TERRY FRANCIS DAVIES

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc New genetic insights from autoimmune thyroid disease
    Terry F Davies
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, NY 10468, USA
    J Thyroid Res 2012:623852. 2012
  2. pmc Clinical review: The emerging cell biology of thyroid stem cells
    Terry F Davies
    Thyroid Research Unit, Mount Sinai School of Medicine, and the James J Peters Veterans Affairs Medical Center, New York, New York 10468, USA
    J Clin Endocrinol Metab 96:2692-702. 2011
  3. pmc Thyrotropin receptor-associated diseases: from adenomata to Graves disease
    Terry F Davies
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 115:1972-83. 2005
  4. pmc The TSH receptor reveals itself
    Terry Davies
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Clin Invest 110:161-4. 2002
  5. pmc The genetics of the thyroid stimulating hormone receptor: history and relevance
    Terry F Davies
    Thyroid Research Unit, James J Peters VA Medical Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 20:727-36. 2010
  6. ncbi Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases
    Yaron Tomer
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 87:404-7. 2002
  7. ncbi Antibody-induced modulation of TSH receptor post-translational processing
    Takao Ando
    Thyroid Research Unit, Mount Sinai School of Medicine, The James J Peters VA Medical Center, Box 1055, 1 Gustave L Levy Place, New York, New York 10029, USA
    J Endocrinol 195:179-86. 2007
  8. pmc Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy
    Xiaoming Yin
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, New York, USA
    Thyroid 18:1201-6. 2008
  9. ncbi Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis
    Yaron Tomer
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Autoimmun 29:69-77. 2007
  10. pmc TSH receptor autoantibodies
    Krzysztof Michalek
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, NY 10468, USA
    Autoimmun Rev 9:113-6. 2009

Research Grants

  1. Monoclonal Thyroid Stimulating Antibodies
    TERRY FRANCIS DAVIES; Fiscal Year: 2010
  2. Monoclonal Thyroid Stimulating Antibodies
    Terry Davies; Fiscal Year: 2006
  3. INTACT AND SCID MOUSE MODELS FOR GRAVES' DISEASE
    Terry Davies; Fiscal Year: 1999
  4. Monoclonal Thyroid Stimulating Antibodies
    Terry Davies; Fiscal Year: 2009
  5. Monoclonal Thyroid Stimulating Antibodies
    Terry Davies; Fiscal Year: 2007
  6. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2002
  7. INTACT AND SCID MOUSE MODELS FOR GRAVES' DISEASE
    Terry Davies; Fiscal Year: 2002
  8. INTACT AND SCID MOUSE MODELS FOR GRAVES' DISEASE
    Terry Davies; Fiscal Year: 2001
  9. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 1999
  10. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2000

Collaborators

Detail Information

Publications55

  1. pmc New genetic insights from autoimmune thyroid disease
    Terry F Davies
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, NY 10468, USA
    J Thyroid Res 2012:623852. 2012
    ..For the clinician, this means that genetic profiling of such patients is unlikely to be fruitful in the near future...
  2. pmc Clinical review: The emerging cell biology of thyroid stem cells
    Terry F Davies
    Thyroid Research Unit, Mount Sinai School of Medicine, and the James J Peters Veterans Affairs Medical Center, New York, New York 10468, USA
    J Clin Endocrinol Metab 96:2692-702. 2011
    ..The use of stem cells in regenerative medicine holds great promise for the treatment of many diseases, including those of the thyroid gland...
  3. pmc Thyrotropin receptor-associated diseases: from adenomata to Graves disease
    Terry F Davies
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 115:1972-83. 2005
    ..However, it may also provide decoys for TSHR antibodies, thus influencing their biological action and clinical effects. This review discusses the role of the TSHR in the physiological and pathological stimulation of the thyroid...
  4. pmc The TSH receptor reveals itself
    Terry Davies
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Clin Invest 110:161-4. 2002
  5. pmc The genetics of the thyroid stimulating hormone receptor: history and relevance
    Terry F Davies
    Thyroid Research Unit, James J Peters VA Medical Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 20:727-36. 2010
    ..The gene for the TSHR on chromosome 14q31 has been implicated as coding for the major autoantigen in the autoimmune hyperthyroidism of Graves' disease (GD) to which T cells and autoantibodies are directed...
  6. ncbi Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases
    Yaron Tomer
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 87:404-7. 2002
    ..Transmission disequilibrium test (TDT) analysis also showed an association of Tgms2 with AITD (p = 0.02). We concluded therefore that the Tg gene was a major AITD susceptibility gene because it was both linked and associated with AITD...
  7. ncbi Antibody-induced modulation of TSH receptor post-translational processing
    Takao Ando
    Thyroid Research Unit, Mount Sinai School of Medicine, The James J Peters VA Medical Center, Box 1055, 1 Gustave L Levy Place, New York, New York 10029, USA
    J Endocrinol 195:179-86. 2007
    ..We propose that this aberrant process, whereby TSHR-Abs influence antigen processing, is a novel mechanism for the maintenance and exacerbation of autoimmune thyroid disease...
  8. pmc Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy
    Xiaoming Yin
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, New York, USA
    Thyroid 18:1201-6. 2008
    ....
  9. ncbi Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis
    Yaron Tomer
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Autoimmun 29:69-77. 2007
    ..In view of the significant genetic heterogeneity observed in AITD, analyzing subsets is an efficient way to resolve heterogeneity and identify novel genes...
  10. pmc TSH receptor autoantibodies
    Krzysztof Michalek
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, NY 10468, USA
    Autoimmun Rev 9:113-6. 2009
    ..Recently non-classical signaling elicited by neutral antibodies has also been described, raising the need for a new classification of TSHR-Abs...
  11. pmc Directed differentiation of mouse embryonic stem cells into thyroid follicular cells
    Maria C Arufe
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 147:3007-15. 2006
    ..In addition, I- uptake activity was observed in these cells. Our results indicate that ES cells can be induced to differentiate into thyroid follicular cells, providing a powerful tool to study embryonic thyroid development and function...
  12. ncbi CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4
    Yang Xu
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Immunol 215:133-40. 2002
    ..In conclusion, both the extrinsic and intrinsic actions of human CTLA-4 were not affected by the signal peptide A49G polymorphism. Therefore, the linkage of the CTLA-4 A49G SNP to AITD is most likely secondary to linkage disequilibrium...
  13. pmc Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss
    Li Sun
    The Mount Sinai Bone Program and The Thyroid Research Unit at the Bronx Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:4289-94. 2008
    ..In contrast, loss of function of a mutant TSHR (Pro --> Leu at 556) in congenital hypothyroid mice activates osteoclast differentiation, confirming once again our premise that TSHRs have a critical role in regulating bone remodeling...
  14. ncbi TSH is a negative regulator of skeletal remodeling
    Etsuko Abe
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 115:151-62. 2003
    ..These studies define a role for TSH as a single molecular switch in the independent control of both bone formation and resorption...
  15. pmc Autoimmune thyroid disease in pregnancy: a review
    Juan C Galofre
    Thyroid Research Unit, Mount Sinai School of Medicine, The Mount Sinai Hospital and the James J Peters VA Medical Center, New York, New York, USA
    J Womens Health (Larchmt) 18:1847-56. 2009
    ..5 and 2.5 mU/L...
  16. pmc Thyrotropin-independent induction of thyroid endoderm from embryonic stem cells by activin A
    Risheng Ma
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters Veterans Affairs Medical Center, New York, New York 10468, USA
    Endocrinology 150:1970-5. 2009
    ..Activin A is clearly a major regulator of thyroid endoderm...
  17. pmc Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades
    Syed A Morshed
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters Veterans Affairs Medical Center, New York, New York 10468, USA
    Endocrinology 151:5537-49. 2010
    ..This may help explain the inflammatory nature of this common disorder...
  18. ncbi TSH and bone loss
    Li Sun
    Department of Medicine, Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1068:309-18. 2006
    ..The evidence that low TSH levels predispose to osteoporosis in hyperthyroidism is discussed in view of the emerging role of pituitary hormones in bone biology...
  19. pmc A tyrosine residue on the TSH receptor stabilizes multimer formation
    Rauf Latif
    Thyroid Research Unit, James J Peters VA Medical Center, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e9449. 2010
    ..Here, we have examined the contribution of the ectodomain to constitutive multimerization of the TSHR and determined the possible residue(s) that may be involved in this interaction...
  20. ncbi Thyroid-stimulating hormone, thyroid hormones, and bone loss
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Osteoporos Rep 7:47-52. 2009
    ..TSH and its receptor could become valuable drug targets in treating bone loss...
  21. pmc Subunit interactions influence TSHR multimerization
    Rauf Latif
    Mount Sinai School of Medicine, James J Peters Veterans Affairs Medical Center, New York, New York 10468, USA
    Mol Endocrinol 24:2009-18. 2010
    ..Hence, the degree of intramolecular cleavage must also modulate TSHR signaling...
  22. pmc Characterization of thyrotropin receptor antibody-induced signaling cascades
    Syed A Morshed
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters Veterans Affairs Medical Center, New York, New York 10468, USA
    Endocrinology 150:519-29. 2009
    ..Because downstream thyroid cell signaling by the TSHR is both ligand dependent and independent, this may explain why TSHR-Abs are able to have variable influences on thyroid cell biology...
  23. doi The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling
    Rauf Latif
    Thyroid Research Unit, Mount Sinai School of Medicine and the James J Peters VA Medical Center, New York, NY 10468, USA
    Endocrinol Metab Clin North Am 38:319-41, viii. 2009
    ..Knowledge of the structure/function relationship of the TSHR is beginning to provide a greater understanding of thyroid physiology and thyroid autoimmunity...
  24. ncbi New insights: elevated follicle-stimulating hormone and bone loss during the menopausal transition
    Mone Zaidi
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Rheumatol Rep 11:191-5. 2009
    ..Potential therapeutic implications include the development of antagonists to circulating FSH and its osteoclastic receptor...
  25. ncbi Increased risk of Graves' disease after pregnancy
    Dana Benhaim Rochester
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 15:1287-90. 2005
    ..The mechanism of this long-standing increased susceptibility requires further delineation...
  26. ncbi Induction of thyroid-stimulating hormone receptor autoimmunity in hamsters
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 144:671-80. 2003
    ..The data also indicated that the intrathyroidal cellular immunity in this model was not related to TSHR-Ab formation and was an independent reflection of the T-cell immune response to TSHR antigen...
  27. ncbi Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function
    Yaron Tomer
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocr Rev 24:694-717. 2003
    ..It is hoped that in the near future additional AITD susceptibility genes will be identified and the mechanisms by which they induce AITD will be unraveled...
  28. ncbi Dissecting linear and conformational epitopes on the native thyrotropin receptor
    Takao Ando
    Mount Sinai School of Medicine, Box 1055, 1 Gustave L Levy Place, New York, New York 10029, USA
    Endocrinology 145:5185-93. 2004
    ..Hence, TSHR-stimulating and blocking antibodies cannot be distinguished purely on the basis of their conformational epitope recognition...
  29. pmc A monoclonal thyroid-stimulating antibody
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 110:1667-74. 2002
    ..The isolation and characterization of MS-1 provides a novel explanation for the prolonged thyroid stimulation in this disease which may be secondary to the lack of receptor cleavage in addition to the prolonged half-life of IgG itself...
  30. ncbi Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor
    Rauf Latif
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 277:45059-67. 2002
    ..Inhibition of these oligomeric forms by ligand binding returns the TSHR to an activated state...
  31. ncbi Analysis of immune regulatory genes in familial and sporadic Graves' disease
    Yoshiyuki Ban
    Division of Endocrinology, Diabetes, and Bone Diseases, Box 1055, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Clin Endocrinol Metab 89:4562-8. 2004
    ..However, HLA-DR3 and CTLA-4 did not have a stronger effect in the familial GD patients, suggesting that additional genes must contribute to the aggregation of GD within families...
  32. pmc Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families
    Yaron Tomer
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 73:736-47. 2003
    ..The loci that continue to show evidence for linkage in the expanded data set represent serious candidate regions for gene identification...
  33. ncbi Intrathyroidal fetal microchimerism in Graves' disease
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Clin Endocrinol Metab 87:3315-20. 2002
    ..Thus, fetal male cells are valid candidates for modulating autoimmune thyroid disease in pregnancy and postpartum...
  34. ncbi Clinical Review 160: Postpartum autoimmune thyroid disease: the potential role of fetal microchimerism
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 88:2965-71. 2003
    ....
  35. ncbi Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro
    Reigh Yi Lin
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 144:2644-9. 2003
    ....
  36. ncbi Bone loss in thyroid disease: role of low TSH and high thyroid hormone
    Etsuko Abe
    Mount Sinai Bone Program and The Thyroid Research Unit at the James Peter s Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:383-91. 2007
    ..We can now provide results that not thyroid hormones but also TSH itself has an equally important role to play in bone remodeling...
  37. ncbi The influence of human leucocyte antigen (HLA) genes on autoimmune thyroid disease (AITD): results of studies in HLA-DR3 positive AITD families
    Yoshiyuki Ban
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Clin Endocrinol (Oxf) 57:81-8. 2002
    ..The aim of the present study was to investigate the role of HLA in AITD and to explain the observed associations, but lack of linkage, by examining only AITD families with the associated allele, DR3...
  38. pmc Concentration-dependent regulation of thyrotropin receptor function by thyroid-stimulating antibody
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 113:1589-95. 2004
    ..Thus, inactivation of the TSHR by stimulating TSHR autoantibodies (TSHR-Ab's) in Graves disease patients may provide a functional explanation for the poor correlation between thyroid function and serum TSHR-Ab concentrations...
  39. ncbi Analysis of HLA genes in families with autoimmune diabetes and thyroiditis
    Lara Levin
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Hum Immunol 65:640-7. 2004
    ..g., DR4) are phenotype specific; and that because the logarithm of odds score for T1D + HT was lower than for T1D alone, additional non-HLA loci must contribute to the shared genetic susceptibility to T1D and AITD...
  40. pmc Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves' hyperthyroidism
    Stavros Stavrakis
    Department of Medicine, University of Oklahoma Health Sciences Center and Veterans Affairs Medical Center, Oklahoma City, Oklahoma 73104, USA
    J Am Coll Cardiol 54:1309-16. 2009
    ..We studied activating autoantibodies to beta-1 adrenergic receptors (AAbeta1AR) and activating autoantibodies to M2 muscarinic receptors (AAM2R) in the genesis of atrial fibrillation (AF) in Graves' hyperthyroidism...
  41. pmc Increased postpartum thyroxine replacement in Hashimoto's thyroiditis
    Juan C Galofre
    Thyroid Research Unit, Mount Sinai School of Medicine, The Mount Sinai Hospital, The James J Peters VA Medical Center, New York, NY 10029, USA
    Thyroid 20:901-8. 2010
    ..The aim of this study was to determine the impact of pregnancy on Hashimoto's thyroiditis as revealed by changes in postpregnancy levothyroxine requirements...
  42. ncbi Thyrotropin receptor antibodies: new insights into their actions and clinical relevance
    Takao Ando
    Department of Medicine, One Gustave L Levy Place, P O Box 1055, Mount Sinai School of Medicine, New York, NY 10029, USA
    Best Pract Res Clin Endocrinol Metab 19:33-52. 2005
    ..TSHR-Abs can be detected by competition assays of TSHR-Abs for labeled TSH, or monoclonal TSHR-Ab binding to solubilized TSHRs, or by bioassays using thyroid cells or mammalian cells expressing recombinant TSHRs...
  43. pmc TNFalpha mediates the skeletal effects of thyroid-stimulating hormone
    Hidenori Hase
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:12849-54. 2006
    ..The results suggest that TNFalpha is the critical cytokine mediating the downstream antiresorptive effects of TSH on the skeleton...
  44. ncbi The thyroid and pregnancy: a novel risk factor for very preterm delivery
    Alex Stagnaro-Green
    Department of Medicine, UMDNJ New Jersey Medical School, Division of Endocrinology and Metabolism, 185 South Orange Avenue, Newark, NJ 17101 6035, USA
    Thyroid 15:351-7. 2005
    ..There were no significant associations between TSH level or thyroglobulin antibody positivity and the risk of moderately preterm delivery...
  45. ncbi Derivation and characterization of thyrocyte-like cells from embryonic stem cells in vitro
    Reigh Yi Lin
    Division of Endocrinology Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 330:249-61. 2006
    ..Access to specific early-developing cell populations, such as the thyroid stem cells in the embryonic stem cell system, provides an experimental approach to characterizing key molecular events involved in thyrocyte commitment...
  46. ncbi A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome
    Sheera Siegel
    Division of Endocrinology Diabetes and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Fertil Steril 78:1240-3. 2002
    ..To examine whether the insulin receptor (INSR) gene contributes to genetic susceptibility to the polycystic ovary syndrome (PCOS)...
  47. ncbi Self-recognition and the role of fetal microchimerism
    Takao Ando
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, Box 1055, 1 Gustave L Levy Place, New York, NY 10029, USA
    Best Pract Res Clin Endocrinol Metab 18:197-211. 2004
    ....
  48. pmc Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice
    Francesca Menconi
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 105:14034-9. 2008
    ..Because the HT- and EAT-associated pockets are structurally different, it is likely that distinct antigenic peptides are associated with HT and EAT...
  49. ncbi Evaluation and treatment of thyroid nodules: a clinical guide
    Juan C Galofre
    Thyroid Research Unit, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, NY, USA
    Mt Sinai J Med 75:299-311. 2008
    ..Clinical guidelines have a very arbitrary recommendation of aspiration biopsy in all lesions greater than 1 cm in size, but this proposal has no scientific basis and should always be viewed in the clinical context...
  50. pmc Monoclonal antibodies to the thyrotropin receptor
    Takao Ando
    Department of Medicine, Mount Sinai School of Medicine, Box 1055, 1 Gustave L Levy Place, New York, NY 10029, USA
    Clin Dev Immunol 12:137-43. 2005
    ..One such stimulating mAb has demonstrated a number of differences in its regulation of TSHR post-translational processing. These differences are likely to be reflective of TSHR-Abs seen in Graves' disease...
  51. ncbi By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse
    Naoko Arata
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, Box 1055, 1 Gustave L Levy Place, New York, NY 10029, USA
    Clin Immunol 121:108-17. 2006
    ..This model of bystander cell detection confirmed that such an effect occurs in EAT and adds weight to the importance of this phenomenon in the initiation of autoimmune thyroid disease...
  52. ncbi Thyroid epigenetics: X chromosome inactivation in patients with autoimmune thyroid disease
    Xiaoming Yin
    Department of Medicine, Mount Sinai School of Medicine, and James J Peters Veterans Affairs Medical Center, New York, New York, USA
    Ann N Y Acad Sci 1110:193-200. 2007
    ..6%). Statistical analysis confirmed that XCI skewing was significantly associated with AITD (P = 0.004, OR = 4.0), demonstrating that the degree of XCI is an important contributor to the increased risk of females in developing AITD...
  53. ncbi Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease
    Susan E Hodge
    Division of Clinical Genetic Epidemiology, New York State Psychiatric Institute, New York, New York
    Thyroid 16:351-5. 2006
    ..053). Our results may suggest an interaction between the R- and CC variants in conferring susceptibility to GD. These results, if confirmed, may imply that these two variants interact biologically to increase the odds of GD...
  54. doi CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism
    Andrea P Martin
    Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Immunol 183:3073-80. 2009
    ..These results demonstrate the complexity in the generation of multiple autoimmune phenotypes in NOD mice and indicate that CCR7 is a key molecule in their development...
  55. ncbi Skeletal morphofunctional considerations and the pituitary-thyroid axis
    Jameel Iqbal
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    Front Biosci (Schol Ed) 1:92-107. 2009
    ..The current review describes these molecular mechanisms in relation to the way thyroid hormones, and the pituitary hormone thyrotropin (TSH), regulate skeletal morphogenesis and remodeling...

Research Grants24

  1. Monoclonal Thyroid Stimulating Antibodies
    TERRY FRANCIS DAVIES; Fiscal Year: 2010
    ..abstract_text> ..
  2. Monoclonal Thyroid Stimulating Antibodies
    Terry Davies; Fiscal Year: 2006
    ....
  3. INTACT AND SCID MOUSE MODELS FOR GRAVES' DISEASE
    Terry Davies; Fiscal Year: 1999
    ....
  4. Monoclonal Thyroid Stimulating Antibodies
    Terry Davies; Fiscal Year: 2009
    ..abstract_text> ..
  5. Monoclonal Thyroid Stimulating Antibodies
    Terry Davies; Fiscal Year: 2007
    ....
  6. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2002
    ..These studies will provide more definitive data on the linked and associated loci contributing to AITD. ..
  7. INTACT AND SCID MOUSE MODELS FOR GRAVES' DISEASE
    Terry Davies; Fiscal Year: 2002
    ....
  8. INTACT AND SCID MOUSE MODELS FOR GRAVES' DISEASE
    Terry Davies; Fiscal Year: 2001
    ....
  9. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 1999
    ....
  10. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2000
    ....
  11. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    TERRY FRANCIS DAVIES; Fiscal Year: 2010
    ..The benefit to the individual and society is potentially great in alleviating suffering due to the more severe forms of this thyroid disorder, especially Graves'ophthalmopathy. ..
  12. Interdisciplinary Program in Cell & Mol Endocrinology
    Terry Davies; Fiscal Year: 2007
    ..for 4 pre-doctoral and 5 post-doctoral trainees who will be assigned to an experienced group of preceptors to provide training and research in fundamental cellular and molecular biological techniques in a wide choice of endocrine systems ..
  13. Monoclonal Thyroid Stimulating Antibodies
    TERRY FRANCIS DAVIES; Fiscal Year: 2010
    ..abstract_text> ..
  14. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2006
    ..These studies will provide more definitive data on the linked and associated loci contributing to AITD. ..
  15. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2005
    ..These studies will provide more definitive data on the linked and associated loci contributing to AITD. ..
  16. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2004
    ..These studies will provide more definitive data on the linked and associated loci contributing to AITD. ..
  17. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    Terry Davies; Fiscal Year: 2003
    ..These studies will provide more definitive data on the linked and associated loci contributing to AITD. ..
  18. INTACT AND SCID MOUSE MODELS FOR GRAVES' DISEASE
    Terry Davies; Fiscal Year: 2000
    ....