Robert P Fisher

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. Parua P, Booth G, Sansó M, Benjamin B, Tanny J, Lis J, et al. A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II. Nature. 2018;558:460-464 pubmed publisher
  2. Fisher R. Taking Aim at Glycolysis with CDK8 Inhibitors. Trends Endocrinol Metab. 2018;29:281-282 pubmed publisher
    ..Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery. ..
  3. Kalan S, Amat R, Schachter M, Kwiatkowski N, Abraham B, Liang Y, et al. Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. Cell Rep. 2017;21:467-481 pubmed publisher
    ..Apoptosis was dependent on death receptor DR5, a p53 transcriptional target whose expression was refractory to Cdk7 inhibition. Therefore, p53 activation induces transcriptional dependency to sensitize cancer cells to Cdk7 inhibition. ..