Samuel Gandy

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease
    Hannah Brautigam
    Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Mol Neurodegener 7:58. 2012
  2. doi request reprint Microglia as dynamic and essential components of the amyloid hypothesis
    Sam Gandy
    Icahn School of Medicine and James J Peters VA Medical Center, New York, NY 10029, USA Electronic address
    Neuron 78:575-7. 2013
  3. pmc Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress
    Sam Gandy
    Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, New York, New York 10029, USA
    Annu Rev Med 64:367-83. 2013
  4. pmc Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease
    Ina Caesar
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    BMC Med 10:36. 2012
  5. pmc Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1
    Rachel F Lane
    Department of Neurology, Mount Sinai School of Medicine, New York NY 10029, USA
    Mol Neurodegener 5:62. 2010
  6. pmc Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo
    John W Steele
    Departments of Neurology, Psychiatry and Alzheimer s Disease Research Center, Mount Sinai School of Medicine, New York, NY, 10029, USA
    Mol Neurodegener 4:51. 2009
  7. pmc Novel cerebrovascular pathology in mice fed a high cholesterol diet
    Sonia Franciosi
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 4:42. 2009
  8. pmc Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
  9. pmc Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers
    Sam Gandy
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 68:220-30. 2010
  10. ncbi request reprint Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 10:417-22. 2006

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease
    Hannah Brautigam
    Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Mol Neurodegener 7:58. 2012
    ..We investigated whether two APP mouse models characterized by different folding states of amyloid showed different neuronal densities using an accurate method of cell counting...
  2. doi request reprint Microglia as dynamic and essential components of the amyloid hypothesis
    Sam Gandy
    Icahn School of Medicine and James J Peters VA Medical Center, New York, NY 10029, USA Electronic address
    Neuron 78:575-7. 2013
    ..AD brains have increased CD33 and CD33-positive microglia. Mice lacking CD33 have less AD pathology suggesting a role of microglia for Aβ clearance and development of future therapies...
  3. pmc Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress
    Sam Gandy
    Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, New York, New York 10029, USA
    Annu Rev Med 64:367-83. 2013
    ..AD trials deriving from new biological information involve extraordinary international collaboration and may hold the best hope for success in the fight against AD...
  4. pmc Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease
    Ina Caesar
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    BMC Med 10:36. 2012
    ..This 'double whammy' result opens up a new direction for studies aimed at elucidating the relevant neurobiological activities of APOE isoforms in the pathogenesis of AD...
  5. pmc Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1
    Rachel F Lane
    Department of Neurology, Mount Sinai School of Medicine, New York NY 10029, USA
    Mol Neurodegener 5:62. 2010
    ..abstract:..
  6. pmc Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo
    John W Steele
    Departments of Neurology, Psychiatry and Alzheimer s Disease Research Center, Mount Sinai School of Medicine, New York, NY, 10029, USA
    Mol Neurodegener 4:51. 2009
    ..In the current study, we assessed the effect of acute dosing of latrepirdine on levels of extracellular Abeta using in vitro and in vivo experimental systems...
  7. pmc Novel cerebrovascular pathology in mice fed a high cholesterol diet
    Sonia Franciosi
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 4:42. 2009
    ..abstract:..
  8. pmc Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
    ..abstract:..
  9. pmc Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers
    Sam Gandy
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 68:220-30. 2010
    ..We sought to study the bioactivities of endogenously formed oAbeta/ADDLs generated in situ from the physiological processing of human amyloid precursor protein (APP) and presenitin1 (PS1) transgenes...
  10. ncbi request reprint Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Alzheimers Dis 10:417-22. 2006
    ..Collectively, the study suggests that investigation of the role of CR in non-human primates may provide a valuable approach for further clarifying the role of CR in AD...
  11. pmc Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease
    Yuji Kajiwara
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 5:1. 2010
    ..There is good evidence that the cytoplasmic domain of LRP1 is involved in protein-protein interactions, important in the cell biology of LRP1...
  12. pmc Role of vascular risk factors and vascular dysfunction in Alzheimer's disease
    Dara L Dickstein
    Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:82-102. 2010
    ..Here we discuss vascular factors with respect to Alzheimer's disease and dementia and review the factors that give rise to vascular dysfunction and contribute to Alzheimer's disease...
  13. ncbi request reprint Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...

Research Grants10

  1. ESTROGEN MODULATION OF BRAIN ABETA METABOLISM IN VIVO
    Samuel Gandy; Fiscal Year: 2004
    ....
  2. PRESENILIN DOMAINS AND RECONSTITUTION OF CATALYSIS
    Samuel Gandy; Fiscal Year: 2006
    ..This investigation will permit the identification of the minimal functional unit for gamma-secretase activity and potentially support the notion that PS1 is indeed the catalytic component of the gamma-secretase complex. ..