D A Greenberg

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Reproducibility and complications in gene searches: linkage on chromosome 6, heterogeneity, association, and maternal inheritance in juvenile myoclonic epilepsy
    D A Greenberg
    Mount Sinai School of Medicine, Box 1229, New York, NY 10029, USA
    Am J Hum Genet 66:508-16. 2000
  2. ncbi request reprint Determining trait locus position from multipoint analysis: accuracy and power of three different statistics
    D A Greenberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genet Epidemiol 21:299-314. 2001
  3. pmc Excess of twins among affected sibling pairs with autism: implications for the etiology of autism
    D A Greenberg
    Division of Statistical Genetics, Department of Biostatistics, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Hum Genet 69:1062-7. 2001
  4. pmc The power to detect linkage in complex disease by means of simple LOD-score analyses
    D A Greenberg
    Departments of Psychiatry and Biomathematics, Mount Sinai Medical Center, New York, NY 10029, USA
    Am J Hum Genet 63:870-9. 1998
  5. pmc A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, USA
    Am J Hum Genet 63:1749-56. 1998
  6. pmc Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity
    J D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY, 10029, USA
    Am J Hum Genet 68:1514-20. 2001
  7. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease
    G Barbesino
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:3290-5. 1998
  8. ncbi request reprint Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 84:4656-64. 1999
  9. ncbi request reprint CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 86:1687-93. 2001
  10. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:4321-7. 1998

Collaborators

Detail Information

Publications24

  1. pmc Reproducibility and complications in gene searches: linkage on chromosome 6, heterogeneity, association, and maternal inheritance in juvenile myoclonic epilepsy
    D A Greenberg
    Mount Sinai School of Medicine, Box 1229, New York, NY 10029, USA
    Am J Hum Genet 66:508-16. 2000
    ..These data also suggest that JME may be predominantly maternally inherited and that the HLA-linked form is more likely to occur in families of European origin...
  2. ncbi request reprint Determining trait locus position from multipoint analysis: accuracy and power of three different statistics
    D A Greenberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genet Epidemiol 21:299-314. 2001
    ..For finding linkage to one locus of several contributing to disease expression, assuming the dominant and recessive models with reduced penetrance is a good approximation of the mode of inheritance at that locus...
  3. pmc Excess of twins among affected sibling pairs with autism: implications for the etiology of autism
    D A Greenberg
    Division of Statistical Genetics, Department of Biostatistics, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Hum Genet 69:1062-7. 2001
    ..Either risk factors (related to twinning or to fetal development) or other factors (genetic or nongenetic) in the parents may contribute to autism...
  4. pmc The power to detect linkage in complex disease by means of simple LOD-score analyses
    D A Greenberg
    Departments of Psychiatry and Biomathematics, Mount Sinai Medical Center, New York, NY 10029, USA
    Am J Hum Genet 63:870-9. 1998
    ..Thus, a limited set of simple genetic models in LOD-score analysis can work well in testing for linkage...
  5. pmc A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, USA
    Am J Hum Genet 63:1749-56. 1998
    ..There was no evidence for heterogeneity in our sample. In our view, these results indicate strong evidence for linkage and suggest the presence of a major GD-susceptibility gene on chromosome 20q11.2...
  6. pmc Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity
    J D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY, 10029, USA
    Am J Hum Genet 68:1514-20. 2001
    ....
  7. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease
    G Barbesino
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:3290-5. 1998
    ..We found a locus on Xq21.33-22 linked to GD that may help to explain the female predisposition to GD. Confirmation of these data in HT may require study of an extended number of families because of possible heterogeneity...
  8. ncbi request reprint Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 84:4656-64. 1999
    ..One of them (GD-2) was fine-mapped to a 1-cM interval...
  9. ncbi request reprint CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 86:1687-93. 2001
    ....
  10. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:4321-7. 1998
    ..These data again suggest the presence of a major Graves' disease susceptibilitygene (GD-1) on chromosome 14q31. This locus is close to the recently identified multinodular goiter-1 locus...
  11. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected immunoregulatory genes. International Consortium for the Genetics of Autoimmune Thyroid Disease
    G Barbesino
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:1580-4. 1998
    ..The lack of linkage for the immunoregulatory genes that were studied indicated, therefore, that they were not major contributors to disease etiology...
  12. ncbi request reprint Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease
    Y Ban
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Genes Immun 5:203-8. 2004
    ..Our results suggested that structural heterogeneity of the DR beta-chain peptide-binding pocket P4 at residue 74 predispose some at risk individuals to GD...
  13. ncbi request reprint Genome scan of idiopathic generalized epilepsy: evidence for major susceptibility gene and modifying genes influencing the seizure type
    M Durner
    Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA
    Ann Neurol 49:328-35. 2001
    ..We hypothesize that interactions of different combinations of these loci produce the related heterogeneous phenotypes seen in IGE families...
  14. ncbi request reprint Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease
    Y Ban
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine Box 1055, New York, NY 10029, USA
    Genes Immun 4:586-93. 2003
    ..We concluded that: (1) the AITD gene in the 2q33 locus is the CTLA-4 gene and not the CD28 or ICOS genes; and (2) the G allele is associated with decreased function of CTLA-4...
  15. pmc Further evidence for the increased power of LOD scores compared with nonparametric methods
    M Durner
    Department of Psychiatry, Mount Sinai Medical Center, New York, USA
    Am J Hum Genet 64:281-9. 1999
    ..In the analysis by Dizier et al., segregation analysis led to estimates of dominance parameters that were grossly misspecified for the locus tested in those models in which ASP tests appeared to be more powerful than LOD-score analyses...
  16. ncbi request reprint Using lod scores to detect sex differences in male-female recombination fractions
    B Feenstra
    Division of Statistical Genetics, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, N Y, USA
    Hum Hered 57:100-8. 2004
    ..This fact is important because often investigators cannot control the proportions of paternally and maternally informative families. In conclusion, it is possible to reliably detect sex differences in recombination fraction...
  17. pmc Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study
    S E Hodge
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 60:217-27. 1997
    ..By quantifying the increase in significance level (or, correspondingly, the increase in Z), our findings will enable users to rationally assess the advantages versus the disadvantages of mod scores...
  18. ncbi request reprint Effect of misspecification of gene frequency on the two-point LOD score
    D K Pal
    Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA
    Eur J Hum Genet 9:855-9. 2001
    ..1 for a recessive gene, appears to be a reasonable tactic in the majority of realistic situations because underestimating the gene frequency, even when the true gene frequency is high, leads to little penalty in the LOD score...
  19. pmc HLA class I and II alleles are associated with microvascular complications of type 1 diabetes
    E M Lipner
    Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY, USA
    Hum Immunol 74:538-44. 2013
    ..27; p=0.008) suggested a strong positive association with complications. Our results show that in type 1 diabetes patients, specific HLA alleles may be involved in susceptibility to, or protection from, microvascular complications...
  20. ncbi request reprint Sibling recurrence risk in autoimmune thyroid disease
    R Villanueva
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 13:761-4. 2003
    ..9 for AITD, 11.6 for GD, and 28.0 for HT. These results confirm the significant contribution of genetic factors to the development of AITD...
  21. ncbi request reprint Association between a GABRB3 polymorphism and autism
    J D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Psychiatry 7:311-6. 2002
    ..These findings support a role for genetic variants within the GABA receptor gene complex in 15q11-13 in autistic disorder...
  22. ncbi request reprint Possible association of juvenile myoclonic epilepsy with HLA-DRw6
    M Durner
    Department of Psychiatry, Mount Sinai Medical Center, New York, New York 10029
    Epilepsia 33:814-6. 1992
    ..The highest difference was noted in the frequency of DRw6 (39.5% in patients vs. 22.1% in controls). This weak association is open to question because DRw6 is known to split into DRw13 and DRw14...
  23. ncbi request reprint Autoimmune thyroid disease susceptibility loci in a large Chinese family
    R Villanueva
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Clin Endocrinol (Oxf) 56:45-51. 2002
    ..The aim of our study was to dissect the genetic predisposition to GD and HT in one large Chinese family with multiple members affected with AITD...
  24. ncbi request reprint Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus
    S Tucci
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Endocrinol Metab 86:446-9. 2001
    ..Since insulin stimulates androgen secretion by the ovarian stroma it is likely that INSR function in the ovary is involved in the genetic susceptibility ot PCOS...