Hayden William Courtland

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Fourier transform infrared imaging microspectroscopy and tissue-level mechanical testing reveal intraspecies variation in mouse bone mineral and matrix composition
    Hayden William Courtland
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Calcif Tissue Int 83:342-53. 2008
  2. pmc Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1
    Sebastien Elis
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Bone Miner Res 25:1257-66. 2010
  3. pmc Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production
    Hayden William Courtland
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Bone Miner Res 26:761-8. 2011
  4. pmc Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression
    Sebastien Elis
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Aging Cell 10:547-50. 2011
  5. pmc Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner
    Hayden William Courtland
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e14762. 2011
  6. pmc Unbound (bioavailable) IGF1 enhances somatic growth
    Sebastien Elis
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dis Model Mech 4:649-58. 2011
  7. pmc Genetic variation in mouse femoral tissue-level mineral content underlies differences in whole bone mechanical properties
    Hayden William Courtland
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cells Tissues Organs 189:237-40. 2009
  8. pmc Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
    Karl J Jepsen
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, USA
    Mamm Genome 18:492-507. 2007
  9. pmc Genetically determined phenotype covariation networks control bone strength
    Karl J Jepsen
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Bone Miner Res 25:1581-93. 2010
  10. pmc Sex-specific regulation of body size and bone slenderness by the acid labile subunit
    Hayden William Courtland
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Bone Miner Res 25:2059-68. 2010

Detail Information

Publications16

  1. pmc Fourier transform infrared imaging microspectroscopy and tissue-level mechanical testing reveal intraspecies variation in mouse bone mineral and matrix composition
    Hayden William Courtland
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Calcif Tissue Int 83:342-53. 2008
    ..These results suggest that specific combinations of bone quality and morphological traits are genetically regulated such that mechanically functional bones can be constructed in different ways...
  2. pmc Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1
    Sebastien Elis
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Bone Miner Res 25:1257-66. 2010
    ..Our data indicate that in the absence of tissue igf1 gene expression, maintaining long-term elevations in serum IGF-1 is sufficient to establish normal body size, body composition, and both skeletal architecture and mechanical function...
  3. pmc Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production
    Hayden William Courtland
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Bone Miner Res 26:761-8. 2011
    ....
  4. pmc Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression
    Sebastien Elis
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Aging Cell 10:547-50. 2011
    ..Additionally, in male KO-HIT mice, increases in serum IGF-1 levels were insufficient to protect against age-related muscle loss...
  5. pmc Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner
    Hayden William Courtland
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e14762. 2011
    ....
  6. pmc Unbound (bioavailable) IGF1 enhances somatic growth
    Sebastien Elis
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dis Model Mech 4:649-58. 2011
    ..The KID and KIR models show unequivocally that IGF1-complex formation with the IGFBPs is fundamental for establishing normal body and organ size, and that uncontrolled IGF bioactivity could lead to pathological conditions...
  7. pmc Genetic variation in mouse femoral tissue-level mineral content underlies differences in whole bone mechanical properties
    Hayden William Courtland
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cells Tissues Organs 189:237-40. 2009
    ..The greater stiffness and brittleness of A/J femora are likely due to differential biological control (osteoblast activity) of the amount of mineral...
  8. pmc Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
    Karl J Jepsen
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, USA
    Mamm Genome 18:492-507. 2007
    ..Genetic or environmental perturbations that alter these functional interactions during growth would be expected to lead to loss of function and suboptimal adult bone quality...
  9. pmc Genetically determined phenotype covariation networks control bone strength
    Karl J Jepsen
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Bone Miner Res 25:1581-93. 2010
    ....
  10. pmc Sex-specific regulation of body size and bone slenderness by the acid labile subunit
    Hayden William Courtland
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Bone Miner Res 25:2059-68. 2010
    ..This study revealed age- and sex-specific dependencies of body size and bone size on the ALS. These findings may explain the heterogeneity in growth and BMD measurements reported in human ALS-deficient patients...
  11. pmc Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains
    Karl J Jepsen
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mamm Genome 20:21-33. 2009
    ..Variants that impair this process or that cannot be fully compensated are expected to alter skeletal growth leading to underdesigned (weak) or overdesigned (bulky) structures...
  12. pmc Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging
    Hayden William Courtland
    Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine, New York, NY, 10029, USA
    Age (Dordr) 35:1691-703. 2013
    ..We show here that lifelong reductions in serum IGF-1 compromise skeletal size in development leading to slender bones; they are also associated with decreased intracortical bone remodeling and preservation of bone strength during aging. ..
  13. pmc IGF-1 and bone: New discoveries from mouse models
    Shoshana Yakar
    Division of Endocrinology, University of North Carolina, Chapel Hill, NC, USA
    J Bone Miner Res 25:2543-52. 2010
    ..In this review we present new and old findings from mouse models of the IGF system and discuss their clinical relevance to normal and pathological skeletal physiology...
  14. ncbi request reprint Defining nasal cartilage elasticity: biomechanical testing of the tripod theory based on a cantilevered model
    Richard W Westreich
    Department of Otolaryngology, State University of New York Downstate Medical Center, Brooklyn, NY, USA
    Arch Facial Plast Surg 9:264-70. 2007
    ..To define the modulus of elasticity for nasal septum, auricular, upper lateral, and lower lateral cartilages...
  15. pmc Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact
    Sebastien Elis
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Bone Miner Res 25:2051-8. 2010
    ..Thus enhancement of PTH anabolic actions depends on tissue IGF-1...
  16. pmc Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions
    Shoshana Yakar
    Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Bone Miner Res 24:1481-92. 2009
    ....