Ming Hu Han

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders
    Ming Hu Han
    Department of Pharmacology and Systems Therapeutics, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Neuropharmacology 62:89-100. 2012
  2. pmc Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
    Jessica J Walsh
    1 Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:27-9. 2014
  3. pmc BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
  4. pmc Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience
    Allyson K Friedman
    Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Science 344:313-9. 2014
  5. pmc G9a influences neuronal subtype specification in striatum
    Ian Maze
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York, USA
    Nat Neurosci 17:533-9. 2014
  6. pmc Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation
    Pamela J Kennedy
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 16:434-40. 2013
  7. pmc Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons
    Michelle S Mazei-Robison
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 72:977-90. 2011
  8. pmc Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
    Daniel J Christoffel
    1 Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
    Nat Neurosci 18:962-4. 2015
  9. pmc Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
    Elizabeth A Heller
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:1720-7. 2014
  10. pmc Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Neuropsychopharmacology 39:2646-53. 2014

Collaborators

  • Scott J Russo
  • Mary Kay Lobo
  • Deveroux Ferguson
  • Li Shen
  • Mitra Heshmati
  • Jian Feng
  • Jeffrey M Friedman
  • Dipesh Chaudhury
  • Ian Maze
  • Feng Zhang
  • Jing Wang
  • Dani Dumitriu
  • Zhenyu Yue
  • Vaishnav Krishnan
  • Solomon H Snyder
  • Anne Schaefer
  • Roger Cachope
  • Javier Gonzalez-Maeso
  • Gustavo Turecki
  • Eric J Nestler
  • Allyson K Friedman
  • Ja Wook Koo
  • Jessica J Walsh
  • Daniel J Christoffel
  • Sam A Golden
  • Rachael L Neve
  • David M Dietz
  • Michelle S Mazei-Robison
  • Elizabeth A Heller
  • Haosheng Sun
  • Barbara Juarez
  • Pamela J Kennedy
  • Stacy M Ku
  • Jessica L Ables
  • Ezekiell Mouzon
  • Mitsumasa Kurita
  • ALFRED J ROBISON
  • Matthew L Shapiro
  • Hossein Aleyasin
  • Lena A Khibnik
  • Georgia E Hodes
  • Robert C Malenka
  • Aditi Dey
  • Gabriel A Ben-Dor
  • Nicole Rebusi
  • Kevin G Guise
  • Karl Deisseroth
  • Madeline Pfau
  • Milo Smith
  • Ines Ibanez-Tallon
  • H Steve Zhang
  • Michelle Mazei-Robison
  • Christian Nievera
  • Benoit Labonte
  • James P Herman
  • Mark A Gerber
  • Catherine J Pena
  • Elizabeth Heller
  • Veronica L Burnham
  • Carol S Tamminga
  • Scott Knight
  • Allyson Friedman
  • Hannah M Cates
  • Catherine Jensen Peña
  • Xianting Li
  • Nina Pan
  • Ningyi Shao
  • LISA POMERANZ
  • Vincent F Vialou
  • Rhonda Bassel-Duby
  • Diane M Damez-Werno
  • Stephen J Haggarty
  • Ana Badimon
  • A J Robison
  • Eric N Olson
  • Yoshinori N Ohnishi
  • Adrienne Umali
  • Marshall Crumiller
  • Terrell Holloway
  • Luis F Callado
  • Kimberly N Scobie
  • Diane Damez-Werno
  • Aintzane García-Bea
  • Yoko H Ohnishi
  • Jose L Moreno
  • J Javier Meana
  • Joseph D Buxbaum
  • Alexey Kozlenkov
  • Quincey LaPlant
  • Nagahide Takahashi

Detail Information

Publications15

  1. pmc Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders
    Ming Hu Han
    Department of Pharmacology and Systems Therapeutics, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Neuropharmacology 62:89-100. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  2. pmc Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
    Jessica J Walsh
    1 Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:27-9. 2014
    ..This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit. ..
  3. pmc BDNF is a negative modulator of morphine action
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 338:124-8. 2012
    ..These findings provide insight into the molecular basis of morphine-induced neuroadaptations in the brain's reward circuitry...
  4. pmc Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience
    Allyson K Friedman
    Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Science 344:313-9. 2014
    ..These results indicate a potential therapeutic path of promoting natural resilience for depression treatment...
  5. pmc G9a influences neuronal subtype specification in striatum
    Ian Maze
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York, USA
    Nat Neurosci 17:533-9. 2014
    ....
  6. pmc Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation
    Pamela J Kennedy
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 16:434-40. 2013
    ..Our findings suggest a new mechanism by which prolonged and selective HDAC inhibition can alter behavioral and molecular adaptations to cocaine and inform the development of therapeutics for cocaine addiction...
  7. pmc Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons
    Michelle S Mazei-Robison
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 72:977-90. 2011
    ..Together, these findings demonstrate a novel role for AKT-mTORC2 signaling in mediating neuroadaptations to opiate drugs of abuse...
  8. pmc Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
    Daniel J Christoffel
    1 Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
    Nat Neurosci 18:962-4. 2015
    ..Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance. ..
  9. pmc Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
    Elizabeth A Heller
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Neurosci 17:1720-7. 2014
    ..This approach allowed us to relate the epigenetic landscape at a given gene directly to regulation of its expression and to its subsequent effects on reward behavior. ..
  10. pmc Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition
    Ja Wook Koo
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Neuropsychopharmacology 39:2646-53. 2014
    ..Together, these data provide evidence for the enhancement of morphine reward through reduction of inhibitory GABAAR responses, an adaptation mediated by morphine-induced reduction of BDNF-TrkB signaling in D1-type MSNs. ..
  11. pmc Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 330:385-90. 2010
    ..These results provide insight into the molecular control of D1+ and D2+ neuronal activity as well as the circuit-level contribution of these cell types to cocaine reward...
  12. pmc ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli
    Mary Kay Lobo
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, Departments of Psychiatry and of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, Department of Pharmacology and Toxicology and the Research Institute on Addictions, State University of New York at Buffalo, New York, New York 14214, and Institut National de la Sante et de la Recherche Medicale, U952, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7224, UPMC, Paris, 75005, France
    J Neurosci 33:18381-95. 2013
    ..Together, these findings establish selective patterns of ΔFosB induction in striatal MSN subtypes in response to chronic stimuli and provide novel insight into the circuit-level mechanisms of ΔFosB induction in striatum. ..
  13. pmc IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity
    Daniel J Christoffel
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:314-21. 2011
    ..These studies establish a causal role for IKK in regulating stress-induced adaptive plasticity and may present a novel target for drug development in the treatment of mood and anxiety disorders in humans...
  14. pmc Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
    Dipesh Chaudhury
    Department of Pharmacology and Systems Therapeutics, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 493:532-6. 2013
    ..Overall, these studies reveal novel firing-pattern- and neural-circuit-specific mechanisms of depression...
  15. pmc HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
    Mitsumasa Kurita
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1245-54. 2012
    ..These observations support the view of HDAC2 as a promising new target for schizophrenia treatment...