Research Topics
Genomes and Genes | Janine D FlorySummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
A comparison of d, l-fenfluramine and citalopram challenges in healthy adultsJanine D Flory
Behavioral Physiology Laboratory 506 OEH, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 174:376-80. 2004..49, P's< or =0.02). The magnitude of the correlations is notable given the length of time between challenges. The results support the use of citalopram as an alternate neuroendocrine challenge to index CNS serotonergic responsivity...- Dispositional impulsivity in normal and abnormal samplesJanine D Flory
Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
J Psychiatr Res 40:438-47. 2006..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related... - Serotonergic function in the central nervous system is associated with daily ratings of positive moodJanine D Flory
Department of Psychology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
Psychiatry Res 129:11-9. 2004..e., Neuroticism). These results suggest that deficiencies in serotonergic function may reflect the relative absence of positive mood... - COMT val158Met and executive control: a test of the benefit of specific deficits to translational researchAngus W MacDonald
Department of Psychology, University of Pittsburgh, USA
J Abnorm Psychol 116:306-12. 2007..These data suggest that the interpretability gained by including task manipulations to uncover specific deficits can enhance associations between cognitive and genetic levels of analysis... - Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosisMatthew F Muldoon
Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Stroke 38:2228-33. 2007..This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis... - Irritable assault and variation in the COMT geneJanine D Flory
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
Psychiatr Genet 17:344-6. 2007..These findings provide limited support for a role of COMT in modulating aggressive behavior, and are extended to people with personality disorders... - The socio-economic status of communities predicts variation in brain serotonergic responsivityStephen B Manuck
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA 15260, USA
Psychol Med 35:519-28. 2005..Here we examine whether serotonergic responsivity covaries similarly with the SES of communities, as indexed by US Census data in the same study sample... - The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteersMatthew F Muldoon
Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
J Clin Endocrinol Metab 91:718-21. 2006..The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism... 
Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteersStephen B Manuck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Psychosom Med 72:35-45. 2010....- Parental education is related to C-reactive protein among female middle-aged community volunteersJennifer E Phillips
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Brain Behav Immun 23:677-83. 2009..This association may help explain the increased risk of atherosclerotic cardiovascular morbidity and mortality conferred by low childhood socioeconomic status... - Perigenual anterior cingulate morphology covaries with perceived social standingPeter J Gianaros
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Soc Cogn Affect Neurosci 2:161-73. 2007..The pACC may represent a neuroanatomical substrate by which perceived social standing relates to mental and physical health... - Impulsiveness and cigarette smokingJanine D Flory
Department of Psychology, Queens College, 65 30 Kissena Blvd, Flushing, NY 11367, USA
Psychosom Med 71:431-7. 2009..g., any tobacco use versus dependence) or considered more than one variety of impulsiveness simultaneously... - Central nervous system serotonergic responsivity and aggressive disposition in menStephen B Manuck
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA, USA
Physiol Behav 77:705-9. 2002..This finding suggests that association of the MAO-A promoter polymorphism with this behavioral phenotype may be mediated, in part, by allele-specific variation in central serotonergic responsivity... - Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groupsMichael J Minzenberg
Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
Psychiatr Genet 16:117-24. 2006..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder... - Alcohol dependence, disinhibited behavior and variation in the prodynorphin geneJanine D Flory
Department of Psychology, Queens College and The Graduate Center, City University of New York, New York, NY, USA
Biol Psychol 88:51-6. 2011..g., drug use, sexual activity)... 
Trait negative affect: toward an integrated model of understanding psychological risk for impairment in cardiac autonomic functionMaria E Bleil
Department of Psychiatry, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94143 0848, USA
Psychosom Med 70:328-37. 2008..g., autonomic nervous system [ANS] dysfunction), the degree to which a general tendency to experience negative emotions may account for these relations is not known...- Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic regionStephen B Manuck
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 506 EH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
Psychoneuroendocrinology 29:651-68. 2004..We conclude that allelic variation at 5-HTTLPR moderates the influence of social position on CNS serotonergic responsivity... - Citalopram intervention for hostility: results of a randomized clinical trialThomas W Kamarck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Consult Clin Psychol 77:174-88. 2009..04). The findings have implications for understanding the central nervous system correlates of hostility, its associations with other psychosocial risk factors for CVD, and, potentially, the design of effective interventions... - Citalopram improves metabolic risk factors among high hostile adults: results of a placebo-controlled interventionThomas W Kamarck
Department of Psychology, University of Pittsburgh, 4403 Sennott Square, 210 S Bouquet St, Pittsburgh, PA 15260, United States
Psychoneuroendocrinology 36:1070-9. 2011..01). In addition, the changes in blood glucose were significantly mediated by treatment-related changes in hostility (p<.05). Mechanisms accounting for these associations remain to be explored... - Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in menStephen B Manuck
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United States
Psychoneuroendocrinology 35:94-104. 2010.... - Delay discounting and smoking: association with the Fagerström Test for Nicotine Dependence but not cigarettes smoked per dayMaggie M Sweitzer
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nicotine Tob Res 10:1571-5. 2008..These results suggest that DD among smokers is not simply the result of nicotine exposure, but may be an important marker for dependence, especially urgency to smoke in the morning... - Self-reported sleep duration is associated with the metabolic syndrome in midlife adultsMartica H Hall
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Sleep 31:635-43. 2008..In the present study, we evaluated the relationship between sleep duration and presence of the metabolic syndrome, which is a cluster of physiologically interrelated risk factors for cardiometabolic disease... - Childhood trauma and basal cortisol in people with personality disordersJanine D Flory
Department of Psychology, Queens College CUNY, Flushing, NY 11367, USA
Compr Psychiatry 50:34-7. 2009..36, P = .02), after controlling for other forms of abuse. Results are consistent with the view that childhood trauma has long-lasting neurobiological effects and suggest that different forms of trauma may have distinct biological effects... - High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticismSarah M Conklin
Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
Psychosom Med 69:932-4. 2007..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults... - Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorderJanine D Flory
Department of Psychology, Queens College, City University of New York, 65 30 Kissena Boulevard, SB 318 Flushing, NY 11367, USA
Br J Psychiatry 190:410-4. 2007..Impulsive aggression in adulthood is associated with disturbances in serotonergic function. In contrast, research examining this association in childhood has yielded inconsistent results... - Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteersAnna L Marsland
Behavioral Immunology Laboratory, Department of Psychology, 3943 O Hara Street, Pittsburgh, PA 15260, USA
Psychosom Med 68:895-903. 2006..The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains... - Neurobiologic function and temperament in subjects with personality disordersVivian Mitropoulou
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
CNS Spectr 8:725-30. 2003.... - Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivityMatthew F Muldoon
Divisions of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Clin Endocrinol Metab 89:266-71. 2004..These findings reveal a heretofore unrecognized association between reduced central serotonergic responsivity and the metabolic syndrome... - Retest reliability of prolactin response to dl-fenfluramine challenge in adultsJanine D Flory
Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 26:269-72. 2002..57 for PRL "area under the curve," p <.0001). These findings are consistent with speculation that variability in indices of central serotonergic function reflects a temporally stable dimension of individual differences... - Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activityAhmad R Hariri
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 26:13213-7. 2006..They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction... - Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-αStephen B Manuck
Behavioral Physiology Laboratory, University of Pittsburgh, 506 OEH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
Dev Psychopathol 23:69-83. 2011.... - Maternal exposure to the holocaust and health complaints in offspringJanine D Flory
Department of Psychology, Queens College and The Graduate Center, City University of New York, Flushing, USA
Dis Markers 30:133-9. 2011..The mechanism linking these health outcomes and maternal exposure deserves further investigation, including the possibility that fetal or early developmental programming is involved... - Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorderAntonia S New
James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
Biol Psychiatry 66:1107-14. 2009..Preclinical studies show that orbital frontal cortex (OFC) plays a role in regulating impulsive aggression. Prior work has found OFC dysfunction in BPD... - Pergolide treatment of cognitive deficits associated with schizotypal personality disorder: continued evidence of the importance of the dopamine system in the schizophrenia spectrumMargaret M McClure
VA VISN 3 Mental Illness Research, Education, and Clinical Center, Bronx, NY, USA
Neuropsychopharmacology 35:1356-62. 2010..These results suggest that dopamine agonists may provide benefit for the cognitive abnormalities of schizophrenia spectrum disorders... - Context processing in schizotypal personality disorder: evidence of specificity of impairment to the schizophrenia spectrumMargaret M McClure
VA VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, New York 10468, USA
J Abnorm Psychol 117:342-54. 2008..These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology... - Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSDRachel Yehuda
Department of Psychiatry, James J Peters Veterans Affairs Medical Center, 526 OOMH, 130 W Kingsbridge Rd, Bronx, NY, USA
Psychopharmacology (Berl) 212:405-17. 2010..Given similarities between neuroendocrine aspects of PTSD and ELS, such as in reduced cortisol signaling and glucocorticoid receptor (GR) responsiveness, some aspects of the biology of PTSD may reflect biological correlates of risk... - Neural basis of individual differences in impulsivity: contributions of corticolimbic circuits for behavioral arousal and controlSarah M Brown
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Emotion 6:239-45. 2006..Together, these findings suggest that dispositional impulsivity is influenced by the functional interplay of corticolimbic behavioral arousal and control circuits... - The role of genes in defining a molecular biology of PTSDRachel Yehuda
Department of Psychiatry, James J Peters Veterans Affairs Medical Center, Bronx, New York, USA
Dis Markers 30:67-76. 2011..Since inherited genetic variation may also influence the extent of epigenetic or gene expression changes resulting from the environment, such studies should optimally be followed up by studies of genotype... - Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality DisordersJanine D Flory
Department of Psychiatry, Mount Sinai School of Medicine MSSM, One Gustave L Levy Place, NY 10029, USA
Depress Res Treat 2012:350461. 2012.... - Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adultsMatthew F Muldoon
Center for Clinical Pharmacology, University of Pittsburgh, Pennsylvania 15260, USA
Am J Med 117:823-9. 2004..The current study was designed to confirm and extend those findings... - A convergent-divergent approach to context processing, general intellectual functioning, and the genetic liability to schizophreniaAngus W MacDonald
Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
Neuropsychology 19:814-21. 2005.... - Hostile mood and social strain during daily life: a test of the transactional modelElizabeth J Vella
Department of Psychology, University of Southern Maine, Portland, ME 04103, USA
Ann Behav Med 44:341-52. 2012..Hostility is a multidimensional construct related to cardiovascular (CV) disease risk. Daily hostile mood and social interactions may precipitate stress-related CV responses in hostile individuals... - Short-term suppression of ovarian function and immune measures in healthy womenJanine D Flory
Department of Psychology, University of Pittsburgh, PA, USA
Psychoneuroendocrinology 27:749-68. 2002..Basal and acute stress-induced cell counts showed moderate to high temporal stability over a six to ten month time interval... - Developing an agenda for translational studies of resilience and vulnerability following trauma exposureRachel Yehuda
Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
Ann N Y Acad Sci 1071:379-96. 2006..Understanding why this is so will provide clues for the development of therapeutic interventions for those people who do develop stress-related psychopathology, or even for the prevention of adverse outcomes... - Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic functionSerina A Neumann
Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23501
Biol Psychiatry 60:1155-62. 2006..Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism (SNP) in CHT1 on regional brain reactivity relevant to autonomic (cholinergic) function...