Valentin Fuster

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint From treating complex coronary artery disease to promoting cardiovascular health: therapeutic transitions and challenges, 2010-2020
    J C Kovacic
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    Clin Pharmacol Ther 90:509-18. 2011
  2. doi request reprint Global cardiovascular health: urgent need for an intersectoral approach
    Valentin Fuster
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    J Am Coll Cardiol 58:1208-10. 2011
  3. pmc Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 59:2080-8. 2012
  4. pmc Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging
    Esad Vucic
    Translational and Molecular Imaging Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    JACC Cardiovasc Imaging 4:1100-9. 2011
  5. doi request reprint Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL(wild-type)
    Borja Ibanez
    Atherothrombosis Research Unit, The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Atherosclerosis 220:72-7. 2012
  6. pmc Regression of inflammation in atherosclerosis by the LXR agonist R211945: a noninvasive assessment and comparison with atorvastatin
    Esad Vucic
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA
    JACC Cardiovasc Imaging 5:819-28. 2012
  7. doi request reprint Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients: FDG-PET and CT imaging study
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 4:1195-205. 2011
  8. doi request reprint Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis
    Meerarani Purushothaman
    FACC, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029
    Arterioscler Thromb Vasc Biol 32:2769-75. 2012
  9. doi request reprint Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis
    Chiara Giannarelli
    Atherothrombosis Research Unit, Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Eur Heart J 33:264-73. 2012
  10. doi request reprint Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis
    K Raman Purushothaman
    Zena and Michael A Weiner Cardiovascular Institute, Marie Josee and Henry R Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Coll Cardiol 60:112-9. 2012

Collaborators

Detail Information

Publications88

  1. doi request reprint From treating complex coronary artery disease to promoting cardiovascular health: therapeutic transitions and challenges, 2010-2020
    J C Kovacic
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    Clin Pharmacol Ther 90:509-18. 2011
    ..In this article, we critically review the key challenges that we face in the coming decade as we strive to transition and apply our growing knowledge of complex CAD to promoting global cardiovascular health...
  2. doi request reprint Global cardiovascular health: urgent need for an intersectoral approach
    Valentin Fuster
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    J Am Coll Cardiol 58:1208-10. 2011
    ..Improved control of global CVD is eminently possible but requires an intersectoral approach involving a diversity of actors and stakeholders...
  3. pmc Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 59:2080-8. 2012
    ..In this study, the impact of noninsulin-dependent type 2 diabetes mellitus on carotid wall (18)F-fluorodeoxyglucose (FDG) uptake in patients with documented or suspected cardiovascular disease was evaluated...
  4. pmc Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging
    Esad Vucic
    Translational and Molecular Imaging Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    JACC Cardiovasc Imaging 4:1100-9. 2011
    ..We sought to determine the antiatherosclerotic properties of pioglitazone using multimethod noninvasive imaging techniques...
  5. doi request reprint Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL(wild-type)
    Borja Ibanez
    Atherothrombosis Research Unit, The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Atherosclerosis 220:72-7. 2012
    ..The aim of this study was to compare the effects of HDL(Milano) and HDL(wild-type), on regression and stabilization of atherosclerosis...
  6. pmc Regression of inflammation in atherosclerosis by the LXR agonist R211945: a noninvasive assessment and comparison with atorvastatin
    Esad Vucic
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA
    JACC Cardiovasc Imaging 5:819-28. 2012
    ..The aim of this study was to noninvasively detect the anti-inflammatory properties of the novel liver X receptor agonist R211945...
  7. doi request reprint Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients: FDG-PET and CT imaging study
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 4:1195-205. 2011
    ..We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients...
  8. doi request reprint Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis
    Meerarani Purushothaman
    FACC, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029
    Arterioscler Thromb Vasc Biol 32:2769-75. 2012
    ..We tested the hypothesis that hemoglobin clearance may be deficient in diabetic atheroma from patients with Hp2-2, triggering increased oxidative, inflammatory, and angiogenic patterns compared with controls...
  9. doi request reprint Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis
    Chiara Giannarelli
    Atherothrombosis Research Unit, Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Eur Heart J 33:264-73. 2012
    ..The aim of this study was to investigate the effects of liver X receptors (LXRs)-β preferential activation by LXR-623 (WAY-252623), a novel LXRs agonist, on plaque progression/regression in a rabbit model of advanced atherosclerosis...
  10. doi request reprint Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis
    K Raman Purushothaman
    Zena and Michael A Weiner Cardiovascular Institute, Marie Josee and Henry R Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Coll Cardiol 60:112-9. 2012
    ..The purpose of this study was to test the hypothesis that increased oxidative stress is associated with apoptosis in human plaques with the haptoglobin (Hp) 2-2 genotype...
  11. doi request reprint RV dysfunction in pulmonary hypertension is independently related to pulmonary artery stiffness
    Gerin R Stevens
    Montefiore Einstein Center for Heart and Vascular Care, Albert Einstein College of Medicine, Bronx, New York, New York, USA
    JACC Cardiovasc Imaging 5:378-87. 2012
    ..This study investigated whether right ventricular (RV) adaptation to chronic pressure overload is associated with pulmonary artery (PA) stiffness beyond the degree of severity of pulmonary hypertension (PH)...
  12. doi request reprint Carvedilol administration in acute myocardial infarction results in stronger inhibition of early markers of left ventricular remodeling than metoprolol
    Giovanni Cimmino
    Atherothrombosis Research Unit, Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cardiol 153:256-61. 2011
    ..We sought to compare the effect of 2 of the most prescribed β-blocker agents in early markers of LV remodelling after AMI...
  13. doi request reprint Usefulness of cardiac computed tomographic delayed contrast enhancement of the left atrial appendage before pulmonary vein ablation
    Simonette T Sawit
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 109:677-84. 2012
    ..00). In conclusion, delayed CCT provided an increase in diagnostic accuracy of CCT for detection of LAA thrombus in patients with atrial fibrillation before ablation, which may decrease the need for routine TEE before the procedure...
  14. doi request reprint Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis
    Chiara Giannarelli
    Atherothrombosis Research Unit, Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 3:1256-64. 2010
    ....
  15. doi request reprint Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis
    Pedro R Moreno
    Zena and Michael A Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 142:895-901. 2011
    ..We hypothesize that aortic valve stenosis evolves from a more aggressive inflammatory process, with increased macrophage/T-cell and neovessel content in congenital bicuspid aortic valveswhen compared with that seen in tricuspid valves...
  16. doi request reprint Right ventriculo-arterial coupling in pulmonary hypertension: a magnetic resonance study
    Javier Sanz
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, USA
    Heart 98:238-43. 2012
    ..To quantify right ventriculo-arterial coupling in pulmonary hypertension by combining standard right heart catheterisation (RHC) and cardiac magnetic resonance (CMR) and to estimate it non-invasively with CMR alone...
  17. pmc The cardioprotection granted by metoprolol is restricted to its administration prior to coronary reperfusion
    Borja Ibanez
    Atherothrombosis Research Unit, Mount Sinai School of Medicine, New York, NY, USA
    Int J Cardiol 147:428-32. 2011
    ..We also studied the effect on suspected markers of reperfusion injury...
  18. pmc Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries
    Stephane S Silvera
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Atherosclerosis 207:139-43. 2009
    ....
  19. doi request reprint Adeno-associated virus serotype 8 ApoA-I gene transfer reduces progression of atherosclerosis in ApoE-KO mice: comparison of intramuscular and intravenous administration
    Giovanni Cimmino
    Atherothrombosis Research Unit, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cardiovasc Pharmacol 57:325-33. 2011
    ....
  20. doi request reprint Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
    ..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
  21. doi request reprint Non-invasive estimation of pulmonary vascular resistance with cardiac magnetic resonance
    Ana García-Alvarez
    The Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York 10029, USA
    Eur Heart J 32:2438-45. 2011
    ..97; 95% confidence interval: 0.89-1.00). CONCLUSIONS Non-invasive estimation of PVR using CMR is feasible and may be valuable for PH diagnosis and/or follow-up...
  22. doi request reprint Evaluation of pulmonary artery stiffness in pulmonary hypertension with cardiac magnetic resonance
    Javier Sanz
    Clinical Cardiac MR CT Program, Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 2:286-95. 2009
    ..This study sought to evaluate indexes of pulmonary artery (PA) stiffness in patients with pulmonary hypertension (PH) using same-day cardiac magnetic resonance (CMR) and right heart catheterization (RHC)...
  23. pmc Monitoring of arterial wall remodelling in atherosclerotic rabbits with a magnetic resonance imaging contrast agent binding to matrix metalloproteinases
    Fabien Hyafil
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Eur Heart J 32:1561-71. 2011
    ....
  24. ncbi request reprint A cross-sectional study of cardiovascular disease and associated factors
    Farhad Islami
    Tisch Cancer Institute and Institute for Transitional Epidemiology, Mount Sinai School of Medicine, New York, United States
    Ann Agric Environ Med 18:255-9. 2011
    ..Data on risk factors of CVD in this country are limited. The presented study investigated risk factors of self-reported CVD within the Polish- Norwegian Study (PONS)...
  25. pmc Inverse relationship between body mass index and coronary artery calcification in patients with clinically significant coronary lesions
    Jason C Kovacic
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, United States
    Atherosclerosis 221:176-82. 2012
    ..We sought to explore this hypothesis in a large group of patients with coronary artery disease undergoing percutaneous coronary intervention (PCI)...
  26. doi request reprint Apical right ventricular dysfunction in patients with pulmonary hypertension demonstrated with magnetic resonance
    Leticia Fernandez-Friera
    The Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, USA
    Heart 97:1250-6. 2011
    ..To evaluate segmental right ventricular (RV) dysfunction in pulmonary hypertension (PH) using cardiac magnetic resonance (CMR)...
  27. doi request reprint Polypill and global cardiovascular health strategies
    Gines Sanz
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Semin Thorac Cardiovasc Surg 23:24-9. 2011
    ..This review analyzes the potential role of the polypill strategy in primary and secondary CV prevention...
  28. doi request reprint Evaluation of right ventricular function and post-operative findings using cardiac computed tomography in patients with left ventricular assist devices
    Ana García-Alvarez
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai Medical Center, New York, New York, USA
    J Heart Lung Transplant 30:896-903. 2011
    ..We hypothesized that, after LVAD implantation, electrocardiographic-gated cardiac computed tomography (CCT) allows RV evaluation with higher feasibility and reproducibility compared with echocardiography...
  29. pmc Variations in atherosclerosis and remodeling patterns in aorta and carotids
    Katsumi Hayashi
    Imaging Science Laboratories, Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Med, New York, NY, USA
    J Cardiovasc Magn Reson 12:10. 2010
    ..The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period...
  30. doi request reprint Expression of angiotensin-converting enzyme 2 and its end product angiotensin 1-7 is increased in diabetic atheroma: implications for inflammation and neovascularization
    K Raman Purushothaman
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Cardiovasc Pathol 22:42-8. 2013
    ..We tested the hypothesis that ACE2 is increased in diabetic peripheral atheroma, concomitantly with Ang1-7, angiotensin II receptor 1 (AT1R), proinflammatory cytokines, macrophage infiltration, and plaque neovascularization...
  31. pmc Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells
    Elisa Yaniz-Galende
    Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Res 111:1434-45. 2012
    ..Even though the ability of exogenously introducing c-kit(+) cells to injured myocardium has been established, the capability of recruiting these cells through modulation of local signaling pathways by gene transfer has not been tested...
  32. doi request reprint Inflammation, neovascularization and intra-plaque hemorrhage are associated with increased reparative collagen content: implication for plaque progression in diabetic atherosclerosis
    K Raman Purushothaman
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Vasc Med 16:103-8. 2011
    ..58; p < 0.001) in DM plaques. In conclusion, our study suggests that enhanced type III collagen deposition was associated with inflammation, neovascularization and IPH, and may be a contributing factor in DM plaque progression...
  33. doi request reprint Promoting global cardiovascular health ensuring access to essential cardiovascular medicines in low- and middle-income countries
    Sandeep P Kishore
    Weill Cornell Rockefeller Sloan Kettering Tri Institutional MD PhD Program, New York, New York, USA
    J Am Coll Cardiol 57:1980-7. 2011
    ..Here, we use cardiovascular disease as a specific case study to examine the issue, outlining early solutions while drawing parallels and analogies to the HIV experience...
  34. doi request reprint Rationale and design of dal-PLAQUE: a study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography
    Zahi A Fayad
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am Heart J 162:214-221.e2. 2011
    ..Results are expected in 2011...
  35. pmc Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events
    Venkatesh Mani
    Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
    J Cardiovasc Magn Reson 11:10. 2009
    ..The purpose of this study was to determine if patients with traditional risk factors and prior MACE had increased cardiovascular magnetic resonance (CMR) plaque burden measures compared to patients with risk factors but no prior events...
  36. pmc Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Circ Cardiovasc Imaging 2:107-15. 2009
    ..We also tested the hypotheses that the degree of local arterial inflammation measured by PET is correlated with the extent of systemic inflammation and presence of risk factors for vascular disease...
  37. doi request reprint New index α improves detection of pulmonary hypertension in comparison with other cardiac magnetic resonance indices
    Sergio Moral
    The Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, USA
    Int J Cardiol 161:25-30. 2012
    ..Cardiovascular magnetic resonance (CMR) has been proposed for the evaluation of patients with pulmonary hypertension (PH). However, there is no consensus on the optimal method for PH diagnosis using CMR...
  38. doi request reprint Rate or rhythm control for atrial fibrillation: update and controversies
    Jason S Chinitz
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Am J Med 125:1049-56. 2012
    ..Because safer and more effective pharmacologic and interventional therapies are now available, an individualized approach to atrial fibrillation management is essential...
  39. doi request reprint Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques
    Jagat Narula
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 61:1041-51. 2013
    ..The goal of this study was to identify histomorphologic characteristics of atherosclerotic plaques and to determine the amenability of some of these components to be used as markers for invasive and noninvasive imaging...
  40. doi request reprint Study design for the "effect of METOprolol in CARDioproteCtioN during an acute myocardial InfarCtion" (METOCARD-CNIC): A randomized, controlled parallel-group, observer-blinded clinical trial of early pre-reperfusion metoprolol administration in ST-segmen
    Borja Ibanez
    Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain Hospital Clínico San Carlos, Madrid, Spain Electronic address
    Am Heart J 164:473-480.e5. 2012
    ..To date, there is not a single trial comparing the pre- vs. post-reperfusion β-blocker initiation in STEMI...
  41. doi request reprint Anticoagulation during pregnancy in patients with a prosthetic heart valve
    José M Castellano
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, P O Box 1030, New York, NY 10029 6574, USA
    Nat Rev Cardiol 9:415-24. 2012
    ....
  42. doi request reprint Atrial fibrillation, stroke, and quality of life
    Jason S Chinitz
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann N Y Acad Sci 1254:140-50. 2012
    ..High-bleeding risks associated with the concomitant use of multiple antithrombotics remains a major obstacle in patients with indications for both antiplatelet and anticoagulant therapy...
  43. doi request reprint Up-regulation of reverse cholesterol transport key players and rescue from global inflammation by ApoA-I(Milano)
    Giovanni Cimmino
    Cardiovascular Biology Research Laboratory, Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    J Cell Mol Med 13:3226-35. 2009
    ..The Milano form of apoA-I seems to be more efficient in RCT than the apoA-I wild-type...
  44. pmc Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression
    M Urooj Zafar
    Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Eur Heart J 31:1573-82. 2010
    ..We investigated the associations of depression and anxiety with serotonin-mediated platelet hyperactivity in coronary artery disease (CAD) patients in a cross-sectional study...
  45. doi request reprint Diagnostic value of coronary artery calcium scoring in low-intermediate risk patients evaluated in the emergency department for acute coronary syndrome
    Leticia Fernandez-Friera
    The Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 107:17-23. 2011
    ....
  46. doi request reprint Challenges and opportunities for cardiovascular disease prevention
    Manuel Franco
    Department of Epidemiology, Atherothrombosis and Imaging, National Center for Cardiovascular Research, Madrid, Spain
    Am J Med 124:95-102. 2011
    ....
  47. doi request reprint Changes in plaque lipid content after short-term intensive versus standard statin therapy: the YELLOW trial (reduction in yellow plaque by aggressive lipid-lowering therapy)
    Annapoorna S Kini
    Mount Sinai School of Medicine, New York, NY, USA
    J Am Coll Cardiol 62:21-9. 2013
    ..This study sought to determine the impact of short-term intensive statin therapy on intracoronary plaque lipid content...
  48. doi request reprint Percutaneous left atrial appendage closure for stroke prevention in patients with atrial fibrillation: an assessment of net clinical benefit
    Sandeep R Gangireddy
    Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York City, NY, USA
    Eur Heart J 33:2700-8. 2012
    ..We aim to estimate the net clinical benefit (NCB) of percutaneous LAA closure...
  49. pmc Effect of computed tomography scanning parameters on gold nanoparticle and iodine contrast
    Merav Weill Galper
    Translational and Molecular Imaging, Mount Sinai School of Medicine, New York, NY 10029, USA
    Invest Radiol 47:475-81. 2012
    ....
  50. doi request reprint Strategies for multivessel revascularization in patients with diabetes
    Michael E Farkouh
    Mount Sinai School of Medicine, New York, NY 10029, USA
    N Engl J Med 367:2375-84. 2012
    ..We sought to discover whether aggressive medical therapy and the use of drug-eluting stents could alter the revascularization approach for patients with diabetes and multivessel coronary artery disease...
  51. pmc Associations of LV hypertrophy with prevalent and incident valve calcification: Multi-Ethnic Study of Atherosclerosis
    Sammy Elmariah
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    JACC Cardiovasc Imaging 5:781-8. 2012
    ..The aim of this study was to evaluate the relationship between percentage of predicted left ventricular mass (%PredLVM) and valve calcification in the MESA (Multi-Ethnic Study of Atherosclerosis) study...
  52. doi request reprint The fixed-dose combination drug for secondary cardiovascular prevention project: improving equitable access and adherence to secondary cardiovascular prevention with a fixed-dose combination drug. Study design and objectives
    Gines Sanz
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Am Heart J 162:811-817.e1. 2011
    ..5, 5, or 10 mg), and simvastatin (40 mg) or receiving the same 3 drugs separately...
  53. doi request reprint In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging
    Ahmed Klink
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1428 Madison Avenue, New York, NY 10029, USA
    J Am Coll Cardiol 58:2522-30. 2011
    ..The goal of this study was to use noninvasive conventional and molecular magnetic resonance imaging (MRI) to detect and characterize abdominal aortic aneurysms (AAAs) in vivo...
  54. pmc Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Radiology 256:774-82. 2010
    ....
  55. doi request reprint Safe and sustained overexpression of functional apolipoprotein A-I/high-density lipoprotein in apolipoprotein A-I-null mice by muscular adeno-associated viral serotype 8 vector gene transfer
    Giovanni Cimmino
    Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cardiovasc Pharmacol 54:405-11. 2009
    ..Our data suggest that intramuscular AAV8-mediated gene transfer of human ApoA-I results in a significant and maintained increase in ApoA-I and functional HDL...
  56. doi request reprint Lethal myocardial reperfusion injury: a necessary evil?
    Borja Ibanez
    Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III C N I C, Madrid, Spain
    Int J Cardiol 151:3-11. 2011
    ..Currently, no intervention has been consistently shown to reduce reperfusion injury in large randomized multicenter trials, but the research in this field is intense and the future is highly promising...
  57. doi request reprint Are we ignoring the dilated thoracic aorta?
    José M Castellano
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann N Y Acad Sci 1254:164-74. 2012
    ..Clinical trials in TAA are required before medical therapies, such as β-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, or macrolide antibiotics, can be recommended...
  58. doi request reprint Can we dramatically reduce the incidence of coronary heart disease?
    Michael Domanski
    Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Rev Cardiol 8:721-5. 2011
    ..We also consider the feasibility and basic design considerations for a clinical trial to assess the validity of this public health and primary prevention approach...
  59. doi request reprint Diabetes: making sense of the rosiglitazone controversy
    Michael E Farkouh
    Clinical Trials Unit, Mount Sinai Cardiovascular Institute, One Gustave L Levy Place, Box 1074, New York, NY 10029, USA
    Nat Rev Cardiol 7:366-7. 2010
    ..A trial in which rosiglitazone and glipizide were compared supports earlier findings that rosiglitazone does not have an adverse effect on the progression of coronary atherosclerosis...
  60. doi request reprint Fixed-dose combination therapy and secondary cardiovascular prevention: rationale, selection of drugs and target population
    Gines Sanz
    Department of Translational Research, CNIC, Madrid, Spain
    Nat Clin Pract Cardiovasc Med 6:101-10. 2009
    ..Here we examine the use of fixed-dose combination therapy (a 'polypill'), and how this therapy could improve adherence to treatment, reduce the cost and improve treatment affordability in low-income countries...
  61. pmc Perspectives and opportunities for nanomedicine in the management of atherosclerosis
    Mark E Lobatto
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York 10029, USA
    Nat Rev Drug Discov 10:835-52. 2011
    ..This Review elaborates on nanoparticle-targeting concepts in atherosclerotic disease, provides an overview of the use of nanomedicine in atherosclerosis, and discusses potential future applications and clinical benefits...
  62. doi request reprint Evolving anatomic, functional, and molecular imaging in the early detection and prognosis of hypertrophic cardiomyopathy
    Valentin Fuster
    Zena and Michael A Wiener Cardiovascular Institute, and the Marie Josee and Henry R Kravis Cardiovascular Health Center, Mount Sinai Medical Center, The Mount Sinai School of Medicine, New York, NY, 10029, USA
    J Cardiovasc Transl Res 2:398-406. 2009
    ....
  63. doi request reprint In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis
    Stephen G Worthley
    Zena and Michael A Wiener Cardiovascular Institute, The Mount Sinai Medical Center, New York, NY 10029, USA
    Int J Cardiovasc Imaging 25:251-7. 2009
    ..67 +/- 0.02 to 0.53 +/- 0.02, P < 0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model...
  64. pmc Cardiovascular defense challenges at the basic, clinical, and population levels
    Jason C Kovacic
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1254:1-6. 2012
    ..In this review, we outline the basic, clinical, and population level challenges that we face in defending ourselves against this disease...
  65. doi request reprint New anticoagulants for prevention of stroke in patients with atrial fibrillation
    Juan F Viles-Gonzalez
    Cardiovascular Institute, Mount Sinai Medical Center, New York, New York, USA
    J Cardiovasc Electrophysiol 22:948-55. 2011
    ..This review focuses on advances in the development of novel antithrombotic agents to provide practical information to clinicians on the use of these new drugs in patients with AF...
  66. doi request reprint Evolving role of molecular imaging for new understanding: targeting myofibroblasts to predict remodeling
    Hans J de Haas
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1254:33-41. 2012
    ..We define molecular targets on myofibroblasts and discuss the feasibility of molecular imaging of these cells for early detection and treatment of patients at risk for development of HF after myocardial infarction...
  67. doi request reprint [Fixed-dose compounds and the secondary prevention of ischemic heart disease]
    Valentin Fuster
    Mount Sinai Medical Center, 1 Gustave L Levy Place, Box 1030, New York, NY 10029 6574, USA
    Rev Esp Cardiol 64:3-9. 2011
    ..The results of this study could provide the basis for a new therapeutic approach to the management of not only cardiovascular disease but also diabetes and stroke...
  68. doi request reprint Diagnostic and therapeutic strategies for small abdominal aortic aneurysms
    Ahmed Klink
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1428 Madison Avenue, New York, NY 10029, USA
    Nat Rev Cardiol 8:338-47. 2011
    ..We also describe the diagnostic potential of new imaging techniques and therapeutic potential of new treatments for the management of small AAA...
  69. doi request reprint Cardiovascular risk factors in patients with chronic kidney disease
    Sarina van der Zee
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Rev Cardiol 6:580-9. 2009
    ..Therapeutic paradigms for patients with chronic kidney disease and cardiovascular risk factors must be evaluated in randomized trials, from which such patients have often been excluded...
  70. doi request reprint Urgent need for human resources to promote global cardiovascular health
    Rajesh Vedanthan
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, One Gustave Levy Place, New York, NY 10029, USA
    Nat Rev Cardiol 8:114-7. 2011
    ..In light of the current global epidemiologic transition from communicable to noncommunicable diseases, now is the time for the global health community to focus on CVD-related human resource needs...
  71. doi request reprint Anticoagulation for mechanical heart valves in patients with and without atrial fibrillation
    Usman Baber
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Cardiol Rep 12:133-9. 2010
    ..Novel anticoagulants, including inhibitors of factor IIa and Xa, are currently being evaluated and may emerge as alternatives to vitamin K antagonists...
  72. pmc Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model
    Brian G Choi
    Cardiovascular Biology Research Laboratory, Mount Sinai School of Medicine, New York, NY, USA
    Atherosclerosis 201:76-84. 2008
    ..Osteoporosis trials suggest raloxifene decreased cardiovascular events in women with pre-existing atherosclerosis. We assessed the hypothesis that selective estrogen receptor modulation induces plaque stability in "menopausal" animals...
  73. pmc Macrophage-specific lipid-based nanoparticles improve cardiac magnetic resonance detection and characterization of human atherosclerosis
    Michael J Lipinski
    Translational and Molecular Imaging Institute, Mount Sinai Medical Center, New York, New York, USA
    JACC Cardiovasc Imaging 2:637-47. 2009
    ..We sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36) improve cardiac magnetic resonance (CMR) detection and characterization of human atherosclerosis...
  74. pmc Bisphosphonate Use and Prevalence of Valvular and Vascular Calcification in Women MESA (The Multi-Ethnic Study of Atherosclerosis)
    Sammy Elmariah
    Zena and Michael A Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 56:1752-9. 2010
    ..the aim of this study was to determine whether nitrogen-containing bisphosphonate (NCBP) therapy is associated with the prevalence of cardiovascular calcification...
  75. ncbi request reprint [Visualizing arterial macrophage warfare with nuclear magnetic resonance, positron-emission tomography and computerized tomography]
    Valentin Fuster
    Mount Sinai Medical Center, 1 Gustave L Levy Place, Box 1030, New York, NY 10029 6574, USA
    Rev Esp Cardiol 62:2-8. 2009
    ....
  76. doi request reprint Exercise performance in patients with pulmonary hypertension linked to cardiac magnetic resonance measures
    Gerin R Stevens
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York, USA
    J Heart Lung Transplant 28:899-905. 2009
    ....
  77. doi request reprint Quantification of serial changes in plaque burden using multi-detector computed tomography in experimental atherosclerosis
    Borja Ibanez
    Cardiovascular Biology Research Laboratory, Mount Sinai School of Medicine, New York, NY 10029, USA
    Atherosclerosis 202:185-91. 2009
    ..We sought to test the ability of MDCT to detect and quantify serial changes in atheroma burden in comparison with magnetic resonance imaging (MRI)...
  78. ncbi request reprint Late medical versus interventional therapy for stable ST-segment elevation myocardial infarction
    Sammy Elmariah
    Mount Sinai Medical Center, New York, NY, USA
    Nat Clin Pract Cardiovasc Med 5:42-52. 2008
    ....
  79. pmc Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis
    Mark E Lobatto
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, United States
    Mol Pharm 7:2020-9. 2010
    ..Importantly, we demonstrate unprecedented rapid anti-inflammatory effects in atherosclerotic lesions after the nanomedical therapy...
  80. doi request reprint Promoting mechanisms of vascular health: circulating progenitor cells, angiogenesis, and reverse cholesterol transport
    Pedro R Moreno
    Zena and Michael A Wiener Cardiovascular Institute, Marie Josee and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 53:2315-23. 2009
    ....
  81. doi request reprint Chronic renal insufficiency, cardiovascular disease and mortality in women: a causal relationship or coincidence?
    Miriam L Fishman
    Department of Medicine, Mount Sinai School of Medicine, NY, USA
    Womens Health (Lond Engl) 5:617-23. 2009
    ....
  82. doi request reprint Early identification of atherosclerotic disease by noninvasive imaging
    Valentin Fuster
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, Box 1030, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Rev Cardiol 7:327-33. 2010
    ..In this Review, we address the potential progress in CVD prevention brought about by the use of noninvasive imaging techniques to identify subclinical atherosclerosis...
  83. doi request reprint The year in atherothrombosis
    Javier Sanz
    The Zena and Michael A Wiener Cardiovascular Institute Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 51:944-55. 2008
  84. doi request reprint Prologue: relevance of molecular imaging in clinical medicine
    Zahi A Fayad
    Department of Radiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 5:S1. 2008
  85. doi request reprint Surgery for asymptomatic degenerative aortic and mitral valve disease
    Prashant Vaishnava
    Zena and Michael A Wiener Cardiovascular Institute, Marie Jose and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Rev Cardiol 8:173-7. 2011
    ....
  86. doi request reprint Rhythm control for management of patients with atrial fibrillation: balancing the use of antiarrhythmic drugs and catheter ablation
    Juan F Viles-Gonzalez
    Cardiovascular Institute, Mount Sinai Heart, Mount Sinai School of Medicine, New York, New York, USA
    Clin Cardiol 34:23-9. 2011
    ..Herein, we review the most current evidence supporting the use of AAD and catheter ablation in atrial fibrillation...
  87. ncbi request reprint Low priority of cardiovascular and chronic diseases on the global health agenda: a cause for concern
    Valentin Fuster
    The Zena and Michael A Wiener Cardiovascular Institute Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, 1 Gustave L Levy Pl, Box 1030, New York, NY 10029 6574, USA
    Circulation 116:1966-70. 2007
  88. doi request reprint Fatty infiltration of the right ventricle assessed by computed tomography and magnetic resonance imaging
    Santo Dellegrottaglie
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Cardiovasc Med (Hagerstown) 9:753. 2008