Research Topics
Species | Kenneth DavisSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controlsCheuk Y Tang
Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
BMC Psychiatry 7:25. 2007..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions...
Commentary: What happens when a combined entity is lesser than the sum of its parts?Kenneth Davis
The Mount Sinai Medical Center, New York, New York, USA
Acad Med 85:1815-6. 2010..He examines the reasons behind dissolving the merger and the factors that have led to Mount Sinai's success since then...
White matter changes in schizophrenia: evidence for myelin-related dysfunctionKenneth L Davis
Department of Psychiatry, Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10021, USA
Arch Gen Psychiatry 60:443-56. 2003....- Possible contributions of myelin and oligodendrocyte dysfunction to schizophreniaDaniel G Stewart
Mount Sinai School of Medicine, Department of Psychiatry, New York, NY 10029, USA
Int Rev Neurobiol 59:381-424. 2004 - Global expression-profiling studies and oligodendrocyte dysfunction in schizophrenia and bipolar disorderKenneth L Davis
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Lancet 362:758. 2003 - Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nucleiWilliam Byne
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
Schizophr Res 98:118-28. 2008..All markers were differentially expressed across nuclei... - Correlates of change in functional status of institutionalized geriatric schizophrenic patients: focus on medical comorbidityJoseph I Friedman
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Psychiatry 159:1388-94. 2002..While cognitive impairment has proven to be a major predictor of overall functional deficit in schizophrenia, other potential factors, such as medical comorbidity, need to be considered... - Caudate and putamen volumes in good and poor outcome patients with schizophreniaMonte S Buchsbaum
Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
Schizophr Res 64:53-62. 2003..This suggests the possibility that the expansion of putamen size may be a physiological correlate of neuroleptic responsiveness or that small putamen size at disease onset may be a predictor of outcome... - Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patientsStella Dracheva
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
Neurobiol Dis 21:531-40. 2006..Thus, OMR gene and protein expression deficits in schizophrenia are brain-region specific, and the affected components may share regulatory elements... - Working memory performance in poor outcome schizophrenia: relationship to age and executive functioningSusan R McGurk
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
J Clin Exp Neuropsychol 26:153-60. 2004..These findings indicate that LNS may be an index of executive functioning, particularly in patients who cannot perform the WCST... - GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophreniaStella Dracheva
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
J Neurosci Res 76:581-92. 2004.... - Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology studyPavel Katsel
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029 6575, USA
Schizophr Res 79:157-73. 2005.... - Diffusion tensor imaging in schizophreniaMonte S Buchsbaum
Neuroscience Positron Emission Tomography Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
Biol Psychiatry 60:1181-7. 2006..Alignment of white matter axons as inferred from diffusion tensor imaging has indicated changes in schizophrenia in frontal and frontotemporal white matter... - The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophreniaVahram Haroutunian
Department of Psychiatry, Rm 4F 33A, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
Am J Psychiatry 163:1834-7. 2006..The authors sought to understand the origins of oligodendrocyte/myelin gene expression abnormalities in the brains of persons with schizophrenia... - Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophreniaVahram Haroutunian
Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6575, USA
Int J Neuropsychopharmacol 10:565-73. 2007.... - Introduction to the special section: Myelin and oligodendrocyte abnormalities in schizophreniaVahram Haroutunian
Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
Int J Neuropsychopharmacol 10:499-502. 2007.... - Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytesPavel Katsel
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
Neuropsychopharmacology 33:2993-3009. 2008..These data suggest that the normal patterns of cell cycle gene and protein expression are disrupted in SZ and that this disruption may contribute to the oligodendroglial deficits observed in SZ... - Diffusion tensor imaging findings in first-episode and chronic schizophrenia patientsJoseph I Friedman
Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Am J Psychiatry 165:1024-32. 2008.... - Temporal characteristics of tract-specific anisotropy abnormalities in schizophreniaDavid M Carpenter
Department of Radiology ISL, Box 1234, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Neuroreport 19:1369-72. 2008..The findings suggest that there are white matter tract-specific degenerative mechanisms that may be present at the point of illness onset and may progress throughout the illness... - The pathophysiology of schizophrenia disorders: perspectives from the spectrumLarry J Siever
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Am J Psychiatry 161:398-413. 2004..A pathophysiological model of the relationship between schizotypal personality disorder and schizophrenia was developed based on this data... - Kraepelinian and non-Kraepelinian schizophrenia subgroup differences in cerebral metabolic rateMonte S Buchsbaum
Neuroscience PET Laboratory and Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
Schizophr Res 55:25-40. 2002..A combined frontal/temporal deficit or greater cortical change may be associated with poorer longitudinal course... - Cortical and subcortical cognitive deficits in schizophrenia: convergence of classifications based on language and memory skill areasPhilip D Harvey
Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY 10029, USA
J Clin Exp Neuropsychol 24:55-66. 2002..These data suggest that cortical versus subcortical profiles of cognitive performance in schizophrenia are inconsistent across ability areas, and are not likely to be the result of stable structural or functional brain deficits... - Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophreniaPatrick R Hof
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
Biol Psychiatry 53:1075-85. 2003..The data support recent evidence that several genes encoding myelin-related proteins consistently exhibit reduced expression in schizophrenia... - The effect of citalopram adjunctive treatment added to atypical antipsychotic medications for cognitive performance in patients with schizophreniaJoseph I Friedman
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychopharmacol 25:237-42. 2005..Further research on alternative serotonergic approaches to cognitive enhancement in schizophrenia is warranted... - A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophreniaJoseph I Friedman
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10029, USA
Biol Psychiatry 51:349-57. 2002..An alternative treatment is the allosterically potentiating ligands, which enhance the activity of (sensitize) nicotinic receptors in the presence of acetylcholine... - Molecular and cellular evidence for an oligodendrocyte abnormality in schizophreniaPatrick R Hof
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Neurochem Res 27:1193-200. 2002..Therapies modulating oligodendrocyte survival and differentiation may therefore be beneficial in schizophrenia... - The effects of hypertension and body mass index on cognition in schizophreniaJoseph I Friedman
Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
Am J Psychiatry 167:1232-9. 2010..The authors investigated whether vascular risk factors influence the cognitive impairments of schizophrenia and whether their effects on cognition in schizophrenia are different from those observed in nonpsychiatric comparison subjects... - Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autismNicolas Ramoz
Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Psychiatry 161:662-9. 2004..In the present study, genes across the 2q24-q33 interval were analyzed to identify an autism susceptibility gene in this region... - The course of functional decline in geriatric patients with schizophrenia: cognitive-functional and clinical symptoms as determinants of changePhilip D Harvey
Mt Sinai School of Medicine, New York, NY 10029, USA
Am J Geriatr Psychiatry 11:610-9. 2003..Authors sought to use a cognitive assessment instrument validated for assessing low-functioning patients to broaden knowledge about the rate and correlates of functional decline... - Type 2 diabetes is negatively associated with Alzheimer's disease neuropathologyMichal Schnaider Beeri
Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
J Gerontol A Biol Sci Med Sci 60:471-5. 2005..Future studies are encouraged to examine a variety of other characteristics such as age that may interact with diabetes affecting the incidence of AD... - Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer diseaseMichael Serby
Departments of Psychiatry and Psychology, Mount Sinai School of Medicine, New York, NY, USA
Am J Geriatr Psychiatry 11:371-4. 2003..CONCLUSION: The co-occurrence of AD and LB pathology is associated with higher numbers of LBs and more severe dementia than when classical AD or LB lesions occur alone... - Validity and stability of performance-based estimates of premorbid educational functioning in older patients with schizophreniaPhilip D Harvey
Department of Psychiatry, Mt Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
J Clin Exp Neuropsychol 28:178-92. 2006..The results of these two studies suggest that word-recognition reading skills are useful screening instruments to estimate premorbid functioning even in deteriorated patients with schizophrenia... - Seasonality effects on schizophrenic births in multiplex families in a tropical islandJOSE R CARRION-BARALT
Department of Psychiatry, Box 1230, Mt Sinai School of Medicine, New York, NY 10029, USA
Psychiatry Res 142:93-7. 2006.... - Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjectsJoseph I Friedman
Schizophr Res 100:356-8. 2008 - Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophreniaSarah M Clinton
Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
Am J Psychiatry 160:1100-9. 2003..They hypothesized that this reduction is associated with specific NR(1) isoforms and that NMDA receptor-related postsynaptic density proteins are abnormally expressed... - Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophreniaRobert E McCullumsmith
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
Schizophr Res 90:15-27. 2007..Our results support the hypothesis that myelination and oligodendrocyte function are impaired in schizophrenia... - Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophreniaOxana O Polesskaya
Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci Res 74:111-22. 2003..These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors... - Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophreniaHelena T Mueller
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Brain Res Mol Brain Res 121:60-9. 2004..These data support the hypothesis that schizophrenia may involve alterations in dopamine-glutamate interactions... - Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophreniaCarmen M Martin-Ruiz
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
Biol Psychiatry 54:1222-33. 2003..Further investigations are required to establish whether the reduction in alpha7 protein in the dorsal lateral prefrontal cortex is associated with clinical features other than dementia in schizophrenia... - Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophreniaLyudmila Georgieva
Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
Proc Natl Acad Sci U S A 103:12469-74. 2006..Our data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function... - Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's diseasePavel L Katsel
Department of Psychiatry, The Mount Sinai School of Medicine New York, New York 10029 USA
Int Rev Neurobiol 63:41-82. 2005 - Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophreniaDaya S Gupta
Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
Synapse 57:123-31. 2005.... - Mitochondrial enzymes in schizophreniaParvesh Bubber
Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, NY, 10605, USA
J Mol Neurosci 24:315-21. 2004..However, in schizophrenia, unlike a number of neurodegenerative diseases, reductions in the activities of the key mitochondrial enzymes KGDHC and PDHC are not frequent... - Long-term outcomes in chronically hospitalized geriatric patients with schizophrenia: retrospective comparison of first generation and second generation antipsychoticsLeonard White
Clinical Neuroscience Center, Pilgrim Psychiatric Center, West Brentwood, NY 11717, USA
Schizophr Res 88:127-34. 2006..Although many of these patients experience minimal reduction of psychotic symptoms, there may be beneficial effects of antipsychotic treatments on cognitive functions and functional capacity... - Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patientsMartin R Gluck
Departmnent of Neurology, Medical Research Building, Bronx Veterans Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
Am J Psychiatry 159:1165-73. 2002.... - Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilinSarah M Clinton
Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Am J Psychiatry 162:1859-71. 2005..In this study, the authors studied this question by measuring in postmortem brain the expression of molecules associated with dopaminergic neurotransmission... - Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophreniaEmile G Bruneau
Mental Health Research Institute and Department of Psychiatry, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Schizophr Res 75:27-34. 2005..Increased PAG and GS transcripts suggest enhanced glutamatergic neurotransmission in the thalamus and its efferent targets in schizophrenia... - Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trialPaul S Aisen
Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA
JAMA 289:2819-26. 2003.... - Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometryDaniel H Mathalon
Arch Gen Psychiatry 60:846-8; author reply 848-9. 2003 - Special issue: Molecular mechanisms of schizophreniaJoseph I Friedman
Biol Psychiatry 60:527-9. 2006
Research Grants
- MENTAL HEALTH CRC TO STUDY GERIATRIC SCHIZOPHRENIAKenneth Davis; Fiscal Year: 2002....
- FACILITY RENOVATION AND ANNENBERG CAGE WASH FACILITIYKenneth Davis; Fiscal Year: 2003..e. soiled nonhuman primate cages). ..