Zahi Fayad

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Variations in atherosclerosis and remodeling patterns in aorta and carotids
    Katsumi Hayashi
    Imaging Science Laboratories, Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Med, New York, NY, USA
    J Cardiovasc Magn Reson 12:10. 2010
  2. ncbi Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events
    Venkatesh Mani
    Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
    J Cardiovasc Magn Reson 11:10. 2009
  3. ncbi Utility of atherosclerosis imaging in the evaluation of high-density lipoprotein-raising therapies
    Raphael Duivenvoorden
    Academic Medical Center, Amsterdam, The Netherlands
    Curr Atheroscler Rep 13:277-84. 2011
  4. ncbi Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI
    Zahi A Fayad
    Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Imaging Science Laboratories, Box 1234, New York, NY 10029, USA
    Neuroimaging Clin N Am 12:461-71. 2002
  5. ncbi In vivo magnetic resonance evaluation of atherosclerotic plaques in the human thoracic aorta: a comparison with transesophageal echocardiography
    Z A Fayad
    Zena and Michael A Wiener Cardiovascular Institute, Department of Radiology, Mount Sinai School of Medicine, New York, USA
    Circulation 101:2503-9. 2000
  6. ncbi Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
  7. ncbi Prologue: relevance of molecular imaging in clinical medicine
    Zahi A Fayad
    Department of Radiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 5:S1. 2008
  8. ncbi MR imaging for the noninvasive assessment of atherothrombotic plaques
    Zahi A Fayad
    Department of Radiology, The Zena and Michael A Wiener Cardiovascular Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Magn Reson Imaging Clin N Am 11:101-13. 2003
  9. ncbi Magnetic resonance imaging of coronary atherosclerosis
    Zahi A Fayad
    Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029, USA
    Curr Atheroscler Rep 5:411-7. 2003
  10. ncbi Atherothrombotic plaques and the need for imaging
    Zahi A Fayad
    Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Imaging Science Laboratories, Box 1234, New York, NY 10029, USA
    Neuroimaging Clin N Am 12:351-64. 2002

Research Grants

  1. IN VIVO MOLECULAR MRI OF ATHEROTHROMBOTIC LESIONS
    Zahi Fayad; Fiscal Year: 2009
  2. Nanoparticles for Molecular MRI of Atherosclerosis
    Zahi Fayad; Fiscal Year: 2007
  3. IN VIVO MOLECULAR MRI OF ATHEROTHROMBOTIC LESIONS
    Zahi Fayad; Fiscal Year: 2007
  4. IN VIVO MOLECULAR MRI OF ATHEROTHROMBOTIC LESIONS
    Zahi Fayad; Fiscal Year: 2004
  5. Nanoparticles for Molecular MRI of Atherosclerosis
    Zahi A Fayad; Fiscal Year: 2010

Detail Information

Publications97

  1. ncbi Variations in atherosclerosis and remodeling patterns in aorta and carotids
    Katsumi Hayashi
    Imaging Science Laboratories, Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Med, New York, NY, USA
    J Cardiovasc Magn Reson 12:10. 2010
    ..The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period...
  2. ncbi Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events
    Venkatesh Mani
    Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
    J Cardiovasc Magn Reson 11:10. 2009
    ..The purpose of this study was to determine if patients with traditional risk factors and prior MACE had increased cardiovascular magnetic resonance (CMR) plaque burden measures compared to patients with risk factors but no prior events...
  3. ncbi Utility of atherosclerosis imaging in the evaluation of high-density lipoprotein-raising therapies
    Raphael Duivenvoorden
    Academic Medical Center, Amsterdam, The Netherlands
    Curr Atheroscler Rep 13:277-84. 2011
    ..In this article we discuss these various imaging techniques and how they can assess efficacy as well as provide pathophysiologic information on the mechanism of action of novel HDL-C-raising drugs...
  4. ncbi Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI
    Zahi A Fayad
    Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Imaging Science Laboratories, Box 1234, New York, NY 10029, USA
    Neuroimaging Clin N Am 12:461-71. 2002
    ..This may aid early intervention (e.g., lipid lowering drug regiments) in both primary and secondary treatment of vascular disease in all arterial beds...
  5. ncbi In vivo magnetic resonance evaluation of atherosclerotic plaques in the human thoracic aorta: a comparison with transesophageal echocardiography
    Z A Fayad
    Zena and Michael A Wiener Cardiovascular Institute, Department of Radiology, Mount Sinai School of Medicine, New York, USA
    Circulation 101:2503-9. 2000
    ..The structure and composition of aortic atherosclerotic plaques are associated with the risk of future cardiovascular events. Magnetic resonance (MR) imaging may allow accurate visualization and characterization of aortic plaques...
  6. ncbi Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
    ..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
  7. ncbi Prologue: relevance of molecular imaging in clinical medicine
    Zahi A Fayad
    Department of Radiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 5:S1. 2008
  8. ncbi MR imaging for the noninvasive assessment of atherothrombotic plaques
    Zahi A Fayad
    Department of Radiology, The Zena and Michael A Wiener Cardiovascular Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Magn Reson Imaging Clin N Am 11:101-13. 2003
    ..This may aid early intervention (eg, lipid-lowering drug regiments) in both primary and secondary treatment of vascular disease in all arterial beds...
  9. ncbi Magnetic resonance imaging of coronary atherosclerosis
    Zahi A Fayad
    Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029, USA
    Curr Atheroscler Rep 5:411-7. 2003
  10. ncbi Atherothrombotic plaques and the need for imaging
    Zahi A Fayad
    Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Imaging Science Laboratories, Box 1234, New York, NY 10029, USA
    Neuroimaging Clin N Am 12:351-64. 2002
    ..The use of some of the available imaging modalities for the study of regression and progression of atherothrombosis are described in more detail in the subsequent articles...
  11. ncbi Magnetic resonance imaging and computed tomography in assessment of atherosclerotic plaque
    Zahi A Fayad
    Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Curr Atheroscler Rep 6:232-42. 2004
    ..MDCT and MRI, therefore, may help in selecting appropriate treatments...
  12. ncbi Noninvasive in vivo human coronary artery lumen and wall imaging using black-blood magnetic resonance imaging
    Z A Fayad
    Zena and Michael A Wiener Cardiovascular Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 102:506-10. 2000
    ..Coronary artery imaging by MR has been limited by artifacts related to blood flow and motion and by low spatial resolution...
  13. ncbi Clinical imaging of the high-risk or vulnerable atherosclerotic plaque
    Z A Fayad
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Res 89:305-16. 2001
    ....
  14. ncbi The assessment of the vulnerable atherosclerotic plaque using MR imaging: a brief review
    Z A Fayad
    The Zena and Michael A Wiener Cardiovascular Institute, and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cardiovasc Imaging 17:165-77. 2001
    ..Application of MR imaging opens up whole new areas for diagnosis, prevention, and treatment of atherosclerosis...
  15. ncbi Rationale and design of dal-PLAQUE: a study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography
    Zahi A Fayad
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am Heart J 162:214-221.e2. 2011
    ..Results are expected in 2011...
  16. ncbi Computed tomography and magnetic resonance imaging for noninvasive coronary angiography and plaque imaging: current and potential future concepts
    Zahi A Fayad
    Zena and Michael A. Wiener Cardiovascular Institute, New York, NY, USA
    Circulation 106:2026-34. 2002
  17. ncbi Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET
    Claudia Calcagno
    FAHA, FACC, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 28:1311-7. 2008
    ..Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis...
  18. ncbi Magnetic resonance molecular imaging of thrombosis in an arachidonic acid mouse model using an activated platelet targeted probe
    Ahmed Klink
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, Atran BM 24, Box 1234, One Gustave L Levy Place, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 30:403-10. 2010
    ..We sought to determine whether the noninvasive in vivo visualization of activated platelets was effective when using a target-specific MRI contrast agent to identify thrombi, hallmarks of vulnerable or high-risk atherosclerotic plaques...
  19. ncbi Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of atherosclerotic plaque angiogenesis
    Claudia Calcagno
    Imaging Science Laboratories, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Angiogenesis 13:87-99. 2010
    ..Finally, we will examine the current limitations and challenges faced by DCE-MRI and briefly discuss its future applications in the context of atherosclerosis...
  20. ncbi In vivo detection of embryonic stem cell-derived cardiovascular progenitor cells using Cy3-labeled Gadofluorine M in murine myocardium
    Eric D Adler
    Cardiovascular Institute and Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 2:1114-22. 2009
    ....
  21. ncbi Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach
    Eric Lancelot
    Department of Radiology, The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, Box 1234, One Gustave L Levy Place, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 28:425-32. 2008
    ..This study evaluated the ability of the novel gadolinium-based MRI contrast agent P947 to target MMPs in atherosclerotic plaques...
  22. ncbi High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis
    Torjus Skajaa
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 30:169-76. 2010
    ..By rerouting of HDL away from plaque macrophages, imaging of biological processes in diseases besides atherosclerosis may also be achieved...
  23. ncbi Evaluation of neovessels in atherosclerotic plaques of rabbits using an albumin-binding intravascular contrast agent and MRI
    Jean Christophe Cornily
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Magn Reson Imaging 27:1406-11. 2008
    ..To test whether B-22956/1, a novel intravascular contrast agent with a high affinity to serum albumin (Bracco Imaging SpA.), allowed quantifying neovessel and macrophage density in atherosclerotic plaques of rabbits using MRI...
  24. ncbi Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Circ Cardiovasc Imaging 2:107-15. 2009
    ..We also tested the hypotheses that the degree of local arterial inflammation measured by PET is correlated with the extent of systemic inflammation and presence of risk factors for vascular disease...
  25. ncbi MRI of carotid atherosclerosis: clinical implications and future directions
    Hunter R Underhill
    Department of Radiology, University of Washington, 815 Mercer Street, Box 358050, Seattle, WA 98109, USA
    Nat Rev Cardiol 7:165-73. 2010
    ....
  26. ncbi Prenatal detection of embryo resorption in osteopontin-deficient mice using serial noninvasive magnetic resonance microscopy
    Andrea S Weintraub
    The Mount Sinai School of Medicine, Box 1508, One Gustave L Levy Place, New York, NY 10029, USA
    Pediatr Res 55:419-24. 2004
    ..However, targeted disruption of one or more OPN alleles had no effect on embryo number at any gestational age. Thus, MRM may be a powerful noninvasive method for in vivo prenatal developmental study of genetically engineered mice...
  27. ncbi Vascular MRI in the diagnosis and therapy of the high risk atherosclerotic plaque
    Jolanda J Wentzel
    Zena and Michael A. Wiener Cardiovascular Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    J Interv Cardiol 16:129-42. 2003
    ..It possibly will identify asymptomatic patients with subclinical atherosclerosis. This has potential significance for the improvement of strategies in primary and secondary prevention...
  28. ncbi A novel nonobstructive intravascular MRI coil: in vivo imaging of experimental atherosclerosis
    Stephen G Worthley
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Arterioscler Thromb Vasc Biol 23:346-50. 2003
    ..However, the resolution achievable using surface radiofrequency coils is limited by the signal to noise ratio. We studied the utility of a new intravascular (IV) MRI probe for high-resolution in vivo imaging of atherosclerotic lesions...
  29. ncbi Parallel and nonparallel simultaneous multislice black-blood double inversion recovery techniques for vessel wall imaging
    Vitalii V Itskovich
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    J Magn Reson Imaging 19:459-67. 2004
    ..The DIR-RARE-GRAPPA multislice sequence showed 8.35-fold time improvement vs. single-slice DIR-2RARE sequence. CONCLUSION: Future MRI atherosclerotic plaque studies can be performed in substantially shorter times using these methods...
  30. ncbi Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries
    Stephane S Silvera
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Atherosclerosis 207:139-43. 2009
    ....
  31. ncbi (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 50:892-6. 2007
    ..This study tested the near-term reproducibility of (18)fluorodeoxyglucose positron emission tomography (FDG-PET) imaging of atherosclerosis...
  32. ncbi Does shear stress modulate both plaque progression and regression in the thoracic aorta? Human study using serial magnetic resonance imaging
    Jolanda J Wentzel
    Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 45:846-54. 2005
    ..The purpose of this study was to investigate the role of shear stress (SS) in plaque regression...
  33. ncbi Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging
    Roberto Corti
    Cardiovascular Biology Research Laboratory, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 106:2884-7. 2002
    ..Our observations indicate that lipid-lowering therapy is associated with sustained vascular remodeling and emphasize the need for longer-term treatment...
  34. ncbi Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques
    Juan C Frias
    Imaging Science Laboratories, Department of Radiology, Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Am Chem Soc 126:16316-7. 2004
    ..It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition...
  35. ncbi Atherosclerotic lesions in genetically modified mice quantified in vivo by non-invasive high-resolution magnetic resonance microscopy
    Robin P Choudhury
    The Cardiovascular Institute, Mount Sinai School of Medicine, Box 1030, 1 Gustave L. Levy Place, New York, NY 10029-6574, USA
    Atherosclerosis 162:315-21. 2002
    ..0001) to be accommodated entirely by 'positive remodeling', confirming the importance of determining plaque size directly. MRM accurately quantifies mouse aortic atherosclerosis and will enhance studies in this important animal model...
  36. ncbi Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaques of atherosclerotic rabbits
    Claudia Calcagno
    Translational and Molecular Imaging Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Magn Reson Imaging 32:191-8. 2010
    ....
  37. ncbi Mouse model of heterotopic aortic arch transplantation
    Igor Chereshnev
    Department of Medicine and the Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Surg Res 111:171-6. 2003
    ..Because lesion development is more rapid and exuberant in the aortic arch, a technique of transplantation of the mouse aortic arch was developed...
  38. ncbi Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging
    Marc Sirol
    , Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    Circulation 109:2890-6. 2004
    ..CONCLUSIONS: Gadofluorine-enhanced MRI improves atherosclerotic plaque detection. The IR-DIFF-TFL method allows early detection of atherosclerotic plaque within 1 hour after gadofluorine injection...
  39. ncbi Serial studies of mouse atherosclerosis by in vivo magnetic resonance imaging detect lesion regression after correction of dyslipidemia
    Eugene Trogan
    Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Arterioscler Thromb Vasc Biol 24:1714-9. 2004
    ..Serial in vivo MRI will enhance studies of plaque regression in animal models in response to therapeutic interventions...
  40. ncbi Cross-sectional, prospective study of MRI reproducibility in the assessment of plaque burden of the carotid arteries and aorta
    Hamza El Aidi
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 6:219-28. 2009
    ..We did a cross-sectional, prospective study to test reproducibility of MRI when imaging arteries, to assess risk of cardiovascular disease and correlations with age and sex...
  41. ncbi Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
    Fabien Hyafil
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, New York 10029, USA
    Nat Med 13:636-41. 2007
    ..This contrast agent may become an important adjunct to the clinical evaluation of coronary arteries with CT...
  42. ncbi Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    J Nucl Med 49:871-8. 2008
    ..We also reviewed the literature on quantification methods to determine the optimal measures of arterial 18F-FDG uptake for future studies...
  43. ncbi Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes
    Karen C Briley-Saebo
    Imaging Science Laboratory, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 117:3206-15. 2008
    ....
  44. ncbi In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis
    Stephen G Worthley
    Zena and Michael A Wiener Cardiovascular Institute, The Mount Sinai Medical Center, New York, NY 10029, USA
    Int J Cardiovasc Imaging 25:251-7. 2009
    ..67 +/- 0.02 to 0.53 +/- 0.02, P < 0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model...
  45. ncbi Magnetic resonance microscopy quantifies the disease progression in Marfan syndrome mice
    Vitalii V Itskovich
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    J Magn Reson Imaging 17:435-9. 2003
    ..05). CONCLUSION: MRM detected the differences in aortic size between WT and mutant mice over time, demonstrating a potential for noninvasive technique for the assessment of potential therapies in MFS mice...
  46. ncbi Imaging of atherosclerotic cardiovascular disease
    Javier Sanz
    The Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nature 451:953-7. 2008
    ....
  47. ncbi Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging
    Willem J M Mulder
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    Acc Chem Res 42:904-14. 2009
    ....
  48. ncbi Progression and regression of atherosclerotic lesions: monitoring with serial noninvasive magnetic resonance imaging
    Gerard Helft
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Circulation 105:993-8. 2002
    ..Our aim was to monitor changes in burden and composition of atherosclerotic plaques in a rabbit model of complex atherosclerosis using serial noninvasive magnetic resonance imaging (MRI)...
  49. ncbi Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Radiology 256:774-82. 2010
    ....
  50. ncbi Magnetic resonance molecular imaging contrast agents and their application in atherosclerosis
    Willem J M Mulder
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Top Magn Reson Imaging 18:409-17. 2007
    ..Subsequent to the discussion of the above topics, we will describe some examples of molecular imaging agents that successfully detect specific markers in atherosclerotic plaques that are of interest in several stages of this disease...
  51. ncbi Effects of aggressive versus conventional lipid-lowering therapy by simvastatin on human atherosclerotic lesions: a prospective, randomized, double-blind trial with high-resolution magnetic resonance imaging
    Roberto Corti
    Cardiovascular Biology Research Laboratory, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 46:106-12. 2005
    ..No difference in vessel wall changes was seen between high and conventional doses of simvastatin. Changes in vessel wall parameters are more related to LDL-C reduction rather than to the dose of statin...
  52. ncbi Comparison of gated and non-gated fast multislice black-blood carotid imaging using rapid extended coverage and inflow/outflow saturation techniques
    Venkatesh Mani
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    J Magn Reson Imaging 22:628-33. 2005
    ..CONCLUSION: Non-gated sequences may be used instead of gated sequences in atherosclerotic vessel wall imaging without compromising image quality. This may shorten examination time and improve patient comfort...
  53. ncbi Macrophage-specific lipid-based nanoparticles improve cardiac magnetic resonance detection and characterization of human atherosclerosis
    Michael J Lipinski
    Translational and Molecular Imaging Institute, Mount Sinai Medical Center, New York, New York, USA
    JACC Cardiovasc Imaging 2:637-47. 2009
    ..We sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36) improve cardiac magnetic resonance (CMR) detection and characterization of human atherosclerosis...
  54. ncbi Quantification of inflammation within rabbit atherosclerotic plaques using the macrophage-specific CT contrast agent N1177: a comparison with 18F-FDG PET/CT and histology
    Fabien Hyafil
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Nucl Med 50:959-65. 2009
    ..In this study, we tested whether the intensity of enhancement detected with CT in the aortic wall of rabbits injected with N1177 correlated with inflammatory activity evaluated with (18)F-FDG PET/CT and macrophage density on histology...
  55. ncbi Cardiac magnetic resonance imaging: a "one-stop-shop" evaluation of myocardial dysfunction
    Michael Poon
    Cardiac MRI Program, The Zena and Michael A Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Opin Cardiol 17:663-70. 2002
    ....
  56. ncbi Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atherosclerosis
    Stephen G Worthley
    Cardiovascular Biology Research Laboratory, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Pathophysiol Haemost Thromb 36:9-17. 2007
    ..007) and in combination with avasimibe (p = 0.04) versus controls. In this animal model, the addition of avasimibe to atorvastatin has beneficial effects on both atherosclerotic plaque regression and stabilization...
  57. ncbi Atherosclerosis and matrix metalloproteinases: experimental molecular MR imaging in vivo
    Vardan Amirbekian
    Translational and Molecular Imaging Institute, Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Schoolof Medicine, New York, NY 10029, USA
    Radiology 251:429-38. 2009
    ....
  58. ncbi In vivo noninvasive detection and age definition of arterial thrombus by MRI
    Roberto Corti
    Cardiovascular Biology Research Laboratory, Mount Sinai Medical Center, New York, New York, USA
    J Am Coll Cardiol 39:1366-73. 2002
    ..79). CONCLUSIONS: Magnetic resonance imaging is a promising tool to noninvasively detect arterial thrombosis. Measurement of SI and the characteristic visual appearance of the thrombus have the potential to define thrombus age...
  59. ncbi Feasibility of in vivo identification of endogenous ferritin with positive contrast MRI in rabbit carotid crush injury using GRASP
    Venkatesh Mani
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    Magn Reson Med 56:1096-106. 2006
    ..GRASP sequences in combination with conventional GRE sequences may be used to detect the presence of ferritin deposition in in vitro thrombi and in vivo crush-injured rabbit carotid arteries...
  60. ncbi Nanotechnology in medical imaging: probe design and applications
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 29:992-1000. 2009
    ..In this review we discuss the different factors that are considered when designing a nanoparticle probe and highlight some of the most advanced examples...
  61. ncbi Serial, noninvasive, in vivo magnetic resonance microscopy detects the development of atherosclerosis in apolipoprotein E-deficient mice and its progression by arterial wall remodeling
    Robin P Choudhury
    The Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029-6574, USA
    J Magn Reson Imaging 17:184-9. 2003
    ..By following the same aortic lesions over time, MRM demonstrated that progression of atherosclerosis in mice is associated with positive arterial remodeling...
  62. ncbi Multimodality nanotracers for cardiovascular applications
    Willem J M Mulder
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 5:S103-11. 2008
    ..Lastly, several examples of cardiovascular applications are discussed, including combined imaging and therapy approaches...
  63. ncbi Atherothrombosis and high-risk plaque: part I: evolving concepts
    Valentin Fuster
    Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 46:937-54. 2005
    ..In the final thrombosis section, focal and circulating tissue factor associated with apoptotic macrophages and circulatory monocytes is examined, closing the link between inflammation, plaque rupture, and blood thrombogenicity...
  64. ncbi Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes
    Karen C Briley Saebo
    Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, New York, USA
    J Magn Reson Imaging 26:460-79. 2007
    ..We also discuss molecular imaging strategies that are currently being used to design specific imaging probes targeted to biochemical and cellular markers of atherosclerotic plaque vulnerability...
  65. ncbi Gadolinium mixed-micelles: effect of the amphiphile on in vitro and in vivo efficacy in apolipoprotein E knockout mouse models of atherosclerosis
    Karen C Briley-Saebo
    Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    Magn Reson Med 56:1336-46. 2006
    ..was not influenced by the choice of amphiphile. The results of this study strongly suggest that liver uptake and wall enhancement may be regulated by the surface properties of the micelle and not by other factors, such as micelle size...
  66. ncbi MRI to detect atherosclerosis with gadolinium-containing immunomicelles targeting the macrophage scavenger receptor
    Michael J Lipinski
    Zena and Michael A. Wiener Cardiovascular Institute, , Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Magn Reson Med 56:601-10. 2006
    ..Immunomicelles and micelles improve in vitro and ex vivo MR detection of macrophages, and may prove useful in the detection of macrophage-rich plaques...
  67. ncbi Quantification of human atherosclerotic plaques using spatially enhanced cluster analysis of multicontrast-weighted magnetic resonance images
    Vitalii V Itskovich
    Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    Magn Reson Med 52:515-23. 2004
    ..MRI combined with SECA provides an objective method for atherosclerotic plaque component characterization and quantification...
  68. ncbi Comparison of 3D-diffusion-prepared segmented steady-state free precession and 2D fast spin echo imaging of femoral artery atherosclerosis
    Katsumi Hayashi
    Imaging Science Laboratories, Room BM24, Department of Radiology, Box 1234, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Int J Cardiovasc Imaging 26:309-21. 2010
    ..Inter-observer reproducibility for the 3D plaque burden measures was excellent. 3D-DP-SSFP may be a useful and reproducible technique for evaluating atherosclerosis in peripheral arteries...
  69. ncbi Non-invasive MRI of mouse models of atherosclerosis
    David B Weinreb
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    NMR Biomed 20:256-64. 2007
    ..Emergence of novel contrast agents that target a diverse set of molecules within the plaque are now helping to elucidate the changes at the cellular and molecular levels during plaque progression and regression...
  70. ncbi Magnetic and fluorescent nanoparticles for multimodality imaging
    Willem J M Mulder
    Mount Sinai School of Medicine, Imaging Science Laboratories, Department of Radiology, New York, NY 10029, USA
    Nanomedicine (Lond) 2:307-24. 2007
    ..This review gives a survey of the different types of fluorescent and magnetic nanoparticles that have been employed for both magnetic resonance and optical imaging studies...
  71. ncbi Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance imaging
    Atsushi Yonemura
    National Defense Medical College, Saitama, Japan
    J Am Coll Cardiol 45:733-42. 2005
    ..Thoracic and abdominal aortic plaques may have different susceptibilities to lipid lowering...
  72. ncbi Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: a comparative study using intravascular ultrasound
    Alexander W Leber
    Department of Cardiology, Klinikum Grosshadern, University of Munich, Munich, Germany
    J Am Coll Cardiol 47:672-7. 2006
    ..We evaluated the accuracy of a new 64-slice computed tomography (CT) scanner, compared with intravascular ultrasound, to visualize atherosclerosis in the proximal coronary system...
  73. ncbi Automated classification of atherosclerotic plaque from magnetic resonance images using predictive models
    RUSSELL W ANDERSON
    ISCHEM Corporation, La Jolla, CA 92037, USA
    Biosystems 90:456-66. 2007
    ..This translates to a 50% higher true positive rate over given levels of false positives. This work indicates that it is feasible to build an automated system of plaque detection using MRI and data mining...
  74. ncbi Chronic thrombus detection with in vivo magnetic resonance imaging and a fibrin-targeted contrast agent
    Marc Sirol
    Department of Cardiology, , Paris, France
    Circulation 112:1594-600. 2005
    ....
  75. ncbi Imaging of atherosclerosis. Coronary wall imaging with MRI
    Robin P Choudhury
    Department of Cardiovascular Medicine, University of Oxford Medical School, Oxford, UK
    J Cardiovasc Risk 9:263-70. 2002
    ..Current and future applications of MRI, including the development of new contrast agents, targeted molecular imaging and the application of MRI to percutaneous coronary intervention are also discussed...
  76. ncbi MRI and characterization of atherosclerotic plaque: emerging applications and molecular imaging
    Robin P Choudhury
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Arterioscler Thromb Vasc Biol 22:1065-74. 2002
    ..Present and future applications of MRI, including real-time vascular intervention, new contrast agents, and molecular imaging, are also discussed...
  77. ncbi Assessment of myocardial perfusion and viability from routine contrast-enhanced 16-detector-row computed tomography of the heart: preliminary results
    Konstantin Nikolaou
    Department of Clinical Radiology, Ludwig Maximilians University of Munich, Germany
    Eur Radiol 15:864-71. 2005
    ..01). Routine, contrast-enhanced 16-detector row CT of the heart can detect chronic myocardial infarctions in the majority of cases, but ischemic perfusion defects are not reliably detected under resting conditions...
  78. ncbi In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography
    Hiroaki Taniguchi
    National Defense Medical College, Saitama, Japan
    Am Heart J 148:137-43. 2004
    ..However, plasma inflammatory markers appear to reflect total extent of aortic atherosclerosis. Although aortic plaques are common in patients with CAD, only thoracic plaques are an independent factor for CAD...
  79. ncbi Multimodality imaging of atherosclerosis (magnetic resonance imaging/computed tomography/positron emission tomography-computed tomography)
    James H F Rudd
    Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Top Magn Reson Imaging 18:379-88. 2007
    ..Future directions and challenges ahead for plaque imaging are also highlighted...
  80. ncbi Molecular, cellular and functional imaging of atherothrombosis
    Robin P Choudhury
    Department of Cardiovascular Medicine, University of Oxford, Level 5, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Drug Discov 3:913-25. 2004
    ..Emphasis is given to the potential contribution of magnetic resonance imaging methods to therapeutic monitoring, drug delivery and drug discovery...
  81. ncbi ACCF/AHA 2007 Clinical Competence Statement on vascular imaging with computed tomography and magnetic resonance
    Christopher M Kramer
    Society of Cardiovascular Computed Tomography Representative
    Vasc Med 12:359-78. 2007
  82. ncbi Optimization of ex vivo CT- and MR- imaging of atherosclerotic vessel wall changes
    Konstantin Nikolaou
    Department of Clinical Radiology, Ludwig Maximilian University, Klinikum Grosshadern, Munich, Germany
    Int J Cardiovasc Imaging 20:327-34. 2004
    ..To optimize a methodology for ex vivo imaging of atherosclerotic vessel wall changes using multidetector-row computed tomography (MDCT) and multi-contrast magnetic resonance imaging (MRI)...
  83. ncbi Multidetector-row computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries
    Konstantin Nikolaou
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Marchioninistr 15, 81377 Munich, Germany
    Atherosclerosis 174:243-52. 2004
    ..Using the information presented in this study, in vivo coronary artery wall imaging using MDCT as well as MRI could be facilitated and supported for future investigations on this subject...
  84. ncbi Risk scores predict atherosclerotic lesions in young people
    C Alex McMahan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Arch Intern Med 165:883-90. 2005
    ..Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons...
  85. ncbi Atherosclerotic plaque characterization by MR imaging
    Brian K Rutt
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Curr Drug Targets Cardiovasc Haematol Disord 4:147-59. 2004
    ..With these developments in place or soon to be available, MR imaging of the diseased carotid artery and aortic wall may prove to be even more important than MR angiography or other current clinical tests...
  86. ncbi Atherothrombosis and high-risk plaque: Part II: approaches by noninvasive computed tomographic/magnetic resonance imaging
    Valentin Fuster
    Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 46:1209-18. 2005
    ..In addition, such technology facilitates the understanding of the processes involved in the development and progression of atherothrombosis responsible for coronary, cerebral, and peripheral ischemic events...
  87. ncbi Complementary results of computed tomography and magnetic resonance imaging of the heart and coronary arteries: a review and future outlook
    Konstantin Nikolaou
    Department of Clinical Radiology, Ludwig-Maximilians-University, Bavariaring 19, D-80336, Munich, Germany
    Cardiol Clin 21:639-55. 2003
    ..Additional studies are also needed to address the cost effectiveness of such a combined approach versus other currently available imaging modalities...
  88. ncbi Fractionated Feridex and positive contrast: in vivo MR imaging of atherosclerosis
    Karen C Briley-Saebo
    Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Magn Reson Med 59:721-30. 2008
    ..No signal attenuation or iron deposition was observed in the vessel wall of rabbits administered Feridex. Results of this study suggest that it may be possible to optimize USPIOs for intraplaque macrophage detection...
  89. ncbi Aortic plaque imaging and monitoring atherosclerotic plaque interventions
    Yukihiko Momiyama
    National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Top Magn Reson Imaging 18:349-55. 2007
    ..Intensive lipid-lowering therapy can regress aortic plaques, but the susceptibility to lipid lowering and the process of plaque regression may differ between the thoracic and abdominal aortic plaques...
  90. ncbi ACCF/AHA 2007 clinical competence statement on vascular imaging with computed tomography and magnetic resonance. A report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Com
    Christopher M Kramer
    J Am Coll Cardiol 50:1097-114. 2007
  91. ncbi ACCF/AHA 2007 clinical competence statement on vascular imaging with computed tomography and magnetic resonance: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Com
    Christopher M Kramer
    Circulation 116:1318-35. 2007
  92. ncbi Imaging atherosclerotic plaque inflammation
    James H F Rudd
    Cardiovascular Medicine at Cambridge University and Addenbrooke s Hospital, Cambridge, UK
    Nat Clin Pract Cardiovasc Med 5:S11-7. 2008
    ..We summarize several alternative imaging techniques--CT, MRI, and nuclear imaging--that are close to the clinical arena, and we provide the relative advantages of each...
  93. ncbi "Positive contrast" inversion-recovery with ON[corrected]-resonant water suppression magnetic resonance imaging: a change for the better?
    Michael J Lipinski
    J Am Coll Cardiol 52:492-4. 2008
  94. ncbi Clearance of iron oxide particles in rat liver: effect of hydrated particle size and coating material on liver metabolism
    Karen C Briley-Saebo
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Invest Radiol 41:560-71. 2006
    ..We sought to evaluate the effect of the particle size and coating material of various iron oxide preparations on the rate of rat liver clearance...
  95. ncbi Carotid black blood MRI burden of atherosclerotic disease assessment correlates with ultrasound intima-media thickness
    Venkatesh Mani
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    J Cardiovasc Magn Reson 8:529-34. 2006
    ..2 mm. Vessel wall measurements assessed by black-blood MRI may be potentially used clinically to evaluate plaque progression and regression...
  96. ncbi A possible association between coronary plaque instability and complex plaques in abdominal aorta
    Yukihiko Momiyama
    National Defense Medical College, Saitama 359 8513, Japan
    Arterioscler Thromb Vasc Biol 26:903-9. 2006
    ..Complex carotid plaques were reported to be prevalent in unstable angina. We investigated associations between coronary plaque instability, such as MI and angiographic complex coronary lesions, and aortic plaques...
  97. ncbi Magnetic resonance evaluation of the associations of thoracic and abdominal aortic plaques with the presence and extent of coronary artery stenosis
    Kazuhiro Ashida
    National Defense Medical College, Saitama, Japan
    J Cardiovasc Magn Reson 9:855-61. 2007
    ..Thus, the total plaque extent in the aortas was found to be more closely associated with the presence and extent of coronary stenosis than the thoracic or abdominal aortic plaque extent...

Research Grants13

  1. IN VIVO MOLECULAR MRI OF ATHEROTHROMBOTIC LESIONS
    Zahi Fayad; Fiscal Year: 2009
    ..abstract_text> ..
  2. Nanoparticles for Molecular MRI of Atherosclerosis
    Zahi Fayad; Fiscal Year: 2007
    ..These studies will provide the basis for future advances in experimental studies of atherosclerogenesis and new clinical applications of non-invasive, in vivo MR imaging of atherosclerotic lesions. ..
  3. IN VIVO MOLECULAR MRI OF ATHEROTHROMBOTIC LESIONS
    Zahi Fayad; Fiscal Year: 2007
    ....
  4. IN VIVO MOLECULAR MRI OF ATHEROTHROMBOTIC LESIONS
    Zahi Fayad; Fiscal Year: 2004
    ..abstract_text> ..
  5. Nanoparticles for Molecular MRI of Atherosclerosis
    Zahi A Fayad; Fiscal Year: 2010
    ..Thus, novel imaging techniques offer new prospects to detect early stages and identify those individuals with higher risk. ..