Nikolaos P Daskalakis

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Schizophrenia in the Spectrum of Gene-Stress Interactions: The FKBP5 Example
    Nikolaos P Daskalakis
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY Mental Health Care Center, James J Peters Veterans Affairs Medical Center, Bronx, NY
    Schizophr Bull 41:323-9. 2015
  2. doi request reprint Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes
    Nikolaos P Daskalakis
    Departments of Psychiatry, Mental Health Patient Care Center, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468 and
    Proc Natl Acad Sci U S A 111:13529-34. 2014
  3. doi request reprint Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Academic Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden University, Leiden, The Netherlands Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA Mental Health Care Center, PTSD Clinical Research Program and Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J Peters Veterans Affairs Medical Center, Bronx, USA Electronic address
    Psychoneuroendocrinology 39:39-57. 2014
  4. doi request reprint Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment
    Nikolaos P Daskalakis
    Traumatic Stress Studies Division, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Endocrinol Metab Clin North Am 42:503-13. 2013
  5. pmc The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
    Nikolaos P Daskalakis
    Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA Mental Health Care Center, PTSD Clinical Research Program and Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J Peters Veterans Affairs Medical Center, Bronx, USA Division of Medical Pharmacology, Leiden Academic Center for Drug Research and Leiden University Medical Center, Leiden University, Leiden, The Netherlands Electronic address
    Psychoneuroendocrinology 38:1858-73. 2013
  6. doi request reprint Early handling modulates outcome of neonatal dexamethasone exposure
    Sanne E F Claessens
    Division of Medical Pharmacology, LACDR LUMC, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Horm Behav 62:433-41. 2012
  7. doi request reprint The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Gorlaeus Laboratories, The Netherlands
    Horm Behav 60:165-76. 2011
  8. doi request reprint Lower Methylation of Glucocorticoid Receptor Gene Promoter 1F in Peripheral Blood of Veterans with Posttraumatic Stress Disorder
    Rachel Yehuda
    Mental Health Care Center RY, JDF, LMB, AL, FD, IM, NPD, James J Peters Veterans Affairs Medical Center, Bronx, New York Traumatic Stress Studies Division RY, JDF, LMB, AL, FD, IM, NPD, Icahn School of Medicine at Mount Sinai, New York, New York Department of Psychiatry RY, JDF, LMB, AL, FD, IM, NPD, Icahn School of Medicine at Mount Sinai, NewYork, NewYork Electronic address
    Biol Psychiatry 77:356-64. 2015
  9. doi request reprint Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Physiol Behav 106:707-21. 2012
  10. pmc Elevation of 11β-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure
    Linda M Bierer
    James J Peters VA Medical Center, Bronx, NY, United States Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
    Psychoneuroendocrinology 48:1-10. 2014

Detail Information

Publications13

  1. doi request reprint Schizophrenia in the Spectrum of Gene-Stress Interactions: The FKBP5 Example
    Nikolaos P Daskalakis
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY Mental Health Care Center, James J Peters Veterans Affairs Medical Center, Bronx, NY
    Schizophr Bull 41:323-9. 2015
    ..We take the example of the FKBP5 gene to illustrate G × E interactions that predict pleiotropic psychiatric outcomes, including schizophrenia. ..
  2. doi request reprint Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes
    Nikolaos P Daskalakis
    Departments of Psychiatry, Mental Health Patient Care Center, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468 and
    Proc Natl Acad Sci U S A 111:13529-34. 2014
    ..Blood-based biomarkers can predict aspects of brain signaling. GR signaling is a convergent signaling pathway, associated with trauma-related individual differences in both sexes. ..
  3. doi request reprint Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Academic Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden University, Leiden, The Netherlands Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA Mental Health Care Center, PTSD Clinical Research Program and Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J Peters Veterans Affairs Medical Center, Bronx, USA Electronic address
    Psychoneuroendocrinology 39:39-57. 2014
    ..In conclusion, programming of an adult fearful phenotype linked to amygdala priming develops if pups are repeatedly isolated from peers in a novel-environment, while away from the dam for a prolonged period of time...
  4. doi request reprint Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment
    Nikolaos P Daskalakis
    Traumatic Stress Studies Division, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Endocrinol Metab Clin North Am 42:503-13. 2013
    ..Discussion includes novel treatment innovations and directions for future research. ..
  5. pmc The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
    Nikolaos P Daskalakis
    Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA Mental Health Care Center, PTSD Clinical Research Program and Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J Peters Veterans Affairs Medical Center, Bronx, USA Division of Medical Pharmacology, Leiden Academic Center for Drug Research and Leiden University Medical Center, Leiden University, Leiden, The Netherlands Electronic address
    Psychoneuroendocrinology 38:1858-73. 2013
    ....
  6. doi request reprint Early handling modulates outcome of neonatal dexamethasone exposure
    Sanne E F Claessens
    Division of Medical Pharmacology, LACDR LUMC, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Horm Behav 62:433-41. 2012
    ..In conclusion, these findings indicate that handling of the neonate enhances maternal care and attenuates specific DEX-induced alterations in the adult behavioral phenotype...
  7. doi request reprint The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Gorlaeus Laboratories, The Netherlands
    Horm Behav 60:165-76. 2011
    ..In conclusion, separation environment, maternal care and genotype do not affect adrenal desensitization to repeated 8 h-MS itself, but may modulate the adrenal stress-responsiveness of separated pups...
  8. doi request reprint Lower Methylation of Glucocorticoid Receptor Gene Promoter 1F in Peripheral Blood of Veterans with Posttraumatic Stress Disorder
    Rachel Yehuda
    Mental Health Care Center RY, JDF, LMB, AL, FD, IM, NPD, James J Peters Veterans Affairs Medical Center, Bronx, New York Traumatic Stress Studies Division RY, JDF, LMB, AL, FD, IM, NPD, Icahn School of Medicine at Mount Sinai, New York, New York Department of Psychiatry RY, JDF, LMB, AL, FD, IM, NPD, Icahn School of Medicine at Mount Sinai, NewYork, NewYork Electronic address
    Biol Psychiatry 77:356-64. 2015
    ..Epigenetic factors have emerged as one potential mechanism that account for how trauma exposure leads to sustained PTSD symptoms given that PTSD develops in only a subset of trauma survivors...
  9. doi request reprint Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Physiol Behav 106:707-21. 2012
    ..For this purpose the combined effects of early-life adversity and later-life stress exposure on behavioral markers of psychosis susceptibility were studied in male Wistar rats...
  10. pmc Elevation of 11β-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure
    Linda M Bierer
    James J Peters VA Medical Center, Bronx, NY, United States Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
    Psychoneuroendocrinology 48:1-10. 2014
    ....
  11. doi request reprint Animal models in translational studies of PTSD
    Nikolaos P Daskalakis
    Traumatic Stress Studies Division and Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA Mental Health Care Center, PTSD Clinical Research Program and Laboratory of Clinical Neuroendocrinology and Neurochemistry, James J Peters Veterans Affairs Medical Center, Bronx, USA
    Psychoneuroendocrinology 38:1895-911. 2013
    ..The current review covers recent translational approaches to bridge the gap between human and animal PTSD research and to create a framework for discovery of biomarkers and novel therapeutics. ..
  12. pmc Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences
    Sanne E F Claessens
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    Psychopharmacology (Berl) 214:141-54. 2011
    ..The interplay between genes and environment underlies this phenomenon...
  13. pmc Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors
    Amy Lehrner
    James J Peters Veterans Affairs Medical Center, Bronx, NY, United States Electronic address
    Psychoneuroendocrinology 40:213-20. 2014
    ..Although indirect, these findings are consistent with the hypothesis that epigenetic programming may be involved in the intergenerational transmission of trauma-related effects on glucocorticoid regulation. ..