Research Topics
Genomes and Genes
| John C HeSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Renoprotective effect of combined inhibition of Angiotensin-converting enzyme and histone deacetylaseYifei Zhong
Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1243, New York, NY 10029, or Dr Avi Ma ayan computational part, Department of Pharmacology and Systems Therapeutics, One Gustave L Levy Place, Box 1215, Mount Sinai School of Medicine, New York, NY 10029
J Am Soc Nephrol 24:801-11. 2013..In addition, this study provides proof-of-concept that drug-induced expression signatures have potential use in predicting the effects of combination drug therapy...- Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathwayJohn Cijiang He
Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Am Soc Nephrol 18:93-102. 2007..These results demonstrate the mechanism by which atRA reverses the proliferation of podocytes that is induced by HIV-1... 
Role of the Go/i signaling network in the regulation of neurite outgrowthJohn Cijiang He
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Can J Physiol Pharmacol 84:687-94. 2006..We also analyze the role neurotransmitters, which stimulate Go/i to activate a complex signaling network controlling neurite outgrowth, play in regeneration after neuronal injury...- Systems biology of kidney diseasesJohn Cijiang He
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Kidney Int 81:22-39. 2012..This integration of experimental approaches and computational modeling is expected to generate new knowledge that can help to identify marker sets to guide the diagnosis, monitor disease progression, and identify new therapeutic targets... - Signaling in regulation of podocyte phenotypesPeter Y Chuang
Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Nephron Physiol 111:p9-15. 2009..At the level of intracellular signaling, it appears that different extracellular signals can converge onto a few pathways to induce changes in the phenotype of podocytes... - Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathwaysJohn Cijiang He
Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
J Clin Invest 114:643-51. 2004..These data suggest that Nef-induced activation of Stat3 and Ras-MAPK1,2 via Src-dependent pathways is responsible for podocyte proliferation and dedifferentiation, a characteristic finding in collapsing FSGS of HIVAN... - Expression of HIV transgene aggravates kidney injury in diabetic miceSandeep K Mallipattu
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
Kidney Int 83:626-34. 2013..Thus, our study found that expression of HIV-1 genes aggravates diabetic kidney disease... - Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitusPeter Y Chuang
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
PLoS ONE 6:e23566. 2011..Strategies to preserve Sirt1 expression or reduce Foxo4 acetylation could be used to prevent podocyte loss in diabetes... - Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiationSandeep K Mallipattu
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Biol Chem 287:19122-35. 2012..These results indicate a critical role of KLF15 in mediating podocyte differentiation and in protecting podocytes against injury... - Protein kinase target discovery from genome-wide messenger RNA expression profilingAVI MA'AYAN
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 77:345-9. 2010.... - Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failureYifei Zhong
Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Kidney Int 81:856-64. 2012..Thus, phosphodiesterase 4 inhibitors could be used in combination with RARα agonists to provide additional renal protection... - Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosisLewis Kaufman
Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 285:25677-85. 2010..We conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in FSGS and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function... - Role of the retinoic acid receptor-α in HIV-associated nephropathyKrishna K Ratnam
Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
Kidney Int 79:624-34. 2011..Thus, a defect in the endogenous synthesis of retinoic acid contributes to loss of the protection by retinoic acid in HIVAN. Hence, RARα agonists may be potential agents for the treatment of HIVAN... - HIV-associated nephropathy: pathogenesisRaj K Medapalli
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
Curr Opin Nephrol Hypertens 20:306-11. 2011..In this review, we provide a summary of the current state of knowledge about the mechanisms involved in the pathogenesis of HIVAN... - HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cellsAlexandra Snyder
Department of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
AIDS 24:1107-19. 2010..HIV-1 viral protein r (Vpr) has been implicated in HIV-induced RTEC apoptosis but the mechanisms of Vpr-induced RTEC apoptosis are unknown. The aim of this study was therefore to determine the mechanisms of Vpr-induced apoptosis in RTEC... 
JAK/STAT signaling in renal diseasesPeter Y Chuang
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Kidney Int 78:231-4. 2010..Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model...- Molecular targets for treatment of kidney fibrosisPeter Y Chuang
Division of Nephrology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1243, New York, NY, 10029, USA
J Mol Med (Berl) 91:549-59. 2013..This review considers key molecular mediators of renal fibrosis and their potential as targets for treatment of renal fibrosis... - Role of advanced glycation endproducts and potential therapeutic interventions in dialysis patientsSandeep K Mallipattu
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Semin Dial 25:529-38. 2012..This article reviews the role of AGEs, especially those of dietary origin, in ESRD patients as well as potential therapeutic anti-AGE strategies in this population... - Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptorWeijing Cai
Division of Experimental Diabetes and Aging, Brookdale Department of Geriatrics, and Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 103:13801-6. 2006..AGER1 could serve as a model for developing therapeutic targets against vascular and kidney disorders related to diabetes and aging... - Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespanWeijing Cai
Department of Geriatrics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Am J Pathol 173:327-36. 2008..Therefore, the beneficial effects of a CR diet may be partly related to reduced oxidant intake, a principal determinant of oxidant status in aging mice, rather than decreased energy intake... - The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3John Cijiang He
Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 280:33426-34. 2005..Overall, this study demonstrated that G alpha(o/i)-coupled CB1R triggers neurite outgrowth in Neuro-2A through the activation of a signaling network containing two pathways that bifurcate at Src and converge at Stat3... - HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVANMohammad Husain
Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
AIDS 19:1975-80. 2005..To determine the specific role of Nef in the pathogenesis of HIV-associated nephropathy... - Animal models of HIV-associated nephropathyTing-chi Lu
Mount Sinai School of Medicine, New York, New York 10029, USA
Curr Opin Nephrol Hypertens 15:233-7. 2006..SUMMARY: Transgenic animal models of HIV-1-associated nephropathy have contributed greatly to the progress made toward understanding the pathogenesis of this disease... - Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytesTing Chi Lu
Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Mol Cell Biol 28:5785-94. 2008..The mechanism involves a feed-forward loop where activation of one transcription factor (TF) (CREB) leads to induction of a second TF (USF1)... - Podocytes in HIV-associated nephropathyTing Chi Lu
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Nephron Clin Pract 106:c67-71. 2007..Activation of the cAMP/PKA pathway with all-trans-retinoic acid appears to modulate these changes and returns podocytes to a differentiated, nonproliferating phenotype... - HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting proteinTing Chi Lu
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Biol Chem 283:8173-82. 2008..We conclude that in HIV-infected podocytes, Nef, through the recruitment of DIP and p190RhoAGAP to Nef-Src complex, activates p190RhoAGAP and down-regulates RhoA activity... - HIV-1 upregulates VEGF in podocytesSonal Navin Korgaonkar
Department of, New York, Mount Sinai School of Medicine, New York, USA
J Am Soc Nephrol 19:877-83. 2008..In conclusion, HIV-1 induces VEGF and VEGFR2 expression in podocytes, and this may be a critical step in the pathogenesis of HIVAN... - Regulation of neurite outgrowth by G(i/o) signaling pathwaysKenneth D Bromberg
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Front Biosci 13:4544-57. 2008.... - Critical role for Nef in HIV-1-induced podocyte dedifferentiationMasaaki Sunamoto
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Kidney Int 64:1695-701. 2003..These data suggest that Nef induces many of the changes we observe in HIV transgenic model and, as a result, this now defines the pathway for exploration of host responses to HIV-1 infection... - AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylationWeijing Cai
Division of Diabetes and Aging Research, The Brookdale Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10019, USA
Am J Physiol Cell Physiol 294:C145-52. 2008..This represents a key mechanism by which AGER1 maintains cellular resistance against OS. Thus the decrease of AGER1 noted in aging and diabetes may further enhance OS and reduce innate antioxidant defenses... - Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPIIJ Dedrick Jordan
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 280:11413-21. 2005..Thus, the G(alpha)o/i-coupled cannabinoid receptor, by regulating the proteasomal degradation of Rap1GAPII, activates Rap1 to induce neurite outgrowth... - Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cellsChangyong Lu
Department of Geriatrics and Adult Development, Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 101:11767-72. 2004.... - High levels of dietary advanced glycation end products transform low-density lipoprotein into a potent redox-sensitive mitogen-activated protein kinase stimulant in diabetic patientsWeijing Cai
Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Circulation 110:285-91. 2004..CONCLUSIONS: Exposure to daily dietary glycoxidants enhances LDL-induced vascular toxicity via redox-sensitive mitogen-activated protein kinase activation. This can be prevented by dietary AGE restriction...
Research Grants
- Pathogenesis of HIVAN: the role of NefJOHN HE; Fiscal Year: 2007..These studies should elucidate essential mechanism responsible for the development of HIV-associated nephropathy and how Nef plays a role in this pathologic process. ..
- Cellular and molecular mechanism of retinoids in podocytesJOHN HE; Fiscal Year: 2009..Our study may lead to discover new targets of intervention for glomerular diseases and identify new therapy regimes of retinoids by enhancing its beneficial effects and reducing its side effects in patients with kidney diseases. ..
- Cellular and molecular mechanism of retinoids in podocytesJohn C He; Fiscal Year: 2010..Our study may lead to discover new targets of intervention for glomerular diseases and identify new therapy regimes of retinoids by enhancing its beneficial effects and reducing its side effects in patients with kidney diseases. ..
- Role of HIPK2 in Kidney Tubulointerstitial InjuryAVI MA apos AYAN; Fiscal Year: 2010....