Joseph george

Summary

Affiliation: Mount Sinai
Location: New York, USA
URL: http://www.josorge.com/
Summary:
See my webpage
Publications:
1. Mormone E, George J, Nieto N. Related Citations
Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches.
Chem Biol Interact. 2011 Jul 22. [Epub ahead of print]
PMID: [PubMed - indexed for MEDLINE]

2. George J, Sun J, DArmiento J. Related Citations
Transgenic expression of human matrix metalloproteinase-1 attenuated pulmonary arterial hypertension in mice.
Clin Sci (Lond). 2011 Jul 27. [Epub ahead of print]
PMID: [PubMed - indexed for MEDLINE]

3. George J, DArmiento J. Related Citations
Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice.
J Hypertens. 2011 Feb;29(2):299-308.
PMID: [PubMed - indexed for MEDLINE]

4. George J, Banik NL, Ray SK. Related Citations
Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo.
Neuro Oncol. 2010 Nov;12(11):1088-101. Epub 2010 Aug 2.
PMID: [PubMed - indexed for MEDLINE]

5. George J, Banik NL, Ray SK. Related Citations
Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines.
Int J Biochem Cell Biol. 2010 Jul;42(7):1164-73. Epub 2010 Apr 13.
PMID: [PubMed - indexed for MEDLINE]

6. George J, Banik NL, Ray SK. Related Citations
Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells.
J Neurosci Res. 2010 Mar;88(4):877-86.
PMID: [PubMed - indexed for MEDLINE]

7. George J, Banik NL, Ray SK. Related Articles
Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma.
Clin Cancer Res. 2009 Dec 1;15(23):7186-95. Epub 2009 Nov 24.
PMID: [PubMed - indexed for MEDLINE]

8. George J, Banik NL, Ray SK. Related Articles
Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth.
J Cell Mol Med. 2009 Oct 13. [Epub ahead of print]
PMID: [PubMed - indexed for MEDLINE]

9. George J, Banik NL, Ray SK. Related Articles
Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells.
Neurochem Res. 2009 Jan;34(1):66-78. Epub 2008 Mar 21.
PMID: [PubMed - indexed for MEDLINE]

10. George J, Onodera J, Miyata T. Related Articles
Biodegradable honeycomb collagen scaffold for dermal tissue engineering.
J Biomed Mater Res A. 2008 Dec 15;87(4):1103-11.
PMID: [PubMed - indexed for MEDLINE]

11. George J. Related Articles
Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats.
Biochem Cell Biol. 2008 Jun;86(3):235-43.
PMID: [PubMed - indexed for MEDLINE]

12. George J, Gondi CS, Dinh DH, Gujrati M, Rao JS. Related Articles
Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis.
Clin Cancer Res. 2007 Jun 15;13(12):3507-17.
PMID: [PubMed - indexed for MEDLINE]

13. George J, Tsutsumi M. Related Articles
siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats.
Gene Ther. 2007 May;14(10):790-803. Epub 2007 Mar 8.
PMID: [PubMed - indexed for MEDLINE ]

14. George J. Related Articles
Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis.
Clin Biochem. 2006 Oct;39(10):984-91. Epub 2006 Jul 26.
PMID: [PubMed - indexed for MEDLINE]

15. Tsutsumi M, George J, Ishizawa K, Fukumura A, Takase S. Related Articles
Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.
J Gastroenterol Hepatol. 2006 May;21(5):805-13.
PMID: [PubMed - indexed for MEDLINE]

16. George J, Kuboki Y, Miyata T. Related Articles
Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds. Biotechnol Bioeng. 2006 Oct 20;95(3):404-11.
PMID: [PubMed - indexed for MEDLINE ]

17. George J, Stern R. Related Articles
Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury.
Clin Chim Acta. 2004 Oct;348(1-2):189-97.
PMID: [PubMed - indexed for MEDLINE]

18. George J, Tsutsumi M, Takase S. Related Articles
Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats.
Int J Biochem Cell Biol. 2004 Feb;36(2):307-19.
PMID: [PubMed - indexed for MEDLINE]


19. George J. Related Articles
Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats.
Clin Chim Acta. 2003 Sep;335(1-2):39-47.
PMID: [PubMed - indexed for MEDLINE]

20. Onodera J, Saito A, George J, Iwasaki T, Ito H, Aso Y, Hamano T,
Kanai A, Miyata T, Nagai Y. Related Articles
Application of atelocollagen solution for lacrimal duct occlusion.
Adv Exp Med Biol. 2002;506(Pt B):1277-81. No abstract available.
PMID: [PubMed - indexed for MEDLINE]

21. George J, Rao KR, Stern R, Chandrakasan G. Related Articles
Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.
Toxicology. 2001 Jan 2;156(2-3):129-38.
PMID: [PubMed - indexed for MEDLINE]

22. George J, Chandrakasan G. Related Articles
Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine.
Clin Biochem. 2000 Oct;33(7):563-70.
PMID: [PubMed - indexed for MEDLINE]

23. George J, Chandrakasan G. Related Articles
Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats.
Int J Biochem Cell Biol. 1996 Mar;28(3):353-61.
PMID: 8920645 [PubMed - indexed for MEDLINE]

24. George J, Chandrakasan G. Related Articles
Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen.
Biochim Biophys Acta. 1996 Feb 8;1292(2):215-22.
PMID: 8597566 [PubMed - indexed for MEDLINE]

25. George J, Bhatia VN, Balakrishnan S, Ramu G. Related Articles
Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states.
Int J Lepr Other Mycobact Dis. 1991 Mar;59(1):20-4.
PMID: 2030313 [PubMed - indexed for MEDLINE]

26. George J, Rajendran M, Bhatia VN. Related Articles
Serum beta-glucuronidase in subtypes of leprosy.
Indian J Med Res. 1990 Mar;91:106-10.
PMID: 2345017 [PubMed - indexed for MEDLINE]

27. George J, Balakrishnan S, Bhatia VN. Related Articles
Drug interaction during multidrug regimens for treatment of leprosy.
Indian J Med Res. 1988 Feb;87:151-6. No abstract available.
PMID: 3397146 [PubMed - indexed for MEDLINE]

Publications

  1. ncbi request reprint Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states
    J George
    Department of Biochemistry, Central Leprosy Teaching and Research Institute, Chengalpattu, Tamil Nadu, India
    Int J Lepr Other Mycobact Dis 59:20-4. 1991
  2. pmc Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis
    Joseph George
    Department of Cancer Biology, University of Illinois, College of Medicine at Peoria, Peoria, Illinois, USA
    Clin Cancer Res 13:3507-17. 2007
  3. doi request reprint Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells
    Joseph George
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC, 29425, USA
    Neurochem Res 34:66-78. 2009
  4. doi request reprint Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats
    Joseph George
    Department of Biochemistry, Central Leather Research Institute Adyar, Madras, India
    Biochem Cell Biol 86:235-43. 2008
  5. doi request reprint Biodegradable honeycomb collagen scaffold for dermal tissue engineering
    Joseph George
    Division of Tissue Engineering, Koken Bioscience Institute, 2 13 10 Ukima, Kita ku, Tokyo 115 0051, Japan
    J Biomed Mater Res A 87:1103-11. 2008
  6. doi request reprint Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis and tumour growth
    Joseph George
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA
    J Cell Mol Med 13:4205-18. 2009
  7. pmc Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    J Neurosci Res 88:877-86. 2010
  8. pmc Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29209, USA
    Clin Cancer Res 15:7186-95. 2009
  9. pmc Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Int J Biochem Cell Biol 42:1164-73. 2010
  10. pmc Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA
    Neuro Oncol 12:1088-101. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states
    J George
    Department of Biochemistry, Central Leprosy Teaching and Research Institute, Chengalpattu, Tamil Nadu, India
    Int J Lepr Other Mycobact Dis 59:20-4. 1991
    ..In contrast, the copper levels were not decreased, indicating that oral zinc therapy can restore normal zinc levels in leprosy patients but is unable to reduce the increased copper levels...
  2. pmc Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis
    Joseph George
    Department of Cancer Biology, University of Illinois, College of Medicine at Peoria, Peoria, Illinois, USA
    Clin Cancer Res 13:3507-17. 2007
    ..Tissue factor pathway inhibitor-2 (TFPI-2) is a protease inhibitor that is abundant in the extracellular matrix and highly expressed in noninvasive cells but absent or undetectable in highly invasive human glioblastoma cells...
  3. doi request reprint Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells
    Joseph George
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC, 29425, USA
    Neurochem Res 34:66-78. 2009
    ..Thus, combination of taxol and Bcl-2 siRNA offers a novel therapeutic strategy for controlling the malignant growth of human glioblastoma cells...
  4. doi request reprint Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats
    Joseph George
    Department of Biochemistry, Central Leather Research Institute Adyar, Madras, India
    Biochem Cell Biol 86:235-43. 2008
    ..In this study, we also elucidated the mechanism of increased beta-glucuronidase and other lysosomal glycohydrolases in the serum during hepatic fibrosis...
  5. doi request reprint Biodegradable honeycomb collagen scaffold for dermal tissue engineering
    Joseph George
    Division of Tissue Engineering, Koken Bioscience Institute, 2 13 10 Ukima, Kita ku, Tokyo 115 0051, Japan
    J Biomed Mater Res A 87:1103-11. 2008
    ....
  6. doi request reprint Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis and tumour growth
    Joseph George
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA
    J Cell Mol Med 13:4205-18. 2009
    ..Therefore, the combination of a low dose of taxol and Bcl-2 siRNA is a promising therapeutic strategy for controlling the aggressive growth of human glioblastoma...
  7. pmc Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    J Neurosci Res 88:877-86. 2010
    ..Therefore, this strategy could serve as a potential therapeutic regimen to inhibit the growth of human malignant neuroblastoma...
  8. pmc Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina 29209, USA
    Clin Cancer Res 15:7186-95. 2009
    ..IFN-gamma modulates several cellular activities, including signaling pathways and cell cycle, through transcriptional regulation...
  9. pmc Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Int J Biochem Cell Biol 42:1164-73. 2010
    ..Therefore, the combination of hTERT siRNA and IFN-gamma offers a potential therapeutic strategy for controlling growth of human glioblastoma cells...
  10. pmc Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo
    Joseph George
    Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA
    Neuro Oncol 12:1088-101. 2010
    ..Our data demonstrated that survivin knockdown and concurrent 4-HPR treatment could be a novel therapeutic strategy for controlling growth of human glioblastomas...
  11. pmc Transgenic expression of human matrix metalloproteinase-9 augments monocrotaline-induced pulmonary arterial hypertension in mice
    Joseph George
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York, USA
    J Hypertens 29:299-308. 2011
    ..This investigation was aimed to examine the effects of transgenic expression of human matrix metalloproteinase-9 (MMP-9) in the pathogenesis of PAH...
  12. pmc Transgenic expression of human matrix metalloproteinase-1 attenuates pulmonary arterial hypertension in mice
    Joseph George
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Clin Sci (Lond) 122:83-92. 2012
    ..Our results indicate that up-regulation of MMP-1 could attenuate the debilitation of human PAH and provide an option for therapeutic intervention...
  13. ncbi request reprint siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats
    J George
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY, USA
    Gene Ther 14:790-803. 2007
    ..The data further suggest that knockdown of CTGF upregulation using siRNA has potential therapeutic application to prevent hepatic fibrogenesis...
  14. ncbi request reprint Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis
    Joseph George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Madras 600 020, India
    Clin Biochem 39:984-91. 2006
    ..In the present investigation, we have monitored serum and liver concentrations of calcium, magnesium, sodium and potassium during experimentally induced hepatic fibrosis in rats...
  15. ncbi request reprint Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats
    Mikihiro Tsutsumi
    Division of Gastroenterology, Department of Internal Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    J Gastroenterol Hepatol 21:805-13. 2006
    ..The role of alcohol abuse in the carcinogenic action of N-nitrosomethylbenzylamine, which induces tumors in the esophagus, has been evaluated...
  16. ncbi request reprint Serum beta-glucuronidase in subtypes of leprosy
    J George
    Central Leprosy Teaching and Research Institute, Chengalpattu
    Indian J Med Res 91:106-10. 1990
    ..5 SU and the maximum was 54.0 SU. The results suggest that in leprosy patients, especially in those on daily multidrug regimens, there is an extensive damage of leucocytes and liver cells where the enzyme is largely present...
  17. ncbi request reprint Drug interaction during multidrug regimens for treatment of leprosy
    J George
    Indian J Med Res 87:151-6. 1988
  18. ncbi request reprint Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen
    J George
    Department of Biochemistry, Central Leather Research Institute, Madras, India
    Biochim Biophys Acta 1292:215-22. 1996
    ..The data of the present investigation revealed that the DMN induced fibrotic liver collagen is more cross-linked than normal liver collagen and the deposition of type III collagen in more prominent than type I collagen in early fibrosis...
  19. ncbi request reprint Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats
    J George
    Department of Biochemistry, Central Leather Research Institute, Madras, India
    Int J Biochem Cell Biol 28:353-61. 1996
    ..The results suggest that glycoproteins undergo changes in both synthesis and the degradation during hepatic fibrosis. The relative alterations in these processes will play a vital role in determining the progression of hepatic fibrosis...
  20. ncbi request reprint Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine
    J George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Madras 600 020, India
    Clin Biochem 33:563-70. 2000
    ..To obtain more information about the alteration of biochemical and metabolic parameters during alcoholic liver fibrosis, we have monitored the changes of certain important biochemical compounds in experimentally induced hepatic fibrosis...
  21. ncbi request reprint Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen
    J George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai600 020, India
    Toxicology 156:129-38. 2001
    ..DMN-induced liver injury in rats appears to be a potential animal model for early human cirrhosis and the rapid deposition of collagen, and may serve as a convenient procedure for screening antifibrotic agents...
  22. ncbi request reprint Application of atelocollagen solution for lacrimal duct occlusion
    Jun Onodera
    Kaken Bioscience Institute, Tokyo, Japan
    Adv Exp Med Biol 506:1277-81. 2002
  23. ncbi request reprint Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats
    Joseph George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Madras 600 020, India
    Clin Chim Acta 335:39-47. 2003
    ..In the present investigation, ascorbic acid and lipid peroxides were monitored in the blood and liver samples during the progression of experimentally induced hepatic fibrosis...
  24. ncbi request reprint Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats
    Joseph George
    Division of Gastroenterology, Department of Internal Medicine, Kanazawa Medical University, Uchinada, Ishikawa, 920 0293, Japan
    Int J Biochem Cell Biol 36:307-19. 2004
    ..In latter stages the increase of both serum and liver HA is contributed by the increased synthesis by the activated stellate cells and reduced clearance by the impaired sinusoidal endothelial cells...
  25. ncbi request reprint Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury
    Joseph George
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Clin Chim Acta 348:189-97. 2004
    ..We test the hypothesis that elevated levels of circulating hyaluronan and hyaluronidase could provide indicators of very early liver damage...
  26. ncbi request reprint Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds
    Joseph George
    Koken Bioscience Institute, 2 13 10 Ukima, Tokyo 115 0051, Japan
    Biotechnol Bioeng 95:404-11. 2006
    ..The data further proved that honeycomb collagen is an effective substrate for tissue engineering applications, and is very useful in the advancing field of stem cell technology and cell-based therapy...
  27. pmc Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
    Elisabetta Mormone
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, NY 10029, USA
    Chem Biol Interact 193:225-31. 2011
    ..In this review, we discuss some aspects on the etiology of liver fibrosis, the cells involved, the molecular pathogenesis, and the current therapeutic approaches...