Research Topics
Genomes and GenesSpecies | Jia ChenSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based studyXinran Xu
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
FASEB J 26:2657-66. 2012..018). LINE-1 methylation was associated with neither breast cancer risk nor 1-carbon metabolism. Our results show that global promoter hypermethylation measured in peripheral blood was associated with breast cancer risk...- Haplotype-phenotype relationships of paraoxonase-1Jia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 14:731-4. 2005..9% in neonates. Haplotype information offered a slightly increased power in predicting PON1 activity; they explained 35.5% and 19.3% of PON1 variability in neonates and mothers, respectively... - One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancerJia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
Cancer Res 65:1606-14. 2005..96) or total folate intake (OR, 1.71; 95% CI, 1.08-2.71). From a public heath perspective, it is important to identify risk factors, such as low B vitamin consumption, that may guide an effective prevention strategy against the disease... - Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomasJia Chen
Department of Community and Preventive Medicine, Box 1043, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 13:2247-50. 2004..007). These findings lend additional support that one-carbon metabolism is an important process in pathogenesis of colorectal cancer... - Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective studyJia Chen
Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Int J Cancer 110:617-20. 2004..Findings from our prospective investigation indicate that these newly identified polymorphisms in one-carbon metabolizing genes have limited functionality in modifying folate status and related CRC risk... - Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancerJia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Cancer Epidemiol Biomarkers Prev 12:958-62. 2003.... - Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancerJia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
Pharmacogenetics 12:339-42. 2002..We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism... - B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancerXinran Xu
Department of Community and Preventive Medicine, Box 1043, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 17:2109-16. 2008..Our results indicate that one-carbon metabolism may be an important pathway that could be targeted to improve breast cancer survival... - A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin usersXinran Xu
Departments of Community and Preventive Medicine and Epidemiology and Medicine, Columbia University, New York, NY, USA
Am J Clin Nutr 85:1098-102. 2007..Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions... - High intakes of choline and betaine reduce breast cancer mortality in a population-based studyXinran Xu
Department of Community and Preventive Medicine, Box 1057, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
FASEB J 23:4022-8. 2009..Our study supports the important roles of choline and betaine in breast carcinogenesis. It suggests that high intake of these nutrients may be a promising strategy to prevent the development of breast cancer and to reduce its mortality... - Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based studyXinran Xu
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Carcinogenesis 28:1504-9. 2007..Although the pathway is a network of interrelated enzymes, redundancy exists; evaluating the rate-limiting enzyme and its interaction with environment and other genes within the same pathway is critical in assessing breast cancer risk... - Choline metabolism and risk of breast cancer in a population-based studyXinran Xu
Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
FASEB J 22:2045-52. 2008..We observed a significant interaction between dietary betaine intake and the PEMT rs7926 polymorphism (P(interaction)=0.04). Our findings suggest that choline metabolism may play an important role in breast cancer etiology... - Gene promoter methylation is associated with increased mortality among women with breast cancerXinran Xu
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
Breast Cancer Res Treat 121:685-92. 2010..Our results suggest that promoter methylation could be promising epigenetic markers to be considered for breast cancer survival... - Increased influence of genetic variation on PON1 activity in neonatesJia Chen
The Derald H Ruttenberg Cancer Center, and Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 111:1403-9. 2003..The Caribbean Hispanics fall between these two groups. Surprisingly, significant LD also was observed between the promoter polymorphisms and C311S in PON2. LD between the promoter polymorphisms and Q192R was not significant... - Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypesJames G Wetmur
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Nucleic Acids Res 33:2615-9. 2005..We have demonstrated here a powerful molecular haplotyping technology that can be applied in population studies... - Differential expression of imprinted genes in normal and IUGR human placentasAndreas I Diplas
Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Epigenetics 4:235-40. 2009..Our study suggests that genomic imprinting may play a role in IUGR pathogenesis, but mechanisms other than LOI may contribute to dysregulation of imprinted genes... - Differential methylation of imprinted genes in growth-restricted placentasLuca Lambertini
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Reprod Sci 18:1111-7. 2011..These findings warrant caution in interpreting the significance of genes carrying clustered DMRs because the distribution of DMRs in a gene may be attributed as a function of its length rather than as a specific biological role... - Prognostic significance of gene-specific promoter hypermethylation in breast cancer patientsYoon Hee Cho
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th St, New York, NY 10032, USA
Breast Cancer Res Treat 131:197-205. 2012..002), although confidence intervals were wide. Our results suggest that promoter methylation, particularly for a panel of genes, has the potential to be used as a biomarker for predicting prognosis in breast cancer... - BRCA1 promoter methylation is associated with increased mortality among women with breast cancerXinran Xu
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, P O Box 1043, One Gustave L Levy Place, New York, NY 10029, USA
Breast Cancer Res Treat 115:397-404. 2009..Our results indicate that BRCA1 promoter methylation is an important factor to consider in predicting breast cancer survival... - An emulsion polymerase chain reaction-based method for molecular haplotypingJames G Wetmur
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
Methods Mol Biol 410:351-61. 2008..PON1 is an enzyme with multiple activities, including detoxification of organophosphates... - Genomic loss of imprinting in first-trimester human placentaYevgeniya Pozharny
Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY, USA
Am J Obstet Gynecol 202:391.e1-8. 2010..The purpose of this study was to investigate imprinting patterns in first-trimester human placentas... - Demonstration of all-or-none loss of imprinting in mRNA expression in single cellsAndreas I Diplas
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Nucleic Acids Res 37:7039-46. 2009..All-or-none LOI could lead to a second distinct cell population that may have a selective advantage, leading to variation of LOI in normal tissues, such as the placenta, or in neoplastic cells... - Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomasEdward Giovannucci
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:970-9. 2003.... - Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhoodStephanie M Engel
University of California Berkeley, Center for Environmental Research and Children s Health, School of Public Health, Berkeley, California, USA
Environ Health Perspect 119:1182-8. 2011..Prenatal exposure to organophosphate pesticides has been shown to negatively affect child neurobehavioral development. Paraoxonase 1 (PON1) is a key enzyme in the metabolism of organophosphates... - Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype dataSylvan Wallenstein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10032, USA
Mol Genet Metab 89:270-3. 2006.... - Gene expression profiles of the one-carbon metabolism pathwayYin Leng Lee
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York 10029, USA
J Genet Genomics 36:277-82. 2009..The components identified by the program agreed with existing knowledge about one-carbon metabolism. This study helps us better understand the biological functions of one-carbon metabolism... - One-carbon metabolism and breast cancer: an epidemiological perspectiveXinran Xu
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Genet Genomics 36:203-14. 2009..More results are expected and will be translated to guidance to the general population for disease prevention as well as to clinicians for treatment and management of the disease... - Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York CityYin Leng Lee
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Genet 89:417-23. 2010..In summary, a minimal set of 35 AIMs is sufficient to detect population stratification and estimate the proportion of individual genetic admixture; however, the utility of these markers remains questionable... - Diet, epigenetic, and cancer preventionJia Chen
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, USA
Adv Genet 71:237-55. 2010.... - Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girlsMary S Wolff
Mount Sinai School of Medicine, New York, NY 10029, USA
Environ Health Perspect 118:1039-46. 2010..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins... - Structure and function of the mammalian egg zona pellucidaP Wassarman
Department of Cell Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Exp Zool 285:251-8. 1999..Here we describe some aspects of zona pellucida structure and function as they relate to mammalian fertilization. J. Exp. Zool. (Mol. Dev. Evol.) 285:251-258, 1999... - Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in MexicoMarina Lacasaña-Navarro
Center for Population Health Research, National Institute of Public Health, Av Universidad No 655, Col Santa Ma Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
Eur J Cancer 42:528-33. 2006..Our results suggest that the high prevalence of MTHFR 677T allele may be a contributor to the high rate of morbidity and mortality in GC in Mexico... - Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspringAmir Miodovnik
Department of Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, PO Box 1057, New York, NY 10029, USA
Psychiatr Genet 22:115-22. 2012..We investigated maternal functional polymorphisms of CYP17, CYP19, and CYP1B1, which control three major enzymatic steps in sex steroid biosynthesis and metabolism, in relation to childhood behaviors... - The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant womenMichele La Merrill
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Matern Fetal Neonatal Med 25:133-7. 2012..Our aim was to evaluate possible associations between consumption of micronutrients involved in one-carbon metabolism, MTHFR genotypes, and global DNA methylation in pregnant women... - A sensitive functional assay reveals frequent loss of genomic imprinting in human placentaLuca Lambertini
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Epigenetics 3:261-9. 2008..Our results indicate that LOI is common in human placentas. Because LOI in placenta is common, it may be an important new biomarker for influences on prenatal epigenetics... - Linking emulsion PCR haplotype analysisJames G Wetmur
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
Methods Mol Biol 687:165-75. 2011..LE-PCR is illustrated for polymorphisms in human paraoxonase 1 (PON1) that have been shown to affect transcriptional activity and substrate specificity in the detoxification of organophosphates... - Ovarian development in mice bearing homozygous or heterozygous null mutations in zona pellucida glycoprotein gene mZP3P M Wassarman
Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Histol Histopathol 13:293-300. 1998..It seems likely that the pleiotropic effects of the homozygous null mutation on ovarian development may be due, at least in part, to disruption of intercellular communication between growing oocytes and their surrounding follicle cells... - Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genesLiviu A Sicinschi
Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Int J Cancer 118:649-57. 2006..pylori. Our results support the identification of the IL1B-31 promoter polymorphism as a useful marker for risk of intestinal type gastric cancer in persons with CagA positive H. pylori infections... - Kinetic polymerase chain reaction on pooled DNA: a high-throughput, high-efficiency alternative in genetic epidemiological studiesJia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 11:131-6. 2002..The results were comparable between both platforms and among all three polymerases. The results demonstrate a powerful new technology for determining frequencies of single-nucleotide polymorphisms in an epidemiological study... - Insulin receptor substrate-1 regulates the transformed phenotype of BT-20 human mammary cancer cellsOzlem Dalmizrak
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Cancer Res 67:2124-30. 2007..Targeting of IRS-1 could be effective in inhibiting the proliferation of mammary cancer cells... - Elevation of blood beta-carboline alkaloids in essential tremorE D Louis
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Neurology 59:1940-4. 2002..beta-Carboline alkaloids are normal body constituents but are also potent tremor-producing chemicals that are naturally present in the food chain... - Electrogastrographic norms in children: toward the development of standard methods, reproducible results, and reliable normative dataJ Levy
Department of Pediatrics, Babies and Children's Hospital of New York, Columbia University College of Physicians and Surgeons, New York, New York 10032-3784, USA
J Pediatr Gastroenterol Nutr 33:455-61. 2001..Differences in test conditions of signal detection and analytic methods influence EGG results substantially, and caution should be used when comparing results across centers... - Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tractP R Wade
Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, 10032, USA
J Neurosci 16:2352-64. 1996..Mucosal epithelial cells thus express a plasmalemmal 5-HT transporter identical to that of serotonergic neurons. This molecule seems to play a critical role in the peristaltic reflex... - Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancerHaiping Pei
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
J Proteome Res 6:2495-501. 2007..The aim of this study is to investigate the LNM-associated proteins and to evaluate the clinicopathological characteristics of these target proteins' expression in CRC... - AtHAP3b plays a crucial role in the regulation of flowering time in Arabidopsis during osmotic stressNai Zhi Chen
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
J Biochem Mol Biol 40:1083-9. 2007..These results suggest that the AtHAP3b gene plays more important roles in the control of lowering under osmotic stress in Arabidopsis... - Using a modified TA cloning method to create entry clonesQi-Jun Chen
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
Anal Biochem 358:120-5. 2006..Using Gateway T vectors prepared by this improved method, entry clones for PCR products or restriction enzyme fragments can be created simply, efficiently, and inexpensively while at the same time introducing greater compatibility... - Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neuronsWilliam J Freed
Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse, National Institutes of Health NIH, Baltimore, Maryland, USA
PLoS ONE 3:e1422. 2008..We initiated differentiation of human embryonic stem cells (hESCs) into dopamine neurons, obtained a purified population of neuronal precursor cells by cell sorting, and determined patterns of gene transcription... - Zinc finger protein 1 (ThZF1) from salt cress (Thellungiella halophila) is a Cys-2/His-2-type transcription factor involved in drought and salt stressShouming Xu
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China
Plant Cell Rep 26:497-506. 2007..Finally, ectopic expression of ThZF1 in Arabidopsis mutant azf2 suggested that ThZF1 may have similar roles as Arabidopsis AZF2 in plant development as well as regulation of downstream gene... - Tomato stress-responsive factor TSRF1 interacts with ethylene responsive element GCC box and regulates pathogen resistance to Ralstonia solanacearumHongbo Zhang
The National Plant Gene Research Center Beijing, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Plant Mol Biol 55:825-34. 2004..solanacearum, but also provides further clues to understanding the mechanism of host regulatory proteins in response to the infection of pathogens... - Identification and characterization of Bacillus anthracis by multiplex PCR on DNA chipShi-Hua Wang
Department of Analytical Biochemistry, Biotech Wuchang, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
Biosens Bioelectron 20:807-13. 2004..anthracis and distinguished 'anthrax-like' strains from other B. cereus group bacteria were unambiguously identified, while the genera other than Bacillus gave no positive signal... - AtHsfA2 modulates expression of stress responsive genes and enhances tolerance to heat and oxidative stress in ArabidopsisChunguang Li
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
Sci China C Life Sci 48:540-50. 2005..So we suggest that AtHsfA2 plays an important role in linking heat shock with oxidative stress signals... - Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasoneLi Yang
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yueyang Rd, Shanghai 200031, China
Cell Res 14:315-23. 2004.... - NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protectionMao Feng Chai
National Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100094 Beijing, China
Plant Mol Biol 59:553-64. 2005..These results suggest that NADK2 may be a chloroplast NAD kinase and play a vital role in chlorophyll synthesis and chloroplast protection against oxidative damage...
Research Grants
- GENE-ENVIRONMENT INTERACTION AND COLON CARCINOGENESISJia Chen; Fiscal Year: 2002b>Jia Chen received her Sc.D. in 1994 in the fields of Toxicology and Environmental Engineering from Massachusetts Institute of Technology...
- Dietary Methyl Content, Epigenetics and Breast CancerJia Chen; Fiscal Year: 2010..To identify the factors that determine the patterns of methylation can provide evidence for the mechanisms of the disease as well as identify at-risk populations in which appropriate diet-based intervention can be provided. ..
- Dietary Methyl Content, Epigenetics and Breast CancerJia Chen; Fiscal Year: 2009..To identify the factors that determine the patterns of methylation can provide evidence for the mechanisms of the disease as well as identify at-risk populations in which appropriate diet-based intervention can be provided. ..