Lap Ho

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 USA
    Mol Neurodegener 6:7. 2011
  2. pmc Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
  3. pmc Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration
    Lap Ho
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    J Alzheimers Dis 16:59-72. 2009
  4. ncbi request reprint Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
  5. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
  6. ncbi request reprint Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    FASEB J 20:2313-20. 2006
  7. ncbi request reprint Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    FASEB J 18:902-4. 2004
  8. ncbi request reprint Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
  9. ncbi request reprint Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    Weiping Qin
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:50970-7. 2003
  10. pmc Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
    Bing Gong
    Department of Neurology, Center of Excellence for Novel Approaches to Neurotherapeutics, Mount Sinai School of Medicine, New York, NY, USA
    Neurobiol Aging 34:1581-8. 2013

Collaborators

Detail Information

Publications48

  1. pmc Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 USA
    Mol Neurodegener 6:7. 2011
    ..Proper interpretations of these clinical observations, as well as future development of dimebon in AD treatment are complicated by the lack of concrete information on the mechanisms by which dimebon might benefit AD...
  2. pmc Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
    ..abstract:..
  3. pmc Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration
    Lap Ho
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    J Alzheimers Dis 16:59-72. 2009
    ..Results from these studies suggest the possibility of developing a "combination" of dietary polyphenolic compounds for AD prevention and/or therapy by modulating multiple Abeta-related mechanisms...
  4. ncbi request reprint Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
    ....
  5. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
    ....
  6. ncbi request reprint Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    FASEB J 20:2313-20. 2006
    ....
  7. ncbi request reprint Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    FASEB J 18:902-4. 2004
    ....
  8. ncbi request reprint Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
  9. ncbi request reprint Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    Weiping Qin
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:50970-7. 2003
    ....
  10. pmc Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
    Bing Gong
    Department of Neurology, Center of Excellence for Novel Approaches to Neurotherapeutics, Mount Sinai School of Medicine, New York, NY, USA
    Neurobiol Aging 34:1581-8. 2013
    ..Our studies suggest that dietary treatment with NR might benefit AD cognitive function and synaptic plasticity, in part by promoting PGC-1α-mediated BACE1 ubiquitination and degradation, thus preventing Aβ production in the brain...
  11. pmc Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:3393-402. 2007
    ..These preclinical studies suggest that certain antihypertensive drugs may have AD-modifying activity and may protect against progressive Abeta-related memory deficits in subjects with AD or in those at high risk of developing AD...
  12. pmc Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 28:6388-92. 2008
    ..Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD...
  13. pmc Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration
    Weiping Qin
    Department of Psychiatry, Mount Sinnai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1147:335-47. 2008
    ..This study provides a novel metabolic pathway for prevention and/or treatment of AD...
  14. doi request reprint Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy
    Wei Zhao
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 34:417-29. 2013
    ....
  15. pmc Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies
    Giulio Maria Pasinetti
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurochem 114:1557-68. 2010
    ..In this mini-review article, we discuss the biochemical characterization of GSPE in our laboratory and its potential preventative and therapeutic role in model systems of abnormal tau processing pertinent to PSP and related tauopathies...
  16. ncbi request reprint Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    FASEB J 19:659-61. 2005
    ....
  17. doi request reprint Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization
    Wei Zhao
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Alzheimers Dis 16:49-57. 2009
    ..Our studies suggest that certain antihypertensive compounds may prevent AD-type neuropathology through inhibition of Abeta oligomer formation...
  18. doi request reprint Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 22:653-61. 2010
    ....
  19. pmc GSPE interferes with tau aggregation in vivo: implication for treating tauopathy
    Ismael Santa-Maria
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 33:2072-81. 2012
    ..Our studies support further evaluation of GSPE for preventing and/or treating of tauopathies in humans...
  20. pmc Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 32:5144-50. 2012
    ....
  21. ncbi request reprint Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    Zhongmin Xiang
    Neuroinflammation Research Laboratories, Department of Psychiatry, and Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Gene Expr 10:271-8. 2002
    ..Collectively these data suggest that COX-2 influences APP processing and promotes amyloidosis in the brain...
  22. pmc Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease
    Lap Ho
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 31:301-13. 2012
    ..Induction of MCP-1 in response to TBI might be a potential predisposing factor that may increase the risk for development of Alzheimer's disease...
  23. doi request reprint Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice
    Lap Ho
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nutr Neurosci 15:37-45. 2012
    ..As coffee is also a rich source of chlorogenic acids and many bioactive compounds other than caffeine, we hypothesized that decaffeinated coffee drinks may exert beneficial effects on the brain...
  24. pmc A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis
    Zhong Zhao
    Neuroinflammation Research Laboratories, Department of Psychiatry, USA
    BMC Neurosci 7:29. 2006
    ..The cause of neuronal death in amyotrophic lateral sclerosis (ALS) is uncertain but mitochondrial dysfunction may play an important role. Ketones promote mitochondrial energy production and membrane stabilization...
  25. pmc S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    PLoS ONE 4:e4183. 2009
    ....
  26. ncbi request reprint Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology
    Zhongmin Xiang
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurobiol Aging 23:327-34. 2002
    ....
  27. ncbi request reprint Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications
    Giulio Maria Pasinetti
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Interdiscip Top Gerontol 35:159-75. 2007
    ....
  28. doi request reprint The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology
    Jun Wang
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochim Biophys Acta 1804:1690-4. 2010
    ..We will discuss Sirt1 as a potential novel target, in addition to the development of Sirt1 activators for the prevention and treatment of Alzheimer's disease...
  29. pmc Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies
    Lap Ho
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 16:433-9. 2009
    ....
  30. pmc Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia
    Zhongmin Xiang
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, 10029 6574, USA
    Dis Markers 22:95-102. 2006
    ..These results suggest that microglia activation increases with the progression of AD, with the increase varying depending on the involved brain region...
  31. pmc Carvedilol as a potential novel agent for the treatment of Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 32:2321.e1-12. 2011
    ..Our novel observation that carvedilol interferes with the neuropathologic, biochemical, and electrophysiological mechanisms underlying cognitive deterioration in AD supports the potential development of carvedilol as a treatment for AD...
  32. pmc Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applications
    Lap Ho
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, and Center of Excellence in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1137, New York, NY 10029, USA
    Exp Gerontol 45:15-22. 2010
    ..The availability of biomarkers that promote early disease diagnosis, particularly among asymptomatic patients, will lead to the application of personalized medicine in AD...
  33. ncbi request reprint Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neurobiol Dis 10:8-19. 2002
    ..These studies suggest that PS-1 plays a role in regulating neurogenesis in adult hippocampus and that FAD mutants may have deleterious properties independent of their effects on amyloid deposition...
  34. ncbi request reprint Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease
    Patrick N Pompl
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Neurol 60:369-76. 2003
    ..Caspase gene expression has previously been reported in terminal Alzheimer disease (AD) brain, but, currently, little is known about the temporal pattern of caspase gene expression relative to the onset and clinical progression of AD...
  35. ncbi request reprint Is there a future for cyclo-oxygenase inhibitors in Alzheimer's disease?
    Lap Ho
    Department of Psychiatry, The Mount Sinai School of Medicine, Neuroinflammation Research Laboratories, New York, New York 10029, USA
    CNS Drugs 20:85-98. 2006
    ....
  36. pmc Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model
    Jun Wang
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ, USA
    Mol Nutr Food Res 57:2091-102. 2013
    ....
  37. doi request reprint Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols
    Hanna Ksiezak-Reding
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 33:1427-39. 2012
    ..Collectively, our results suggest that GSPE has a significant potential for therapeutic development by neutralizing phospho-epitopes and disrupting fibrillary conformation leading to disintegration of PHFs...
  38. ncbi request reprint From proteomics to biomarker discovery in Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories of the Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res Brain Res Rev 48:360-9. 2005
    ....
  39. pmc Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases
    Lap Ho
    Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, New York, NY 10029, USA
    Int J Alzheimers Dis 2012:321280. 2012
    ..Outcomes from our study support the development of insulin-sensitizing therapeutic strategies to stimulate downstream IR signaling in nondiabetic AD cases...
  40. doi request reprint Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders
    Giulio Maria Pasinetti
    Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, 1498 Madison Avenue, New York, NY 10029, USA
    Exp Neurol 232:1-6. 2011
    ..study and discusses the further prospects of resveratrol and other polyphenols, including novel grape-derived polyphenols, in the treatment of HD and other neurodegenerative disorders...
  41. doi request reprint Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding
    Lap Ho
    Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer s Disease, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Expert Rev Proteomics 7:579-89. 2010
    ..Collectively, available information supports continued development of the GSPE for treating a variety of neurodegenerative disorders involving misfolded protein-mediated neuropathologic mechanisms...
  42. doi request reprint Immunomodulation with glatiramer acetate prevents long-term inflammatory pain
    Naresh Sharma
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Int J Neurosci 118:433-53. 2008
    ..This study is consistent with the hypothesis that a novel mechanism through which GA immunization therapy may beneficially influence long-term allodynia and hyperalgesia is through central regulation of fractalkine-mediated responses...
  43. doi request reprint Personalized medicine in traumatic brain injury
    Giulio Maria Pasinetti
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1137, New York, NY 10029, USA
    Psychiatr Clin North Am 33:905-13. 2010
    ..It is possible that the availability of TBI biomarkers may provide potential elements with clinical relevance to prevention, prognosis, and treatment of postconcussive disorders...
  44. doi request reprint Investigation of nebivolol as a novel therapeutic agent for the treatment of Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 33:1147-56. 2013
    ..Our studies support the continued investigation of nebivolol for the treatment of AD at very early stages of the disease...
  45. ncbi request reprint Expression profile of genes associated with antimetastatic gene: nm23-mediated metastasis inhibition in breast carcinoma cells
    Hui Zhao
    Department of Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    Int J Cancer 109:65-70. 2004
    ....
  46. ncbi request reprint Amyloid immunization in Alzheimer's disease: do we promote amyloid scavenging at the cost of inflammatory degeneration?
    Giulio Maria Pasinetti
    Department of Psychiatry, Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10089, USA
    Neurobiol Aging 23:665-6. 2002
  47. pmc Caloric intake, dietary lifestyles, macronutrient composition, and alzheimer' disease dementia
    Giulio Maria Pasinetti
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Alzheimers Dis 2011:806293. 2011
    ..We further discuss how the consumption of certain foods or food components can help to reduce one's risk for Alzheimer's disease and may possibly be developed as a therapeutic agent...
  48. ncbi request reprint Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2
    Lauren Spielman
    Neuroinflammation Research Laboratories, Department of Psychiatry, Box 1229, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Acta Neuropathol 103:157-62. 2002
    ..Because there is extensive evidence that C1q and other complement components are involved in Alzheimer's disease (AD) neurodegeneration, this study advances our understanding of the apparent benefits of COX-2 inhibition in AD...