Avrom Caplan

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation
    Atin K Mandal
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 176:319-28. 2007
  2. pmc The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability
    Paul Lee
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 159:1051-9. 2002
  3. pmc Hsp90 reaches new heights. Conference on the Hsp90 chaperone machine
    Avrom J Caplan
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    EMBO Rep 4:126-30. 2003
  4. pmc What is a co-chaperone?
    Avrom J Caplan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Stress Chaperones 8:105-7. 2003
  5. ncbi request reprint Molecular chaperones and protein kinase quality control
    Avrom J Caplan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Cell Biol 17:87-92. 2007
  6. ncbi request reprint Teaching resources. Protein kinases
    Avrom Caplan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci STKE 2005:tr7. 2005
  7. ncbi request reprint C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation
    Christopher P Cardozo
    Department of Medicine, Mount Sinai School of Medicine, Box 1232, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Biochem Biophys 410:134-40. 2003
  8. pmc Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor
    Kenneth Robzyk
    Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell Endocrinol 268:67-74. 2007
  9. pmc Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context
    Maria A Theodoraki
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Cell Res 313:3851-8. 2007
  10. pmc Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins
    Nadinath B Nillegoda
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Cell 21:2102-16. 2010

Research Grants

  1. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2002
  2. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2006
  3. Hsp90 Chaperone Machine Structure and Function
    Avrom Caplan; Fiscal Year: 2007
  4. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2003
  5. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2004
  6. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2005
  7. Hsp90 Chaperone Machine Structure and Function
    Avrom Caplan; Fiscal Year: 2006
  8. Hsp90 Chaperone Machine Structure and Function
    Avrom Caplan; Fiscal Year: 2009

Collaborators

Detail Information

Publications19

  1. pmc Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation
    Atin K Mandal
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 176:319-28. 2007
    ..Our studies demonstrate that Cdc37 has a general role in kinome biogenesis...
  2. pmc The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability
    Paul Lee
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 159:1051-9. 2002
    ..This may be a form of regulation by which cells restrict access to Cdc37 until it has passed through a triage involving other chaperones such as Hsp70 and Hsp90...
  3. pmc Hsp90 reaches new heights. Conference on the Hsp90 chaperone machine
    Avrom J Caplan
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    EMBO Rep 4:126-30. 2003
  4. pmc What is a co-chaperone?
    Avrom J Caplan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Stress Chaperones 8:105-7. 2003
  5. ncbi request reprint Molecular chaperones and protein kinase quality control
    Avrom J Caplan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Trends Cell Biol 17:87-92. 2007
    ..This requirement might relate to conformational changes that take place during the protein kinase activity cycle...
  6. ncbi request reprint Teaching resources. Protein kinases
    Avrom Caplan
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci STKE 2005:tr7. 2005
    ....
  7. ncbi request reprint C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation
    Christopher P Cardozo
    Department of Medicine, Mount Sinai School of Medicine, Box 1232, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Biochem Biophys 410:134-40. 2003
    ..These results are discussed in terms of the role played by molecular chaperones in AR biogenesis...
  8. pmc Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor
    Kenneth Robzyk
    Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell Endocrinol 268:67-74. 2007
    ....
  9. pmc Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context
    Maria A Theodoraki
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Cell Res 313:3851-8. 2007
    ..This suggests that NPM-ALK protects the mature kinase. Furthermore, Akt failed to bind to the Cdc37 chaperone in cells expressing NPM-ALK, which also correlates with increased Akt stability...
  10. pmc Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins
    Nadinath B Nillegoda
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Cell 21:2102-16. 2010
    ..Ubr1 and Ubr2 therefore represent E3 components of a novel quality control pathway for proteins synthesized on cytosolic ribosomes...
  11. pmc Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation
    Atin K Mandal
    Department of Biology, City College New York, Convent Avenue at 138th Street, New York, NY 10031, USA
    Mol Cell Biol 28:4434-44. 2008
    ..Our results suggest that Ydj1 can both protect nascent chains against degradation and control the rate of kinase maturation...
  12. pmc Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system
    Atin K Mandal
    Department of Biology, The City College of New York, New York, NY 10031, USA
    Mol Biol Cell 21:1439-48. 2010
    ..These findings support a model in which Hsp110 chaperones contribute significantly to the decision made by Hsp70 to fold or degrade a client protein...
  13. pmc Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase
    Paul Lee
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Biol Cell 15:1785-92. 2004
    ..These data suggest that Cdc37 and Sti1 have functional overlap in stabilizing Hsp90:client complexes. Finally, we show that Cns1 functions in MAP kinase signaling in association with Cpr7...
  14. ncbi request reprint Differential effects of the organochlorine pesticide DDT and its metabolite p,p'-DDE on p-glycoprotein activity and expression
    Arsalan Shabbir
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicol Appl Pharmacol 203:91-8. 2005
    ..These results suggest that DDT, but not p,p'-DDE, induces an endoplasmic reticulum stress response...
  15. ncbi request reprint Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4
    Qiang Zhao
    Department of Oncology, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA
    J Biol Chem 279:12560-4. 2004
    ..Under the same conditions, p16 binding to wild type Cdk4 was suppressed. Our findings show that the interaction of Cdc37 with its client protein kinases requires amino acid residues within a motif that is present in many protein kinases...
  16. pmc Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activity
    Jennifer L Goeckeler
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Mol Biol Cell 13:2760-70. 2002
    ..Because the folding of both v-Src kinase and human androgen receptor in yeast requires the Hsp90 complex, these data suggest that Ydj1p and Sse1p are interacting cochaperones in the Hsp90 complex and facilitate Hsp90-dependent activity...
  17. ncbi request reprint The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1
    Chun Yang Fan
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
    J Biol Chem 280:695-702. 2005
    ..On the other hand, protein folding is dependent upon the action of both ZBDI and ZBDII because each is required for Hsp70 to capture non-native polypeptides from Ydj1...
  18. pmc Multiple kinases and system robustness: a link between Cdc37 and genome integrity
    Avrom J Caplan
    Cell Cycle 6:3145-7. 2007
    ..A network analysis approach related these machines to a small group of cell cycle checkpoint kinases...
  19. ncbi request reprint Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner
    Jingbo Zhao
    Rehabilitation and Research Development Center of Excellence for the Medical Consequences of Spinal Cord Injury, VA Medical Center, Bronx, NY, USA
    Steroids 69:357-66. 2004
    ..These data indicate a novel action of oxandrolone to suppress glucocorticoid action via crosstalk between AR and GR...

Research Grants9

  1. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2002
    ..abstract_text> ..
  2. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2006
    ..abstract_text> ..
  3. Hsp90 Chaperone Machine Structure and Function
    Avrom Caplan; Fiscal Year: 2007
    ..In the second sub-aim we will assay for chaperone activity of novel co-chaperones that are important for protein kinase folding. Finally, we will distinguish between the role of Cdc37 in Cdk folding and cyclin binding. ..
  4. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2003
    ..abstract_text> ..
  5. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2004
    ..abstract_text> ..
  6. ANDROGEN RECEPTOR DEGRADATION
    Avrom Caplan; Fiscal Year: 2005
    ..abstract_text> ..
  7. Hsp90 Chaperone Machine Structure and Function
    Avrom Caplan; Fiscal Year: 2006
    ..In the second sub-aim we will assay for chaperone activity of novel co-chaperones that are important for protein kinase folding. Finally, we will distinguish between the role of Cdc37 in Cdk folding and cyclin binding. ..
  8. Hsp90 Chaperone Machine Structure and Function
    Avrom Caplan; Fiscal Year: 2009
    ..In the second sub-aim we will assay for chaperone activity of novel co-chaperones that are important for protein kinase folding. Finally, we will distinguish between the role of Cdc37 in Cdk folding and cyclin binding. ..