John C He

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Capturing the in vivo molecular signature of the podocyte
    Peter Y Chuang
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 83:986-8. 2013
  2. pmc Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase
    Yifei Zhong
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1243, New York, NY 10029, USA
    J Am Soc Nephrol 24:801-11. 2013
  3. pmc Signaling in regulation of podocyte phenotypes
    Peter Y Chuang
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Nephron Physiol 111:p9-15. 2009
  4. ncbi request reprint Role of the Go/i signaling network in the regulation of neurite outgrowth
    John Cijiang He
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Can J Physiol Pharmacol 84:687-94. 2006
  5. pmc Systems biology of kidney diseases
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 81:22-39. 2012
  6. pmc Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 18:93-102. 2007
  7. pmc Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 114:643-51. 2004
  8. pmc Expression of HIV transgene aggravates kidney injury in diabetic mice
    Sandeep K Mallipattu
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 83:626-34. 2013
  9. doi request reprint Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy
    Leyi Gu
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS 27:1091-8. 2013
  10. pmc Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus
    Peter Y Chuang
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e23566. 2011

Collaborators

Detail Information

Publications36

  1. pmc Capturing the in vivo molecular signature of the podocyte
    Peter Y Chuang
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 83:986-8. 2013
    ..Boerries et al. overcame some of these barriers and characterized the transcriptome and proteome of freshly isolated podocytes. These data sets and isolation protocol are valuable resources for the podocyte research community...
  2. pmc Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase
    Yifei Zhong
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1243, New York, NY 10029, USA
    J Am Soc Nephrol 24:801-11. 2013
    ..In addition, this study provides proof-of-concept that drug-induced expression signatures have potential use in predicting the effects of combination drug therapy...
  3. pmc Signaling in regulation of podocyte phenotypes
    Peter Y Chuang
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Nephron Physiol 111:p9-15. 2009
    ..At the level of intracellular signaling, it appears that different extracellular signals can converge onto a few pathways to induce changes in the phenotype of podocytes...
  4. ncbi request reprint Role of the Go/i signaling network in the regulation of neurite outgrowth
    John Cijiang He
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Can J Physiol Pharmacol 84:687-94. 2006
    ..We also analyze the role neurotransmitters, which stimulate Go/i to activate a complex signaling network controlling neurite outgrowth, play in regeneration after neuronal injury...
  5. pmc Systems biology of kidney diseases
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 81:22-39. 2012
    ..This integration of experimental approaches and computational modeling is expected to generate new knowledge that can help to identify marker sets to guide the diagnosis, monitor disease progression, and identify new therapeutic targets...
  6. pmc Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 18:93-102. 2007
    ..These results demonstrate the mechanism by which atRA reverses the proliferation of podocytes that is induced by HIV-1...
  7. pmc Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 114:643-51. 2004
    ..These data suggest that Nef-induced activation of Stat3 and Ras-MAPK1,2 via Src-dependent pathways is responsible for podocyte proliferation and dedifferentiation, a characteristic finding in collapsing FSGS of HIVAN...
  8. pmc Expression of HIV transgene aggravates kidney injury in diabetic mice
    Sandeep K Mallipattu
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 83:626-34. 2013
    ..Thus, our study found that expression of HIV-1 genes aggravates diabetic kidney disease...
  9. doi request reprint Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy
    Leyi Gu
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS 27:1091-8. 2013
    ..We confirm here that deletion of podocyte STAT3 is sufficient to mitigate the glomerular as well as tubulointerstitial findings of HIVAN...
  10. pmc Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus
    Peter Y Chuang
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e23566. 2011
    ..Strategies to preserve Sirt1 expression or reduce Foxo4 acetylation could be used to prevent podocyte loss in diabetes...
  11. pmc Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis
    Yan Dai
    1 Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA 2 Division of Nephrology, Shanghai First People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Kidney Int 84:950-61. 2013
    ..Thus, podocyte STAT3 activation is critical for the development of crescentic glomerulonephritis. ..
  12. pmc Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation
    Sandeep K Mallipattu
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 287:19122-35. 2012
    ..These results indicate a critical role of KLF15 in mediating podocyte differentiation and in protecting podocytes against injury...
  13. pmc Protein kinase target discovery from genome-wide messenger RNA expression profiling
    AVI MA'AYAN
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:345-9. 2010
    ....
  14. pmc Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure
    Yifei Zhong
    Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Kidney Int 81:856-64. 2012
    ..Thus, phosphodiesterase 4 inhibitors could be used in combination with RARα agonists to provide additional renal protection...
  15. pmc Role of the retinoic acid receptor-α in HIV-associated nephropathy
    Krishna K Ratnam
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Kidney Int 79:624-34. 2011
    ..Thus, a defect in the endogenous synthesis of retinoic acid contributes to loss of the protection by retinoic acid in HIVAN. Hence, RARα agonists may be potential agents for the treatment of HIVAN...
  16. pmc Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis
    Lewis Kaufman
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 285:25677-85. 2010
    ..We conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in FSGS and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function...
  17. pmc HIV-associated nephropathy: pathogenesis
    Raj K Medapalli
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Curr Opin Nephrol Hypertens 20:306-11. 2011
    ..In this review, we provide a summary of the current state of knowledge about the mechanisms involved in the pathogenesis of HIVAN...
  18. pmc HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells
    Alexandra Snyder
    Department of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS 24:1107-19. 2010
    ..HIV-1 viral protein r (Vpr) has been implicated in HIV-induced RTEC apoptosis but the mechanisms of Vpr-induced RTEC apoptosis are unknown. The aim of this study was therefore to determine the mechanisms of Vpr-induced apoptosis in RTEC...
  19. doi request reprint JAK/STAT signaling in renal diseases
    Peter Y Chuang
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 78:231-4. 2010
    ..Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model...
  20. pmc Molecular targets for treatment of kidney fibrosis
    Peter Y Chuang
    Division of Nephrology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1243, New York, NY 10029, USA
    J Mol Med (Berl) 91:549-59. 2013
    ..This review considers key molecular mediators of renal fibrosis and their potential as targets for treatment of renal fibrosis...
  21. doi request reprint Role of advanced glycation endproducts and potential therapeutic interventions in dialysis patients
    Sandeep K Mallipattu
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Semin Dial 25:529-38. 2012
    ..This article reviews the role of AGEs, especially those of dietary origin, in ESRD patients as well as potential therapeutic anti-AGE strategies in this population...
  22. pmc Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan
    Weijing Cai
    Department of Geriatrics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Pathol 173:327-36. 2008
    ..Therefore, the beneficial effects of a CR diet may be partly related to reduced oxidant intake, a principal determinant of oxidant status in aging mice, rather than decreased energy intake...
  23. pmc Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor
    Weijing Cai
    Division of Experimental Diabetes and Aging, Brookdale Department of Geriatrics, and Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:13801-6. 2006
    ..AGER1 could serve as a model for developing therapeutic targets against vascular and kidney disorders related to diabetes and aging...
  24. ncbi request reprint The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3
    John Cijiang He
    Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:33426-34. 2005
    ..Overall, this study demonstrated that G alpha(o/i)-coupled CB1R triggers neurite outgrowth in Neuro-2A through the activation of a signaling network containing two pathways that bifurcate at Src and converge at Stat3...
  25. ncbi request reprint HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN
    Mohammad Husain
    Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    AIDS 19:1975-80. 2005
    ..To determine the specific role of Nef in the pathogenesis of HIV-associated nephropathy...
  26. ncbi request reprint Animal models of HIV-associated nephropathy
    Ting Chi Lu
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Curr Opin Nephrol Hypertens 15:233-7. 2006
    ..This review summarizes the manner in which different transgenic animal models contribute to our knowledge of the pathogenesis of HIV-1-associated nephropathy...
  27. ncbi request reprint Podocytes in HIV-associated nephropathy
    Ting Chi Lu
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Nephron Clin Pract 106:c67-71. 2007
    ..Activation of the cAMP/PKA pathway with all-trans-retinoic acid appears to modulate these changes and returns podocytes to a differentiated, nonproliferating phenotype...
  28. ncbi request reprint Critical role for Nef in HIV-1-induced podocyte dedifferentiation
    Masaaki Sunamoto
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 64:1695-701. 2003
    ..These data suggest that Nef induces many of the changes we observe in HIV transgenic model and, as a result, this now defines the pathway for exploration of host responses to HIV-1 infection...
  29. pmc HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein
    Ting Chi Lu
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Biol Chem 283:8173-82. 2008
    ..We conclude that in HIV-infected podocytes, Nef, through the recruitment of DIP and p190RhoAGAP to Nef-Src complex, activates p190RhoAGAP and down-regulates RhoA activity...
  30. pmc HIV-1 upregulates VEGF in podocytes
    Sonal Navin Korgaonkar
    Department of, New York, Mount Sinai School of Medicine, New York, USA
    J Am Soc Nephrol 19:877-83. 2008
    ..In conclusion, HIV-1 induces VEGF and VEGFR2 expression in podocytes, and this may be a critical step in the pathogenesis of HIVAN...
  31. pmc Regulation of neurite outgrowth by G(i/o) signaling pathways
    Kenneth D Bromberg
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Front Biosci 13:4544-57. 2008
    ....
  32. pmc Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes
    Ting Chi Lu
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Cell Biol 28:5785-94. 2008
    ..The mechanism involves a feed-forward loop where activation of one transcription factor (TF) (CREB) leads to induction of a second TF (USF1)...
  33. ncbi request reprint Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII
    J Dedrick Jordan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:11413-21. 2005
    ..Thus, the G(alpha)o/i-coupled cannabinoid receptor, by regulating the proteasomal degradation of Rap1GAPII, activates Rap1 to induce neurite outgrowth...
  34. pmc Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells
    Changyong Lu
    Department of Geriatrics and Adult Development, Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 101:11767-72. 2004
    ....
  35. ncbi request reprint High levels of dietary advanced glycation end products transform low-density lipoprotein into a potent redox-sensitive mitogen-activated protein kinase stimulant in diabetic patients
    Weijing Cai
    Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Circulation 110:285-91. 2004
    ..It remains unclear, however, whether exogenous (diet-derived) AGEs influence glycoxidation and endothelial cell toxicity of diabetic LDL...
  36. ncbi request reprint AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation
    Weijing Cai
    Division of Diabetes and Aging Research, The Brookdale Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10019, USA
    Am J Physiol Cell Physiol 294:C145-52. 2008
    ..This represents a key mechanism by which AGER1 maintains cellular resistance against OS. Thus the decrease of AGER1 noted in aging and diabetes may further enhance OS and reduce innate antioxidant defenses...

Research Grants7

  1. Pathogenesis of HIVAN: the role of Nef
    JOHN HE; Fiscal Year: 2007
    ..These studies should elucidate essential mechanism responsible for the development of HIV-associated nephropathy and how Nef plays a role in this pathologic process. ..
  2. Cellular and molecular mechanism of retinoids in podocytes
    JOHN HE; Fiscal Year: 2009
    ..Our study may lead to discover new targets of intervention for glomerular diseases and identify new therapy regimes of retinoids by enhancing its beneficial effects and reducing its side effects in patients with kidney diseases. ..
  3. Cellular and molecular mechanism of retinoids in podocytes
    John C He; Fiscal Year: 2010
    ..Our study may lead to discover new targets of intervention for glomerular diseases and identify new therapy regimes of retinoids by enhancing its beneficial effects and reducing its side effects in patients with kidney diseases. ..
  4. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA apos AYAN; Fiscal Year: 2010
    ....