Michael E Farkouh

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint A comparison of the blood pressure changes of lumiracoxib with those of ibuprofen and naproxen
    Michael E Farkouh
    Clinical Trials Unit, Mount Sinai Cardiovascular Institute, New York, NY 10029, USA
    J Clin Hypertens (Greenwich) 10:592-602. 2008
  2. pmc Clinical risk stratification in the emergency department predicts long-term cardiovascular outcomes in a population-based cohort presenting with acute chest pain: primary results of the Olmsted county chest pain study
    Michael E Farkouh
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Medicine (Baltimore) 88:307-13. 2009
  3. doi request reprint Relationship between ST-segment recovery and clinical outcomes after primary percutaneous coronary intervention: the HORIZONS-AMI ECG substudy report
    Michael E Farkouh
    Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON, Canada
    Circ Cardiovasc Interv 6:216-23. 2013
  4. pmc Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events
    Venkatesh Mani
    Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
    J Cardiovasc Magn Reson 11:10. 2009
  5. ncbi request reprint CRP has little incremental value over traditional cardiovascular risk factors in risk stratification
    Michael E Farkouh
    Mount Sinai Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 4:290-1. 2007
  6. doi request reprint Design of the Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) Trial
    Michael E Farkouh
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Am Heart J 155:215-23. 2008
  7. ncbi request reprint Risk profiling patients for selective use of drug-eluting stents is warranted
    Michael E Farkouh
    Mount Sinai Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 USA
    Nat Clin Pract Cardiovasc Med 4:346-7. 2007
  8. doi request reprint An evidence-based review of the cardiovascular risks of nonsteroidal anti-inflammatory drugs
    Michael E Farkouh
    Mount Sinai Heart Clinical Trials Unit, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 103:1227-37. 2009
  9. ncbi request reprint An early revascularization strategy is associated with a survival benefit for diabetic patients in cardiogenic shock after acute myocardial infarction
    Michael E Farkouh
    Cardiovascular Institute, Mount Sinai School of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA
    Clin Cardiol 29:204-10. 2006
  10. pmc Usefulness of diabetes mellitus to predict long-term outcomes in patients with unstable angina pectoris
    Michael E Farkouh
    Mount Sinai School of Medicine, Cardiovascular Institute, New York, New York, USA
    Am J Cardiol 104:492-7. 2009

Research Grants

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint A comparison of the blood pressure changes of lumiracoxib with those of ibuprofen and naproxen
    Michael E Farkouh
    Clinical Trials Unit, Mount Sinai Cardiovascular Institute, New York, NY 10029, USA
    J Clin Hypertens (Greenwich) 10:592-602. 2008
    ..0001) and +0.43 with lumiracoxib compared with +1.80 mm Hg with naproxen (P<.0001). In conclusion, the use of lumiracoxib and traditional NSAIDs results in differing BP changes; these might be of clinical relevance...
  2. pmc Clinical risk stratification in the emergency department predicts long-term cardiovascular outcomes in a population-based cohort presenting with acute chest pain: primary results of the Olmsted county chest pain study
    Michael E Farkouh
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Medicine (Baltimore) 88:307-13. 2009
    ..This algorithm, when applied in the ED, affords an excellent opportunity to identify patients who might benefit from a more aggressive cardiovascular risk factor management strategy...
  3. doi request reprint Relationship between ST-segment recovery and clinical outcomes after primary percutaneous coronary intervention: the HORIZONS-AMI ECG substudy report
    Michael E Farkouh
    Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON, Canada
    Circ Cardiovasc Interv 6:216-23. 2013
    ..We sought to determine the long-term prognostic value of STR after primary PCI in ST-segment-elevation myocardial infarction...
  4. pmc Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events
    Venkatesh Mani
    Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
    J Cardiovasc Magn Reson 11:10. 2009
    ..The purpose of this study was to determine if patients with traditional risk factors and prior MACE had increased cardiovascular magnetic resonance (CMR) plaque burden measures compared to patients with risk factors but no prior events...
  5. ncbi request reprint CRP has little incremental value over traditional cardiovascular risk factors in risk stratification
    Michael E Farkouh
    Mount Sinai Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 4:290-1. 2007
  6. doi request reprint Design of the Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) Trial
    Michael E Farkouh
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Am Heart J 155:215-23. 2008
    ..The FREEDOM Trial is designed to determine whether CABG or percutaneous coronary intervention (PCI) is the superior approach for revascularization of diabetic patients...
  7. ncbi request reprint Risk profiling patients for selective use of drug-eluting stents is warranted
    Michael E Farkouh
    Mount Sinai Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 USA
    Nat Clin Pract Cardiovasc Med 4:346-7. 2007
  8. doi request reprint An evidence-based review of the cardiovascular risks of nonsteroidal anti-inflammatory drugs
    Michael E Farkouh
    Mount Sinai Heart Clinical Trials Unit, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 103:1227-37. 2009
    ....
  9. ncbi request reprint An early revascularization strategy is associated with a survival benefit for diabetic patients in cardiogenic shock after acute myocardial infarction
    Michael E Farkouh
    Cardiovascular Institute, Mount Sinai School of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA
    Clin Cardiol 29:204-10. 2006
    ..The role of diabetes mellitus (DM) in cardiogenic shock (CS) complicating an acute myocardial infarction (AMI) is not well understood. Previous studies have reported an in-hospital mortality rate for patients with DM and CS of about 60%...
  10. pmc Usefulness of diabetes mellitus to predict long-term outcomes in patients with unstable angina pectoris
    Michael E Farkouh
    Mount Sinai School of Medicine, Cardiovascular Institute, New York, New York, USA
    Am J Cardiol 104:492-7. 2009
    ..DM should be included as a high-risk variable in national acute coronary syndrome guidelines...
  11. pmc Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib
    M E Farkouh
    Mount Sinai Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1074, New York, NY 10029, USA
    Ann Rheum Dis 66:764-70. 2007
    ..However, evidence from prospective studies of currently available COX-2 inhibitors and non-selective NSAIDs is lacking in patients at high cardiovascular risk who are taking aspirin...
  12. pmc Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 59:2080-8. 2012
    ..In this study, the impact of noninsulin-dependent type 2 diabetes mellitus on carotid wall (18)F-fluorodeoxyglucose (FDG) uptake in patients with documented or suspected cardiovascular disease was evaluated...
  13. pmc Relationship of serum inflammatory biomarkers with plaque inflammation assessed by FDG PET/CT: the dal-PLAQUE study
    Raphael Duivenvoorden
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York
    JACC Cardiovasc Imaging 6:1087-94. 2013
    ....
  14. pmc Aspirin use is associated with an improved long-term survival in an unselected population presenting with unstable angina
    Louai Razzouk
    Division of Cardiology Department of Medicine, NYU Langone Medical Center, New York, NY, USA
    Clin Cardiol 33:553-8. 2010
    ..Few published data are available on the benefits of aspirin use in patients with unstable angina (UA)...
  15. ncbi request reprint Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial
    Michael E Farkouh
    Cardiovascular Clinical Research Center, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA
    Lancet 364:675-84. 2004
    ....
  16. ncbi request reprint Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
    ..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
  17. doi request reprint NSAIDs are associated with lower depression scores in patients with osteoarthritis
    Rupa L Iyengar
    Zena and Michael A Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY School of Medicine, St George s University, St George s, Grenada
    Am J Med 126:1017.e11-8. 2013
    ....
  18. doi request reprint Biomarkers after risk stratification in acute chest pain (from the BRIC Study)
    Shiny Mathewkutty
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 111:493-8. 2013
    ..There is potential for their use in the early discharge of low-risk patients after clinical risk stratification...
  19. doi request reprint Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients: FDG-PET and CT imaging study
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 4:1195-205. 2011
    ..We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients...
  20. ncbi request reprint Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial: study design and rationale
    Gregg W Stone
    Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY 10022, USA
    Am Heart J 148:764-75. 2004
    ..Pilot trials suggest that the thrombin-specific anticoagulant bivalirudin may improve clinical outcomes in ACS...
  21. ncbi request reprint Impact of female sex on death and bleeding after fibrinolytic treatment of myocardial infarction in GUSTO V
    Harmony R Reynolds
    Cardiovascular Clinical Research Center, New York University School of Medicine, New York, USA
    Arch Intern Med 167:2054-60. 2007
    ..Use of diagnostic and therapeutic modalities may also differ. There is controversy regarding whether female sex is an independent risk factor for death and/or bleeding...
  22. doi request reprint Assessing patient-reported outcomes and preferences for same-day discharge after percutaneous coronary intervention: results from a pilot randomized, controlled trial
    Michael Kim
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Cardiovasc Qual Outcomes 6:186-92. 2013
    ..Same-day discharge after percutaneous coronary intervention (PCI) may be safe for some patients. Few data are available on patient-reported outcomes and preferences for same-day discharge after PCI...
  23. doi request reprint Outcomes and care of patients with acute heart failure syndromes and cardiac troponin elevation
    Juarez R Braga
    Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Canada
    Circ Heart Fail 6:193-202. 2013
    ..Cardiac troponins (cTn) may be elevated among patients with acute heart failure syndromes (AHFS). However, the optimal approach to management of AHFS with elevated cTn is unknown...
  24. ncbi request reprint Effect of exercise treadmill testing and stress imaging on the triage of patients with chest pain: CHEER substudy
    Gautam Ramakrishna
    Department of Internal Medicine and Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:322-9. 2005
    ....
  25. pmc Rationale and design of dal-PLAQUE: a study assessing efficacy and safety of dalcetrapib on progression or regression of atherosclerosis using magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography
    Zahi A Fayad
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am Heart J 162:214-221.e2. 2011
    ..Results are expected in 2011...
  26. doi request reprint C-reactive protein predicts long-term mortality independently of low-density lipoprotein cholesterol in patients undergoing percutaneous coronary intervention
    Louai Razzouk
    Cardiac Catheterization Laboratory and Clinical Trials Unit, Cardiovascular Institute, Mount Sinai Heart, New York, NY, USA
    Am Heart J 158:277-83. 2009
    ..Few data are available on the association of high-sensitivity C-reactive protein (hs-CRP) and mortality independent of low-density lipoprotein (LDL) cholesterol in patients undergoing percutaneous coronary intervention (PCI)...
  27. pmc Long-term cardiovascular outcomes in patients with angina pectoris presenting with bundle branch block
    Sameer Bansilal
    Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Am J Cardiol 107:1565-70. 2011
    ..In conclusion, appearance of LBBB or RBBB in patients presenting with angina predicts adverse long-term cardiovascular outcomes compared to patients without BBB...
  28. ncbi request reprint Causes of death and re-hospitalization in cardiogenic shock
    Raban V Jeger
    Cardiovascular Clinical Research Center, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA
    Acute Card Care 9:25-33. 2007
    ..In cardiogenic shock, causes of death usually are cardiac. However, a systemic inflammatory response syndrome may influence outcome...
  29. pmc Arterial and fat tissue inflammation are highly correlated : a prospective (18)F-FDG PET/CT study
    Jan Bucerius
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, P O Box 1234, New York, NY, 10029, USA
    Eur J Nucl Med Mol Imaging 41:934-45. 2014
    ..18)F-FDG uptake on PET is a surrogate marker of vessel wall inflammation. The aim of the study was to measure FDG uptake in both regions using PET and identify links between adipose and arterial inflammation...
  30. pmc Optimizing 18F-FDG PET/CT imaging of vessel wall inflammation: the impact of 18F-FDG circulation time, injected dose, uptake parameters, and fasting blood glucose levels
    Jan Bucerius
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, P O Box 1234, New York, NY, 10029, USA
    Eur J Nucl Med Mol Imaging 41:369-83. 2014
    ..However, limited data are available on the impact of methodological variables, i.e. prescan fasting glucose, FDG circulation time and injected FDG dose, and of different FDG uptake parameters, in vascular FDG PET imaging...
  31. doi request reprint Outcomes in patients with chest pain evaluated in a chest pain unit: the chest pain evaluation in the emergency room study cohort
    Michael W Cullen
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Am Heart J 161:871-7. 2011
    ..Limited data exist on the long-term outcomes of patients who undergo evaluation in a chest pain unit (CPU)...
  32. doi request reprint The Future REvascularization Evaluation in patients with Diabetes mellitus: optimal management of Multivessel disease (FREEDOM) trial: clinical and angiographic profile at study entry
    Sameer Bansilal
    Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Am Heart J 164:591-9. 2012
    ....
  33. ncbi request reprint The incremental value of troponin-I testing in patients with intermediate risk unstable angina
    Evan Appelbaum
    Cardiovascular Institute, Mount Sinai School of Medicine, New York, USA
    Clin Cardiol 27:646-51. 2004
    ..Cardiac troponin-I elevation may identify patients at higher risk, but the incremental value may vary with AHCPR clinical risk...
  34. doi request reprint Thrombolysis In Myocardial Infarction (TIMI) risk score and mortality in patients with advanced chronic kidney disease and on dialysis
    Usman Baber
    Cardiac Catheterization Laboratory, Cardiovascular Institute, Mount Sinai Hospital, New York, New York, USA
    Am J Cardiol 103:1513-7. 2009
    ..67 (95% CI 1.52 to 8.86), respectively, for patients on dialysis. In conclusion, the TIMI risk score for UAP/non-ST elevation myocardial infarction discriminates mortality risk across the full range of CKD, including patients on dialysis...
  35. ncbi request reprint Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients
    M Urooj Zafar
    Zena and Michael A Wiener, Cardiovascular Institute, New York, NY 10029, USA
    Thromb Haemost 97:487-92. 2007
    ..Plasma levels of ZK-807834 show a strong linear correlation with PT ratio. This direct factor-Xa inhibitor may reduce the need for additional potent glycoprotein IIbIIIa inhibition...
  36. doi request reprint Association between physician follow-up and outcomes of care after chest pain assessment in high-risk patients
    Andrew Czarnecki
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Circulation 127:1386-94. 2013
    ..Although guidelines recommend primary care physician (PCP) follow-up for patients who are subsequently discharged, little is known about the relationship between physician follow-up and clinical outcomes...
  37. ncbi request reprint Strategies for multivessel revascularization in patients with diabetes
    Michael E Farkouh
    Mount Sinai School of Medicine, New York, NY 10029, USA
    N Engl J Med 367:2375-84. 2012
    ..We sought to discover whether aggressive medical therapy and the use of drug-eluting stents could alter the revascularization approach for patients with diabetes and multivessel coronary artery disease...
  38. doi request reprint Is measuring C-reactive protein useful for guiding treatment in women > or = 60 years and men > or = 50 years of age?
    Paul Muntner
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Am J Cardiol 104:354-8. 2009
    ..Given the demonstrated benefits of statin therapy, cost of measuring CRP, and large percentage of older US adults with high CRP, universal statin therapy for older US adults warrants investigation...
  39. doi request reprint Relation of high-density lipoprotein cholesterol to mortality after percutaneous coronary interventions in patients with low-density lipoprotein <70 mg/dl
    Annapoorna S Kini
    Cardiac Catheterization Laboratory of the Cardiovascular Institute, Mount Sinai Hospital, New York, NY, USA
    Am J Cardiol 103:350-4. 2009
    ..58 to 0.79). In conclusion, in patients with LDL cholesterol levels <70 mg/dl who underwent percutaneous coronary intervention, a strong inverse association was present between HDL cholesterol level and all-cause mortality...
  40. pmc The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis
    Claudia Calcagno
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY, 10029, USA
    Eur J Nucl Med Mol Imaging 40:1884-93. 2013
    ..We studied the relationship between DCE-MRI and (18)F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473)...
  41. ncbi request reprint Relation between the degree of procedural anticoagulation and complications after coronary stent implantation
    Dale T Ashby
    Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, New York 10022, USA
    Am J Cardiol 92:319-22. 2003
    ..High levels of procedural anticoagulation with heparin were found to increase hemorrhagic complications without improving clinical or angiographic outcomes...
  42. doi request reprint Periprocedural myocardial enzyme elevation: prognostic implications for current practice
    Sanjum S Sethi
    Zena and Michael A Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Cardiol Rep 14:424-32. 2012
    ..In this review, we highlight significant concepts in the diagnosis, prognosis, and clinical impact of periprocedural myocardial enzyme elevation...
  43. ncbi request reprint Elevated homocysteine levels in patients with end-stage renal disease
    Ajith P Nair
    Department of Internal Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 72:365-73. 2005
    ..To examine the effect of hemodialysis on plasma homocysteine levels, and the relationship of these values to clinical cardiovascular events in patients with end-stage renal disease (ESRD)...
  44. doi request reprint Clustering of metabolic abnormalities among obese patients and mortality after percutaneous coronary intervention
    Sameer Bashey
    The Mount Sinai Cardiovascular Institute, New York, New York, USA
    Am J Cardiol 107:1415-20. 2011
    ..In conclusion, BMI levels of 25.0 to 29.9 and 30 to 34.9 kg/m(2) were associated with lower all-cause mortality after PCI. However, an increased number of metabolic abnormalities translated into increased all-cause mortality...
  45. ncbi request reprint Optimal treatment of the diabetic patient with multivessel disease
    Sameer Bansilal
    Zena and Michael A Wiener Cardiovascular Institute, Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Cardiol Rep 10:272-84. 2008
    ..In this article, we assess the evidence accumulated to date and discuss ongoing studies that will help better inform this intricate decision-making process...
  46. doi request reprint Diabetes: making sense of the rosiglitazone controversy
    Michael E Farkouh
    Clinical Trials Unit, Mount Sinai Cardiovascular Institute, One Gustave L Levy Place, Box 1074, New York, NY 10029, USA
    Nat Rev Cardiol 7:366-7. 2010
    ..A trial in which rosiglitazone and glipizide were compared supports earlier findings that rosiglitazone does not have an adverse effect on the progression of coronary atherosclerosis...
  47. pmc Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET
    Claudia Calcagno
    FAHA, FACC, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 28:1311-7. 2008
    ..Our aim was to test 2 techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, to quantify inflammation expressed as plaque neovessels content in a rabbit model of atherosclerosis...
  48. doi request reprint Noninvasive cardiovascular imaging in rheumatoid arthritis: current modalities and the emerging role of magnetic resonance and positron emission tomography imaging
    Victoria Furer
    Division of Rheumatology, New York University Hospital for Joint Diseases, New York, New York 10003, USA
    Semin Arthritis Rheum 41:676-88. 2012
    ....
  49. ncbi request reprint Diminished benefits of drug-eluting stents versus bare metal stents in patients with severe renal insufficiency
    Michael A Rosenblum
    Department of Internal Medicine, The Mount Sinai Medical Center, New York, N Y, USA
    Nephron Clin Pract 113:c198-202. 2009
    ..However, these benefits have not been reproduced in patients with severe renal disease (SRD). This study compared TLR rates in patients with severe renal insufficiency treated with DES vs. BMS...
  50. doi request reprint Crushed clopidogrel administered via nasogastric tube has faster and greater absorption than oral whole tablets
    M Urooj Zafar
    Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Interv Cardiol 22:385-9. 2009
    ..To compare the absorption of 300 mg clopidogrel administered crushed via nasogastric (NG) tube versus whole tablets taken orally in healthy volunteers...
  51. pmc Magnetic resonance molecular imaging of thrombosis in an arachidonic acid mouse model using an activated platelet targeted probe
    Ahmed Klink
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, Atran BM 24, Box 1234, One Gustave L Levy Place, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 30:403-10. 2010
    ..We sought to determine whether the noninvasive in vivo visualization of activated platelets was effective when using a target-specific MRI contrast agent to identify thrombi, hallmarks of vulnerable or high-risk atherosclerotic plaques...
  52. pmc Variations in atherosclerosis and remodeling patterns in aorta and carotids
    Katsumi Hayashi
    Imaging Science Laboratories, Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Med, New York, NY, USA
    J Cardiovasc Magn Reson 12:10. 2010
    ..The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period...
  53. ncbi request reprint The vulnerable plaque and acute coronary syndromes
    Roberto Corti
    Cardiovascular Biology Research Laboratory, Mount Sinai School of Medicine, New York, New York, USA
    Am J Med 113:668-80. 2002
    ..These regimens focus on inhibiting thrombin, preventing thrombi generation, blocking the initiation of coagulation, inhibiting platelet activation, and increasing fibrinolysis...
  54. doi request reprint Risk factor control for coronary artery disease secondary prevention in large randomized trials
    Michael E Farkouh
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 61:1607-15. 2013
    ....
  55. doi request reprint Diabetes mellitus and acute coronary syndrome: lessons from randomized clinical trials
    Sanjum S Sethi
    Zena and Michael A Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Diab Rep 12:294-304. 2012
    ....
  56. pmc Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed tomography imaging study
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Circ Cardiovasc Imaging 2:107-15. 2009
    ..We also tested the hypotheses that the degree of local arterial inflammation measured by PET is correlated with the extent of systemic inflammation and presence of risk factors for vascular disease...
  57. ncbi request reprint Role of insulin resistance and hyperglycemia in the development of atherosclerosis
    Sameer Bansilal
    The Zena and Michael A Wiener Cardiovascular Institute and The Marie Josee and Henry R Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Cardiol 99:6B-14B. 2007
    ..Efforts to prevent or slow the epidemic of atherothrombotic CVD must focus on the reversal of the disturbances in glucose and lipid homeostasis through the amelioration of IR...
  58. ncbi request reprint Cardiovascular disease in diabetics: pharmacology and revascularization
    Sarang S Mangalmurti
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mt Sinai J Med 71:375-83. 2004
    ....
  59. ncbi request reprint Magnetic resonance imaging and computed tomography in assessment of atherosclerotic plaque
    Zahi A Fayad
    Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Curr Atheroscler Rep 6:232-42. 2004
    ..MDCT and MRI, therefore, may help in selecting appropriate treatments...
  60. ncbi request reprint Prenatal detection of embryo resorption in osteopontin-deficient mice using serial noninvasive magnetic resonance microscopy
    Andrea S Weintraub
    The Mount Sinai School of Medicine, Box 1508, One Gustave L Levy Place, New York, NY 10029, USA
    Pediatr Res 55:419-24. 2004
    ..However, targeted disruption of one or more OPN alleles had no effect on embryo number at any gestational age. Thus, MRM may be a powerful noninvasive method for in vivo prenatal developmental study of genetically engineered mice...
  61. doi request reprint Evaluation of neovessels in atherosclerotic plaques of rabbits using an albumin-binding intravascular contrast agent and MRI
    Jean Christophe Cornily
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Magn Reson Imaging 27:1406-11. 2008
    ..To test whether B-22956/1, a novel intravascular contrast agent with a high affinity to serum albumin (Bracco Imaging SpA.), allowed quantifying neovessel and macrophage density in atherosclerotic plaques of rabbits using MRI...
  62. ncbi request reprint Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI
    Zahi A Fayad
    Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Imaging Science Laboratories, Box 1234, New York, NY 10029, USA
    Neuroimaging Clin N Am 12:461-71. 2002
    ..This may aid early intervention (e.g., lipid lowering drug regiments) in both primary and secondary treatment of vascular disease in all arterial beds...
  63. pmc High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis
    Torjus Skajaa
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 30:169-76. 2010
    ..By rerouting of HDL away from plaque macrophages, imaging of biological processes in diseases besides atherosclerosis may also be achieved...
  64. ncbi request reprint Vascular MRI in the diagnosis and therapy of the high risk atherosclerotic plaque
    Jolanda J Wentzel
    Zena and Michael A Wiener Cardiovascular Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    J Interv Cardiol 16:129-42. 2003
    ..It possibly will identify asymptomatic patients with subclinical atherosclerosis. This has potential significance for the improvement of strategies in primary and secondary prevention...
  65. doi request reprint Prologue: relevance of molecular imaging in clinical medicine
    Zahi A Fayad
    Department of Radiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1030, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 5:S1. 2008
  66. doi request reprint Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach
    Eric Lancelot
    Department of Radiology, The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, Box 1234, One Gustave L Levy Place, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 28:425-32. 2008
    ..This study evaluated the ability of the novel gadolinium-based MRI contrast agent P947 to target MMPs in atherosclerotic plaques...
  67. ncbi request reprint MR imaging for the noninvasive assessment of atherothrombotic plaques
    Zahi A Fayad
    Department of Radiology, The Zena and Michael A Wiener Cardiovascular Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Magn Reson Imaging Clin N Am 11:101-13. 2003
    ..This may aid early intervention (eg, lipid-lowering drug regiments) in both primary and secondary treatment of vascular disease in all arterial beds...
  68. ncbi request reprint Computed tomography and magnetic resonance imaging for noninvasive coronary angiography and plaque imaging: current and potential future concepts
    Zahi A Fayad
    Zena and Michael A Wiener Cardiovascular Institute, New York, NY, USA
    Circulation 106:2026-34. 2002
  69. ncbi request reprint Magnetic resonance imaging of coronary atherosclerosis
    Zahi A Fayad
    Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Curr Atheroscler Rep 5:411-7. 2003
  70. ncbi request reprint Atherothrombotic plaques and the need for imaging
    Zahi A Fayad
    Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Imaging Science Laboratories, Box 1234, New York, NY 10029, USA
    Neuroimaging Clin N Am 12:351-64. 2002
    ..The use of some of the available imaging modalities for the study of regression and progression of atherothrombosis are described in more detail in the subsequent articles...
  71. pmc In vivo detection of embryonic stem cell-derived cardiovascular progenitor cells using Cy3-labeled Gadofluorine M in murine myocardium
    Eric D Adler
    Cardiovascular Institute and Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    JACC Cardiovasc Imaging 2:1114-22. 2009
    ....
  72. ncbi request reprint Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of atherosclerotic plaque angiogenesis
    Claudia Calcagno
    Imaging Science Laboratories, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Angiogenesis 13:87-99. 2010
    ..Finally, we will examine the current limitations and challenges faced by DCE-MRI and briefly discuss its future applications in the context of atherosclerosis...
  73. ncbi request reprint Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options
    Ashish Aneja
    The Mount Sinai Cardiovascular Institute, New York, NY 10029, USA
    Am J Med 121:748-57. 2008
    ..Although glycemic control and early administration of neurohormonal antagonists remain the cornerstones of therapeutic approaches, newer treatment targets are currently being explored...
  74. ncbi request reprint Serum cystatin C and increased coronary heart disease prevalence in US adults without chronic kidney disease
    Paul Muntner
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Am J Cardiol 102:54-7. 2008
    ..06 to 2.56) for myocardial infarction, angina, and stroke, respectively. In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease...
  75. ncbi request reprint Association between troponin I levels and mortality in stable hemodialysis patients
    Michael E Farkouh
    Cardiovascular Institute, Mount Sinai Medical Center, New York, New York, USA
    Am J Med 114:224-6. 2003
  76. ncbi request reprint Imaging outcomes in cardiovascular clinical trials
    Louai Razzouk
    Mount Sinai Cardiovascular Institute, New York, NY 10029, USA
    Nat Rev Cardiol 6:524-31. 2009
    ..In the future, imaging modalities will be fundamental to research and drug development and an increased emphasis will be placed on the relationship between the results of imaging studies and clinical outcomes...
  77. ncbi request reprint A novel nonobstructive intravascular MRI coil: in vivo imaging of experimental atherosclerosis
    Stephen G Worthley
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Arterioscler Thromb Vasc Biol 23:346-50. 2003
    ..However, the resolution achievable using surface radiofrequency coils is limited by the signal to noise ratio. We studied the utility of a new intravascular (IV) MRI probe for high-resolution in vivo imaging of atherosclerotic lesions...
  78. ncbi request reprint Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging
    Roberto Corti
    Cardiovascular Biology Research Laboratory, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 106:2884-7. 2002
    ..Noninvasive MRI allows serial monitoring of atherosclerotic plaque size changes. Our aim was to investigate the effects of lipid lowering with simvastatin on atherosclerotic lesions...
  79. ncbi request reprint Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging
    Marc Sirol
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josée and Henry R Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Circulation 109:2890-6. 2004
    ..We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non-lipid-rich plaques...
  80. ncbi request reprint Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques
    Juan C Frias
    Imaging Science Laboratories, Department of Radiology, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Am Chem Soc 126:16316-7. 2004
    ..It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition...
  81. ncbi request reprint Does shear stress modulate both plaque progression and regression in the thoracic aorta? Human study using serial magnetic resonance imaging
    Jolanda J Wentzel
    Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 45:846-54. 2005
    ..The purpose of this study was to investigate the role of shear stress (SS) in plaque regression...
  82. pmc Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries
    Stephane S Silvera
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Atherosclerosis 207:139-43. 2009
    ....
  83. ncbi request reprint (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    J Am Coll Cardiol 50:892-6. 2007
    ..This study tested the near-term reproducibility of (18)fluorodeoxyglucose positron emission tomography (FDG-PET) imaging of atherosclerosis...
  84. ncbi request reprint Parallel and nonparallel simultaneous multislice black-blood double inversion recovery techniques for vessel wall imaging
    Vitalii V Itskovich
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Magn Reson Imaging 19:459-67. 2004
    ..To reduce long examination times of black-blood vessel wall imaging by acquiring multiple slices simultaneously and by using parallel acquisition techniques...
  85. ncbi request reprint Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaques of atherosclerotic rabbits
    Claudia Calcagno
    Translational and Molecular Imaging Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Magn Reson Imaging 32:191-8. 2010
    ....
  86. ncbi request reprint Mouse model of heterotopic aortic arch transplantation
    Igor Chereshnev
    Department of Medicine and the Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Surg Res 111:171-6. 2003
    ..Because lesion development is more rapid and exuberant in the aortic arch, a technique of transplantation of the mouse aortic arch was developed...
  87. ncbi request reprint Serial studies of mouse atherosclerosis by in vivo magnetic resonance imaging detect lesion regression after correction of dyslipidemia
    Eugene Trogan
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Arterioscler Thromb Vasc Biol 24:1714-9. 2004
    ..We determined the effects of sustained normocholesterolemia on advanced mouse atherosclerosis and whether changes in plaque size and composition can be detected noninvasively by MRI...
  88. ncbi request reprint Atherosclerotic lesions in genetically modified mice quantified in vivo by non-invasive high-resolution magnetic resonance microscopy
    Robin P Choudhury
    The Cardiovascular Institute, Mount Sinai School of Medicine, Box 1030, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Atherosclerosis 162:315-21. 2002
    ..0001) to be accommodated entirely by 'positive remodeling', confirming the importance of determining plaque size directly. MRM accurately quantifies mouse aortic atherosclerosis and will enhance studies in this important animal model...
  89. doi request reprint Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis
    Jacob A Udell
    Women s College Research Institute and Cardiovascular Division, Department of Medicine, Women s College Hospital, University of Toronto, Toronto, Ontario, Canada
    JAMA 310:1711-20. 2013
    ..Among nontraditional cardiovascular risk factors, recent influenzalike infection is associated with fatal and nonfatal atherothrombotic events...
  90. doi request reprint Does acetylsalicylic acid or warfarin affect the accuracy of fecal occult blood tests?
    Sumeet Gandhi
    Department of Medicine Division of Internal Medicine, University of Toronto, Toronto, Canada
    J Gastroenterol Hepatol 28:931-6. 2013
    ..Current guidelines for screening of colorectal cancer do not offer specific recommendations for cessation of antithrombotic agents prior to fecal occult blood test (FOBT)...
  91. doi request reprint Tumour necrosis factor antagonist use and associated risk reduction of cardiovascular events among patients with rheumatoid arthritis
    Jeffrey D Greenberg
    Department of Rheumatology, New York University Hospital for Joint Diseases, 301 East 17th Street, Suite 1410, New York, NY 10003, USA
    Ann Rheum Dis 70:576-82. 2011
    ..To examine the association of cardiovascular events with tumour necrosis factor (TNF) α antagonist use compared with non-biological disease-modifying antirheumatic drug (DMARD) utilisation in patients with rheumatoid arthritis (RA)...
  92. pmc Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Radiology 256:774-82. 2010
    ....
  93. ncbi request reprint Progression and regression of atherosclerotic lesions: monitoring with serial noninvasive magnetic resonance imaging
    Gerard Helft
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Circulation 105:993-8. 2002
    ..Our aim was to monitor changes in burden and composition of atherosclerotic plaques in a rabbit model of complex atherosclerosis using serial noninvasive magnetic resonance imaging (MRI)...
  94. doi request reprint Quantification of inflammation within rabbit atherosclerotic plaques using the macrophage-specific CT contrast agent N1177: a comparison with 18F-FDG PET/CT and histology
    Fabien Hyafil
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Nucl Med 50:959-65. 2009
    ..In this study, we tested whether the intensity of enhancement detected with CT in the aortic wall of rabbits injected with N1177 correlated with inflammatory activity evaluated with (18)F-FDG PET/CT and macrophage density on histology...
  95. ncbi request reprint Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
    Fabien Hyafil
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, New York 10029, USA
    Nat Med 13:636-41. 2007
    ..This contrast agent may become an important adjunct to the clinical evaluation of coronary arteries with CT...
  96. ncbi request reprint Magnetic resonance molecular imaging contrast agents and their application in atherosclerosis
    Willem J M Mulder
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Top Magn Reson Imaging 18:409-17. 2007
    ..Subsequent to the discussion of the above topics, we will describe some examples of molecular imaging agents that successfully detect specific markers in atherosclerotic plaques that are of interest in several stages of this disease...
  97. ncbi request reprint Effects of aggressive versus conventional lipid-lowering therapy by simvastatin on human atherosclerotic lesions: a prospective, randomized, double-blind trial with high-resolution magnetic resonance imaging
    Roberto Corti
    Cardiovascular Biology Research Laboratory, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Coll Cardiol 46:106-12. 2005
    ..This study sought to compare the effects of aggressive and conventional lipid lowering by two different dosages of the same statin on early human atherosclerotic lesions using serial noninvasive magnetic resonance imaging (MRI)...
  98. doi request reprint Imaging of atherosclerotic cardiovascular disease
    Javier Sanz
    The Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nature 451:953-7. 2008
    ....
  99. ncbi request reprint Comparison of gated and non-gated fast multislice black-blood carotid imaging using rapid extended coverage and inflow/outflow saturation techniques
    Venkatesh Mani
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Magn Reson Imaging 22:628-33. 2005
    ..To comparatively analyze two fast in vivo multislice black-blood carotid artery vessel wall imaging techniques with and without cardiac gating...
  100. doi request reprint Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations
    James H F Rudd
    Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York, USA
    J Nucl Med 49:871-8. 2008
    ..We also reviewed the literature on quantification methods to determine the optimal measures of arterial 18F-FDG uptake for future studies...
  101. ncbi request reprint Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes
    Karen C Briley-Saebo
    Imaging Science Laboratory, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 117:3206-15. 2008
    ....

Research Grants2

  1. Novel Imaging to Predict Cardiovascular Events in Diabetes
    Zahi A Fayad; Fiscal Year: 2010
    ..It is our expectation that our data will be utilized to evaluate and improve existent treatment and develop effective new therapies to decrease the burden of atherosclerotic disease in diabetes. ..
  2. Novel Imaging to Predict Cardiovascular Events in Diabetes
    Michael Farkouh; Fiscal Year: 2009
    ..It is our expectation that our data will be utilized to evaluate and improve existent treatment and develop effective new therapies to decrease the burden of atherosclerotic disease in diabetes. ..