Research Topics
Genomes and GenesSpecies | Avrom CaplanSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Teaching resources. Protein kinasesAvrom Caplan
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci STKE 2005:tr7. 2005....
Hsp90 reaches new heights. Conference on the Hsp90 chaperone machineAvrom J Caplan
Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA
EMBO Rep 4:126-30. 2003- What is a co-chaperone?Avrom J Caplan
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Cell Stress Chaperones 8:105-7. 2003 - Molecular chaperones and protein kinase quality controlAvrom J Caplan
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Trends Cell Biol 17:87-92. 2007..This requirement might relate to conformational changes that take place during the protein kinase activity cycle... - Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptorKenneth Robzyk
Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Cell Endocrinol 268:67-74. 2007.... - C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradationChristopher P Cardozo
Department of Medicine, Mount Sinai School of Medicine, Box 1232, One Gustave L Levy Place, New York, NY 10029, USA
Arch Biochem Biophys 410:134-40. 2003..These results are discussed in terms of the role played by molecular chaperones in AR biogenesis... - Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell contextMaria A Theodoraki
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Exp Cell Res 313:3851-8. 2007..This suggests that NPM-ALK protects the mature kinase. Furthermore, Akt failed to bind to the Cdc37 chaperone in cells expressing NPM-ALK, which also correlates with increased Akt stability... - Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteinsNadinath B Nillegoda
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Biol Cell 21:2102-16. 2010..Ubr1 and Ubr2 therefore represent E3 components of a novel quality control pathway for proteins synthesized on cytosolic ribosomes... - The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viabilityPaul Lee
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Cell Biol 159:1051-9. 2002..This may be a form of regulation by which cells restrict access to Cdc37 until it has passed through a triage involving other chaperones such as Hsp70 and Hsp90... - Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturationAtin K Mandal
Department of Biology, City College New York, Convent Avenue at 138th Street, New York, NY 10031, USA
Mol Cell Biol 28:4434-44. 2008..Our results suggest that Ydj1 can both protect nascent chains against degradation and control the rate of kinase maturation... - Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone systemAtin K Mandal
Department of Biology, The City College of New York, New York, NY 10031, USA
Mol Biol Cell 21:1439-48. 2010..These findings support a model in which Hsp110 chaperones contribute significantly to the decision made by Hsp70 to fold or degrade a client protein... - Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinasePaul Lee
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
Mol Biol Cell 15:1785-92. 2004..These data suggest that Cdc37 and Sti1 have functional overlap in stabilizing Hsp90:client complexes. Finally, we show that Cns1 functions in MAP kinase signaling in association with Cpr7... - Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturationAtin K Mandal
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Cell Biol 176:319-28. 2007..Our studies demonstrate that Cdc37 has a general role in kinome biogenesis... - Differential effects of the organochlorine pesticide DDT and its metabolite p,p'-DDE on p-glycoprotein activity and expressionArsalan Shabbir
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Toxicol Appl Pharmacol 203:91-8. 2005..These results suggest that DDT, but not p,p'-DDE, induces an endoplasmic reticulum stress response... - Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4Qiang Zhao
Department of Oncology, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
J Biol Chem 279:12560-4. 2004..Under the same conditions, p16 binding to wild type Cdk4 was suppressed. Our findings show that the interaction of Cdc37 with its client protein kinases requires amino acid residues within a motif that is present in many protein kinases... - Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activityJennifer L Goeckeler
Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
Mol Biol Cell 13:2760-70. 2002..Because the folding of both v-Src kinase and human androgen receptor in yeast requires the Hsp90 complex, these data suggest that Ydj1p and Sse1p are interacting cochaperones in the Hsp90 complex and facilitate Hsp90-dependent activity... - The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1Chun-Yang Fan
Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7090, USA
J Biol Chem 280:695-702. 2005..On the other hand, protein folding is dependent upon the action of both ZBDI and ZBDII because each is required for Hsp70 to capture non-native polypeptides from Ydj1... - Multiple kinases and system robustness: a link between Cdc37 and genome integrityAvrom J Caplan
Cell Cycle 6:3145-7. 2007..A network analysis approach related these machines to a small group of cell cycle checkpoint kinases... - Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent mannerJingbo Zhao
Rehabilitation and Research Development Center of Excellence for the Medical Consequences of Spinal Cord Injury, VA Medical Center, Bronx, NY, USA
Steroids 69:357-66. 2004..These data indicate a novel action of oxandrolone to suppress glucocorticoid action via crosstalk between AR and GR...
Research Grants
- ANDROGEN RECEPTOR DEGRADATIONAvrom Caplan; Fiscal Year: 2006..abstract_text> ..
- Hsp90 Chaperone Machine Structure and FunctionAvrom Caplan; Fiscal Year: 2009..In the second sub-aim we will assay for chaperone activity of novel co-chaperones that are important for protein kinase folding. Finally, we will distinguish between the role of Cdc37 in Cdk folding and cyclin binding. ..