Gregory Elder

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features
    Joseph D Buxbaum
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Autism 3:1. 2012
  2. pmc Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease
    Rita De Gasperi
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Mol Neurodegener 5:38. 2010
  3. pmc Transgenic mouse models of Alzheimer's disease
    Gregory A Elder
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA
    Mt Sinai J Med 77:69-81. 2010
  4. pmc Presenilin transgenic mice as models of Alzheimer's disease
    Gregory A Elder
    Neurology Service 3E16, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA
    Brain Struct Funct 214:127-43. 2010
  5. pmc Novel cerebrovascular pathology in mice fed a high cholesterol diet
    Sonia Franciosi
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 4:42. 2009
  6. ncbi request reprint Presence of unmyelinated axons in the lumbar ventral roots of the 129 mouse strain
    G A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurosci Lett 287:101-4. 2000
  7. ncbi request reprint Research update: neurogenesis in adult brain and neuropsychiatric disorders
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:931-40. 2006
  8. ncbi request reprint The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 188:224-37. 2004
  9. ncbi request reprint Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, P O Box 1229, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Neurosci Lett 318:53-6. 2002
  10. ncbi request reprint Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neurobiol Dis 10:8-19. 2002

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features
    Joseph D Buxbaum
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Autism 3:1. 2012
    ..abstract:..
  2. pmc Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease
    Rita De Gasperi
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Mol Neurodegener 5:38. 2010
    ..Here we investigated whether Psen1 might regulate hypoxic responses by modulating induction of the transcription factor hypoxia inducible factor 1-α (HIF-1α)...
  3. pmc Transgenic mouse models of Alzheimer's disease
    Gregory A Elder
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA
    Mt Sinai J Med 77:69-81. 2010
    ..These models will, without a doubt, continue to play central roles in preclinical testing and be used as tools for developing insights into the biological basis of Alzheimer's disease...
  4. pmc Presenilin transgenic mice as models of Alzheimer's disease
    Gregory A Elder
    Neurology Service 3E16, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA
    Brain Struct Funct 214:127-43. 2010
    ..The relevance of PS transgenic mice as models of AD is discussed...
  5. pmc Novel cerebrovascular pathology in mice fed a high cholesterol diet
    Sonia Franciosi
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 4:42. 2009
    ..abstract:..
  6. ncbi request reprint Presence of unmyelinated axons in the lumbar ventral roots of the 129 mouse strain
    G A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurosci Lett 287:101-4. 2000
    ..These characteristics must be kept in mind in studies of mutant mice that are frequently performed on a mixed genetic background containing a129 contribution...
  7. ncbi request reprint Research update: neurogenesis in adult brain and neuropsychiatric disorders
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:931-40. 2006
    ..While obstacles remain to both approaches, stem-cell-based therapies remain an area of intense research interest...
  8. ncbi request reprint The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 188:224-37. 2004
    ..They also identify a new mechanism whereby PS1 FAD mutants may impair normal neuronal function and may have implications for the physiological functioning of the hippocampus in FAD...
  9. ncbi request reprint Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, P O Box 1229, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Neurosci Lett 318:53-6. 2002
    ..Cells expressing PS-1 and the neural progenitor marker nestin were also found. Thus PS-1 is expressed in neural progenitor cells in adult hippocampus implying its possible role in neurogenesis in adult brain...
  10. ncbi request reprint Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Neurobiol Dis 10:8-19. 2002
    ..These studies suggest that PS-1 plays a role in regulating neurogenesis in adult hippocampus and that FAD mutants may have deleterious properties independent of their effects on amyloid deposition...
  11. doi request reprint Animal transgenesis: an overview
    Miguel A Gama Sosa
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, 10029, USA
    Brain Struct Funct 214:91-109. 2010
    ....
  12. ncbi request reprint Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact
    Miguel A Gama Sosa
    Department of Psychiatry, Mount Sinai School of Medicine of New York University, New York, NY, USA
    Cell Res 17:619-26. 2007
    ..These apparently opposing effects could reflect differential cellular interactions needed for the proper development of the brain...
  13. pmc Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 132:3873-83. 2005
    ..Collectively, these studies demonstrate that Psen1 expression in neural progenitor cells is crucial for cortical development and reveal a novel role for neuroectodermal expression of Psen1 in development of the brain vasculature...
  14. pmc Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations
    Miguel A Gama Sosa
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA
    Am J Pathol 176:353-68. 2010
    ..These studies thus have implications for the role of neuronal to vascular signaling in the pathogenesis of the vascular pathology associated with AD...
  15. doi request reprint Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders
    Takeshi Sakurai
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 67:887-94. 2010
    ..AGC1 is an important component of the malate/aspartate shuttle, a crucial system supporting oxidative phosphorylation and adenosine triphosphate production...
  16. ncbi request reprint Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice
    Paul H Wen
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurosci Lett 371:249-54. 2004
    ..These studies thus argue that premature neuronal differentiation is unlikely to be a core pathophysiological feature underlying the aberrant cortical development that occurs in PS1-/- brain...
  17. pmc The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ
    Rita De Gasperi
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Genesis 46:308-17. 2008
    ..IRG mice should provide a versatile tool for analyzing complex cellular relationships in both neural and nonneural tissues...
  18. ncbi request reprint Human midsized neurofilament subunit induces motor neuron disease in transgenic mice
    Miguel A Gama Sosa
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 184:408-19. 2003
    ..These studies have implications for the use of human neurofilament transgenic mice as models of amyotrophic lateral sclerosis...
  19. pmc Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
    Xianting Li
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:1788-97. 2010
    ..The PD-associated mutation G2019S may exert pathogenic effects by impairing these functions of LRRK2. Our LRRK2 BAC transgenic mice, therefore, could provide a useful model for understanding early PD pathological events...
  20. doi request reprint Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care
    Gregory A Elder
    James J Peters Department of Veterans Affairs Medical Center, Rehabilitation Medicine Service, Bronx, NY, USA
    Mt Sinai J Med 76:111-8. 2009
    ..The high rates of mild traumatic brain injury and posttraumatic stress disorder in the current operations are of significant concern for the long-term health of US veterans with associated economic implications...

Research Grants9

  1. Development of a Nestin Lineage Stem Cell Marking System
    Gregory Elder; Fiscal Year: 2002
    ..Collectively if successful these studies will provide a simple and permanent marking system for identifying and following CNS stem cells in both fetal and adult mouse brain. ..
  2. Role of Presenilin-1 in Neural Injury and Repair
    Gregory Elder; Fiscal Year: 2005
    ..Results from these studies could have implications for understanding how FAD mutants cause AD. ..
  3. Creation of a Nestin Lineage Stem Cell Ablation System
    Gregory Elder; Fiscal Year: 2005
    ....
  4. Development of an Adult CNS Stem Cell Marking System
    Gregory Elder; Fiscal Year: 2006
    ..This system will allow the fate of nestin lineage stem cells to be followed indefinitely in adult brain irrespective of their differentiation along neuronal or non-neuronal lines. ..
  5. Presenilin-1 as an Hypoxia Sensor
    Gregory Elder; Fiscal Year: 2007
    ..The public health relevance of this research lies in its exploration of a novel hypothesis concerning neurovascular signaling and the information that it might contribute to how this signaling is disrupted in AD. ..