T F Davies

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint The thyroid immunology of the postpartum period
    T F Davies
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 9:675-84. 1999
  2. ncbi request reprint Preservation of functioning human thyroid "organoids" in the scid mouse. IV. In vivo selection of an intrathyroidal T cell receptor repertoire
    A Martin
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 138:4868-75. 1997
  3. ncbi request reprint CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 86:1687-93. 2001
  4. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:4321-7. 1998
  5. ncbi request reprint Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes
    R Latif
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 276:45217-24. 2001
  6. ncbi request reprint Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 84:4656-64. 1999
  7. pmc A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, USA
    Am J Hum Genet 63:1749-56. 1998
  8. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease
    G Barbesino
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:3290-5. 1998
  9. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected immunoregulatory genes. International Consortium for the Genetics of Autoimmune Thyroid Disease
    G Barbesino
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:1580-4. 1998
  10. ncbi request reprint Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease
    Y Ban
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Genes Immun 5:203-8. 2004

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The thyroid immunology of the postpartum period
    T F Davies
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 9:675-84. 1999
    ..At this time, the best clinical approach is watchful waiting and postpartum thyroid function testing where suspected...
  2. ncbi request reprint Preservation of functioning human thyroid "organoids" in the scid mouse. IV. In vivo selection of an intrathyroidal T cell receptor repertoire
    A Martin
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 138:4868-75. 1997
    ..The model permitted in vivo T cell selection and/or enrichment of potentially disease relevant human T cells...
  3. ncbi request reprint CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 86:1687-93. 2001
    ....
  4. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:4321-7. 1998
    ..These data again suggest the presence of a major Graves' disease susceptibilitygene (GD-1) on chromosome 14q31. This locus is close to the recently identified multinodular goiter-1 locus...
  5. ncbi request reprint Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes
    R Latif
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Biol Chem 276:45217-24. 2001
    ..This further suggested that cleavage of the holoreceptor into its two-subunit structure, comprising disulfide-linked TSHR-alpha and TSHR-beta subunits, was required for the formation of TSHR dimers and higher order complexes...
  6. ncbi request reprint Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions
    Y Tomer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 84:4656-64. 1999
    ..One of them (GD-2) was fine-mapped to a 1-cM interval...
  7. pmc A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease
    Y Tomer
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, USA
    Am J Hum Genet 63:1749-56. 1998
    ..There was no evidence for heterogeneity in our sample. In our view, these results indicate strong evidence for linkage and suggest the presence of a major GD-susceptibility gene on chromosome 20q11.2...
  8. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease
    G Barbesino
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:3290-5. 1998
    ..We found a locus on Xq21.33-22 linked to GD that may help to explain the female predisposition to GD. Confirmation of these data in HT may require study of an extended number of families because of possible heterogeneity...
  9. ncbi request reprint Linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected immunoregulatory genes. International Consortium for the Genetics of Autoimmune Thyroid Disease
    G Barbesino
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Endocrinol Metab 83:1580-4. 1998
    ..The lack of linkage for the immunoregulatory genes that were studied indicated, therefore, that they were not major contributors to disease etiology...
  10. ncbi request reprint Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease
    Y Ban
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Genes Immun 5:203-8. 2004
    ..Our results suggested that structural heterogeneity of the DR beta-chain peptide-binding pocket P4 at residue 74 predispose some at risk individuals to GD...
  11. ncbi request reprint Non-MHC driven exacerbation of experimental thyroiditis in the postpartum period
    M Imaizumi
    Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, NY 10128, USA
    Autoimmunity 34:95-105. 2001
    ..This indicated that the postpartum exacerbation of autoimmune thyroid disease was not a simple response to fetal antigens but secondary to unique postpartum factors...
  12. ncbi request reprint Post-translational processing of the natural human thyrotropin receptor: demonstration of more than two cleavage sites
    P Graves
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Clin Endocrinol Metab 84:2177-81. 1999
    ..These data demonstrated that post-translational processing of the TSHR in human thyroid tissue involved multiple cleavage sites...
  13. pmc Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice
    R C Marians
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 99:15776-81. 2002
    ....
  14. ncbi request reprint Localization and regulation of thyrotropin receptors within lipid rafts
    R Latif
    Division of Endocrinolgy, Diabetes and Bone Diseases, Department of Medicine, Box 1055, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029 6574, USA
    Endocrinology 144:4725-8. 2003
    ..The relevance of such receptor movement out of the rafts suggested that these may be the receptors critical in the initiation of signal transduction..
  15. ncbi request reprint Autoimmune thyroid disease susceptibility loci in a large Chinese family
    R Villanueva
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Clin Endocrinol (Oxf) 56:45-51. 2002
    ..The aim of our study was to dissect the genetic predisposition to GD and HT in one large Chinese family with multiple members affected with AITD...
  16. ncbi request reprint Intrathyroidal fetal microchimerism in pregnancy and postpartum
    M Imaizumi
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10128, USA
    Endocrinology 143:247-53. 2002
    ..Such active immune cells may have a profound regulatory influence on autoimmune thyroiditis in pregnancy and the postpartum period...
  17. ncbi request reprint Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation
    R Latif
    Division of Endocrinology and Metabolism, James J Peters Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, New York 10468, USA
    Endocrinology 148:3164-75. 2007
    ....
  18. ncbi request reprint Detection of major T cell epitopes on human thyroid stimulating hormone receptor by overriding immune heterogeneity in patients with Graves' disease
    A Martin
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Clin Endocrinol Metab 82:3361-6. 1997
    ....
  19. ncbi request reprint Sibling recurrence risk in autoimmune thyroid disease
    R Villanueva
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 13:761-4. 2003
    ..9 for AITD, 11.6 for GD, and 28.0 for HT. These results confirm the significant contribution of genetic factors to the development of AITD...
  20. ncbi request reprint New insights into the thyroid-stimulating hormone receptor. The major antigen of Graves' disease
    P N Graves
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Endocrinol Metab Clin North Am 29:267-86, vi. 2000
    ....
  21. ncbi request reprint Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease
    Y Ban
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine Box 1055, New York, NY 10029, USA
    Genes Immun 4:586-93. 2003
    ..We concluded that: (1) the AITD gene in the 2q33 locus is the CTLA-4 gene and not the CD28 or ICOS genes; and (2) the G allele is associated with decreased function of CTLA-4...
  22. ncbi request reprint T-cell receptor V region beta-chain gene expression in the autoimmune thyroiditis of non-obese diabetic mice
    N Matsuoka
    Department of Medicine, Mount Sinai School of Medicine, New York, New York
    J Immunol 151:1691-701. 1993
    ..As thyroiditis does not occur uniformly in apparently genetically homogeneous animals, reared under similar environmental conditions, it may not be surprising that different TCR V genes are involved in different animals...
  23. ncbi request reprint Thyroid organoid formation in simulated microgravity: influence of keratinocyte growth factor
    A Martin
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Thyroid 10:481-7. 2000
    ..The above findings may have implications for autoimmune thyroid disease where KGF (if, for example, secreted locally by intraepithelial gammadelta T cells among other cells) may contribute to thyroid cell growth...
  24. ncbi request reprint The thyroid during pregnancy: a physiological and pathological stress test
    M S Shah
    Division of Endocrinology and Metabolism, Department of Medicine, UMDNJ, New Jersey Medical School, Newark, NJ 17103, USA
    Minerva Endocrinol 28:233-45. 2003
    ..Postpartum thyroiditis occurs in 7.2% of women, and euthyroid women who are thyroid antibody positive in the 1(st) trimester of pregnancy have a doubling of the miscarriage rate...
  25. ncbi request reprint Monomerization as a prerequisite for intramolecular cleavage and shedding of the thyrotropin receptor
    R Latif
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Endocrinology 145:5580-8. 2004
    ..In conclusion, these data indicated that monomer formation from multimeric TSHRs might be an important requirement for TSHR cleavage and TSHR ectodomain shedding...
  26. ncbi request reprint The genetics of the autoimmune thyroid diseases
    T F Davies
    Mount Sinai School of Medicine, New York, New York, USA
    Ann Endocrinol (Paris) 64:28-30. 2003
    ....
  27. ncbi request reprint A second thyroglobulin messenger RNA species (rTg-2) in rat thyrocytes
    P N Graves
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029
    Mol Endocrinol 4:155-61. 1990
    ..A putative polypeptide product from rTg-2 mRNA may play an important role in thyroid function and thyroid autoimmunity...
  28. ncbi request reprint Folding-dependent binding of thyrotropin (TSH) and TSH receptor autoantibodies to the murine TSH receptor ectodomain
    H Vlase
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 138:1658-66. 1997
    ....
  29. ncbi request reprint T-cell receptors and autoimmune thyroid disease--signposts for T-cell-antigen driven diseases
    A Martin
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int Rev Immunol 18:111-40. 1999
    ....
  30. ncbi request reprint Graves' disease thyroid tissue transplants in scid mice: persistent selectivity in hTcR Va gene family use
    S De Riu
    Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York 10029, USA
    Autoimmunity 19:271-7. 1994
    ..abstract truncated at 250 words)..
  31. ncbi request reprint Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus
    S Tucci
    Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Endocrinol Metab 86:446-9. 2001
    ..Since insulin stimulates androgen secretion by the ovarian stroma it is likely that INSR function in the ovary is involved in the genetic susceptibility ot PCOS...
  32. ncbi request reprint Functional assessment of the thyrotropin receptor-beta subunit
    I Ciullo
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Endocrinology 144:3176-81. 2003
    ....
  33. ncbi request reprint Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain
    P N Graves
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029
    Biochem Biophys Res Commun 187:1135-43. 1992
    ....
  34. pmc Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland
    M P Postiglione
    Laboratory of Biochemistry and Molecular Biology, Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 99:15462-7. 2002
    ..Furthermore, our data indicate that in embryonic life TSH does not play an equivalent role in controlling gland growth as in the adult thyroid...
  35. ncbi request reprint Participation of Vbeta13(+) and Vbeta1(+) T cells in transfer thyroiditis after activation of mouse thyroglobulin-primed T cells by superantigen staphylococcal enterotoxin A
    Q Wan
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cell Immunol 213:149-57. 2001
    ..Since our previous analyses by RT-PCR of the thyroid infiltrate after either induction or adoptive transfer have implicated both Vbeta13(+) and Vbeta1(+) cells, their activation by SEA to transfer thyroiditis further supports their role...
  36. ncbi request reprint A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma
    E L Mazzaferri
    Division of Endocrinology, Shands Hospital, Gainesville, Florida 32610, USA
    J Clin Endocrinol Metab 88:1433-41. 2003
    ....