M I Fiel

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Increased thickness of abdominal subcutaneous adipose tissue occurs more frequently in steatohepatitis than in simple steatosis
    M Isabel Fiel
    Lillian and Henry M Stratton Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Pathol Lab Med 137:642-6. 2013
  2. doi request reprint Plasma cell hepatitis (de-novo autoimmune hepatitis) developing post liver transplantation
    M Isabel Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, New York, USA
    Curr Opin Organ Transplant 17:287-92. 2012
  3. ncbi request reprint Posttransplant plasma cell hepatitis (de novo autoimmune hepatitis) is a variant of rejection and may lead to a negative outcome in patients with hepatitis C virus
    M Isabel Fiel
    Lillian and Henry M Stratton Hans Popper Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
    Liver Transpl 14:861-71. 2008
  4. doi request reprint Pathology of chronic hepatitis B and chronic hepatitis C
    M Isabel Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, Box 1194, 1468 Madison Avenue, New York, NY 10029, USA
    Clin Liver Dis 14:555-75. 2010
  5. ncbi request reprint Rapid reversal of parenteral-nutrition-associated cirrhosis following isolated intestinal transplantation
    M Isabel Fiel
    Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
    J Gastrointest Surg 13:1717-23. 2009
  6. ncbi request reprint Regression of hepatic fibrosis after intestinal transplantation in total parenteral nutrition liver disease
    M Isabel Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 6:926-33. 2008
  7. ncbi request reprint Development of hepatic granulomas in patients receiving pegylated interferon therapy for recurrent hepatitis C virus post liver transplantation
    M I Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, New York, New York 10029, USA
    Transpl Infect Dis 10:184-9. 2008
  8. ncbi request reprint Plasma cell hepatitis in hepatitis C virus patients post-liver transplantation: case-control study showing poor outcome and predictive features in the liver explant
    Stephen C Ward
    Lillian and Henry M Stratton Hans Popper Department of Pathology, Recanati Miller Transplantation Institute, Mount Sinai Medical Center, New York, NY 10029, USA
    Liver Transpl 15:1826-33. 2009
  9. doi request reprint Outcomes following liver resection and clinical pathologic characteristics of hepatocellular carcinoma occurring in patients with chronic hepatitis B and minimally fibrotic liver
    H S Kadri
    Department of Surgery, The Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Eur J Surg Oncol 39:1371-6. 2013
  10. doi request reprint Image segmentation of liver fibrosis
    H S Wu
    Department of Pathology, Box 1194, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Microsc 231:70-80. 2008

Collaborators

Detail Information

Publications40

  1. doi request reprint Increased thickness of abdominal subcutaneous adipose tissue occurs more frequently in steatohepatitis than in simple steatosis
    M Isabel Fiel
    Lillian and Henry M Stratton Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Pathol Lab Med 137:642-6. 2013
    ..The incidence of obesity is increasing and contributes to the rising incidence of fatty liver. Body mass index (BMI) is used to assess the degree of obesity but does not take into account the pattern of body fat distribution...
  2. doi request reprint Plasma cell hepatitis (de-novo autoimmune hepatitis) developing post liver transplantation
    M Isabel Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, New York, USA
    Curr Opin Organ Transplant 17:287-92. 2012
    ..Its pathogenesis is poorly understood but this entity appears to be a variant of rejection. Herein, we review recent clinical reports of patients developing PCH...
  3. ncbi request reprint Posttransplant plasma cell hepatitis (de novo autoimmune hepatitis) is a variant of rejection and may lead to a negative outcome in patients with hepatitis C virus
    M Isabel Fiel
    Lillian and Henry M Stratton Hans Popper Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
    Liver Transpl 14:861-71. 2008
    ..Treatment by optimization of immunosuppression without the use of corticosteroids appears effective. The development of PCH in the setting of recurrent HCV is a negative prognostic factor for patient outcome and allograft failure...
  4. doi request reprint Pathology of chronic hepatitis B and chronic hepatitis C
    M Isabel Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, Box 1194, 1468 Madison Avenue, New York, NY 10029, USA
    Clin Liver Dis 14:555-75. 2010
    ..The salient histologic features are elucidated in an attempt to provide the clinician with an understanding of the basic histopathology underlying chronic HCV and HBV...
  5. ncbi request reprint Rapid reversal of parenteral-nutrition-associated cirrhosis following isolated intestinal transplantation
    M Isabel Fiel
    Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
    J Gastrointest Surg 13:1717-23. 2009
    ....
  6. ncbi request reprint Regression of hepatic fibrosis after intestinal transplantation in total parenteral nutrition liver disease
    M Isabel Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Gastroenterol Hepatol 6:926-33. 2008
    ..The decision to perform combined transplantation as opposed to an isolated intestinal transplant is based on the presence of hyperbilirubinemia, portal hypertension, and advanced hepatic fibrosis...
  7. ncbi request reprint Development of hepatic granulomas in patients receiving pegylated interferon therapy for recurrent hepatitis C virus post liver transplantation
    M I Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, New York, New York 10029, USA
    Transpl Infect Dis 10:184-9. 2008
    ..Infrequently, hepatitis C (HCV) appears to be the cause of hepatic granulomas. Interferon therapy for HCV has been increasingly associated with the development of sarcoidosis...
  8. ncbi request reprint Plasma cell hepatitis in hepatitis C virus patients post-liver transplantation: case-control study showing poor outcome and predictive features in the liver explant
    Stephen C Ward
    Lillian and Henry M Stratton Hans Popper Department of Pathology, Recanati Miller Transplantation Institute, Mount Sinai Medical Center, New York, NY 10029, USA
    Liver Transpl 15:1826-33. 2009
    ..The association of significant plasma cell infiltrates in native livers of HCV patients developing PCH suggests that some patients may have a predisposition to developing PCH...
  9. doi request reprint Outcomes following liver resection and clinical pathologic characteristics of hepatocellular carcinoma occurring in patients with chronic hepatitis B and minimally fibrotic liver
    H S Kadri
    Department of Surgery, The Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Eur J Surg Oncol 39:1371-6. 2013
    ....
  10. doi request reprint Image segmentation of liver fibrosis
    H S Wu
    Department of Pathology, Box 1194, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    J Microsc 231:70-80. 2008
    ..The proposed algorithm has been applied to quantify the development of progressive fibrosis and its possible regression in liver biopsy specimens from patients with parenteral-induced liver injury undergoing intestinal transplantation...
  11. ncbi request reprint A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
    Josep M Llovet
    Mount Sinai Liver Cancer Program, Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    Gastroenterology 131:1758-67. 2006
    ..Small liver nodules approximately 2 cm are difficult to characterize by radiologic or pathologic examination. Our aim was to identify a molecular signature to diagnose early hepatocellular carcinoma (HCC)...
  12. ncbi request reprint Identification of ultrastructural changes in liver allografts of patients experiencing primary nonfunction
    A Lawal
    Department of Liver Diseases and Transplantation, The Mount Sinai Medical Center, New York, New York 10029, USA
    Transplant Proc 37:4339-42. 2005
    ..Using electron microscopy, we examined the hepatic ultrastructure of donor allografts in patients experiencing PNF and compared the findings with a well-matched group of other donor allografts...
  13. doi request reprint Graft rejection occurring in post-liver transplant patients receiving cytotoxic chemotherapy: a case series
    Hui Hui Tan
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Liver Transpl 15:634-9. 2009
    ..Treatment of rejection or plasma cell hepatitis in this setting should be undertaken in a timely and aggressive fashion to prevent chronic ductopenic rejection...
  14. pmc Liver transplantation for hepatocellular carcinoma: extension of indications based on molecular markers
    Myron Schwartz
    Mount Sinai Liver Cancer Program, Department of Surgery, Recanati Miller Transplantation Institute, Division of Liver Disease, New York, NY 10029, USA
    J Hepatol 49:581-8. 2008
    ..This study uses molecular data to identify a subgroup of patients who, despite having hepatocellular carcinoma beyond Milan criteria, have favorable outcomes...
  15. pmc Restoration of distorted colour microscopic images from transverse chromatic aberration of imperfect lenses
    H S Wu
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Microsc 241:125-31. 2011
    ..Results of real microscopic images are provided. The restored image and the original are compared both visually and quantitatively in terms of the estimated entropies measured for the degree of concentrations using vector distributions...
  16. doi request reprint Liver transplantation is possible in some patients with liver metastasis of colon cancer
    O Uskudar
    Division of Liver Diseases, The Mount Sinai Hospital, Recanati Miller Transplantation Institute, New York, NY, USA
    Transplant Proc 43:2070-4. 2011
    ..This report demonstrates that liver transplantation may be an option in selected patients with colorectal cancer liver metastases that have been well treated...
  17. ncbi request reprint Nevirapine-induced stevens johnson-syndrome and fulminant hepatic failure requiring liver transplantation
    J Jao
    Department of Medicine, Mount Sinai Hospital and School of Medicine, New York, NY, USA
    Am J Transplant 10:1713-6. 2010
    ..On follow-up 2 years later, she remains in good health with an undetectable viral load on an efavirenz-based regimen of HAART. To our knowledge, this is the first report of successful liver transplantation following SJS and FHF...
  18. ncbi request reprint Chronic ductopenic rejection in patients with recurrent hepatitis C virus treated with pegylated interferon alfa-2a and ribavirin
    Carmen M Stanca
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Transplantation 84:180-6. 2007
    ..We examined the incidence of chronic ductopenic rejection (CR) in patients receiving pegylated interferon alfa-2a and ribavirin (PEG) to treat recurrent HCV...
  19. ncbi request reprint Rapidly progressive recurrent hepatitis C virus infection starting 9 days after liver transplantation
    Neeraj Saraf
    Mount Sinai Medical Center Division of Liver Diseases, New York, NY 10029, USA
    Liver Transpl 13:913-7. 2007
    ..To our knowledge, this is the earliest reported case of histological recurrence of HCV after LT. It illustrates the importance of older donor and recipient age in the same patient as cofactors for early HCV recurrence and poor outcome...
  20. ncbi request reprint Pegylated interferon-induced immune-mediated hepatitis post-liver transplantation
    Nickolas Kontorinis
    Division of Liver Diseases, Recanati Miller Transplantation Institute, New York, NY 10029, USA
    Liver Transpl 12:827-30. 2006
    ..We hypothesize that pegylated interferon triggered a severe form of immune-mediated hepatitis...
  21. pmc Impact of liver fibrosis on prognosis following liver resection for hepatitis B-associated hepatocellular carcinoma
    Q Wang
    Department of Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    Br J Cancer 109:573-81. 2013
    ..This study aims to evaluate the impact of liver fibrosis severity on prognosis following liver resection among HBV-HCC patients...
  22. doi request reprint Factors associated with persistent thrombocytopenia after liver transplantation
    C M Stanca
    Division of Liver Diseases, Mount Sinai Medical Center, New York, New York 10029, USA
    Transplant Proc 42:1769-73. 2010
    ..Identifying risk factors associated with persistent post- LT thrombocytopenia may provide important information about its pathogenesis...
  23. doi request reprint Hepatic inflammatory cytokine mRNA expression in hepatitis C virus-human immunodeficiency virus co-infection
    S A Gonzalez
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10065 4896, USA
    J Viral Hepat 15:331-8. 2008
    ..Further studies are needed to assess whether decreased IFN-gamma secretion by HCV-specific CD4+ cells may account for accelerated fibrogenesis in these patients...
  24. ncbi request reprint Drug-induced steatohepatitis leading to cirrhosis: long-term toxicity of amiodarone use
    Kaiser Raja
    Division of Liver Diseases, Recanati Miller Transplantation Institute, The Mount Sinai Medical Center, New York, NewYork 10029, USA
    Semin Liver Dis 29:423-8. 2009
    ..The clinical manifestations of amiodarone-induced hepatotoxicity and the mechanism of toxicity are also discussed...
  25. ncbi request reprint Recurrent hepatitis C after retransplantation: factors affecting graft and patient outcome
    Michal Carmiel-Haggai
    Recanati Miller Transplantation Institute, Mount Sinai Hospital, The Mount Sinai School of Medicine, PO Box 1504, New York, NY 10029 6574, USA
    Liver Transpl 11:1567-73. 2005
    ..Patients experiencing early graft failure due to accelerated forms of HCV should not be denied re-LT with the expectation that a similar disease course will occur after re-LT...
  26. ncbi request reprint Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors
    Thomas D Schiano
    The Recanati Miller Transplantation Institute, The Mount Sinai Hospital, New York, NY, USA
    Hepatology 42:1420-8. 2005
    ..The trend toward a greater initial viral load decrease in patients with LD grafts and the significantly sharper increase suggest that the liver plays a predominant role in both HCV clearance and replication...
  27. ncbi request reprint De novo hepatocellular carcinoma occurring in a transplanted liver: case report and review of the literature
    Anca Croitoru
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, One Gustave L Levy Place, New York, New York 10029, USA
    Dig Dis Sci 51:1780-2. 2006
  28. ncbi request reprint Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study
    Daniel S Fierer
    Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 198:683-6. 2008
    ..No cause of liver damage other than acute HCV infection was identified. The specific pathways leading to periportal fibrosis in HIV-infected men with newly acquired HCV infection require investigation...
  29. ncbi request reprint Hepatocellular carcinoma associated with an atypical presentation of Wilson's disease
    Ruliang Xu
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, New York, New York 10029, USA
    Semin Liver Dis 27:122-7. 2007
  30. pmc Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
    Pippa Newell
    Mount Sinai Liver Cancer Program, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Hepatol 51:725-33. 2009
    ..We investigated the molecular alterations of the Ras pathway in HCC and the antineoplastic effects of sorafenib in combination with rapamycin, an inhibitor of mTOR pathway, in experimental models...
  31. ncbi request reprint Recurrent hepatic sarcoidosis post-liver transplantation manifesting with severe hypercalcemia: a case report and review of the literature
    Cem Cengiz
    Recanati Miller Transplantation Institute, The Mount Sinai School of Medicine, PO Box 1504, New York, NY 10029 6574, USA
    Liver Transpl 11:1611-4. 2005
    ..To date, there has been no report in the literature of symptomatic recurrence of hepatic sarcoidosis following orthotopic liver transplantation...
  32. ncbi request reprint Intrahepatic CD4+ cell depletion in hepatitis C virus/HIV-coinfected patients
    P Wilfredo Canchis
    Center for the Study of Hepatitis C, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Acquir Immune Defic Syndr 37:1125-31. 2004
    ..09 cell/HPF) and monoinfected patients (0.45 +/- 0.08 cell/HPF). In conclusion, HIV coinfection is associated with fewer portal CD4 cells and increased lobular lymphocyte apoptosis that may impact on the natural history of HCV infection...
  33. ncbi request reprint Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes
    Rifaat Safadi
    Division of Liver Diseases, The Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 127:870-82. 2004
    ..Immunomodulatory cytokines, including interleukin-10 (IL-10), may mediate hepatic fibrosis...
  34. ncbi request reprint Hepatoportal sclerosis as a cause of noncirrhotic portal hypertension in patients with HIV
    Thomas D Schiano
    The Recanati Miller Transplantation Institute, and the Division of Liver Diseases, Department of Medicine, The Mount Sinai Medical Center, New York, New York 10029, USA
    Am J Gastroenterol 102:2536-40. 2007
    ..Nodular regenerative hyperplasia (NRH), another cause of noncirrhotic portal hypertension, has also been recently described in HIV patients initially diagnosed as having cryptogenic liver disease...
  35. ncbi request reprint Liver failure in an antimitochondrial antibody-positive patient with sarcoidosis: primary biliary cirrhosis or hepatic sarcoidosis?
    Carmen M Stanca
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Liver Dis 25:364-70. 2005
  36. pmc Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression
    Meena B Bansal
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA
    J Hepatol 42:548-56. 2005
    ..Because studies suggest matrix metalloproteinase-2 (MMP-2) may promote liver injury, we examined whether IL-6 exerted its protective effects via regulation of MMP-2...
  37. pmc Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation
    Feng Hong
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 49:2055-67. 2009
    ..Inhibitor studies suggest that SDF-1alpha/CXCR4-dependent extracellular signal-regulated kinase 1/2 and Akt phosphorylation mediate effects on collagen I expression and stellate cell proliferation...
  38. ncbi request reprint Diagnosis of 6 mercaptopurine hepatotoxicity post liver transplantation utilizing metabolite assays
    Nickolas Kontorinis
    Recanati Miller Transplantation Institute, Mount Sinai Medical Center, New York, NY, USA
    Am J Transplant 4:1539-42. 2004
    ..Monitoring of 6 MP metabolite levels in addition to TPMT allele testing is useful to prevent 6 MP toxicity and to help guide therapy...
  39. ncbi request reprint Liver pathology in obesity
    Arief Suriawinata
    Dartmouth Hitchcock Medical Center, Department of Pathology, One Medical Center Drive, Lebanon, NH 03756, USA
    Semin Liver Dis 24:363-70. 2004
    ..This article will discuss obesity-related liver diseases, focusing on pathologic features in liver biopsies from obese patients, obesity-related hepatocellular carcinoma, and the effect of weight loss treatment on histopathology...
  40. doi request reprint Fractional allelic imbalance could allow for the development of an equitable transplant selection policy for patients with hepatocellular carcinoma
    Igor Dvorchik
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 3236, USA
    Liver Transpl 14:443-50. 2008
    ..Incorporation of these molecular markers of tumor progression could help resolve the ongoing conundrum of organ allocation for patients with HCC...