Andrea D Branch

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. pmc Evidence for a functional RNA element in the hepatitis C virus core gene
    Laura K McMullan
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:2879-84. 2007
  2. pmc Clinicopathologic correlates of hepatitis C virus in brain: a pilot study
    Jacinta Murray
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurovirol 14:17-27. 2008
  3. pmc In HIV/hepatitis C virus co-infected patients, higher 25-hydroxyvitamin D concentrations were not related to hepatitis C virus treatment responses but were associated with ritonavir use
    Andrea D Branch
    Divisions of Liver Diseases and Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Clin Nutr 98:423-9. 2013
  4. pmc Mortality in hepatitis C virus-infected patients with a diagnosis of AIDS in the era of combination antiretroviral therapy
    Andrea D Branch
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Infect Dis 55:137-44. 2012
  5. ncbi request reprint The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others
    Andrea D Branch
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Liver Dis 25:105-17. 2005
  6. ncbi request reprint Antisense gets a grip on miR-122 in chimpanzees
    Andrea D Branch
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Transl Med 2:13ps1. 2010
  7. pmc Rapid progression to decompensated cirrhosis, liver transplant, and death in HIV-infected men after primary hepatitis C virus infection
    Daniel S Fierer
    Divisions of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Clin Infect Dis 56:1038-43. 2013
  8. pmc Molecular and bioinformatic evidence of hepatitis C virus evolution in brain
    Sarah L Fishman
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Infect Dis 197:597-607. 2008
  9. pmc Internal initiation stimulates production of p8 minicore, a member of a newly discovered family of hepatitis C virus core protein isoforms
    Francis J Eng
    Division of Liver Diseases, Mount Sinai School of Medicine, New York 10029, USA
    J Virol 83:3104-14. 2009
  10. pmc Evaluation of hepatitis C virus as a risk factor for HIV-associated neuroretinal disorder
    Andrea D Branch
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
    Clin Infect Dis 57:1618-25. 2013

Research Grants

  1. Clinical Outcomes and the HCV Core Gene
    Andrea D Branch; Fiscal Year: 2010
  2. Modulation of HCV Gene Expression
    Andrea D Branch; Fiscal Year: 2010
  3. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2007
  4. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2007
  5. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2006
  6. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2006
  7. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2005
  8. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2005
  9. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2004
  10. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2004

Collaborators

Detail Information

Publications27

  1. pmc Evidence for a functional RNA element in the hepatitis C virus core gene
    Laura K McMullan
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:2879-84. 2007
    ..We conclude that ARF-encoded proteins initiating at the polyprotein AUG are not essential for HCV replication in cell culture or in vivo. Rather, our results provide evidence for a functionally important RNA element in the ARF region...
  2. pmc Clinicopathologic correlates of hepatitis C virus in brain: a pilot study
    Jacinta Murray
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurovirol 14:17-27. 2008
    ..Differences in abstraction/executive function of HCV/HIV coinfected patients compared to HIV monoinfected warrant further studies to determine if neuropsychiatric effects are predicated upon brain infection...
  3. pmc In HIV/hepatitis C virus co-infected patients, higher 25-hydroxyvitamin D concentrations were not related to hepatitis C virus treatment responses but were associated with ritonavir use
    Andrea D Branch
    Divisions of Liver Diseases and Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Clin Nutr 98:423-9. 2013
    ..Data on the relation between 25(OH)D concentrations and HCV treatment response in HIV-infected patients are limited...
  4. pmc Mortality in hepatitis C virus-infected patients with a diagnosis of AIDS in the era of combination antiretroviral therapy
    Andrea D Branch
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Infect Dis 55:137-44. 2012
    ....
  5. ncbi request reprint The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others
    Andrea D Branch
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Liver Dis 25:105-17. 2005
    ..The preliminary nature of investigations that have not yet been reviewed by peers is noted in the text...
  6. ncbi request reprint Antisense gets a grip on miR-122 in chimpanzees
    Andrea D Branch
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Sci Transl Med 2:13ps1. 2010
    ..Potential therapeutic uses of SPC3649 include the treatment of HCV infection and liver cancer...
  7. pmc Rapid progression to decompensated cirrhosis, liver transplant, and death in HIV-infected men after primary hepatitis C virus infection
    Daniel S Fierer
    Divisions of Infectious Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Clin Infect Dis 56:1038-43. 2013
    ....
  8. pmc Molecular and bioinformatic evidence of hepatitis C virus evolution in brain
    Sarah L Fishman
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Infect Dis 197:597-607. 2008
    ..Neurocognitive deficits in patients with hepatitis C virus (HCV) infection prompted a search for HCV in brain...
  9. pmc Internal initiation stimulates production of p8 minicore, a member of a newly discovered family of hepatitis C virus core protein isoforms
    Francis J Eng
    Division of Liver Diseases, Mount Sinai School of Medicine, New York 10029, USA
    J Virol 83:3104-14. 2009
    ..Infectious viruses of both genotype 1 and 2 HCV express a family of larger isoforms, in addition to p8. Minicores lack significant portions of the RNA binding domain of p21 core. Studies are under way to determine their functions...
  10. pmc Evaluation of hepatitis C virus as a risk factor for HIV-associated neuroretinal disorder
    Andrea D Branch
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
    Clin Infect Dis 57:1618-25. 2013
    ..We investigated associations between HCV and HIV-NRD and between HCV and single-nucleotide polymorphisms (SNPs) in the IL-10 receptor 1 (IL10R1) gene...
  11. ncbi request reprint Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors
    Thomas D Schiano
    The Recanati Miller Transplantation Institute, The Mount Sinai Hospital, New York, NY, USA
    Hepatology 42:1420-8. 2005
    ..The trend toward a greater initial viral load decrease in patients with LD grafts and the significantly sharper increase suggest that the liver plays a predominant role in both HCV clearance and replication...
  12. pmc Cross-genotypic polyclonal anti-HCV antibodies from human ascitic fluid
    Julio A Gutierrez
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol Methods 171:169-75. 2011
    ..Affinity purification allows antibodies to be selected that are comparable to monoclonal antibodies in their ability to react with targeted regions of viral proteins...
  13. pmc Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users
    Kathryn E Childs
    Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS Res Hum Retroviruses 26:855-9. 2010
    ..Because TDF is a potent and widely used antiretroviral drug, information about cofactors that may exacerbate its side effects is of significant clinical value...
  14. ncbi request reprint Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study
    Daniel S Fierer
    Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 198:683-6. 2008
    ..No cause of liver damage other than acute HCV infection was identified. The specific pathways leading to periportal fibrosis in HIV-infected men with newly acquired HCV infection require investigation...
  15. doi request reprint HCV and HCC: clinical update and a review of HCC-associated viral mutations in the core gene
    Jawad Ahmad
    Division of Liver Diseases, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Semin Liver Dis 31:347-55. 2011
    ....
  16. pmc Insulin resistance predicts re-treatment failure in an efficacy study of peginterferon-α-2a and ribavirin in HIV/HCV co-infected patients
    Marie Louise C Vachon
    Division of Liver Diseases, Mount Sinai School of Medicine, NY, USA
    J Hepatol 54:41-7. 2011
    ....
  17. pmc Mutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions
    Jose L Walewski
    Department of Medicine, Division of Liver and Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    RNA 8:557-71. 2002
    ..This study is the first application of Mutation Master, which is now available upon request (http://tandem.biomath.mssm.edu/mutationmaster.html)...
  18. pmc The quasispecies nature and biological implications of the hepatitis C virus
    Sarah L Fishman
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, United States
    Infect Genet Evol 9:1158-67. 2009
    ..We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus...
  19. pmc Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma
    Sarah L Fishman
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Clin Cancer Res 15:3205-13. 2009
    ..Published data implicate the HCV core gene in oncogenesis. We tested the hypothesis that core gene sequences from HCC patients differ from those of patients without cirrhosis/HCC...
  20. pmc A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication
    Shihyun You
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York 10021, USA
    J Virol 78:1352-66. 2004
    ..Understanding the role of 5BSL3.2 and determining how this new CRE functions in the context of previously identified elements at the 5' and 3' ends of the RNA genome should provide new insights into HCV RNA replication...
  21. doi request reprint Vitamin D for your patients with chronic hepatitis C?
    Adeeb H Rahman
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hepatol 58:184-9. 2013
    ....
  22. ncbi request reprint Diabetes mellitus and advanced liver fibrosis are risk factors for severe anaemia during telaprevir-based triple therapy
    James F Crismale
    Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Liver Int 34:1018-24. 2014
    ..Adding telaprevir to pegylated-interferon and ribavirin increased both response rates and side effects of hepatitis C virus (HCV) treatment. We identified variables associated with severe anaemia during telaprevir-based triple therapy...
  23. pmc Vitamin D status of human immunodeficiency virus-positive patients with advanced liver disease enrolled in the solid organ transplantation in HIV: multi-site study
    Andrea D Branch
    Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
    Liver Transpl 20:156-64. 2014
    ..More extensive use of vitamin D supplements, more sun exposure, or both are needed to prevent this deficiency in HIV-positive LT candidates and recipients...
  24. pmc Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization
    Jose L Walewski
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Obes Surg 20:93-107. 2010
    ..The aim of this work is to study the processes determining fat accumulation in adipose tissue from obese patients...
  25. ncbi request reprint Increased prevalence of primary biliary cirrhosis near Superfund toxic waste sites
    Aftab Ala
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 43:525-31. 2006
    ..Significant clusters of both PBC-OLT and PBC-MSSM were identified surrounding SFS. In conclusion, toxin exposure may be a risk factor influencing the clustering of PBC cases...
  26. ncbi request reprint Evaluation of fatigue in U.S. patients with primary biliary cirrhosis
    Carmen M Stanca
    Department of Medicine, The Mount Sinai School of Medicine, 1425 Madison Avenue, Room 1126, New York, NY 10029, USA
    Am J Gastroenterol 100:1104-9. 2005
    ..S. PBC patients. This study examines the extent of fatigue and its effect on quality of life in U.S. PBC patients...
  27. ncbi request reprint Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1
    Feng Wen
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Med Virol 72:230-40. 2004
    ..These results support the hypothesis that enhanced injury in hepatocytes over expressing both HCV core protein and CYP2E1 is mediated by increases in oxidative stress...

Research Grants19

  1. Clinical Outcomes and the HCV Core Gene
    Andrea D Branch; Fiscal Year: 2010
    ..This project investigates the action of these mutations at the molecular level, with the ultimate goal of developing interventions to block the effects of the viral genes influenced by the disease- associated mutations. ..
  2. Modulation of HCV Gene Expression
    Andrea D Branch; Fiscal Year: 2010
    ..New information about HCV's adaptive mechanisms and pathways of gene expression will emerge from these studies and will advance the development of new drugs and vaccines for HCV. ..
  3. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2007
    ..The yeast two-hybrid system will identify human proteins that bind ARFPs. These studies will identify new targets for therapeutics and vaccine development. ..
  4. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2007
    ..New information about HCV's adaptive mechanisms and pathways of gene expression will emerge from these studies and will advance the development of new drugs and vaccines for HCV. ..
  5. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2006
    ..The yeast two-hybrid system will identify human proteins that bind ARFPs. These studies will identify new targets for therapeutics and vaccine development. ..
  6. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2006
    ..New information about HCV's adaptive mechanisms and pathways of gene expression will emerge from these studies and will advance the development of new drugs and vaccines for HCV. ..
  7. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2005
    ..The yeast two-hybrid system will identify human proteins that bind ARFPs. These studies will identify new targets for therapeutics and vaccine development. ..
  8. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2005
    ..New information about HCV's adaptive mechanisms and pathways of gene expression will emerge from these studies and will advance the development of new drugs and vaccines for HCV. ..
  9. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2004
    ..The yeast two-hybrid system will identify human proteins that bind ARFPs. These studies will identify new targets for therapeutics and vaccine development. ..
  10. Modulation of HCV Gene Expression
    Andrea Branch; Fiscal Year: 2004
    ..New information about HCV's adaptive mechanisms and pathways of gene expression will emerge from these studies and will advance the development of new drugs and vaccines for HCV. ..
  11. RIBOZYMES AND RNA GENE THERAPIES FOR LIVER DISEASES
    Andrea Branch; Fiscal Year: 2003
    ..Northern analysis of RNAs extracted from serum samples of patients will establish the size distribution of HCV RNAs containing the terminal sequence. These studies will lead to new treatments for liver diseases. ..
  12. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2003
    ..The yeast two-hybrid system will identify human proteins that bind ARFPs. These studies will identify new targets for therapeutics and vaccine development. ..
  13. RIBOZYMES AND RNA GENE THERAPIES FOR LIVER DISEASES
    Andrea Branch; Fiscal Year: 2001
    ..Northern analysis of RNAs extracted from serum samples of patients will establish the size distribution of HCV RNAs containing the terminal sequence. These studies will lead to new treatments for liver diseases. ..
  14. RIBOZYMES AND RNA GENE THERAPIES FOR LIVER DISEASES
    Andrea Branch; Fiscal Year: 2000
    ..Northern analysis of RNAs extracted from serum samples of patients will establish the size distribution of HCV RNAs containing the terminal sequence. These studies will lead to new treatments for liver diseases. ..
  15. RIBOZYMES AND RNA GENE THERAPIES FOR LIVER DISEASES
    Andrea Branch; Fiscal Year: 1999
    ..Northern analysis of RNAs extracted from serum samples of patients will establish the size distribution of HCV RNAs containing the terminal sequence. These studies will lead to new treatments for liver diseases. ..
  16. Optimizing Vitamin D Treatment in HIV/AIDS: An RCT
    DOUGLAS THOMAS DIETERICH; Fiscal Year: 2010
    ..Our study will help physicians make evidence-based decisions about the most effective way to use vitamin D in their patients and enable the design of large multi-center trials in the future. ..