Jia Chen

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study
    Jia Chen
    Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 110:617-20. 2004
  2. ncbi request reprint CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls
    Theresa Ryan Stueve
    Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    BMC Pediatr 14:78. 2014
  3. pmc DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study
    Xinran Xu
    Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
    FASEB J 26:2657-66. 2012
  4. ncbi request reprint Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas
    Jia Chen
    Department of Community and Preventive Medicine, Box 1043, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 13:2247-50. 2004
  5. ncbi request reprint Haplotype-phenotype relationships of paraoxonase-1
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 14:731-4. 2005
  6. ncbi request reprint Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Epidemiol Biomarkers Prev 12:958-62. 2003
  7. ncbi request reprint One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 65:1606-14. 2005
  8. ncbi request reprint Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Pharmacogenetics 12:339-42. 2002
  9. pmc B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer
    Xinran Xu
    Department of Community and Preventive Medicine, Box 1043, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 17:2109-16. 2008
  10. ncbi request reprint A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users
    Xinran Xu
    Departments of Community and Preventive Medicine and Epidemiology and Medicine, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1098-102. 2007

Detail Information

Publications57

  1. ncbi request reprint Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study
    Jia Chen
    Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 110:617-20. 2004
    ..Findings from our prospective investigation indicate that these newly identified polymorphisms in one-carbon metabolizing genes have limited functionality in modifying folate status and related CRC risk...
  2. ncbi request reprint CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls
    Theresa Ryan Stueve
    Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    BMC Pediatr 14:78. 2014
    ..If present in early life, it is conceivable similar methylation aberrations may result in hormone perturbations that alter pubertal timing...
  3. pmc DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study
    Xinran Xu
    Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
    FASEB J 26:2657-66. 2012
    ..018). LINE-1 methylation was associated with neither breast cancer risk nor 1-carbon metabolism. Our results show that global promoter hypermethylation measured in peripheral blood was associated with breast cancer risk...
  4. ncbi request reprint Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas
    Jia Chen
    Department of Community and Preventive Medicine, Box 1043, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 13:2247-50. 2004
    ..007). These findings lend additional support that one-carbon metabolism is an important process in pathogenesis of colorectal cancer...
  5. ncbi request reprint Haplotype-phenotype relationships of paraoxonase-1
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 14:731-4. 2005
    ..9% in neonates. Haplotype information offered a slightly increased power in predicting PON1 activity; they explained 35.5% and 19.3% of PON1 variability in neonates and mothers, respectively...
  6. ncbi request reprint Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Epidemiol Biomarkers Prev 12:958-62. 2003
    ....
  7. ncbi request reprint One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 65:1606-14. 2005
    ..96) or total folate intake (OR, 1.71; 95% CI, 1.08-2.71). From a public heath perspective, it is important to identify risk factors, such as low B vitamin consumption, that may guide an effective prevention strategy against the disease...
  8. ncbi request reprint Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Pharmacogenetics 12:339-42. 2002
    ..We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism...
  9. pmc B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer
    Xinran Xu
    Department of Community and Preventive Medicine, Box 1043, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 17:2109-16. 2008
    ..Our results indicate that one-carbon metabolism may be an important pathway that could be targeted to improve breast cancer survival...
  10. ncbi request reprint A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users
    Xinran Xu
    Departments of Community and Preventive Medicine and Epidemiology and Medicine, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1098-102. 2007
    ..Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions...
  11. pmc High intakes of choline and betaine reduce breast cancer mortality in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Box 1057, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 23:4022-8. 2009
    ..Our study supports the important roles of choline and betaine in breast carcinogenesis. It suggests that high intake of these nutrients may be a promising strategy to prevent the development of breast cancer and to reduce its mortality...
  12. ncbi request reprint Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Carcinogenesis 28:1504-9. 2007
    ..Although the pathway is a network of interrelated enzymes, redundancy exists; evaluating the rate-limiting enzyme and its interaction with environment and other genes within the same pathway is critical in assessing breast cancer risk...
  13. pmc Choline metabolism and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 22:2045-52. 2008
    ..We observed a significant interaction between dietary betaine intake and the PEMT rs7926 polymorphism (P(interaction)=0.04). Our findings suggest that choline metabolism may play an important role in breast cancer etiology...
  14. pmc Gene promoter methylation is associated with increased mortality among women with breast cancer
    Xinran Xu
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res Treat 121:685-92. 2010
    ..Our results suggest that promoter methylation could be promising epigenetic markers to be considered for breast cancer survival...
  15. pmc Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes
    James G Wetmur
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nucleic Acids Res 33:2615-9. 2005
    ..We have demonstrated here a powerful molecular haplotyping technology that can be applied in population studies...
  16. ncbi request reprint Differential expression of imprinted genes in normal and IUGR human placentas
    Andreas I Diplas
    Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Epigenetics 4:235-40. 2009
    ..Our study suggests that genomic imprinting may play a role in IUGR pathogenesis, but mechanisms other than LOI may contribute to dysregulation of imprinted genes...
  17. pmc Increased influence of genetic variation on PON1 activity in neonates
    Jia Chen
    The Derald H Ruttenberg Cancer Center, and Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 111:1403-9. 2003
    ..The Caribbean Hispanics fall between these two groups. Surprisingly, significant LD also was observed between the promoter polymorphisms and C311S in PON2. LD between the promoter polymorphisms and Q192R was not significant...
  18. doi request reprint Differential methylation of imprinted genes in growth-restricted placentas
    Luca Lambertini
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Reprod Sci 18:1111-7. 2011
    ..These findings warrant caution in interpreting the significance of genes carrying clustered DMRs because the distribution of DMRs in a gene may be attributed as a function of its length rather than as a specific biological role...
  19. pmc Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients
    Yoon Hee Cho
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Breast Cancer Res Treat 131:197-205. 2012
    ..002), although confidence intervals were wide. Our results suggest that promoter methylation, particularly for a panel of genes, has the potential to be used as a biomarker for predicting prognosis in breast cancer...
  20. pmc BRCA1 promoter methylation is associated with increased mortality among women with breast cancer
    Xinran Xu
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, P O Box 1043, One Gustave L Levy Place, New York, NY 10029, USA
    Breast Cancer Res Treat 115:397-404. 2009
    ..Our results indicate that BRCA1 promoter methylation is an important factor to consider in predicting breast cancer survival...
  21. pmc Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York City
    Yin Leng Lee
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Genet 89:417-23. 2010
    ..In summary, a minimal set of 35 AIMs is sufficient to detect population stratification and estimate the proportion of individual genetic admixture; however, the utility of these markers remains questionable...
  22. doi request reprint Genomic loss of imprinting in first-trimester human placenta
    Yevgeniya Pozharny
    Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY, USA
    Am J Obstet Gynecol 202:391.e1-8. 2010
    ..The purpose of this study was to investigate imprinting patterns in first-trimester human placentas...
  23. pmc Demonstration of all-or-none loss of imprinting in mRNA expression in single cells
    Andreas I Diplas
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nucleic Acids Res 37:7039-46. 2009
    ..All-or-none LOI could lead to a second distinct cell population that may have a selective advantage, leading to variation of LOI in normal tissues, such as the placenta, or in neoplastic cells...
  24. ncbi request reprint An emulsion polymerase chain reaction-based method for molecular haplotyping
    James G Wetmur
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 410:351-61. 2008
    ..PON1 is an enzyme with multiple activities, including detoxification of organophosphates...
  25. ncbi request reprint Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:970-9. 2003
    ....
  26. pmc Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake
    Manuela A Orjuela
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Cancer 118:5912-9. 2012
    ..Maternal intake of naturally occurring folate from vegetables during pregnancy is associated inversely with the risk of retinoblastoma in offspring...
  27. pmc Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspring
    Amir Miodovnik
    Department of Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, PO Box 1057, New York, NY 10029, USA
    Psychiatr Genet 22:115-22. 2012
    ..We investigated maternal functional polymorphisms of CYP17, CYP19, and CYP1B1, which control three major enzymatic steps in sex steroid biosynthesis and metabolism, in relation to childhood behaviors...
  28. pmc Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood
    Stephanie M Engel
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Environ Health Perspect 119:1182-8. 2011
    ..Prenatal exposure to organophosphate pesticides has been shown to negatively affect child neurobehavioral development. Paraoxonase 1 (PON1) is a key enzyme in the metabolism of organophosphates...
  29. pmc One-carbon metabolism and breast cancer: an epidemiological perspective
    Xinran Xu
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Genet Genomics 36:203-14. 2009
    ..More results are expected and will be translated to guidance to the general population for disease prevention as well as to clinicians for treatment and management of the disease...
  30. ncbi request reprint Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data
    Sylvan Wallenstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10032, USA
    Mol Genet Metab 89:270-3. 2006
    ....
  31. pmc Gene expression profiles of the one-carbon metabolism pathway
    Yin Leng Lee
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York 10029, USA
    J Genet Genomics 36:277-82. 2009
    ..The components identified by the program agreed with existing knowledge about one-carbon metabolism. This study helps us better understand the biological functions of one-carbon metabolism...
  32. doi request reprint Diet, epigenetic, and cancer prevention
    Jia Chen
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, USA
    Adv Genet 71:237-55. 2010
    ....
  33. ncbi request reprint Structure and function of the mammalian egg zona pellucida
    P Wassarman
    Department of Cell Biology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Exp Zool 285:251-8. 1999
    ..Here we describe some aspects of zona pellucida structure and function as they relate to mammalian fertilization. J. Exp. Zool. (Mol. Dev. Evol.) 285:251-258, 1999...
  34. pmc Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls
    Mary S Wolff
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 118:1039-46. 2010
    ..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins...
  35. ncbi request reprint Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico
    Marina Lacasaña-Navarro
    Center for Population Health Research, National Institute of Public Health, Av Universidad No 655, Col Santa Ma Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
    Eur J Cancer 42:528-33. 2006
    ..Our results suggest that the high prevalence of MTHFR 677T allele may be a contributor to the high rate of morbidity and mortality in GC in Mexico...
  36. pmc Global methylation in the placenta and umbilical cord blood from pregnancies with maternal gestational diabetes, preeclampsia, and obesity
    Yoko Nomura
    1Department of Psychology, Queens College, CUNY, Flushing, NY, USA
    Reprod Sci 21:131-7. 2014
    ..While preliminary, it is possible that the placenta tissue, but not umbilical cord blood, may be epigenetically programmed by maternal GDM, preeclampsia, and obesity to carry out its own specific functions that influence fetal growth. ..
  37. pmc The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women
    Michele La Merrill
    Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Matern Fetal Neonatal Med 25:133-7. 2012
    ..Our aim was to evaluate possible associations between consumption of micronutrients involved in one-carbon metabolism, MTHFR genotypes, and global DNA methylation in pregnant women...
  38. doi request reprint Linking emulsion PCR haplotype analysis
    James G Wetmur
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 687:165-75. 2011
    ..LE-PCR is illustrated for polymorphisms in human paraoxonase 1 (PON1) that have been shown to affect transcriptional activity and substrate specificity in the detoxification of organophosphates...
  39. pmc A sensitive functional assay reveals frequent loss of genomic imprinting in human placenta
    Luca Lambertini
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Epigenetics 3:261-9. 2008
    ..Our results indicate that LOI is common in human placentas. Because LOI in placenta is common, it may be an important new biomarker for influences on prenatal epigenetics...
  40. ncbi request reprint Ovarian development in mice bearing homozygous or heterozygous null mutations in zona pellucida glycoprotein gene mZP3
    P M Wassarman
    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Histol Histopathol 13:293-300. 1998
    ..It seems likely that the pleiotropic effects of the homozygous null mutation on ovarian development may be due, at least in part, to disruption of intercellular communication between growing oocytes and their surrounding follicle cells...
  41. ncbi request reprint Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes
    Liviu A Sicinschi
    Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Int J Cancer 118:649-57. 2006
    ..pylori. Our results support the identification of the IL1B-31 promoter polymorphism as a useful marker for risk of intestinal type gastric cancer in persons with CagA positive H. pylori infections...
  42. ncbi request reprint Kinetic polymerase chain reaction on pooled DNA: a high-throughput, high-efficiency alternative in genetic epidemiological studies
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 11:131-6. 2002
    ..The results were comparable between both platforms and among all three polymerases. The results demonstrate a powerful new technology for determining frequencies of single-nucleotide polymorphisms in an epidemiological study...
  43. pmc Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity
    She Chen
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 24:26-40. 2013
    ..Together, these results demonstrate a role for mPar3 in directly regulating microtubule organization that is crucial for neuronal polarization...
  44. ncbi request reprint Insulin receptor substrate-1 regulates the transformed phenotype of BT-20 human mammary cancer cells
    Ozlem Dalmizrak
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Cancer Res 67:2124-30. 2007
    ..Targeting of IRS-1 could be effective in inhibiting the proliferation of mammary cancer cells...
  45. ncbi request reprint Electrogastrographic norms in children: toward the development of standard methods, reproducible results, and reliable normative data
    J Levy
    Department of Pediatrics, Babies and Children's Hospital of New York, Columbia University College of Physicians and Surgeons, New York, New York 10032-3784, USA
    J Pediatr Gastroenterol Nutr 33:455-61. 2001
    ..Differences in test conditions of signal detection and analytic methods influence EGG results substantially, and caution should be used when comparing results across centers...
  46. ncbi request reprint Elevation of blood beta-carboline alkaloids in essential tremor
    E D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Neurology 59:1940-4. 2002
    ..beta-Carboline alkaloids are normal body constituents but are also potent tremor-producing chemicals that are naturally present in the food chain...
  47. pmc Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract
    P R Wade
    Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, 10032, USA
    J Neurosci 16:2352-64. 1996
    ..Mucosal epithelial cells thus express a plasmalemmal 5-HT transporter identical to that of serotonergic neurons. This molecule seems to play a critical role in the peristaltic reflex...
  48. ncbi request reprint Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone
    Li Yang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yueyang Rd, Shanghai 200031, China
    Cell Res 14:315-23. 2004
    ....
  49. ncbi request reprint Identification and characterization of Bacillus anthracis by multiplex PCR on DNA chip
    Shi hua Wang
    Department of Analytical Biochemistry, Biotech Wuchang, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Biosens Bioelectron 20:807-13. 2004
    ..anthracis and distinguished 'anthrax-like' strains from other B. cereus group bacteria were unambiguously identified, while the genera other than Bacillus gave no positive signal...
  50. ncbi request reprint Tomato stress-responsive factor TSRF1 interacts with ethylene responsive element GCC box and regulates pathogen resistance to Ralstonia solanacearum
    Hongbo Zhang
    The National Plant Gene Research Center Beijing, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Plant Mol Biol 55:825-34. 2004
    ..solanacearum, but also provides further clues to understanding the mechanism of host regulatory proteins in response to the infection of pathogens...
  51. ncbi request reprint NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protection
    Mao Feng Chai
    National Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, 100094 Beijing, China
    Plant Mol Biol 59:553-64. 2005
    ..These results suggest that NADK2 may be a chloroplast NAD kinase and play a vital role in chlorophyll synthesis and chloroplast protection against oxidative damage...
  52. ncbi request reprint Using a modified TA cloning method to create entry clones
    Qi Jun Chen
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Anal Biochem 358:120-5. 2006
    ..Using Gateway T vectors prepared by this improved method, entry clones for PCR products or restriction enzyme fragments can be created simply, efficiently, and inexpensively while at the same time introducing greater compatibility...
  53. ncbi request reprint Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer
    Haiping Pei
    Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
    J Proteome Res 6:2495-501. 2007
    ..The aim of this study is to investigate the LNM-associated proteins and to evaluate the clinicopathological characteristics of these target proteins' expression in CRC...
  54. ncbi request reprint Zinc finger protein 1 (ThZF1) from salt cress (Thellungiella halophila) is a Cys-2/His-2-type transcription factor involved in drought and salt stress
    Shouming Xu
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China
    Plant Cell Rep 26:497-506. 2007
    ..Finally, ectopic expression of ThZF1 in Arabidopsis mutant azf2 suggested that ThZF1 may have similar roles as Arabidopsis AZF2 in plant development as well as regulation of downstream gene...
  55. ncbi request reprint AtHAP3b plays a crucial role in the regulation of flowering time in Arabidopsis during osmotic stress
    Nai Zhi Chen
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    J Biochem Mol Biol 40:1083-9. 2007
    ..These results suggest that the AtHAP3b gene plays more important roles in the control of lowering under osmotic stress in Arabidopsis...
  56. pmc Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neurons
    William J Freed
    Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse, National Institutes of Health NIH, Baltimore, Maryland, USA
    PLoS ONE 3:e1422. 2008
    ..We initiated differentiation of human embryonic stem cells (hESCs) into dopamine neurons, obtained a purified population of neuronal precursor cells by cell sorting, and determined patterns of gene transcription...
  57. ncbi request reprint AtHsfA2 modulates expression of stress responsive genes and enhances tolerance to heat and oxidative stress in Arabidopsis
    Chunguang Li
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Sci China C Life Sci 48:540-50. 2005
    ..So we suggest that AtHsfA2 plays an important role in linking heat shock with oxidative stress signals...

Research Grants7

  1. Dietary Methyl Content, Epigenetics and Breast Cancer
    Jia Chen; Fiscal Year: 2010
    ..To identify the factors that determine the patterns of methylation can provide evidence for the mechanisms of the disease as well as identify at-risk populations in which appropriate diet-based intervention can be provided. ..
  2. GENE-ENVIRONMENT INTERACTION AND COLON CARCINOGENESIS
    Jia Chen; Fiscal Year: 2002
    b>Jia Chen received her Sc.D. in 1994 in the fields of Toxicology and Environmental Engineering from Massachusetts Institute of Technology...
  3. Dietary Methyl Content, Epigenetics and Breast Cancer
    Jia Chen; Fiscal Year: 2006
    ..To identify the factors that determine the patterns of methylation can provide evidence for the mechanisms of the disease as well as identify at-risk populations in which appropriate diet-based intervention can be provided. ..
  4. Dietary Methyl Content, Epigenetics and Breast Cancer
    Jia Chen; Fiscal Year: 2007
    ..To identify the factors that determine the patterns of methylation can provide evidence for the mechanisms of the disease as well as identify at-risk populations in which appropriate diet-based intervention can be provided. ..
  5. Dietary Methyl Content, Epigenetics and Breast Cancer
    Jia Chen; Fiscal Year: 2009
    ..To identify the factors that determine the patterns of methylation can provide evidence for the mechanisms of the disease as well as identify at-risk populations in which appropriate diet-based intervention can be provided. ..
  6. Dietary Methyl Content, Epigenetics and Breast Cancer
    Jia Chen; Fiscal Year: 2009
    ..To identify the factors that determine the patterns of methylation can provide evidence for the mechanisms of the disease as well as identify at-risk populations in which appropriate diet-based intervention can be provided. ..