S Dracheva

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    J Neurochem 87:1402-12. 2003
  2. ncbi request reprint mRNA expression of AMPA receptors and AMPA receptor binding proteins in the cerebral cortex of elderly schizophrenics
    Stella Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 79:868-78. 2005
  3. pmc Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait
    Stella Dracheva
    James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuropsychopharmacology 34:2237-51. 2009
  4. pmc Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
    Alexey Kozlenkov
    VISN 3 Mental Illness Research, Education and Clinical Center MIRECC, James J Peters VA Medical Center, Bronx, NY, USA, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Research Division, Hospital for Special Surgery, New York, NY, USA, Illumina, Inc, San Diego, CA, USA and National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
    Nucleic Acids Res 42:109-27. 2014
  5. pmc Dependencies among editing sites in serotonin 2C receptor mRNA
    Liran Carmel
    Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Edmond J Safra Campus, Givat Ram, Jerusalem, Israel
    PLoS Comput Biol 8:e1002663. 2012
  6. pmc Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease
    Rita De Gasperi
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Mol Neurodegener 5:38. 2010
  7. doi request reprint Altered serotonin 2C receptor RNA splicing in suicide: association with editing
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Neuroreport 19:379-82. 2008
  8. ncbi request reprint Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mol Psychiatry 13:1001-10. 2008
  9. ncbi request reprint Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice
    S Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 905:142-51. 2001
  10. ncbi request reprint N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Am J Psychiatry 158:1400-10. 2001

Collaborators

Detail Information

Publications23

  1. ncbi request reprint RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    J Neurochem 87:1402-12. 2003
    ..Quantitation of 5-HT2CR and 5-HT2CR-tr mRNA variants revealed that the expression of 5-HT2CR-tr was approximately 50% of that observed for the full-length isoform...
  2. ncbi request reprint mRNA expression of AMPA receptors and AMPA receptor binding proteins in the cerebral cortex of elderly schizophrenics
    Stella Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 79:868-78. 2005
    ..Small but significant differences in the amounts of GluR2, GluR3, and GRIP mRNAs were detected between the two cortical areas: more GluR3 and GRIP but less GluR2 were detected in the DLPFC than in the occipital cortex...
  3. pmc Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait
    Stella Dracheva
    James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuropsychopharmacology 34:2237-51. 2009
    ..No differences in the 5-HT(2C)R expression were detected between the behavioral phenotypes. However, editing was higher in the PFC of HRs vs LRs, implicating this region in the pathophysiology of drug abuse liability...
  4. pmc Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
    Alexey Kozlenkov
    VISN 3 Mental Illness Research, Education and Clinical Center MIRECC, James J Peters VA Medical Center, Bronx, NY, USA, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Research Division, Hospital for Special Surgery, New York, NY, USA, Illumina, Inc, San Diego, CA, USA and National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
    Nucleic Acids Res 42:109-27. 2014
    ..Finally, non-CpG methylation was substantially more prevalent in neurons than in nonneuronal cells...
  5. pmc Dependencies among editing sites in serotonin 2C receptor mRNA
    Liran Carmel
    Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science, The Hebrew University of Jerusalem, Edmond J Safra Campus, Givat Ram, Jerusalem, Israel
    PLoS Comput Biol 8:e1002663. 2012
    ..Statistical approach developed here can be applied to other cases of interdependencies among modification sites in RNA and proteins...
  6. pmc Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease
    Rita De Gasperi
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Mol Neurodegener 5:38. 2010
    ..Here we investigated whether Psen1 might regulate hypoxic responses by modulating induction of the transcription factor hypoxia inducible factor 1-α (HIF-1α)...
  7. doi request reprint Altered serotonin 2C receptor RNA splicing in suicide: association with editing
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Neuroreport 19:379-82. 2008
    ..The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo...
  8. ncbi request reprint Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mol Psychiatry 13:1001-10. 2008
    ..Thus, at least in patients with SZ or BPD, overexpression of the VSV isoform in the prefrontal cortex may represent an additional risk factor for suicidal behavior...
  9. ncbi request reprint Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice
    S Dracheva
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 905:142-51. 2001
    ....
  10. ncbi request reprint N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    S Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Am J Psychiatry 158:1400-10. 2001
    ....
  11. ncbi request reprint Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain
    T L Lauriat
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1229, New York, NY 10029, USA
    Neuroscience 137:843-51. 2006
    ..However, because most of the schizophrenic subjects in the cohort had been treated with antipsychotics for many years, it is still possible that changes in transporter expression were masked by medication effects...
  12. ncbi request reprint Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Int J Neuropsychopharmacol 10:565-73. 2007
    ....
  13. ncbi request reprint The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, Rm 4F 33A, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Psychiatry 163:1834-7. 2006
    ..The authors sought to understand the origins of oligodendrocyte/myelin gene expression abnormalities in the brains of persons with schizophrenia...
  14. ncbi request reprint Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton
    Tara L Lauriat
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1121:1-11. 2006
    ..Therefore, KIAA0513 is likely to be involved in signaling pathways related to these processes...
  15. ncbi request reprint Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurobiol Dis 21:531-40. 2006
    ..Thus, OMR gene and protein expression deficits in schizophrenia are brain-region specific, and the affected components may share regulatory elements...
  16. ncbi request reprint GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 76:581-92. 2004
    ....
  17. pmc Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
    Schizophr Res 98:118-28. 2008
    ..All markers were differentially expressed across nuclei...
  18. doi request reprint Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia
    David Kerns
    J J Peters VA Medical Center, 130 West Kingsbridge Ave, Bronx, New York, NY 10468, USA
    Schizophr Res 120:150-8. 2010
    ..These data are consistent with the hypothesis that Ol and myelin deficits in SZ involve a failure of Ol precursors to appropriately exit the cell cycle in order to differentiate and mature into myelinating Ols...
  19. ncbi request reprint Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder
    Kevin Barley
    J J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Ave, Bronx, NY 10468, USA
    Schizophr Res 112:54-64. 2009
    ..These data are discussed in the context of myelin turnover and potential effects of psychiatric illness as well as medications on the developmental fate of OLPs...
  20. doi request reprint TaqMan-based, real-time quantitative polymerase chain reaction method for RNA editing analysis
    Kevin Wong
    James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Anal Biochem 390:173-80. 2009
    ....
  21. ncbi request reprint Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice
    S Dracheva
    Dr Arthur M Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 157:169-79. 1999
    ..These studies demonstrate that altering the levels of D1 receptor expression reverses the effects of D1 agonism on locomotor initiation and rearing...
  22. pmc Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Brain Res 1214:23-34. 2008
    ..These results provide detailed and quantitative information on iGluR subunit expression in multiple nuclei of the human thalamus but suggest that alterations in their expression are not a prominent feature of schizophrenia...
  23. ncbi request reprint Abnormalities in the dopamine system in schizophrenia may lie in altered levels of dopamine receptor-interacting proteins
    Jie Bai
    Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Biol Psychiatry 56:427-40. 2004
    ....

Research Grants1