V Haroutunian

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 56:713-8. 1999
  2. ncbi request reprint Age-dependent spatial memory deficits in transgenic mice expressing the human mid-sized neurofilament gene: I
    V Haroutunian
    Psychiatry Service, Bronx VA Medical Center, NY 10468, USA
    Brain Res Mol Brain Res 42:62-70. 1996
  3. ncbi request reprint Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 55:1185-91. 1998
  4. ncbi request reprint Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions
    V Haroutunian
    Psychiatry Research, Room 3F 02, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Neurol 57:1145-50. 2000
  5. ncbi request reprint Neuropeptide abnormalities in patients with early Alzheimer disease
    K L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, and Jewish Home and Hospital, New York, NY 10029, USA
    Arch Gen Psychiatry 56:981-7. 1999
  6. ncbi request reprint Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and cognitive decline
    S Parvathy
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA
    Arch Neurol 58:2025-32. 2001
  7. pmc Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology
    M S Beeri
    Mount Sinai School of Medicine, Department of Psychiatry, One Gustave Levy Place, Box 1230, New York, NY 10029, USA
    Neurology 71:750-7. 2008
  8. ncbi request reprint Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique
    L Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, New York, USA
    Neurosci Lett 298:191-4. 2001
  9. ncbi request reprint N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Am J Psychiatry 158:1400-10. 2001
  10. ncbi request reprint Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice
    S Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 905:142-51. 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 56:713-8. 1999
    ..Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression...
  2. ncbi request reprint Age-dependent spatial memory deficits in transgenic mice expressing the human mid-sized neurofilament gene: I
    V Haroutunian
    Psychiatry Service, Bronx VA Medical Center, NY 10468, USA
    Brain Res Mol Brain Res 42:62-70. 1996
    ..Whether NF-M transgenic mice exhibit even more severe behavioral impairments when they become aged is currently under study...
  3. ncbi request reprint Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Arch Neurol 55:1185-91. 1998
    ..Do the classical neuropathological lesions of AD precede, follow, or occur in synchrony with the earliest signs of cognitive deterioration?..
  4. ncbi request reprint Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions
    V Haroutunian
    Psychiatry Research, Room 3F 02, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Neurol 57:1145-50. 2000
    ..However, the degree to which the density of LBs in the brain contributes to the severity of dementia has not been clear...
  5. ncbi request reprint Neuropeptide abnormalities in patients with early Alzheimer disease
    K L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, and Jewish Home and Hospital, New York, NY 10029, USA
    Arch Gen Psychiatry 56:981-7. 1999
    ..To determine the relation between level of SLI and CRF-IR in different cerebrocortical regions to the earliest signs of cognitive deterioration in AD...
  6. ncbi request reprint Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and cognitive decline
    S Parvathy
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA
    Arch Neurol 58:2025-32. 2001
    ....
  7. pmc Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology
    M S Beeri
    Mount Sinai School of Medicine, Department of Psychiatry, One Gustave Levy Place, Box 1230, New York, NY 10029, USA
    Neurology 71:750-7. 2008
    ..To examine the association between treatment for diabetes and Alzheimer disease (AD) neuropathology...
  8. ncbi request reprint Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique
    L Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, New York, USA
    Neurosci Lett 298:191-4. 2001
    ..In contrast, we found no changes in synapsin splice variant II of the b-type isoform. Alteration of synapsin expression at the earliest clinical stage of AD may suggest novel strategies for improved treatment...
  9. ncbi request reprint N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Am J Psychiatry 158:1400-10. 2001
    ....
  10. ncbi request reprint Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice
    S Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 905:142-51. 2001
    ....
  11. ncbi request reprint Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease
    I Prohovnik
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Neurology 66:49-55. 2006
    ..Little is known about Alzheimer disease at advanced ages, although its incidence continues to increase at least through the ninth decade of life...
  12. pmc Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons
    L B Hoffman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Neurology 72:1720-6. 2009
    ..To test the hypothesis that use of antihypertensive medication is associated with lower Alzheimer disease (AD) neuropathology...
  13. pmc Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers
    M S Beeri
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neurology 66:1399-404. 2006
    ..To examine the associations between postmortem Alzheimer disease (AD) neuropathology and autopsy-verified cardiovascular disease...
  14. pmc Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles
    G T Lesser
    Department of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, NY, USA
    Curr Alzheimer Res 8:303-12. 2011
    ..Since the associations of TC/LDL with NP were particularly stronger in ε4 carriers, varying prevalence of this allele may explain some discrepancies among prior studies...
  15. ncbi request reprint Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia
    J H Meador-Woodruff
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Arch Gen Psychiatry 54:1089-95. 1997
    ..We determined the expression of transcripts encoding the dopamine receptors in the brains of schizophrenic patients...
  16. ncbi request reprint Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease
    L Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Box 1229, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029, USA
    Arch Neurol 58:487-92. 2001
    ..COX-2 signal was increased in all 3 regions examined among cases characterized by severe dementia. CONCLUSION: Neuronal COX-2 content in subsets of hippocampal pyramidal neurons may be an indicator of progression of dementia in early AD...
  17. ncbi request reprint Clinical, cognitive and functional characteristics of long-stay patients with schizophrenia: a comparison of VA and state hospital patients
    P D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, Box 1229, 10029, New York, NY, USA
    Schizophr Res 43:3-9. 2000
    ..These data indicate that VA patients may have reduced severity of functional and cognitive impairments relative to state hospital patients, but that the relationship between the different illness variables was similar in the two groups...
  18. ncbi request reprint Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mol Psychiatry 13:1001-10. 2008
    ..Thus, at least in patients with SZ or BPD, overexpression of the VSV isoform in the prefrontal cortex may represent an additional risk factor for suicidal behavior...
  19. ncbi request reprint Variations in differential gene expression patterns across multiple brain regions in schizophrenia
    P Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Schizophr Res 77:241-52. 2005
    ....
  20. ncbi request reprint Tau protein abnormalities associated with the progression of alzheimer disease type dementia
    V Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, United States
    Neurobiol Aging 28:1-7. 2007
    ....
  21. ncbi request reprint Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats
    V Haroutunian
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029
    Brain Res 507:261-6. 1990
    ..These results suggest that combined cholinergic/noradrenergic therapy may be of value in the treatment of some Alzheimer's disease patients...
  22. ncbi request reprint Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain
    T L Lauriat
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1229, New York, NY 10029, USA
    Neuroscience 137:843-51. 2006
    ..However, because most of the schizophrenic subjects in the cohort had been treated with antipsychotics for many years, it is still possible that changes in transporter expression were masked by medication effects...
  23. ncbi request reprint Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice
    S Dracheva
    Dr Arthur M Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 157:169-79. 1999
    ..These studies demonstrate that altering the levels of D1 receptor expression reverses the effects of D1 agonism on locomotor initiation and rearing...
  24. pmc Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia
    C Schmauss
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029
    Proc Natl Acad Sci U S A 90:8942-6. 1993
    ..Many variables associated with either the course and/or the therapeutic management of the disease may account for the selective loss of D3 mRNA in the motor, somatosensory, and somatosensory association areas of schizophrenic brains...
  25. ncbi request reprint Elevated cortical zinc in Alzheimer disease
    D Religa
    Neurotec, Experimental Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Neurology 67:69-75. 2006
    ..To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity...
  26. ncbi request reprint Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (mtDNA)
    A M Brown
    Dementia Research Service, Burke Medical Research Institute, White Plains, NY 10605, USA
    J Mol Neurosci 16:41-8. 2001
    ..23; p = 0.034), but not with the density of neuritic plaques (p = 0.109). These results agree with the suggestion that the well-documented impairment in brain-energy metabolism in AD may be a direct cause of the clinical disability...
  27. ncbi request reprint Dysregulation of dynorphins in Alzheimer disease
    T Yakovleva
    Department of Clinical Neuroscience, CMM L8 01, Karolinska Institute and Hospital, SE 17176 Stockholm, Sweden
    Neurobiol Aging 28:1700-8. 2007
    ..Dynorphin A levels correlated with the neuritic plaque density. These results along with the known non-opioid ability of dynorphin A to induce neurodegeneration suggest a role for this neuropeptide in AD neuropathology...
  28. ncbi request reprint Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population
    K F Sheu
    Burke Medical Research Institute, White Plains, NY 10605, USA
    Ann Neurol 45:48-53. 1999
    ..These findings suggest a relationship between APOE4 and a DLST locus in the pathogenesis of AD in very elderly subjects...