Kenneth Davis

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
  2. doi request reprint Commentary: What happens when a combined entity is lesser than the sum of its parts?
    Kenneth Davis
    The Mount Sinai Medical Center, New York, New York, USA
    Acad Med 85:1815-6. 2010
  3. ncbi request reprint White matter changes in schizophrenia: evidence for myelin-related dysfunction
    Kenneth L Davis
    Department of Psychiatry, Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10021, USA
    Arch Gen Psychiatry 60:443-56. 2003
  4. ncbi request reprint Possible contributions of myelin and oligodendrocyte dysfunction to schizophrenia
    Daniel G Stewart
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    Int Rev Neurobiol 59:381-424. 2004
  5. ncbi request reprint Global expression-profiling studies and oligodendrocyte dysfunction in schizophrenia and bipolar disorder
    Kenneth L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 362:758. 2003
  6. pmc Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
    Schizophr Res 98:118-28. 2008
  7. ncbi request reprint Correlates of change in functional status of institutionalized geriatric schizophrenic patients: focus on medical comorbidity
    Joseph I Friedman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 159:1388-94. 2002
  8. ncbi request reprint Caudate and putamen volumes in good and poor outcome patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 64:53-62. 2003
  9. ncbi request reprint Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurobiol Dis 21:531-40. 2006
  10. ncbi request reprint Working memory performance in poor outcome schizophrenia: relationship to age and executive functioning
    Susan R McGurk
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Exp Neuropsychol 26:153-60. 2004

Research Grants

Collaborators

Detail Information

Publications50

  1. pmc Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
    ..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions...
  2. doi request reprint Commentary: What happens when a combined entity is lesser than the sum of its parts?
    Kenneth Davis
    The Mount Sinai Medical Center, New York, New York, USA
    Acad Med 85:1815-6. 2010
    ..He examines the reasons behind dissolving the merger and the factors that have led to Mount Sinai's success since then...
  3. ncbi request reprint White matter changes in schizophrenia: evidence for myelin-related dysfunction
    Kenneth L Davis
    Department of Psychiatry, Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10021, USA
    Arch Gen Psychiatry 60:443-56. 2003
    ....
  4. ncbi request reprint Possible contributions of myelin and oligodendrocyte dysfunction to schizophrenia
    Daniel G Stewart
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
    Int Rev Neurobiol 59:381-424. 2004
  5. ncbi request reprint Global expression-profiling studies and oligodendrocyte dysfunction in schizophrenia and bipolar disorder
    Kenneth L Davis
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 362:758. 2003
  6. pmc Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
    Schizophr Res 98:118-28. 2008
    ..All markers were differentially expressed across nuclei...
  7. ncbi request reprint Correlates of change in functional status of institutionalized geriatric schizophrenic patients: focus on medical comorbidity
    Joseph I Friedman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 159:1388-94. 2002
    ..While cognitive impairment has proven to be a major predictor of overall functional deficit in schizophrenia, other potential factors, such as medical comorbidity, need to be considered...
  8. ncbi request reprint Caudate and putamen volumes in good and poor outcome patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 64:53-62. 2003
    ..This suggests the possibility that the expansion of putamen size may be a physiological correlate of neuroleptic responsiveness or that small putamen size at disease onset may be a predictor of outcome...
  9. ncbi request reprint Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurobiol Dis 21:531-40. 2006
    ..Thus, OMR gene and protein expression deficits in schizophrenia are brain-region specific, and the affected components may share regulatory elements...
  10. ncbi request reprint Working memory performance in poor outcome schizophrenia: relationship to age and executive functioning
    Susan R McGurk
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Exp Neuropsychol 26:153-60. 2004
    ..These findings indicate that LNS may be an index of executive functioning, particularly in patients who cannot perform the WCST...
  11. ncbi request reprint GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    J Neurosci Res 76:581-92. 2004
    ....
  12. ncbi request reprint Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029 6575, USA
    Schizophr Res 79:157-73. 2005
    ....
  13. ncbi request reprint Diffusion tensor imaging in schizophrenia
    Monte S Buchsbaum
    Neuroscience Positron Emission Tomography Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 60:1181-7. 2006
    ..Alignment of white matter axons as inferred from diffusion tensor imaging has indicated changes in schizophrenia in frontal and frontotemporal white matter...
  14. ncbi request reprint The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, Rm 4F 33A, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Psychiatry 163:1834-7. 2006
    ..The authors sought to understand the origins of oligodendrocyte/myelin gene expression abnormalities in the brains of persons with schizophrenia...
  15. ncbi request reprint Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
    Int J Neuropsychopharmacol 10:565-73. 2007
    ....
  16. ncbi request reprint Introduction to the special section: Myelin and oligodendrocyte abnormalities in schizophrenia
    Vahram Haroutunian
    Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Int J Neuropsychopharmacol 10:499-502. 2007
    ....
  17. doi request reprint Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 33:2993-3009. 2008
    ..These data suggest that the normal patterns of cell cycle gene and protein expression are disrupted in SZ and that this disruption may contribute to the oligodendroglial deficits observed in SZ...
  18. doi request reprint Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients
    Joseph I Friedman
    Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Psychiatry 165:1024-32. 2008
    ....
  19. pmc Temporal characteristics of tract-specific anisotropy abnormalities in schizophrenia
    David M Carpenter
    Department of Radiology ISL, Box 1234, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroreport 19:1369-72. 2008
    ..The findings suggest that there are white matter tract-specific degenerative mechanisms that may be present at the point of illness onset and may progress throughout the illness...
  20. ncbi request reprint The pathophysiology of schizophrenia disorders: perspectives from the spectrum
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 161:398-413. 2004
    ..A pathophysiological model of the relationship between schizotypal personality disorder and schizophrenia was developed based on this data...
  21. ncbi request reprint Kraepelinian and non-Kraepelinian schizophrenia subgroup differences in cerebral metabolic rate
    Monte S Buchsbaum
    Neuroscience PET Laboratory and Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 55:25-40. 2002
    ..A combined frontal/temporal deficit or greater cortical change may be associated with poorer longitudinal course...
  22. ncbi request reprint Cortical and subcortical cognitive deficits in schizophrenia: convergence of classifications based on language and memory skill areas
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Clin Exp Neuropsychol 24:55-66. 2002
    ..These data suggest that cortical versus subcortical profiles of cognitive performance in schizophrenia are inconsistent across ability areas, and are not likely to be the result of stable structural or functional brain deficits...
  23. ncbi request reprint Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 53:1075-85. 2003
    ..Brain imaging, molecular genetic, and ultrastructural evidence indicate the existence of pathologic alterations in the cortical and subcortical white matter of schizophrenic patients...
  24. ncbi request reprint The effect of citalopram adjunctive treatment added to atypical antipsychotic medications for cognitive performance in patients with schizophrenia
    Joseph I Friedman
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Clin Psychopharmacol 25:237-42. 2005
    ..Further research on alternative serotonergic approaches to cognitive enhancement in schizophrenia is warranted...
  25. ncbi request reprint A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophrenia
    Joseph I Friedman
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 51:349-57. 2002
    ..Subtle changes in cholinergic function in schizophrenic patients provide the rationale to test the effectiveness of cholinesterase inhibitors in treating cognitive impairment in schizophrenia...
  26. ncbi request reprint Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia
    Patrick R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neurochem Res 27:1193-200. 2002
    ..Therapies modulating oligodendrocyte survival and differentiation may therefore be beneficial in schizophrenia...
  27. doi request reprint The effects of hypertension and body mass index on cognition in schizophrenia
    Joseph I Friedman
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Psychiatry 167:1232-9. 2010
    ..The authors investigated whether vascular risk factors influence the cognitive impairments of schizophrenia and whether their effects on cognition in schizophrenia are different from those observed in nonpsychiatric comparison subjects...
  28. ncbi request reprint Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism
    Nicolas Ramoz
    Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 161:662-9. 2004
    ..In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region...
  29. ncbi request reprint The course of functional decline in geriatric patients with schizophrenia: cognitive-functional and clinical symptoms as determinants of change
    Philip D Harvey
    Mt Sinai School of Medicine, New York, NY 10029, USA
    Am J Geriatr Psychiatry 11:610-9. 2003
    ..Authors sought to use a cognitive assessment instrument validated for assessing low-functioning patients to broaden knowledge about the rate and correlates of functional decline...
  30. pmc Type 2 diabetes is negatively associated with Alzheimer's disease neuropathology
    Michal Schnaider Beeri
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    J Gerontol A Biol Sci Med Sci 60:471-5. 2005
    ..The present descriptive study compared diabetic and nondiabetic subjects on the severity of neuritic plaques and neurofibrillary tangles (NFTs) in the cerebral cortex and in the hippocampus...
  31. ncbi request reprint Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer disease
    Michael Serby
    Departments of Psychiatry and Psychology, Mount Sinai School of Medicine, New York, NY, USA
    Am J Geriatr Psychiatry 11:371-4. 2003
    ....
  32. ncbi request reprint Validity and stability of performance-based estimates of premorbid educational functioning in older patients with schizophrenia
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Clin Exp Neuropsychol 28:178-92. 2006
    ..The results of these two studies suggest that word-recognition reading skills are useful screening instruments to estimate premorbid functioning even in deteriorated patients with schizophrenia...
  33. ncbi request reprint Seasonality effects on schizophrenic births in multiplex families in a tropical island
    JOSE R CARRION-BARALT
    Department of Psychiatry, Box 1230, Mt Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 142:93-7. 2006
    ....
  34. ncbi request reprint Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjects
    Joseph I Friedman
    Schizophr Res 100:356-8. 2008
  35. ncbi request reprint Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia
    Sarah M Clinton
    Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
    Am J Psychiatry 160:1100-9. 2003
    ..They hypothesized that this reduction is associated with specific NR(1) isoforms and that NMDA receptor-related postsynaptic density proteins are abnormally expressed...
  36. pmc Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Schizophr Res 90:15-27. 2007
    ..Our results support the hypothesis that myelination and oligodendrocyte function are impaired in schizophrenia...
  37. ncbi request reprint Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia
    Oxana O Polesskaya
    Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci Res 74:111-22. 2003
    ..These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors...
  38. ncbi request reprint Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia
    Helena T Mueller
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Brain Res Mol Brain Res 121:60-9. 2004
    ..These data support the hypothesis that schizophrenia may involve alterations in dopamine-glutamate interactions...
  39. ncbi request reprint Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia
    Carmen M Martin-Ruiz
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Biol Psychiatry 54:1222-33. 2003
    ..The etiology of dementia that occurs in patients with schizophrenia is not well understood. Nicotinic acetylcholine receptors have been implicated in cognitive function, and deficits in these receptors have been reported in schizophrenia...
  40. pmc Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 103:12469-74. 2006
    ..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function...
  41. ncbi request reprint Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's disease
    Pavel L Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine New York, New York 10029 USA
    Int Rev Neurobiol 63:41-82. 2005
  42. ncbi request reprint Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
    Daya S Gupta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
    Synapse 57:123-31. 2005
    ....
  43. ncbi request reprint Mitochondrial enzymes in schizophrenia
    Parvesh Bubber
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, NY, 10605, USA
    J Mol Neurosci 24:315-21. 2004
    ..However, in schizophrenia, unlike a number of neurodegenerative diseases, reductions in the activities of the key mitochondrial enzymes KGDHC and PDHC are not frequent...
  44. ncbi request reprint Long-term outcomes in chronically hospitalized geriatric patients with schizophrenia: retrospective comparison of first generation and second generation antipsychotics
    Leonard White
    Clinical Neuroscience Center, Pilgrim Psychiatric Center, West Brentwood, NY 11717, USA
    Schizophr Res 88:127-34. 2006
    ..Although many of these patients experience minimal reduction of psychotic symptoms, there may be beneficial effects of antipsychotic treatments on cognitive functions and functional capacity...
  45. ncbi request reprint Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients
    Martin R Gluck
    Departmnent of Neurology, Medical Research Building, Bronx Veterans Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 159:1165-73. 2002
    ....
  46. ncbi request reprint Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilin
    Sarah M Clinton
    Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Am J Psychiatry 162:1859-71. 2005
    ..In this study, the authors studied this question by measuring in postmortem brain the expression of molecules associated with dopaminergic neurotransmission...
  47. ncbi request reprint Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia
    Emile G Bruneau
    Mental Health Research Institute and Department of Psychiatry, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Schizophr Res 75:27-34. 2005
    ..Increased PAG and GS transcripts suggest enhanced glutamatergic neurotransmission in the thalamus and its efferent targets in schizophrenia...
  48. ncbi request reprint Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
    Paul S Aisen
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA
    JAMA 289:2819-26. 2003
    ....
  49. ncbi request reprint Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry
    Daniel H Mathalon
    Arch Gen Psychiatry 60:846-8; author reply 848-9. 2003
  50. ncbi request reprint Special issue: Molecular mechanisms of schizophrenia
    Joseph I Friedman
    Biol Psychiatry 60:527-9. 2006

Research Grants3

  1. MENTAL HEALTH CRC TO STUDY GERIATRIC SCHIZOPHRENIA
    Kenneth Davis; Fiscal Year: 2002
    ....
  2. FACILITY RENOVATION AND ANNENBERG CAGE WASH FACILITIY
    Kenneth Davis; Fiscal Year: 2003
    ..e. soiled nonhuman primate cages). ..