Research Topics
Genomes and GenesSpecies | Julie A BrittonSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
Characteristics of pubertal development in a multi-ethnic population of nine-year-old girlsJulie A Britton
Division of Environmental Health Science, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Epidemiol 14:179-87. 2004..Early age at menarche increases future disease risk. Secular decline in age at menarche has been attributed to body size characteristics, diet, and energy expenditure. Risk factors for puberty have been less frequently explored...- Risk of breast cancer classified by joint estrogen receptor and progesterone receptor status among women 20-44 years of ageJulie A Britton
Division of Environmental Health Science, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Epidemiol 156:507-16. 2002..These findings only modestly support the hypothesis that hormonally related risk factors have differing relations with ER+PR+ versus ER-PR- tumors among younger women... - The development of a questionnaire to assess past year physical activity in a multi-ethnic/racial urban populationJulie A Britton
Division of Environmental Health Science, Mt Sinai School of Medicine, 1 Gustave L Levy Place, Box 1057, New York, NY 10029, USA
Soz Praventivmed 47:178-94. 2002..Describe energy expenditure (EE) patterns in the sample used for questionnaire development... - A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin usersXinran Xu
Departments of Community and Preventive Medicine and Epidemiology and Medicine, Columbia University, New York, NY, USA
Am J Clin Nutr 85:1098-102. 2007..Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions... - Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based studyXinran Xu
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Carcinogenesis 28:1504-9. 2007..Although the pathway is a network of interrelated enzymes, redundancy exists; evaluating the rate-limiting enzyme and its interaction with environment and other genes within the same pathway is critical in assessing breast cancer risk... 
Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study ProjectYu Chen
Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Carcinogenesis 29:766-71. 2008..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...- Improving organochlorine biomarker models for cancer researchMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 14:2224-36. 2005..e., PCB) or long discontinued (i.e., DDE)... - Environmental exposures and puberty in inner-city girlsMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, Box 1057, 1 Gustav L Levy Place, New York, NY 10029, USA
Environ Res 107:393-400. 2008..Hormonally active environmental exposures are suspected to alter onset of puberty in girls, but research on this question has been very limited... - ADH3 genotype, alcohol intake and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA, and Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Carcinogenesis 27:840-7. 2006..9, 95 % CI=1.2-7.1; postmenopausal women OR=1.8, 95% CI=0.9-3.8). These population-based data support the hypothesis that fast metabolizers of alcohol have a higher risk of breast cancer risk, from alcohol intake than slow metabolizers... - Pharmacokinetic variability and modern epidemiology--the example of dichlorodiphenyltrichloroethane, body mass index, and birth cohortMary S Wolff
Division of Environmental and Occupational Medicine, Mt. Sinai School of Medicine, Box 1057, 1 Gustave L Levy Place, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 16:1925-30. 2007 - Body size changes in relation to postmenopausal breast cancer among women on Long Island, New YorkSybil M Eng
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10017, USA
Am J Epidemiol 162:229-37. 2005..55, 95% CI: 0.32, 0.96). These results add to the literature by focusing on the perimenopausal weight trajectory and support efforts urging women to avoid weight gain as they age... - One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancerJia Chen
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
Cancer Res 65:1606-14. 2005..96) or total folate intake (OR, 1.71; 95% CI, 1.08-2.71). From a public heath perspective, it is important to identify risk factors, such as low B vitamin consumption, that may guide an effective prevention strategy against the disease... - Occupation and breast cancer in women 20-44 years of age (United States)Susan L Teitelbaum
Division of Environmental Health Science, Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Cancer Causes Control 14:627-37. 2003..To examine the relation between breast cancer risk and job history among women 20-44 years of age who participated in a multi-center, population-based, case-control study... - Reported residential pesticide use and breast cancer risk on Long Island, New YorkSusan L Teitelbaum
Department of Community Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Am J Epidemiol 165:643-51. 2007..This study is the first known to suggest that self-reported use of residential pesticides may increase breast cancer risk. Further investigation in other populations is necessary to confirm these findings... - Lifetime alcohol intake and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Ann Epidemiol 16:230-40. 2006..Risk is confined to moderate intake and does not vary with the timing of use, with heavier doses, or with the type of alcohol consumed... - Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
Cancer Res 64:7634-9. 2004.... 
Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girlsMary S Wolff
Mount Sinai School of Medicine, Division of Environmental Health Sciences, Department of Community and Preventive Medicine, New York, New York 10029, USA
Environ Health Perspect 115:116-21. 2007..S. children using exposure biomarkers in urine. However, little is known about their variation by race, age, sex, and geography, and no data exist for newly developed biomarkers...- Estrogen metabolism and breast cancerGeoffrey C Kabat
Department of Preventive Medicine, School of Medicine, Stony Brook University, New York, USA
Epidemiology 17:80-8. 2006.... - Association of frequency and duration of aspirin use and hormone receptor status with breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
JAMA 291:2433-40. 2004..67-1.40). CONCLUSION: These data add to the growing evidence that supports the regular use of aspirin and other NSAIDs (which may operate through inhibition of estrogen biosynthesis) as effective chemopreventive agents for breast cancer... - Higher levels of central adiposity in healthy premenopausal women with family histories of premenopausal breast cancerLucia Dettenborn
Department of Oncological Sciences, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1130, New York, New York 10029 6574, USA
Am J Hum Biol 20:355-8. 2008.... - Environmental risk factors for breast cancer among African-American womenMary S Wolff
Department of Community and Preventative Medicine, Mount Sinai School of Medicine, New York, New York, USA
Cancer 97:289-310. 2003..Breast cancer studies should be expanded to examine combinations of chemicals as well as competing or complementary exposures such as endogenous hormones, dietary intake, and behavioral factors... - Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysisMarilie D Gammon
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Arch Environ Health 59:640-9. 2004..These data provide only modest support for an association between PAH-DNA adducts and breast cancer development... - Recreational physical activity and survival among young women with breast cancerPage E Abrahamson
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer 107:1777-85. 2006..Most epidemiologic studies report a reduced risk of developing breast cancer associated with higher levels of recreational physical activity, but little is known regarding its effect on prognosis... - Dietary flavonoid intake and breast cancer risk among women on Long IslandBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Am J Epidemiol 165:514-23. 2007..These results suggest that US women can consume sufficient levels of flavonoids to benefit from their potential chemopreventive effects... - Dietary flavonoid intake and breast cancer survival among women on Long IslandBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 16:2285-92. 2007..However, the effects of flavonoids on survival are not known. In a population-based cohort of breast cancer patients, we investigated whether dietary flavonoid intake before diagnosis is associated with subsequent survival... - Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)Julie A Britton
Department of Epidemiology and Public Health, Imperial College London, Room 151, St Mary s Campus, Norfolk Place W2 1PG, London, UK
Haematologica 93:1666-77. 2008..It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma... - Weight gain prior to diagnosis and survival from breast cancerRebecca J Cleveland
Department of Epidemiology, University of North Carolina, CB 7435 McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 16:1803-11. 2007.... - Cooked meat and risk of breast cancer--lifetime versus recent dietary intakeSusan E Steck
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Epidemiology 18:373-82. 2007..Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens formed in or on the surface of well-done meat, cooked at high temperature... - Active and passive cigarette smoke and breast cancer survivalSharon K Sagiv
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Epidemiol 17:385-93. 2007..The association between active and passive cigarette smoking before breast cancer diagnosis and survival was investigated among a cohort of invasive breast cancer cases (n = 1273) participating in a population-based case-control study... - Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 27:1876-82. 2006..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers... - Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hil, NC 27516, USA
Breast Cancer Res Treat 99:235-40. 2006.... - Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in bloodMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:686-97. 2002..These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women... - The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancerMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
Breast Cancer Res Treat 74:235-54. 2002.... - Correspondence re: Schoen et al., Lack of association between adipose tissue distribution, and insulin-like growth factor-I and insulin-like growth factor binding protein-3 in men and women. Cancer Epidemiol. Biomark. Prev., 11: 581-586, 2002Julie A Britton
Cancer Epidemiol Biomarkers Prev 12:586; author reply 586-7. 2003 - Adipose concentrations of organochlorine compounds and breast cancer recurrence in Long Island, New YorkJoshua E Muscat
Institute for Cancer Prevention, Valhalla, New York 10595, USA
Cancer Epidemiol Biomarkers Prev 12:1474-8. 2003..9-5.1). In contrast to previous data showing no relationship between OC exposure and risk of breast cancer in these women, adipose PCB concentrations were associated with tumor recurrence. Pesticide levels were not related to recurrence... - Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adductsMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:677-85. 2002..These data indicate that PAH-DNA adduct formation may influence breast cancer development, although the association does not appear to be dose dependent and may have a threshold effect... - Environmental tobacco smoke and breast cancer incidenceMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435 McGavern Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Environ Res 96:176-85. 2004..42 for ER+ PR+, 95% CI, 1.00, 2.00). Our data suggest that if there is an effect for ETS on breast cancer, that effect is restricted to selected subgroups of women, such as those with long-term exposure from a smoking spouse... - Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor statusMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 13:1485-94. 2004..Our results support an inverse association for fruit and vegetable intake among postmenopausal but not premenopausal breast cancer, which may be more pronounced among women with ER+ tumors... - TCDD and puberty in girlsMary S Wolff
Environ Health Perspect 113:A17; author reply A18. 2005 - Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement useJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Am J Epidemiol 162:943-52. 2005..CC genotypes were prevalent in approximately 64% of controls; thus, the preventive potential for fruit consumption has widespread implications... - Fruits, vegetables, and micronutrient intake in relation to breast cancer survivalBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 98:199-208. 2006..To determine whether fruit, vegetable, and micronutrient intake 1 year prior to breast cancer diagnosis is associated with a reduction in the subsequent risk of all-cause or breast cancer-specific mortality... - MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
Cancer Causes Control 16:1225-34. 2005..This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk... - IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study ProjectRebecca J Cleveland
Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Carcinogenesis 27:758-65. 2006..Our results demonstrate a role for alleles with fewer than (CA)19 repeats as a risk factor for breast cancer and also suggest that several traditional breast cancer risk factors modify the association of the IGF1 (CA)19 repeat genotype... - Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult femalesSumitra Shantakumar
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
J Expo Anal Environ Epidemiol 15:482-90. 2005..These data suggest that PAH-DNA adducts detected in a population-based sample of adult women with ambient exposure levels reflect some key residential PAH exposure sources assessed in this study, such as cigarette smoking... - Reproductive factors and breast cancer risk among older womenSumitra Shantakumar
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 102:365-74. 2007..Moreover, breastfeeding, one of the few potentially modifiable risk factors for breast cancer, was an important factor in decreasing risk among older parous postmenopausal women... - Electric blanket use and breast cancer on Long IslandGeoffrey C Kabat
Department of Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, NY, USA
Epidemiology 14:514-20. 2003..CONCLUSIONS: The results of this large investigation are consistent with those of most previous studies, and do not support the hypothesis that electric blanket use is associated with increased breast cancer risk... - Re: "Population- and community-based recruitment of African Americans and Latinos: the San Francisco Bay Area Lung Cancer Study"Christine B Ambrosone
Am J Epidemiol 159:620; author reply 621. 2004 - No association between glutathione peroxidase Pro198Leu polymorphism and breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 14:2459-61. 2005 - Age and menopausal effects of hormonal birth control and hormone replacement therapy in relation to breast cancer riskSumitra Shantakumar
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA
Am J Epidemiol 165:1187-98. 2007..These results emphasize that timing of exogenous hormone use is important. Women who used these hormones before menopause had elevated risks, but the harmful effects began to decline with age after menopause...
Research Grants
- Energy Balance and Breast Cancer in Arican AmericansJulie Britton; Fiscal Year: 2006..abstract_text> ..