Genomes and Genes
Affiliation: Mount Sinai School of Medicine
- The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's diseaseHannah Brautigam
Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Mol Neurodegener 7:58. 2012..We investigated whether two APP mouse models characterized by different folding states of amyloid showed different neuronal densities using an accurate method of cell counting...
- Microglia as dynamic and essential components of the amyloid hypothesisSam Gandy
Icahn School of Medicine and James J Peters VA Medical Center, New York, NY 10029, USA Electronic address
Neuron 78:575-7. 2013..AD brains have increased CD33 and CD33-positive microglia. Mice lacking CD33 have less AD pathology suggesting a role of microglia for Aβ clearance and development of future therapies...
- Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progressSam Gandy
Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, New York, New York 10029, USA
Annu Rev Med 64:367-83. 2013..AD trials deriving from new biological information involve extraordinary international collaboration and may hold the best hope for success in the fight against AD...
- Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's diseaseIna Caesar
Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
BMC Med 10:36. 2012..This 'double whammy' result opens up a new direction for studies aimed at elucidating the relevant neurobiological activities of APOE isoforms in the pathogenesis of AD...
- Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1Rachel F Lane
Department of Neurology, Mount Sinai School of Medicine, New York NY 10029, USA
Mol Neurodegener 5:62. 2010..abstract:..
- Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivoJohn W Steele
Departments of Neurology, Psychiatry and Alzheimer s Disease Research Center, Mount Sinai School of Medicine, New York, NY, 10029, USA
Mol Neurodegener 4:51. 2009..In the current study, we assessed the effect of acute dosing of latrepirdine on levels of extracellular Abeta using in vitro and in vivo experimental systems...
- Novel cerebrovascular pathology in mice fed a high cholesterol dietSonia Franciosi
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Mol Neurodegener 4:42. 2009..abstract:..
- Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathologySteve Pedrini
Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
Mol Neurodegener 4:40. 2009..abstract:..
- Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomersSam Gandy
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Neurol 68:220-30. 2010..We sought to study the bioactivities of endogenously formed oAbeta/ADDLs generated in situ from the physiological processing of human amyloid precursor protein (APP) and presenitin1 (PS1) transgenes...
- Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)Weiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Alzheimers Dis 10:417-22. 2006..Collectively, the study suggests that investigation of the role of CR in non-human primates may provide a valuable approach for further clarifying the role of CR in AD...
- Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's diseaseYuji Kajiwara
Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Mol Neurodegener 5:1. 2010..There is good evidence that the cytoplasmic domain of LRP1 is involved in protein-protein interactions, important in the cell biology of LRP1...
- Role of vascular risk factors and vascular dysfunction in Alzheimer's diseaseDara L Dickstein
Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 77:82-102. 2010..Here we discuss vascular factors with respect to Alzheimer's disease and dementia and review the factors that give rise to vascular dysfunction and contribute to Alzheimer's disease...
- Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restrictionWeiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 281:21745-54. 2006..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
- ESTROGEN MODULATION OF BRAIN ABETA METABOLISM IN VIVOSamuel Gandy; Fiscal Year: 2004....
- PRESENILIN DOMAINS AND RECONSTITUTION OF CATALYSISSamuel Gandy; Fiscal Year: 2006..This investigation will permit the identification of the minimal functional unit for gamma-secretase activity and potentially support the notion that PS1 is indeed the catalytic component of the gamma-secretase complex. ..