Research Topics
Genomes and Genes | Douglas ForrestSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retinaHong Liu
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 28:749-56. 2008..These results thus connect the proneural pathway with opsin selection to ensure correct cone patterning during retinal development...
Neurodevelopmental control by thyroid hormone receptorsDouglas Forrest
Department of Human Genetics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
Curr Opin Neurobiol 12:49-56. 2002..Some of the most sensitive processes controlled by these pathways are in the auditory and visual sensory systems...- An intron control region differentially regulates expression of thyroid hormone receptor beta2 in the cochlea, pituitary, and cone photoreceptorsIwan Jones
Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
Mol Endocrinol 21:1108-19. 2007..This specialized genomic organization underlies the unique expression pattern and functions of TRbeta2... - Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor betaMaya Srinivas
Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
Mol Endocrinol 20:1728-41. 2006..The results identify Opn1sw as a target gene for RORbeta and suggest a key role for RORbeta in regulating opsin expression in the color visual system... - Retinoid-related receptor (ROR) alpha mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoformsNandini Vasudevan
Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230, York Ave, New York, NY 10021, USA
Endocrine 26:25-32. 2005..Such differences in RORalpha mRNA expression may play a role in the behavioral alterations resulting from congenital hypothyroidism... - Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signalingXiaoliang L Xu
Dyson Vision Research Institute, Weill Cornell Medical College, New York, NY 10021, USA
Cell 137:1018-31. 2009..These findings provide support for a cone precursor origin of retinoblastoma and suggest that human cone-specific signaling circuitry sensitizes to the oncogenic effects of RB1 mutations... 
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinaseLily Ng
Department of Human Genetics and Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 101:3474-9. 2004..Thus, D2 is essential for hearing, and the results suggest that this hormone-activating enzyme confers on the cochlea the ability to stimulate its own T3 response at a critical developmental period...- The thyroid hormone receptor beta gene: structure and functions in the brain and sensory systemsIwan Jones
Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
Thyroid 13:1057-68. 2003..The Thrb gene illustrates how versatility in neurodevelopmental control can be achieved at the receptor level... - The thyroid and metabolism: the action continuesAnthony N Hollenberg
Division of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cell Metab 8:10-2. 2008..New advances have identified functions previously thought to be distinct from thyroid hormone signaling pathways and suggest new avenues of therapy for metabolic disease... - Multigenic control of thyroid hormone functions in the nervous systemJacques Nunez
National Institutes of Health, NIDDK, Clinical Endocrinology Branch, Bethesda, MD 20892 1772, USA
Mol Cell Endocrinol 287:1-12. 2008..Overall, TH coordinates this variety of events in both central and sensory systems to promote the function of the nervous system as a complete entity... - Twists in the tail-change-of-function mutations in thyroid hormone receptorsDouglas Forrest
Endocrinology 143:2466-8. 2002 - International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptorsFrederic Flamant
Unite Mixte de Recherche, Centre National de la Recherche Scientifique 5665, Laboratoire Associé Institut National de la Recherche Agronomique 913, l Institut Fédératif de Recherches 128, Lyon, France
Pharmacol Rev 58:705-11. 2006 - Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retinaMelanie R Roberts
Graduate Program in Neurobiology and Behavior and Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
Proc Natl Acad Sci U S A 103:6218-23. 2006..These results also suggest that the ratio and patterning of cone types may be determined by TH availability during retinal development... - Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in miceHjalmar Gullberg
Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
Mol Endocrinol 16:1767-77. 2002..That TRalpha1 only in some instances can substitute for TRbeta indicates that T3 regulation of physiological and molecular processes in the liver occurs in an isoform-specific fashion... - Analysis of nuclear receptor function in the mouse auditory systemMatthew W Kelley
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland 20850, USA
Methods Enzymol 364:426-48. 2003 - Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormoneE Dale Abel
Division of Endocrinology, University of Utah School of Medicine, 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, Utah 84112, USA
Mol Endocrinol 17:1767-76. 2003....
Research Grants
- THYROID HORMONE RECEPTORS AND GENETIC CONTROL OF HEARINGDouglas Forrest; Fiscal Year: 2001....
- THYROID HORMONE RECEPTORS AND GENETIC CONTROL OF HEARINGDouglas Forrest; Fiscal Year: 2004..This gene expresses a novel extracellular matrix protein in the cochlear basilar membrane. ..