WILLIAM M BYNE

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Report of the American Psychiatric Association task force on treatment of Gender Identity Disorder
    William Byne
    Department of Psychiatry, JJ Peters VA Medical Center, Bronx, NY, USA
    Arch Sex Behav 41:759-96. 2012
  2. pmc Effects of mental illness and aging in two thalamic nuclei
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    Schizophr Res 106:172-81. 2008
  3. doi request reprint The thalamus and schizophrenia: current status of research
    William Byne
    Department of Psychiatry, James J Peters VA Medical Center, Research Bldg Room 2F39, Bronx, NY 10468, USA
    Acta Neuropathol 117:347-68. 2009
  4. ncbi request reprint Developmental endocrine influences on gender identity: implications for management of disorders of sex development
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:950-9. 2006
  5. ncbi request reprint Reduction of right medial pulvinar volume and neuron number in schizophrenia
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, USA
    Schizophr Res 90:71-5. 2007
  6. ncbi request reprint Schizophrenia-associated reduction of neuronal and oligodendrocyte numbers in the anterior principal thalamic nucleus
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, NY 10467, USA
    Schizophr Res 85:245-53. 2006
  7. ncbi request reprint Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia
    William Byne
    Department of Psychiatry and Pathology, Mount Sinai School of Medicine, New York, USA
    Am J Psychiatry 159:59-65. 2002
  8. ncbi request reprint Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia
    Eileen M Kemether
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 60:983-91. 2003
  9. pmc Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
    Schizophr Res 98:118-28. 2008
  10. doi request reprint Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder
    Kevin Barley
    J J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Ave, Bronx, NY 10468, USA
    Schizophr Res 112:54-64. 2009

Research Grants

Collaborators

Detail Information

Publications25

  1. doi request reprint Report of the American Psychiatric Association task force on treatment of Gender Identity Disorder
    William Byne
    Department of Psychiatry, JJ Peters VA Medical Center, Bronx, NY, USA
    Arch Sex Behav 41:759-96. 2012
    ....
  2. pmc Effects of mental illness and aging in two thalamic nuclei
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    Schizophr Res 106:172-81. 2008
    ..Among subjects with psychiatric diagnoses, exposure to lithium was associated with an increase in the number of oligodendrocytes. No effects were detected for exposure to anticonvulsants or for abuse of alcohol or other substances...
  3. doi request reprint The thalamus and schizophrenia: current status of research
    William Byne
    Department of Psychiatry, James J Peters VA Medical Center, Research Bldg Room 2F39, Bronx, NY 10468, USA
    Acta Neuropathol 117:347-68. 2009
    ..Evidence for anomalies of thalamic structure and function obtained from postmortem and neuroimaging studies is then examined and directions for further research proposed...
  4. ncbi request reprint Developmental endocrine influences on gender identity: implications for management of disorders of sex development
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:950-9. 2006
    ..In keeping with the neuropsychiatry theme of this issue, the focus of this article is on prenatal sexual differentiation of the brain as it pertains to the question of psychosexual neutrality at birth...
  5. ncbi request reprint Reduction of right medial pulvinar volume and neuron number in schizophrenia
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, USA
    Schizophr Res 90:71-5. 2007
    ..The medial pulvinar interconnects various heteromodal cortical regions suggesting that these deficits may contribute to the abnormalities of higher order integrative functions characteristic of schizophrenia...
  6. ncbi request reprint Schizophrenia-associated reduction of neuronal and oligodendrocyte numbers in the anterior principal thalamic nucleus
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, NY 10467, USA
    Schizophr Res 85:245-53. 2006
    ..These findings are consistent with a previous report of reduced neuronal number in the anterior principal nucleus of male SZs and add to a growing body of evidence implicating oligodendrocyte abnormalities in SZ...
  7. ncbi request reprint Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia
    William Byne
    Department of Psychiatry and Pathology, Mount Sinai School of Medicine, New York, USA
    Am J Psychiatry 159:59-65. 2002
    ..The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus...
  8. ncbi request reprint Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia
    Eileen M Kemether
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 60:983-91. 2003
    ..The centromedian nucleus (CMN), important in attention and arousal, has not been previously studied with MRI...
  9. pmc Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
    Schizophr Res 98:118-28. 2008
    ..All markers were differentially expressed across nuclei...
  10. doi request reprint Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder
    Kevin Barley
    J J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Ave, Bronx, NY 10468, USA
    Schizophr Res 112:54-64. 2009
    ..These data are discussed in the context of myelin turnover and potential effects of psychiatric illness as well as medications on the developmental fate of OLPs...
  11. pmc Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait
    Stella Dracheva
    James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuropsychopharmacology 34:2237-51. 2009
    ..No differences in the 5-HT(2C)R expression were detected between the behavioral phenotypes. However, editing was higher in the PFC of HRs vs LRs, implicating this region in the pathophysiology of drug abuse liability...
  12. pmc Effects of sex and normal aging on regional brain activation during verbal memory performance
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Neurobiol Aging 31:826-38. 2010
    ..These results suggest that both age-related metabolic decline and sex differences within frontal regions are more marked in medial frontal and cingulate areas, consistent with some age-related patterns of affective and cognitive change...
  13. ncbi request reprint A lack of dimorphism of sex or sexual orientation in the human anterior commissure
    Mitchell S Lasco
    Department of Applied Psychology, New York University, 239 Greene Street, New York, NY 10003, USA
    Brain Res 936:95-8. 2002
    ..We examined the cross-sectional area of the AC in postmortem material from 120 individuals, and found no variation in the size of the AC with age, HIV status, sex, or sexual orientation...
  14. ncbi request reprint Thalamus size and outcome in schizophrenia
    Adam M Brickman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 71:473-84. 2004
    ..These findings are consistent with post-mortem and MRI measurement suggesting reduction in volume of the pulvinar, which occupies a large proportion of the ventral thalamus and which has prominent connections to the temporal lobe...
  15. pmc Diffusion tensor anisotropy in adolescents and adults
    Jason S Schneiderman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychobiology 55:96-111. 2007
    ..Sex differences were found in the majority of areas but were most marked in the cingulum bundle and internal capsule. These results suggest continuing white matter development between adolescence and adulthood...
  16. ncbi request reprint Metabolic thalamocortical correlations during a verbal learning task and their comparison with correlations among regional volumes
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Brain Res 1114:125-37. 2006
    ....
  17. ncbi request reprint Metabolic disconnection between the mediodorsal nucleus of the thalamus and cortical Brodmann's areas of the left hemisphere in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1733-5. 2005
    ..The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia...
  18. ncbi request reprint Correlations between volumes of the pulvinar, centromedian, and mediodorsal nuclei and cortical Brodmann's areas in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Mount Sinai School of Medicine, Mount Sinai Medical Center, Box 1505, One Gustave L Levy Place, NY 10029, USA
    Neurosci Lett 392:16-21. 2006
    ....
  19. ncbi request reprint Abnormal glucose metabolism in the mediodorsal nucleus of the thalamus in schizophrenia
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 161:305-14. 2004
    ....
  20. ncbi request reprint Thalamocortical circuits: fMRI assessment of the pulvinar and medial dorsal nucleus in normal volunteers
    Monte S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029 6574, USA
    Neurosci Lett 404:282-7. 2006
    ..For the pulvinar, maximal functional connectivity was with parietal BA39; for anterior thalamus, with anterior cingulate...
  21. ncbi request reprint Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia
    Patrick R Hof
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 53:1075-85. 2003
    ..Brain imaging, molecular genetic, and ultrastructural evidence indicate the existence of pathologic alterations in the cortical and subcortical white matter of schizophrenic patients...
  22. doi request reprint Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia
    David Kerns
    J J Peters VA Medical Center, 130 West Kingsbridge Ave, Bronx, New York, NY 10468, USA
    Schizophr Res 120:150-8. 2010
    ..These data are consistent with the hypothesis that Ol and myelin deficits in SZ involve a failure of Ol precursors to appropriately exit the cell cycle in order to differentiate and mature into myelinating Ols...
  23. pmc Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Brain Res 1214:23-34. 2008
    ..These results provide detailed and quantitative information on iGluR subunit expression in multiple nuclei of the human thalamus but suggest that alterations in their expression are not a prominent feature of schizophrenia...
  24. ncbi request reprint Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex
    Kevin Broadbelt
    Department of Biological Sciences, Lehman College, 250 Bedford Park Boulevard, Bronx, New York, NY 10468, USA
    Schizophr Res 58:75-81. 2002
    ..Similarly, in layer III there was also a decrease in both primary (17%) and secondary (15%) basilar dendrites. These findings suggest a decrease in synaptic surface area which could lead to aberrant information processing...
  25. ncbi request reprint Alterations in MAP2 immunocytochemistry in areas 9 and 32 of schizophrenic prefrontal cortex
    Liesl B Jones
    Lehman College, Department Biological Sciences, 250 Bedford Park Blvd, NY 10468, Bronx, USA
    Psychiatry Res 114:137-48. 2002
    ..Neither region exhibited a significant change in the density of pyramidal cells. These data are consistent with the hypothesis of a schizophrenia-associated decrease in dendritic material in the PFC...

Research Grants3

  1. The pulvinar in schizophrenia: a postmortem study
    William Byne; Fiscal Year: 2003
    ..Because thalamocortical neurons provide excitatory input to cortex, we hypothesize that the pulvinar of schizophrenics will exhibit a deficit of cortically projecting neurons identified by immunostaining for parvalbumin and calbindin. ..