Genomes and Genes
Affiliation: Mount Sinai School of Medicine
- Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progressSam Gandy
Mount Sinai School of Medicine and James J Peters Veterans Affairs Medical Center, New York, New York 10029, USA
Annu Rev Med 64:367-83. 2013..AD trials deriving from new biological information involve extraordinary international collaboration and may hold the best hope for success in the fight against AD...
- Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's diseaseIna Caesar
Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
BMC Med 10:36. 2012..This 'double whammy' result opens up a new direction for studies aimed at elucidating the relevant neurobiological activities of APOE isoforms in the pathogenesis of AD...
- Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1Rachel F Lane
Department of Neurology, Mount Sinai School of Medicine, New York NY 10029, USA
Mol Neurodegener 5:62. 2010..abstract:..
- Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivoJohn W Steele
Departments of Neurology, Psychiatry and Alzheimer s Disease Research Center, Mount Sinai School of Medicine, New York, NY, 10029, USA
Mol Neurodegener 4:51. 2009..In the current study, we assessed the effect of acute dosing of latrepirdine on levels of extracellular Abeta using in vitro and in vivo experimental systems...
- Novel cerebrovascular pathology in mice fed a high cholesterol dietSonia Franciosi
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Mol Neurodegener 4:42. 2009..abstract:..
- Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathologySteve Pedrini
Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
Mol Neurodegener 4:40. 2009..abstract:..
- Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomersSam Gandy
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Neurol 68:220-30. 2010..We sought to study the bioactivities of endogenously formed oAbeta/ADDLs generated in situ from the physiological processing of human amyloid precursor protein (APP) and presenitin1 (PS1) transgenes...
- Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus)Weiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Alzheimers Dis 10:417-22. 2006..Collectively, the study suggests that investigation of the role of CR in non-human primates may provide a valuable approach for further clarifying the role of CR in AD...
- Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's diseaseYuji Kajiwara
Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Mol Neurodegener 5:1. 2010..There is good evidence that the cytoplasmic domain of LRP1 is involved in protein-protein interactions, important in the cell biology of LRP1...
- Role of vascular risk factors and vascular dysfunction in Alzheimer's diseaseDara L Dickstein
Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 77:82-102. 2010..Here we discuss vascular factors with respect to Alzheimer's disease and dementia and review the factors that give rise to vascular dysfunction and contribute to Alzheimer's disease...
- Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restrictionWeiping Qin
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 281:21745-54. 2006..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
- ESTROGEN MODULATION OF BRAIN ABETA METABOLISM IN VIVOSamuel Gandy; Fiscal Year: 2004....
- PRESENILIN DOMAINS AND RECONSTITUTION OF CATALYSISSamuel Gandy; Fiscal Year: 2006..This investigation will permit the identification of the minimal functional unit for gamma-secretase activity and potentially support the notion that PS1 is indeed the catalytic component of the gamma-secretase complex. ..