David B Hicks

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations
    David B Hicks
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochim Biophys Acta 1797:1362-77. 2010
  2. pmc Roles of AtpI and two YidC-type proteins from alkaliphilic Bacillus pseudofirmus OF4 in ATP synthase assembly and nonfermentative growth
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Bacteriol 195:220-30. 2013
  3. pmc The ATP synthase a-subunit of extreme alkaliphiles is a distinct variant: mutations in the critical alkaliphile-specific residue Lys-180 and other residues that support alkaliphile oxidative phosphorylation
    Makoto Fujisawa
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 285:32105-15. 2010
  4. pmc Cation/proton antiporter complements of bacteria: why so large and diverse?
    Terry A Krulwich
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Microbiol 74:257-60. 2009
  5. pmc Mutations in a helix-1 motif of the ATP synthase c-subunit of Bacillus pseudofirmus OF4 cause functional deficits and changes in the c-ring stability and mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, New York 10029, USA
    Biochemistry 50:5497-506. 2011
  6. pmc Characterization of the Functionally Critical AXAXAXA and PXXEXXP Motifs of the ATP Synthase c-Subunit from an Alkaliphilic Bacillus
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:8714-25. 2009
  7. pmc Purification of two putative type II NADH dehydrogenases with different substrate specificities from alkaliphilic Bacillus pseudofirmus OF4
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Biochim Biophys Acta 1777:453-61. 2008
  8. pmc Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host
    Talia H Swartz
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Bacteriol 189:3081-90. 2007
  9. ncbi request reprint Replacement of amino acid sequence features of a- and c-subunits of ATP synthases of Alkaliphilic Bacillus with the Bacillus consensus sequence results in defective oxidative phosphorylation and non-fermentative growth at pH 10.5
    ZhenXiong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:26546-54. 2004
  10. pmc The Mrp Na+/H+ antiporter increases the activity of the malate:quinone oxidoreductase of an Escherichia coli respiratory mutant
    Talia H Swartz
    Box 1603, Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Bacteriol 187:388-91. 2005

Collaborators

Detail Information

Publications11

  1. pmc F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations
    David B Hicks
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochim Biophys Acta 1797:1362-77. 2010
    ..ATP synthesis in alkaliphiles depends upon alkaliphile-specific adaptations of the ATP synthase and there is also evidence for alkaliphile-specific adaptations of respiratory chain components...
  2. pmc Roles of AtpI and two YidC-type proteins from alkaliphilic Bacillus pseudofirmus OF4 in ATP synthase assembly and nonfermentative growth
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    J Bacteriol 195:220-30. 2013
    ..Deletion of atpZ caused the largest increase among the mutants in magnesium concentrations needed for pH 7.5 growth. The basis for this phenotype is not yet resolved...
  3. pmc The ATP synthase a-subunit of extreme alkaliphiles is a distinct variant: mutations in the critical alkaliphile-specific residue Lys-180 and other residues that support alkaliphile oxidative phosphorylation
    Makoto Fujisawa
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 285:32105-15. 2010
    ..pseudofirmus OF4. Finally, a mutant B. pseudofirmus OF4 synthase with switched positions of Lys-180 (helix 4) and Gly-212 (helix 5) retained significant coupled synthase activity accompanied by proton leakiness...
  4. pmc Cation/proton antiporter complements of bacteria: why so large and diverse?
    Terry A Krulwich
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Microbiol 74:257-60. 2009
    ..They also provide new perspectives on two large monovalent cation/proton antiporter families, the NhaC and the cation/proton antiporter-3 antiporter families...
  5. pmc Mutations in a helix-1 motif of the ATP synthase c-subunit of Bacillus pseudofirmus OF4 cause functional deficits and changes in the c-ring stability and mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, New York 10029, USA
    Biochemistry 50:5497-506. 2011
    ..However, the functional deficits of mutants did not correlate well with the extent of c-ring stability loss, so this property is unlikely to be a major factor in vivo...
  6. pmc Characterization of the Functionally Critical AXAXAXA and PXXEXXP Motifs of the ATP Synthase c-Subunit from an Alkaliphilic Bacillus
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:8714-25. 2009
    ..The results highlight the requirement for c-subunit adaptations to achieve alkaliphile ATP synthesis with minimal cytoplasmic proton loss and suggest partial suppression of some mutations by changes outside the atp operon...
  7. pmc Purification of two putative type II NADH dehydrogenases with different substrate specificities from alkaliphilic Bacillus pseudofirmus OF4
    Jun Liu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Biochim Biophys Acta 1777:453-61. 2008
    ..They were predominantly cytoplasmic in E. coli, consonant with the absence of antiport activity. The catalytic properties of NDH-2A were more consistent with a major respiratory role than those of NDH-2B...
  8. pmc Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host
    Talia H Swartz
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Bacteriol 189:3081-90. 2007
    ..coli transformants led to a hypothesis explaining how activity of secondary, DeltaPsi-consuming antiporters can elicit increased capacity for DeltaPsi generation in a bacterial host...
  9. ncbi request reprint Replacement of amino acid sequence features of a- and c-subunits of ATP synthases of Alkaliphilic Bacillus with the Bacillus consensus sequence results in defective oxidative phosphorylation and non-fermentative growth at pH 10.5
    ZhenXiong Wang
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:26546-54. 2004
    ..The findings demonstrate that the ATP synthase of extreme alkaliphiles has special features that are required for non-fermentative growth and OXPHOS at high pH...
  10. pmc The Mrp Na+/H+ antiporter increases the activity of the malate:quinone oxidoreductase of an Escherichia coli respiratory mutant
    Talia H Swartz
    Box 1603, Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Bacteriol 187:388-91. 2005
    ....
  11. pmc A tenth atp gene and the conserved atpI gene of a Bacillus atp operon have a role in Mg2+ uptake
    David B Hicks
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 100:10213-8. 2003
    ..Such proteins could provide Mg2+, which is required by ATP synthase, and also support charge compensation, when the enzyme is functioning in the hydrolytic direction; e.g., during cytoplasmic pH regulation...