta 1577:191-207. 2002
  2. ncbi request reprint In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 1. RNA chain initiation, abortive initiation, and promoter escape at three bacteriophage promoters
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, South Hadley, Massachusetts 0l075 6456, USA
    Biochemistry 42:3777-86. 2003
  3. pmc Initial transcribed sequence mutations specifically affect promoter escape properties
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Biochemistry 45:8841-54. 2006
  4. pmc Monitoring abortive initiation
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA
    Methods 47:25-36. 2009
  5. ncbi request reprint An alternate mechanism of abortive release marked by the formation of very long abortive transcripts
    Monica Chander
    Program in Biochemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Biochemistry 46:12687-99. 2007
  6. ncbi request reprint Open season on RNA polymerase
    Lilian M Hsu
    Nat Struct Biol 9:502-4. 2002
  7. ncbi request reprint Changes in conserved region 3 of Escherichia coli sigma 70 reduce abortive transcription and enhance promoter escape
    Michael Cashel
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:5539-47. 2003
  8. ncbi request reprint In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 2. Formation and characterization of two distinct classes of initial transcribing complexes
    Nam V Vo
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Biochemistry 42:3787-97. 2003
  9. ncbi request reprint In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 3. Influences of individual DNA elements within the promoter recognition region on abortive initiation and promoter escape
    Nam V Vo
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Biochemistry 42:3798-811. 2003

Collaborators

  • Nam V Vo
  • Monica Chander
  • Michael J Chamberlin
  • Michael Cashel
  • Caroline M Kane
  • Karyn M Austin
  • Piya Sircar
  • Nwe Nwe Aye-Han
  • V James Hernandez

Detail Information

Publications9

  1. ncbi request reprint Promoter clearance and escape in prokaryotes
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, South Hadley, MA 01075, USA
    Biochim Biophys Acta 1577:191-207. 2002
    ..Based on structural and biochemical evidence, a mechanism for abortive initiation and promoter escape is described...
  2. ncbi request reprint In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 1. RNA chain initiation, abortive initiation, and promoter escape at three bacteriophage promoters
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, South Hadley, Massachusetts 0l075 6456, USA
    Biochemistry 42:3777-86. 2003
    ..Instead, formation of abortive products appears to be determined by intrinsic DNA signals embedded in the promoter recognition region and the initial transcribed sequence region of each promoter...
  3. pmc Initial transcribed sequence mutations specifically affect promoter escape properties
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Biochemistry 45:8841-54. 2006
    ..How the ITS might influence the course of early transcription is discussed within the structural context of an initial transcribing complex...
  4. pmc Monitoring abortive initiation
    Lilian M Hsu
    Program in Biochemistry, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA
    Methods 47:25-36. 2009
    ..This chapter discusses the knowledge gained through the biochemical approach and a high resolution method that yields quantitative and qualitative information regarding abortive initiation-promoter escape at a promoter...
  5. ncbi request reprint An alternate mechanism of abortive release marked by the formation of very long abortive transcripts
    Monica Chander
    Program in Biochemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Biochemistry 46:12687-99. 2007
    ..We discuss how certain features in the ITS, when combined with the N25 promoter, may lead to hyper forward translocation and abortive release at VLAT positions...
  6. ncbi request reprint Open season on RNA polymerase
    Lilian M Hsu
    Nat Struct Biol 9:502-4. 2002
  7. ncbi request reprint Changes in conserved region 3 of Escherichia coli sigma 70 reduce abortive transcription and enhance promoter escape
    Michael Cashel
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:5539-47. 2003
    ..2 segment that permits efficient positioning of the nascent RNA into the RNA exit channel displacing sigma and facilitating sigma release...
  8. ncbi request reprint In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 2. Formation and characterization of two distinct classes of initial transcribing complexes
    Nam V Vo
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Biochemistry 42:3787-97. 2003
    ..Thus, multiple classes of ITCs can be formed during promoter binding and transcript initiation...
  9. ncbi request reprint In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 3. Influences of individual DNA elements within the promoter recognition region on abortive initiation and promoter escape
    Nam V Vo
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Biochemistry 42:3798-811. 2003
    ..These results suggest that strong RNA polymerase-PRR interactions stall the polymerase at the promoter, thereby reducing the rate of promoter escape and consequently enhancing the extent of abortive initiation...