Affiliation: Mount Sinai School of Medicine
- Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse modelsAmit K Tiwari
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Cancer Ther 12:1343-55. 2013..As such it is relevant to examine how polymorphisms in these transporters influence topotecan activity in patients and whether coadministration of transport modulators could positively affect efficacy without increasing toxicity...
- Pharmacokinetic/ pharmacodynamic-driven drug developmentJames M Gallo
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 77:381-8. 2010....
- Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine modelsZhan Wang
Department of Pharmaceutical Sciences, Temple University, Philadelphia, Pennsylvania, USA
Drug Metab Dispos 39:2155-61. 2011..The findings confirmed that both Abcc2 and Abcc3 significantly influenced the PK properties of MTX, and depending on the MTX dose and strain, alternate elimination pathways were elicited and saturable...
- Cells Designed to Deliver Anticancer Drugs by ApoptosisJames Gallo; Fiscal Year: 2006..AIDD is a novel strategy that offers many mechanisms to selectively deliver anticancer drugs to tumors. ..