Ranjan Duara

Summary

Affiliation: Mount Sinai Medical Center
Country: USA

Publications

  1. doi Amyloid positron emission tomography with (18)F-flutemetamol and structural magnetic resonance imaging in the classification of mild cognitive impairment and Alzheimer's disease
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 9:295-301. 2013
  2. doi The basis for disease-modifying treatments for Alzheimer's disease: the Sixth Annual Mild Cognitive Impairment Symposium
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 5:66-74. 2009
  3. pmc Pre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Miami Beach, Florida, USA
    Am J Geriatr Psychiatry 19:951-60. 2011
  4. doi Severity of medial temporal atrophy and amnestic mild cognitive impairment: selecting type and number of memory tests
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 17:1050-8. 2009
  5. doi Comparing new templates and atlas-based segmentations in the volumetric analysis of brain magnetic resonance images for diagnosing Alzheimer's disease
    Qian Shen
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:399-406. 2012
  6. doi Cross-validation of the Florida Cognitive Activities Scale (FCAS) in an Alzheimer's disease research center sample
    John A Schinka
    James A Haley VA Medical Center, Tampa, Florida, USA
    J Geriatr Psychiatry Neurol 23:9-14. 2010
  7. pmc Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment
    Daniel Varon
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 31:276-83. 2011
  8. pmc Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Int J Geriatr Psychiatry 25:282-9. 2010
  9. pmc An investigation of PreMCI: subtypes and longitudinal outcomes
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:172-9. 2012
  10. doi The cognitive change checklist (3CL): cross-validation of a measure of change in everyday cognition
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL, USA
    Int J Geriatr Psychiatry 25:266-74. 2010

Collaborators

Detail Information

Publications48

  1. doi Amyloid positron emission tomography with (18)F-flutemetamol and structural magnetic resonance imaging in the classification of mild cognitive impairment and Alzheimer's disease
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 9:295-301. 2013
    ..To evaluate the contributions of amyloid-positive (Am+) and medial temporal atrophy-positive (MTA+) scans to the diagnostic classification of prodromal and probable Alzheimer's disease (AD)...
  2. doi The basis for disease-modifying treatments for Alzheimer's disease: the Sixth Annual Mild Cognitive Impairment Symposium
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 5:66-74. 2009
    ..The issues were discussed from multiple perspectives by a panel that included a lay representative, neurologist, psychiatrist, primary care physician, and a psychosocial researcher...
  3. pmc Pre-MCI and MCI: neuropsychological, clinical, and imaging features and progression rates
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Miami Beach, Florida, USA
    Am J Geriatr Psychiatry 19:951-60. 2011
    ....
  4. doi Severity of medial temporal atrophy and amnestic mild cognitive impairment: selecting type and number of memory tests
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 17:1050-8. 2009
    ..The authors compared the strength of this biomarker with performance on four memory measures and examined the influence of demographic factors including age, level of education, and primary language (English or Spanish)...
  5. doi Comparing new templates and atlas-based segmentations in the volumetric analysis of brain magnetic resonance images for diagnosing Alzheimer's disease
    Qian Shen
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:399-406. 2012
    ....
  6. doi Cross-validation of the Florida Cognitive Activities Scale (FCAS) in an Alzheimer's disease research center sample
    John A Schinka
    James A Haley VA Medical Center, Tampa, Florida, USA
    J Geriatr Psychiatry Neurol 23:9-14. 2010
    ....
  7. pmc Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment
    Daniel Varon
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 31:276-83. 2011
    ..The significance of very mild atrophy of the ERC and HP on MRI scans among elderly subjects is unknown...
  8. pmc Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Int J Geriatr Psychiatry 25:282-9. 2010
    ..To examine the reliability and validity of the mCDR, a modified version of the clinical dementia rating (CDR) scale...
  9. pmc An investigation of PreMCI: subtypes and longitudinal outcomes
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:172-9. 2012
    ..To investigate the clinical features and rates of progression of conditions that are not considered to be normal, but do not fulfill criteria for mild cognitive impairment (MCI)...
  10. doi The cognitive change checklist (3CL): cross-validation of a measure of change in everyday cognition
    John A Schinka
    James A Haley VA Medical Center, Tampa, FL, USA
    Int J Geriatr Psychiatry 25:266-74. 2010
    ....
  11. pmc Reliability and validity of an algorithm for the diagnosis of normal cognition, mild cognitive impairment, and dementia: implications for multicenter research studies
    Ranjan Duara
    Mount Sinai Medical Center, Wien Center for Alzheimer s Disease and Memory Disorders, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 18:363-70. 2010
    ..As this procedure may be labor intensive and influenced by the philosophy and biases of a clinician, the diagnostic algorithm (AlgDx) was developed to identify individuals as cognitively normal, with MCI, or dementia...
  12. pmc Volumetric and visual rating of magnetic resonance imaging scans in the diagnosis of amnestic mild cognitive impairment and Alzheimer's disease
    Qian Shen
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 7:e101-8. 2011
    ....
  13. pmc Stability of different subtypes of mild cognitive impairment among the elderly over a 2- to 3-year follow-up period
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Fla, USA
    Dement Geriatr Cogn Disord 27:418-23. 2009
    ..To investigate the longitudinal stability and progression of different subtypes of mild cognitive impairment (MCI) in older adults...
  14. ncbi Vulnerability to proactive semantic interference and progression to dementia among older adults with mild cognitive impairment
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 24:363-8. 2007
    ..Vulnerability to proactive interference may be an early manifestation of an early dementing process and may have utility in predicting future progression to dementia...
  15. pmc The utility of a brief memory screen in the diagnosis of mild memory impairment in the elderly: preliminary study
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 17:437-40. 2009
    ..This study evaluated the utility of the Florida Brief Memory Screen (FBMS), a new memory screening measure developed for Spanish-speaking and English-speaking subjects, which takes only 3-4 minutes to administer...
  16. doi Cognitive and structural magnetic resonance imaging features of Lewy body dementia and Alzheimer's disease
    Miriam Jocelyn Rodriguez
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Alzheimers Dement 8:211-8. 2012
    ....
  17. ncbi Using different memory cutoffs to assess mild cognitive impairment
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 14:911-9. 2006
    ....
  18. ncbi The effect of a memory screening program on the early diagnosis of Alzheimer disease
    Warren W Barker
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    Alzheimer Dis Assoc Disord 19:1-7. 2005
    ..Alzheimer Disease (AD) is often diagnosed at a moderately advanced stage, even though its early detection has become increasingly important, because of the continuing development of treatments that may improve its outcome...
  19. ncbi Conversion to dementia among two groups with cognitive impairment. A preliminary report
    Cheryl A Luis
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Fla 33140, USA
    Dement Geriatr Cogn Disord 18:307-13. 2004
    ..To determine the conversion rates to dementia in patients diagnosed with mild cognitive impairment (MCI) thought to be caused by incipient Alzheimer's disease (MCI-AD) or with MCI with features of vascular disease (MCI-Vas)...
  20. doi A comparative analysis of structural brain MRI in the diagnosis of Alzheimer's disease
    Jason Appel
    Mount Sinai Medical Center, Wien Center, Miami Beach, FL 33140, USA
    Behav Neurol 21:13-9. 2009
    ..Multiple neuroimaging methods utilizing visual rating scales, volumetric measurements, and automated methods have been developed to identify, quantify, and track anatomic sequelae of Alzheimer's Disease...
  21. ncbi The use of amnestic and nonamnestic composite measures at different thresholds in the neuropsychological diagnosis of MCI
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    J Clin Exp Neuropsychol 29:300-7. 2007
    ..3%) and the composite measure of both impaired memory and nonmemory measures (sensitivity of 85.0%/specificity of 100%) had high levels of discrimination and may have utility as indices of early impairment as well as severity of MCI...
  22. ncbi Semantic interference deficits and the detection of mild Alzheimer's disease and mild cognitive impairment without dementia
    David A Loewenstein
    Department of Psychiatry, Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    J Int Neuropsychol Soc 10:91-100. 2004
    ..6% and specificity of 96.2% in differentiating mild AD patients from normal older adults. Susceptibility to proactive semantic interference may be an early cognitive feature of MCI and AD patients presenting for clinical evaluation...
  23. ncbi Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies
    David A Loewenstein
    Wein Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Fla, USA
    Dement Geriatr Cogn Disord 21:309-15. 2006
    ..MCI-AD and MCI-vascular patients frequently exhibit both common and overlapping amnestic and nonamnestic features. The implication of these findings for future clinical research is discussed...
  24. doi Patterns of depression in Spanish- and English-speaking patients with Alzheimer's disease
    Raymond L Ownby
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Geriatr Psychiatry Neurol 21:47-55. 2008
    ..Results show that for some patients with Alzheimer's disease, patterns of symptoms of depression are similar to those in younger adult populations. A distinct subtype may exist, however, with prominent anxiety and irritability...
  25. ncbi Influence of sociodemographic variables on neuropsychological test performance in Spanish-speaking older adults
    Amarilis Acevedo
    Center on Aging and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33140, USA
    J Clin Exp Neuropsychol 29:530-44. 2007
    ..These results underscore the impact of educational attainment on neuropsychological test performance among the cognitively normal Spanish-speaking older adult...
  26. ncbi Stability of neurocognitive impairment in different subtypes of mild cognitive impairment
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Dement Geriatr Cogn Disord 23:82-6. 2007
    ....
  27. ncbi Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors
    David A Loewenstein
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 12:395-402. 2004
    ..The authors evaluated the efficacy of a new cognitive rehabilitation program on memory and functional performance of mildly impaired Alzheimer disease (AD) patients receiving a cholinesterase inhibitor...
  28. doi Visual rating system for assessing magnetic resonance images: a tool in the diagnosis of mild cognitive impairment and Alzheimer disease
    Raksha Urs
    Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA
    J Comput Assist Tomogr 33:73-8. 2009
    ....
  29. pmc An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology
    Christian Wider
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    J Neurol Neurosurg Psychiatry 83:424-9. 2012
    ..The study investigates the effects of genetic factors on the pathology of Alzheimer's disease (AD) and Lewy body (LB) diseases, including Parkinson's disease and dementia with Lewy bodies...
  30. ncbi The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave Sarasota, FL, USA
    Neurosci Lett 395:240-3. 2006
    ..464, CI = [.351-.885], p = .013). In this sample, the C allele of COX-2 -765 promoter polymorphism is associated with decreased risk of Alzheimer's disease, a finding which further supports the involvement of COX-2 in AD etiology...
  31. doi Towards an earlier diagnosis of Alzheimer disease (Proceedings of the 5th MCI Symposium, 2007)
    Lisa J Bain
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
    Alzheimer Dis Assoc Disord 22:99-110. 2008
    ..As was intended, the symposium delivered no consensus; however, there was substantial support for the idea that AD can and probably should be diagnosed before the onset of dementia, particularly as new interventions become available...
  32. ncbi A clinical perspective of mild cognitive impairment: what radiologists should know
    Ranjan Duara
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
    Neuroimaging Clin N Am 15:779-88, x. 2005
    ..Treatment trials show no disease-modifying effect. The radiologists' role is to determine whether or not the hallmarks of degenerative and vascular disease of the brain are present, aiding in the diagnosis of the cause of MCI...
  33. ncbi Semantic interference in mild Alzheimer disease: preliminary findings
    David A Loewenstein
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami Beach, FL 33140, USA
    Am J Geriatr Psychiatry 11:252-5. 2003
    ..The authors evaluated the usefulness and psychometric properties of the Semantic Interference Test (SIT) in patients with mild Alzheimer disease (AD)...
  34. ncbi Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank
    Warren W Barker
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Alzheimer Dis Assoc Disord 16:203-12. 2002
    ..These estimates of the a priori probabilities of dementing disorders have implications for clinicians and researchers...
  35. pmc Neuropathologically defined subtypes of Alzheimer's disease differ significantly from neurofibrillary tangle-predominant dementia
    Nicholas J Janocko
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Acta Neuropathol 124:681-92. 2012
    ....
  36. ncbi Prevalence of dementia in three ethnic groups: the South Florida program on aging and health
    Jasenka Demirovic
    School of Public Health, University of Texas Health Science Center, Houston, TX 77225, USA
    Ann Epidemiol 13:472-8. 2003
    ..4% vs. 5.4%). Age (p = 0.001), family history of AD (p = 0.02) and African American (p = 0.0001) or Cuban (p = 0.006) ethnic group were directly and independently associated with the prevalence of AD...
  37. ncbi Apolipoprotein E polymorphism and cognitive impairment in a bi-ethnic community-dwelling elderly sample
    Dylan G Harwood
    Neuropsychiatric Institute and Hospital, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    Alzheimer Dis Assoc Disord 16:8-14. 2002
    ..The epsilon 2 allele of APOE did not confer decreased risk for cognitive impairment among NHW and WH. This study supports the relation of APOE polymorphism to cognitive dysfunction among two ethnic populations residing in the community...
  38. ncbi Apolipoprotein E genotype and cognitive impairment in community-dwelling black older adults
    Dylan G Harwood
    University of California, Los Angeles School of Medicine, USA
    Int J Psychiatry Med 32:55-67. 2002
    ..Therefore, the current study explored the relation of APOE-epsilon4 with cognitive impairment in a sample of community-dwelling English-speaking elderly blacks...
  39. ncbi Depression as a risk factor for Alzheimer disease: the MIRAGE Study
    Robert C Green
    Department of Neurology, Genetics Program, Boston University School of Medicine, MA 02118, USA
    Arch Neurol 60:753-9. 2003
    ..Depression symptoms may be associated with the development of Alzheimer disease (AD)...
  40. ncbi Verbal fluency in bilingual Spanish/English Alzheimer's disease patients
    Judy Salvatierra
    Department of Psychology, Charles Schmidt College of Science, Florida Atlantic University, Davie, Florida 33314 7714, USA
    Am J Alzheimers Dis Other Demen 22:190-201. 2007
    ..This pattern was produced in both languages, implying a related semantic decline in both languages. Results from this study should be considered preliminary because of the small sample size...
  41. ncbi No association between subjective memory complaints and apolipoprotein E genotype in cognitively intact elderly
    Dylan G Harwood
    Neuropsychiatric Institute and Hospital, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, USA
    Int J Geriatr Psychiatry 19:1131-9. 2004
    ....
  42. ncbi Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample
    Dylan G Harwood
    Neuropsychiatric Institute and Hospital, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    Int Psychogeriatr 16:317-26. 2004
    ..This study examined the association between the Apolipoprotein-E epsilon4 allele (APOE epsilon4) and age of disease onset in a bi-ethnic sample of community dwelling Alzheimer's disease (AD) patients...
  43. pmc Association studies between the plasmin genes and late-onset Alzheimer's disease
    Nobuto Shibata
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto and Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
    Neurobiol Aging 28:1041-3. 2007
    ..Thus, the current survey does not support the notion that common polymorphisms in the plasmin genes influence the development of AD...
  44. ncbi Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 66:142-51. 2007
    ..On the other hand, there is no histopathologic feature or combination of features that is pathognomonic. Neuronal intranuclear inclusions are virtually always present, but they can be detected in PGRN(-) cases...
  45. pmc Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI
    Clifford R Jack
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurobiol Aging 29:1285-95. 2008
    ..000). Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI...
  46. pmc TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
    Catalina Amador-Ortiz
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 61:435-45. 2007
    ....
  47. pmc The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 39:168-77. 2007
    ..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...