Dara L Dickstein

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Dendritic spine changes associated with normal aging
    D L Dickstein
    Fishberg Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Neuroscience 251:21-32. 2013
  2. pmc Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
  3. pmc Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010
  4. pmc Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau
    Dara L Dickstein
    Department of Neuroscience, Mount Sinai School of Medicine, Box 1065, One Gustave L Levy Place, New York, NY, 10029, USA
    Brain Struct Funct 214:161-79. 2010
  5. pmc Role of vascular risk factors and vascular dysfunction in Alzheimer's disease
    Dara L Dickstein
    Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:82-102. 2010
  6. pmc Changes in the structural complexity of the aged brain
    Dara L Dickstein
    Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
    Aging Cell 6:275-84. 2007
  7. pmc Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations
    Miguel A Gama Sosa
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA
    Am J Pathol 176:353-68. 2010
  8. pmc Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration
    Lap Ho
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    J Alzheimers Dis 16:59-72. 2009
  9. pmc Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells
    Aniruddha Yadav
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 520:2888-902. 2012
  10. ncbi request reprint Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model
    John W Steele
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, 10065, USA Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
    J Comp Neurol 522:2319-35. 2014

Collaborators

Detail Information

Publications21

  1. pmc Dendritic spine changes associated with normal aging
    D L Dickstein
    Fishberg Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
    Neuroscience 251:21-32. 2013
    ....
  2. pmc Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology
    Steve Pedrini
    Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
    Mol Neurodegener 4:40. 2009
    ..abstract:..
  3. pmc Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
    Ozlem Bozdagi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Autism 1:15. 2010
    ..abstract:..
  4. pmc Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau
    Dara L Dickstein
    Department of Neuroscience, Mount Sinai School of Medicine, Box 1065, One Gustave L Levy Place, New York, NY, 10029, USA
    Brain Struct Funct 214:161-79. 2010
    ..Such alterations in dendrites and spines may result in the deterioration of neuronal function observed in AD, and provide a morphologic substrate for the relationship between synaptic integrity and cognitive decline...
  5. pmc Role of vascular risk factors and vascular dysfunction in Alzheimer's disease
    Dara L Dickstein
    Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 77:82-102. 2010
    ..Here we discuss vascular factors with respect to Alzheimer's disease and dementia and review the factors that give rise to vascular dysfunction and contribute to Alzheimer's disease...
  6. pmc Changes in the structural complexity of the aged brain
    Dara L Dickstein
    Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
    Aging Cell 6:275-84. 2007
    ..Together these multiple alterations in the brain may constitute the substrate for age-related loss of cognitive function...
  7. pmc Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations
    Miguel A Gama Sosa
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA
    Am J Pathol 176:353-68. 2010
    ..These studies thus have implications for the role of neuronal to vascular signaling in the pathogenesis of the vascular pathology associated with AD...
  8. pmc Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration
    Lap Ho
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    J Alzheimers Dis 16:59-72. 2009
    ..Results from these studies suggest the possibility of developing a "combination" of dietary polyphenolic compounds for AD prevention and/or therapy by modulating multiple Abeta-related mechanisms...
  9. pmc Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells
    Aniruddha Yadav
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 520:2888-902. 2012
    ..We also found that mushroom-shaped and stubby spines are predominant in clusters on dendritic segments that display prolific clustering, independently supporting a causal link between spine morphology and synaptic clustering...
  10. ncbi request reprint Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model
    John W Steele
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, 10065, USA Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
    J Comp Neurol 522:2319-35. 2014
    ..These changes, taken together with toxic insults from amyloid-β protein, may underlie the observed neuronal loss...
  11. pmc Presenilin transgenic mice as models of Alzheimer's disease
    Gregory A Elder
    Neurology Service 3E16, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA
    Brain Struct Funct 214:127-43. 2010
    ..The relevance of PS transgenic mice as models of AD is discussed...
  12. pmc The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease
    Hannah Brautigam
    Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Mol Neurodegener 7:58. 2012
    ..We investigated whether two APP mouse models characterized by different folding states of amyloid showed different neuronal densities using an accurate method of cell counting...
  13. pmc Carvedilol as a potential novel agent for the treatment of Alzheimer's disease
    Jun Wang
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 32:2321.e1-12. 2011
    ..Our novel observation that carvedilol interferes with the neuropathologic, biochemical, and electrophysiological mechanisms underlying cognitive deterioration in AD supports the potential development of carvedilol as a treatment for AD...
  14. pmc Novel cerebrovascular pathology in mice fed a high cholesterol diet
    Sonia Franciosi
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Neurodegener 4:42. 2009
    ..abstract:..
  15. pmc Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images
    Alfredo Rodriguez
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 3:e1997. 2008
    ..The technique opens new horizons on the objective evaluation of spine changes with synaptic plasticity, normal development and aging, and with neurodegenerative disorders that impair cognitive function...
  16. pmc Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain
    Sonia Franciosi
    Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Neurosci Methods 163:76-82. 2007
    ..This method should be widely applicable for labeling the brain vasculature of the mouse in aldehyde fixed tissue from both normal and pathological states...
  17. ncbi request reprint Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    FASEB J 20:2313-20. 2006
    ....
  18. ncbi request reprint Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injury
    Miguel A Gama Sosa
    General Medical Research Service, James J, Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, New York, USA
    Acta Neuropathol Commun 2:67. 2014
    ..Rats were sacrificed 24 hours or between 6 and 10 months after exposure. Blast-induced cerebral vascular pathology was examined by a combination of light microscopy, immunohistochemistry, and electron microscopy...
  19. ncbi request reprint Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease
    Dara L Dickstein
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
    FASEB J 20:426-33. 2006
    ..The data therefore provide an intellectual framework for understanding how the immune system can clear amyloid deposits from AD brains and suggest new strategies for limiting disease progression in amyloidopathies...
  20. ncbi request reprint Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    Maki Ujiie
    Biotechnology Laboratory, University of British Columbia, Vancouver V6T 1Z3, Canada
    Microcirculation 10:463-70. 2003
    ....
  21. ncbi request reprint p97 as a biomarker for Alzheimer disease
    Maki Ujiie
    Biotechnology Laboratory and the Biomedical Research Centre Department of Medical Genetics, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3
    Front Biosci 7:e42-7. 2002
    ..The relationship between elevated levels of serum p97 and AD, together with the possible future clinical application of p97 are considered in this report...