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| Andres A CaroSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
| Collaborators |
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Publications
Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionineAndres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Biochem Pharmacol 69:1081-93. 2005....- Oxidative stress, toxicology, and pharmacology of CYP2E1Andres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
Annu Rev Pharmacol Toxicol 44:27-42. 2004..We believe that the linkage between CYP2E1-dependent oxidative stress, mitochondrial injury, and GSH homeostasis contribute to the toxic actions of ethanol on the liver... - Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1Andres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
Arch Biochem Biophys 457:252-63. 2007..These interactions may play a role in alcohol liver toxicity, which requires polyunsaturated fatty acids, and involves induction of CYP2E1... - Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicityAndres A Caro
Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Pharmacol Exp Ther 318:360-72. 2006.... - Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicityAndres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
Free Radic Biol Med 40:364-75. 2006..Inhibition of specific PLA2 and cytochrome P450 isoforms may represent novel therapeutic strategies against these diseases... - Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cellsAndres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:33866-77. 2003.... - Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1Andres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Arch Biochem Biophys 408:162-70. 2002..Ca(2+) mobilization and activation of calpain contributes to the more rapid onset of mitochondrial damage in MEM, while oxidative damage and lipid peroxidation are involved in the Ca(2+)-independent later onset of mitochondrial damage... - Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HEPG2 cellsAndres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 277:104-13. 2002..These results suggest that CYP2E1-dependent toxicity in this model depends on the activation of lipid peroxidation, followed by an increased influx of extracellular Ca2+ and activation of Ca2+-dependent proteases... - Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidationsAndres A Caro
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Free Radic Biol Med 36:1303-16. 2004..This could represent an important mechanism by which SAM exerts cellular protective actions and reduces oxidative stress in biological systems... - S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injuryAparajita Dey
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Am J Physiol Gastrointest Liver Physiol 293:G91-103. 2007..In conclusion, SAM protects against and can also reverse or correct CYP2E1-induced liver damage in ob/ob mice...