Javier Gonzalez-Maeso

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Identification of a serotonin/glutamate receptor complex implicated in psychosis
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 452:93-7. 2008
  2. doi request reprint Psychedelics and schizophrenia
    Javier Gonzalez-Maeso
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Neurosci 32:225-32. 2009
  3. pmc GPCR oligomers in pharmacology and signaling
    Javier Gonzalez-Maeso
    Departments of Psychiatry and Neurology, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Mol Brain 4:20. 2011
  4. ncbi request reprint Agonist-trafficking and hallucinogens
    Javier Gonzalez-Maeso
    Departments of Psychiatry, Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Med Chem 16:1017-27. 2009
  5. ncbi request reprint Quantitative stoichiometry of G-proteins activated by mu-opioid receptors in postmortem human brain
    Javier Gonzalez-Maeso
    Department of Pharmacology, University of the Basque Country, E 48940 Leioa, Vizcaya, Spain
    Eur J Pharmacol 452:21-33. 2002
  6. ncbi request reprint Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells
    Javier Gonzalez-Maeso
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    Eur J Pharmacol 481:15-23. 2003
  7. pmc Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects
    Carolina Muguruza
    Department of Pharmacology, University of the Basque Country UPV EHU, E 48940 Leioa, Bizkaia, Spain
    Eur Neuropsychopharmacol 23:852-64. 2013
  8. pmc Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice
    Mitsumasa Kurita
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Mol Pharmacol 83:1166-75. 2013
  9. pmc Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:44301-19. 2012
  10. pmc Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1229, New York, NY 10029, United States
    Neurosci Lett 493:76-9. 2011

Research Grants

Collaborators

Detail Information

Publications32

  1. pmc Identification of a serotonin/glutamate receptor complex implicated in psychosis
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 452:93-7. 2008
    ..These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis...
  2. doi request reprint Psychedelics and schizophrenia
    Javier Gonzalez-Maeso
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Neurosci 32:225-32. 2009
    ..Recent results on the receptor, signalling and circuit mechanisms underlying the response to psychedelic and antipsychotic drugs might lead to unification of the serotonin and glutamate neurochemical hypotheses of schizophrenia...
  3. pmc GPCR oligomers in pharmacology and signaling
    Javier Gonzalez-Maeso
    Departments of Psychiatry and Neurology, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Mol Brain 4:20. 2011
    ..In this review, we summarize recent advances in our understanding of the structure, function and dynamics of GPCR complexes, as well as the findings obtained in animal models...
  4. ncbi request reprint Agonist-trafficking and hallucinogens
    Javier Gonzalez-Maeso
    Departments of Psychiatry, Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Med Chem 16:1017-27. 2009
    ..In this review, we summarize the current knowledge, as well as unresolved questions, regarding agonist-trafficking and the mechanism of action of hallucinogenic drugs...
  5. ncbi request reprint Quantitative stoichiometry of G-proteins activated by mu-opioid receptors in postmortem human brain
    Javier Gonzalez-Maeso
    Department of Pharmacology, University of the Basque Country, E 48940 Leioa, Vizcaya, Spain
    Eur J Pharmacol 452:21-33. 2002
    ..In conclusion, we have determined the stoichiometric and the kinetic parameters in the mu-opioid receptor-G-protein system...
  6. ncbi request reprint Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells
    Javier Gonzalez-Maeso
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    Eur J Pharmacol 481:15-23. 2003
    ..The internalization was blocked by a selective GABA(B) receptor antagonist. These results represent the first clear visualization of agonist-induced internalization of the unique heterodimeric GABA(B) receptor...
  7. pmc Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects
    Carolina Muguruza
    Department of Pharmacology, University of the Basque Country UPV EHU, E 48940 Leioa, Bizkaia, Spain
    Eur Neuropsychopharmacol 23:852-64. 2013
    ....
  8. pmc Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice
    Mitsumasa Kurita
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Mol Pharmacol 83:1166-75. 2013
    ..Together, these observations suggest that 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex...
  9. pmc Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:44301-19. 2012
    ..Together, these findings provide structural evidence for the unique behavioral function of a GPCR heteromer...
  10. pmc Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1229, New York, NY 10029, United States
    Neurosci Lett 493:76-9. 2011
    ..However, the induction of egr-2 by DOI was eliminated in mGlu2-KO mice. These findings suggest that the 5-HT2AR-mGluR2 complex is necessary for the neuropsychological responses induced by hallucinogens...
  11. pmc Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT₂A and mGlu₂ receptors in the adult offspring
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:1863-72. 2011
    ..Identifying a biochemical alteration that parallels the behavioral changes observed in a mouse model of prenatal viral infection may facilitate targeting therapies for treatment and prevention of schizophrenia...
  12. ncbi request reprint Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 23:8836-43. 2003
    ..Our results demonstrate that chemicals acting at the 5-HT2AR induce specific cellular response patterns in vivo that are reflected in unique changes in the somatosensory cortex transcriptome...
  13. pmc Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychopharmacology (Berl) 225:217-26. 2013
    ..However, single administration of antipsychotic drugs can reverse schizophrenia-like behavioral alterations in rodent models of psychosis. This raises questions about the physiological relevance of such antipsychotic-like activity...
  14. pmc Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs
    Miguel Fribourg
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 147:1011-23. 2011
    ..These observations provide mechanistic insight into antipsychotic action that may advance therapeutic strategies for disorders including schizophrenia and dementia...
  15. ncbi request reprint Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice
    Noelia V Weisstaub
    Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
    Science 313:536-40. 2006
    ..These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment...
  16. ncbi request reprint Validated genomic approach to study differentially expressed genes in complex tissues
    Elisa Wurmbach
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurochem Res 27:1027-33. 2002
    ....
  17. ncbi request reprint Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior
    Javier Gonzalez-Maeso
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 53:439-52. 2007
    ..These studies identify the long-elusive neural and signaling mechanisms responsible for the unique effects of hallucinogens...
  18. pmc Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1229, New York, NY 10029, United States
    Neurosci Lett 536:69-73. 2013
    ..These findings suggest that repeated blockade of the mGlu2 receptor by LY341495 results in reduced 5-HT(2A) receptor-dependent hallucinogenic effects of LSD...
  19. ncbi request reprint Effects of age, postmortem delay and storage time on receptor-mediated activation of G-proteins in human brain
    Javier Gonzalez-Maeso
    Department of Pharmacology, University of the Basque Country, E 48940 Leioa, Bizkaia, Spain
    Neuropsychopharmacology 26:468-78. 2002
    ..A careful match between cases and controls should be taken into account when designing signal transduction studies in human disorders, specially for variables such as age and storage period...
  20. ncbi request reprint Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain
    Pokman Chan
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 482:50-73. 2005
    ..The distribution of epsilon-sarcoglycan in the mouse brain suggests that the symptom complex of M-D may be related to the effects of decreased epsilon-sarcoglycan activity on the development or function of monoaminergic neurons...
  21. pmc HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
    Mitsumasa Kurita
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1245-54. 2012
    ..These observations support the view of HDAC2 as a promising new target for schizophrenia treatment...
  22. pmc Prenatal stress induces schizophrenia-like alterations of serotonin 2A and metabotropic glutamate 2 receptors in the adult offspring: role of maternal immune system
    Terrell Holloway
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 33:1088-98. 2013
    ..These data strengthen pathophysiological hypotheses that propose an early neurodevelopmental origin for schizophrenia and other psychiatric disorders...
  23. ncbi request reprint Preclinical models of antipsychotic drug action
    Jose L Moreno
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA
    Int J Neuropsychopharmacol 16:2131-44. 2013
    ..Here we review recent advances using LSD-like and PCP-like drugs in rodent models that implicate these receptors in the neurobiology of schizophrenia and its treatment. ..
  24. pmc Animal models of serotonergic psychedelics
    James B Hanks
    Department of Psychiatry, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, United States
    ACS Chem Neurosci 4:33-42. 2013
    ....
  25. pmc Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
    Sam A Golden
    Fishberg Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Nat Med 19:337-44. 2013
    ..Taken together, our data identify epigenetic regulation of RAC1 in the NAc as a disease mechanism in depression and reveal a functional role for Rac1 in rodents in regulating stress-related behaviors...
  26. pmc Group II metabotropic glutamate receptors and schizophrenia
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Mol Life Sci 66:3777-85. 2009
    ..This paper reviews the status of general knowledge of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia...
  27. doi request reprint G protein-coupled receptor heterocomplexes in neuropsychiatric disorders
    Jose L Moreno
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, USA
    Prog Mol Biol Transl Sci 117:187-205. 2013
    ..In this chapter, we review current data on the role of GPCR heteromerization in receptor signaling, as well as its potential implication in neuropsychiatric disorders such as schizophrenia, depression, and Parkinson's disease...
  28. pmc Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
    Laura Albizu
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropharmacology 61:770-7. 2011
    ..The existence of this 5-HT(2A)R-D(2)R heteromer and crosstalk may have implications for diseases involving alterations of serotonin and dopamine systems and for the development of new classes of therapeutic drugs...
  29. pmc Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization
    Pokman Chan
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, NY 10029, USA
    Nucleic Acids Res 33:e161. 2005
    ..This approach can facilitate the ultrasensitive simultaneous study of multiple mRNA and protein markers in tissue culture and histological section...
  30. ncbi request reprint p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:39550-60. 2006
    ..These results suggest that abnormalities in p53 signaling play a role in dopaminergic cell death induced by proteasome inhibition and may be relevant to neurodegeneration in PD...
  31. pmc Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics
    Laura Albizu
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    CNS Neurol Disord Drug Targets 9:636-50. 2010
    ..A better understanding of molecular mechanisms underlying drug interactions related to the targeting of receptor heteromers could provide more specific and efficient therapeutic agents for the treatment of brain diseases...
  32. ncbi request reprint Distribution of prolyl endopeptidase activities in rat and human brain
    Jon Irazusta
    Department of Physiology, Medical School, University of the Basque Country, Leioa, P O Box 699, 48, 080 Bilbao, Spain
    Neurochem Int 40:337-45. 2002
    ..The particulate form was enriched in the synaptosomal and the myelinic membranes. The high activity of prolyl endopeptidase in the human cortex suggests that prolyl endopeptidase could play a role in the functions of this brain area...

Research Grants2

  1. Structure and function of the 5HT2A/mGluR2 complex in schizophrenia
    Javier Gonzalez Maeso; Fiscal Year: 2010
    ..The characterization of the structure of the neuroreceptor will extend our understanding of the molecular basis of psychosis, and may provide a route to the development of new, more effective drugs for the treatment of schizophrenia. ..
  2. Structure and function of the 5HT2A/mGluR2 complex in schizophrenia
    Javier Gonzalez Maeso; Fiscal Year: 2009
    ..The characterization of the structure of the neuroreceptor will extend our understanding of the molecular basis of psychosis, and may provide a route to the development of new, more effective drugs for the treatment of schizophrenia. ..