Andres A Caro

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Pharmacol 69:1081-93. 2005
  2. ncbi Oxidative stress, toxicology, and pharmacology of CYP2E1
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Pharmacol Toxicol 44:27-42. 2004
  3. pmc Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Biochem Biophys 457:252-63. 2007
  4. ncbi Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Pharmacol Exp Ther 318:360-72. 2006
  5. ncbi Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 40:364-75. 2006
  6. ncbi Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33866-77. 2003
  7. ncbi Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Biochem Biophys 408:162-70. 2002
  8. ncbi Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HEPG2 cells
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:104-13. 2002
  9. ncbi Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 36:1303-16. 2004
  10. ncbi S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury
    Aparajita Dey
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 293:G91-103. 2007

Detail Information

Publications10

  1. ncbi Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Pharmacol 69:1081-93. 2005
    ....
  2. ncbi Oxidative stress, toxicology, and pharmacology of CYP2E1
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Pharmacol Toxicol 44:27-42. 2004
    ..We believe that the linkage between CYP2E1-dependent oxidative stress, mitochondrial injury, and GSH homeostasis contribute to the toxic actions of ethanol on the liver...
  3. pmc Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Biochem Biophys 457:252-63. 2007
    ..These interactions may play a role in alcohol liver toxicity, which requires polyunsaturated fatty acids, and involves induction of CYP2E1...
  4. ncbi Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Pharmacol Exp Ther 318:360-72. 2006
    ....
  5. ncbi Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 40:364-75. 2006
    ..Inhibition of specific PLA2 and cytochrome P450 isoforms may represent novel therapeutic strategies against these diseases...
  6. ncbi Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33866-77. 2003
    ....
  7. ncbi Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Biochem Biophys 408:162-70. 2002
    ..Ca(2+) mobilization and activation of calpain contributes to the more rapid onset of mitochondrial damage in MEM, while oxidative damage and lipid peroxidation are involved in the Ca(2+)-independent later onset of mitochondrial damage...
  8. ncbi Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HEPG2 cells
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:104-13. 2002
    ..These results suggest that CYP2E1-dependent toxicity in this model depends on the activation of lipid peroxidation, followed by an increased influx of extracellular Ca2+ and activation of Ca2+-dependent proteases...
  9. ncbi Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations
    Andres A Caro
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 36:1303-16. 2004
    ..This could represent an important mechanism by which SAM exerts cellular protective actions and reduces oxidative stress in biological systems...
  10. ncbi S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury
    Aparajita Dey
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 293:G91-103. 2007
    ..In conclusion, SAM protects against and can also reverse or correct CYP2E1-induced liver damage in ob/ob mice...