Douglas Forrest

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina
    Hong Liu
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:749-56. 2008
  2. ncbi Neurodevelopmental control by thyroid hormone receptors
    Douglas Forrest
    Department of Human Genetics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Curr Opin Neurobiol 12:49-56. 2002
  3. ncbi An intron control region differentially regulates expression of thyroid hormone receptor beta2 in the cochlea, pituitary, and cone photoreceptors
    Iwan Jones
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 21:1108-19. 2007
  4. ncbi Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta
    Maya Srinivas
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 20:1728-41. 2006
  5. ncbi Retinoid-related receptor (ROR) alpha mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms
    Nandini Vasudevan
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230, York Ave, New York, NY 10021, USA
    Endocrine 26:25-32. 2005
  6. doi Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling
    Xiaoliang L Xu
    Dyson Vision Research Institute, Weill Cornell Medical College, New York, NY 10021, USA
    Cell 137:1018-31. 2009
  7. pmc Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
    Lily Ng
    Department of Human Genetics and Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 101:3474-9. 2004
  8. ncbi The thyroid hormone receptor beta gene: structure and functions in the brain and sensory systems
    Iwan Jones
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 13:1057-68. 2003
  9. doi The thyroid and metabolism: the action continues
    Anthony N Hollenberg
    Division of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 8:10-2. 2008
  10. pmc Multigenic control of thyroid hormone functions in the nervous system
    Jacques Nunez
    National Institutes of Health, NIDDK, Clinical Endocrinology Branch, Bethesda, MD 20892 1772, USA
    Mol Cell Endocrinol 287:1-12. 2008

Research Grants

Collaborators

Detail Information

Publications16

  1. doi NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina
    Hong Liu
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:749-56. 2008
    ..These results thus connect the proneural pathway with opsin selection to ensure correct cone patterning during retinal development...
  2. ncbi Neurodevelopmental control by thyroid hormone receptors
    Douglas Forrest
    Department of Human Genetics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Curr Opin Neurobiol 12:49-56. 2002
    ..Some of the most sensitive processes controlled by these pathways are in the auditory and visual sensory systems...
  3. ncbi An intron control region differentially regulates expression of thyroid hormone receptor beta2 in the cochlea, pituitary, and cone photoreceptors
    Iwan Jones
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 21:1108-19. 2007
    ..This specialized genomic organization underlies the unique expression pattern and functions of TRbeta2...
  4. ncbi Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta
    Maya Srinivas
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 20:1728-41. 2006
    ..The results identify Opn1sw as a target gene for RORbeta and suggest a key role for RORbeta in regulating opsin expression in the color visual system...
  5. ncbi Retinoid-related receptor (ROR) alpha mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms
    Nandini Vasudevan
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230, York Ave, New York, NY 10021, USA
    Endocrine 26:25-32. 2005
    ..Such differences in RORalpha mRNA expression may play a role in the behavioral alterations resulting from congenital hypothyroidism...
  6. doi Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling
    Xiaoliang L Xu
    Dyson Vision Research Institute, Weill Cornell Medical College, New York, NY 10021, USA
    Cell 137:1018-31. 2009
    ..These findings provide support for a cone precursor origin of retinoblastoma and suggest that human cone-specific signaling circuitry sensitizes to the oncogenic effects of RB1 mutations...
  7. pmc Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
    Lily Ng
    Department of Human Genetics and Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 101:3474-9. 2004
    ..Thus, D2 is essential for hearing, and the results suggest that this hormone-activating enzyme confers on the cochlea the ability to stimulate its own T3 response at a critical developmental period...
  8. ncbi The thyroid hormone receptor beta gene: structure and functions in the brain and sensory systems
    Iwan Jones
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 13:1057-68. 2003
    ..The Thrb gene illustrates how versatility in neurodevelopmental control can be achieved at the receptor level...
  9. doi The thyroid and metabolism: the action continues
    Anthony N Hollenberg
    Division of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 8:10-2. 2008
    ..New advances have identified functions previously thought to be distinct from thyroid hormone signaling pathways and suggest new avenues of therapy for metabolic disease...
  10. pmc Multigenic control of thyroid hormone functions in the nervous system
    Jacques Nunez
    National Institutes of Health, NIDDK, Clinical Endocrinology Branch, Bethesda, MD 20892 1772, USA
    Mol Cell Endocrinol 287:1-12. 2008
    ..Overall, TH coordinates this variety of events in both central and sensory systems to promote the function of the nervous system as a complete entity...
  11. ncbi Twists in the tail-change-of-function mutations in thyroid hormone receptors
    Douglas Forrest
    Endocrinology 143:2466-8. 2002
  12. ncbi International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors
    Frederic Flamant
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique 5665, Laboratoire Associé Institut National de la Recherche Agronomique 913, l Institut Fédératif de Recherches 128, Lyon, France
    Pharmacol Rev 58:705-11. 2006
  13. pmc Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina
    Melanie R Roberts
    Graduate Program in Neurobiology and Behavior and Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Proc Natl Acad Sci U S A 103:6218-23. 2006
    ..These results also suggest that the ratio and patterning of cone types may be determined by TH availability during retinal development...
  14. ncbi Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice
    Hjalmar Gullberg
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Mol Endocrinol 16:1767-77. 2002
    ..That TRalpha1 only in some instances can substitute for TRbeta indicates that T3 regulation of physiological and molecular processes in the liver occurs in an isoform-specific fashion...
  15. ncbi Analysis of nuclear receptor function in the mouse auditory system
    Matthew W Kelley
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland 20850, USA
    Methods Enzymol 364:426-48. 2003
  16. ncbi Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone
    E Dale Abel
    Division of Endocrinology, University of Utah School of Medicine, 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, Utah 84112, USA
    Mol Endocrinol 17:1767-76. 2003
    ....

Research Grants9

  1. THYROID HORMONE RECEPTORS AND GENETIC CONTROL OF HEARING
    Douglas Forrest; Fiscal Year: 2001
    ....
  2. THYROID HORMONE RECEPTORS AND GENETIC CONTROL OF HEARING
    Douglas Forrest; Fiscal Year: 2004
    ..This gene expresses a novel extracellular matrix protein in the cochlear basilar membrane. ..