Robert P Fisher
Affiliation: Mount Sinai School of Medicine
Parua P, Booth G, Sansó M, Benjamin B, Tanny J, Lis J, et al
. A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II. Nature. 2018;558:460-464 pubmed publisher
Fisher R. Taking Aim at Glycolysis with CDK8 Inhibitors. Trends Endocrinol Metab. 2018;29:281-282 pubmed publisher
..Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery. ..
Kalan S, Amat R, Schachter M, Kwiatkowski N, Abraham B, Liang Y, et al
. Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. Cell Rep. 2017;21:467-481 pubmed publisher
..Apoptosis was dependent on death receptor DR5, a p53 transcriptional target whose expression was refractory to Cdk7 inhibition. Therefore, p53 activation induces transcriptional dependency to sensitize cancer cells to Cdk7 inhibition. ..