Theresa L Chang

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Defensins: natural anti-HIV peptides
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    AIDS Rev 6:161-8. 2004
  2. ncbi Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 115:765-73. 2005
  3. ncbi SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, Box 1090, One Gustave L Levy Place, New York, NY 10029, USA
    FEBS Lett 581:4596-602. 2007
  4. ncbi Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, Box 1090, One Gustave L Levy Place, New York, NY 10029, USA
    J Acquir Immune Defic Syndr 53:292-302. 2010
  5. ncbi Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation
    Jian Ding
    Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 184:2814-24. 2010
  6. ncbi Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission
    Mary E Klotman
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Immunol 180:6176-85. 2008
  7. ncbi Defensins in viral infections
    Jian Ding
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    J Innate Immun 1:413-20. 2009
  8. ncbi Defensins in innate antiviral immunity
    Mary E Klotman
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, Box 1090, 1 Gustave L Levy Place, New York 10029, USA
    Nat Rev Immunol 6:447-56. 2006

Research Grants

  1. Mechanism of HIV-1 inhibition by alpha-defensin-1
    Theresa Chang; Fiscal Year: 2005
  2. Defensins in STI-Mediated Enhanced HIV Infectivity
    Theresa L Chang; Fiscal Year: 2010
  3. Defensins in STI-mediated enhancement of HIV Infection
    Theresa Chang; Fiscal Year: 2007

Collaborators

Detail Information

Publications8

  1. ncbi Defensins: natural anti-HIV peptides
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    AIDS Rev 6:161-8. 2004
    ....
  2. ncbi Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 115:765-73. 2005
    ..Studying the complex function of alpha-defensin-1 in innate immunity against HIV has implications for prevention as well as therapeutics...
  3. ncbi SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, Box 1090, One Gustave L Levy Place, New York, NY 10029, USA
    FEBS Lett 581:4596-602. 2007
    ..In addition, SAMMA blocked HIV glycoprotein-mediated cell-cell fusion. This study suggests that SAMMA prevents HIV infection through multiple mechanisms...
  4. ncbi Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates
    Theresa L Chang
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, Box 1090, One Gustave L Levy Place, New York, NY 10029, USA
    J Acquir Immune Defic Syndr 53:292-302. 2010
    ..These primary macrophages could provide a valuable system for investigating the role of primary macrophages in HIV pathogenesis...
  5. ncbi Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation
    Jian Ding
    Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 184:2814-24. 2010
    ..This study provides a molecular mechanism by which nonulcerative sexually transmitted infections mediate enhancement of HIV infection and has implication for HIV prevention and therapeutics...
  6. ncbi Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission
    Mary E Klotman
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Immunol 180:6176-85. 2008
    ..Furthermore, this study demonstrates the complexity of defensins as innate immune mediators in HIV transmission and warrants further investigation of the mechanism by which defensins modulate HIV infection...
  7. ncbi Defensins in viral infections
    Jian Ding
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    J Innate Immun 1:413-20. 2009
    ..This review focuses on the interplay between defensins and viral infections, the mechanisms of action of defensins and the in vivo studies of the role of defensins in viral infections...
  8. ncbi Defensins in innate antiviral immunity
    Mary E Klotman
    Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, Box 1090, 1 Gustave L Levy Place, New York 10029, USA
    Nat Rev Immunol 6:447-56. 2006
    ..Understanding the complex function of defensins in innate immunity against viral infection has implications for the prevention and treatment of viral disease...

Research Grants4

  1. Mechanism of HIV-1 inhibition by alpha-defensin-1
    Theresa Chang; Fiscal Year: 2005
    ..abstract_text> ..
  2. Defensins in STI-Mediated Enhanced HIV Infectivity
    Theresa L Chang; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The goal of this project is aim to understand the role of defensins in sexual transmitted infection (STI)-mediated enhancement of HIV infectivity. ..
  3. Defensins in STI-mediated enhancement of HIV Infection
    Theresa Chang; Fiscal Year: 2007
    ..A longer term outcome could be the development of novel prevention strategies. ..