M Blum

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra
    M Blum
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Nat Neurosci 1:374-7. 1998
  2. ncbi The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival
    M Blum
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 160:413-24. 1999
  3. ncbi Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease
    A Ho
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 18:5614-29. 1998
  4. ncbi Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice
    A Ho
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 148:348-59. 1997
  5. pmc No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta
    S Harroch
    Department of Pharmacology and The Skirball Institute, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 20:7706-15. 2000
  6. ncbi Striatal TGF-alpha: postnatal developmental expression and evidence for a role in the proliferation of subependymal cells
    C S Weickert
    Fishberg Research Center in Neurobiology, Mount Sinai Medical Center, New York, NY 10029, USA
    Brain Res Dev Brain Res 86:203-16. 1995
  7. ncbi GDNF mRNA expression in normal postnatal development, aging, and in Weaver mutant mice
    M Blum
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 16:925-9. 1995
  8. ncbi Estradiol stimulates preoptic area-anterior hypothalamic proGnRH-GAP gene expression in ovariectomized rats
    J L Roberts
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, NY 10029
    Brain Res Mol Brain Res 6:127-34. 1989
  9. ncbi Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay
    L M Lazar
    Fishberg Research Center in Neurobiology, Mount Sinai Medical Center, New York, New York 10029
    J Neurosci 12:1688-97. 1992
  10. ncbi Characterization of gonadotropin-releasing hormone gene transcripts in a mouse hypothalamic neuronal GT1 cell line
    T T Yeo
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res Mol Brain Res 42:255-62. 1996

Collaborators

  • A C Gore
  • J Rosenbluth
  • Leonard D Shultz
  • Joseph Buxbaum
  • G Yamada
  • A Ho
  • S Nakamura
  • S Harroch
  • U Gaio
  • S Kuratani
  • A Schweickert
  • R Haraguchi
  • K Suzuki
  • C C Zhu
  • T T Yeo
  • P Shrager
  • J Schlessinger
  • C S Weickert
  • M Okigaki
  • M Palmeri
  • A Custer
  • I Satokata
  • M Strehle
  • K Kosai
  • T Muller
  • S Britsch
  • C Birchmeier
  • C Ozcelik
  • Y Komatsu
  • W Lankes
  • A N Garratt
  • R Maas
  • A Fischer
  • T Minami
  • J L Roberts
  • H Hasuwa
  • Y Ogino
  • Y Tohno
  • M Sakai
  • K Miyado
  • T Terashi
  • M Jakubowski
  • K W Dong
  • L M Lazar
  • R P Millar
  • C M Dutlow

Detail Information

Publications14

  1. ncbi A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra
    M Blum
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Nat Neurosci 1:374-7. 1998
    ..These studies indicate that TGF-alpha is required for the normal proliferation or differentiation of a select population of dopaminergic neurons within the SN...
  2. ncbi The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival
    M Blum
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 160:413-24. 1999
    ..In summary, we detected reduced levels of serum thyroid hormone in the weaver mutant mouse, which appears to be responsible for delays in somatic growth and the onset of neurodegenerative changes in the midbrain...
  3. ncbi Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease
    A Ho
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 18:5614-29. 1998
    ..These findings strongly suggest that IL-1alpha could play an important role in MPTP-induced plasticity of dopaminergic neurons...
  4. ncbi Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice
    A Ho
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Neurol 148:348-59. 1997
    ..These results suggest that the regulation of bFGF and possibly its receptor signaling efficacy may vary as the brain ages...
  5. pmc No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta
    S Harroch
    Department of Pharmacology and The Skirball Institute, New York University Medical Center, New York, New York 10016, USA
    Mol Cell Biol 20:7706-15. 2000
    ....
  6. ncbi Striatal TGF-alpha: postnatal developmental expression and evidence for a role in the proliferation of subependymal cells
    C S Weickert
    Fishberg Research Center in Neurobiology, Mount Sinai Medical Center, New York, NY 10029, USA
    Brain Res Dev Brain Res 86:203-16. 1995
    ..EGF-R immunoreactive cells were found in the SEL of the adult mouse brain. Taken together, our data suggest that the TGF-alpha/EGF-R signaling pathway is involved in postnatal mitogenic events in the brain...
  7. ncbi GDNF mRNA expression in normal postnatal development, aging, and in Weaver mutant mice
    M Blum
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Neurobiol Aging 16:925-9. 1995
    ....
  8. ncbi Estradiol stimulates preoptic area-anterior hypothalamic proGnRH-GAP gene expression in ovariectomized rats
    J L Roberts
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, NY 10029
    Brain Res Mol Brain Res 6:127-34. 1989
    ..These data support the view that estradiol stimulates the levels of both proGnRH-GAP mRNA and its primary translation product in the POA-AH region of the OVX rat...
  9. ncbi Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay
    L M Lazar
    Fishberg Research Center in Neurobiology, Mount Sinai Medical Center, New York, New York 10029
    J Neurosci 12:1688-97. 1992
    ..Taken together, our findings provide evidence for the synthesis of EGF in brain and suggest a role for both EGF and TGF-alpha in the development and support of the mammalian CNS...
  10. ncbi Characterization of gonadotropin-releasing hormone gene transcripts in a mouse hypothalamic neuronal GT1 cell line
    T T Yeo
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res Mol Brain Res 42:255-62. 1996
    ....
  11. ncbi Malformation of trachea and pelvic region in goosecoid mutant mice
    C C Zhu
    Forschungszentrum Karlsruhe, Institute of Genetics, Germany
    Dev Dyn 211:374-81. 1998
    ..In addition, we discuss evidence for the existence of at least three goosecoid genes in vertebrates, which may account for the lack of a defect of axial patterning in goosecoid mutant mice...
  12. ncbi Middle ear defects associated with the double knock out mutation of murine goosecoid and Msx1 genes
    S Kuratani
    Dept of Biology, Fac of Sciences, Okayama University, Japan
    Cell Mol Biol (Noisy-le-grand) 45:589-99. 1999
    ..Our results also suggested that the patterning of distal portions of the malleus depends on the tympanic membrane, for which normal expressions of both the genes are prerequisite...
  13. ncbi A role of the cryptic gene in the correct establishment of the left-right axis
    U Gaio
    Max Delbrück Centrum for Molecular Medicine, Berlin, 13125, Germany
    Curr Biol 9:1339-42. 1999
    ..Our results provide genetic evidence for a role of cryptic in the signalling cascade that determines left-right asymmetry...
  14. ncbi Aberrant regulation of bone trace elements in motheaten and osteopetrosis mutant mice
    G Yamada
    Research Center for Innovative Cancer Therapy, Kurume University, Fukuoka, Japan
    Cell Mol Biol (Noisy-le-grand) 44:315-9. 1998
    ..An assessment of these trace element spectrum in the two mutant models with respect to each genetic defects are discussed in this paper...