JULIE MAGARIAN BLANDER

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi Designing a type I interferon signaling phagosome
    J Magarian Blander
    The Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 37:947-9. 2012
  2. ncbi Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells
    J Magarian Blander
    Department of Medicine, Mount Sinai School of Medicine, Immunology Institute, 1425 Madison Avenue, New York, NY 10029, USA
    Immunol Res 54:50-68. 2012
  3. ncbi Beyond pattern recognition: five immune checkpoints for scaling the microbial threat
    J Magarian Blander
    Mount Sinai School of Medicine, Immunology Institute, Department of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nat Rev Immunol 12:215-25. 2012
  4. ncbi On regulation of phagosome maturation and antigen presentation
    J Magarian Blander
    Center for Immunobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:1029-35. 2006
  5. ncbi Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation
    J Magarian Blander
    Center for Immunobiology, Mount Sinai School of Medicine, NY 10029, USA
    Trends Immunol 28:19-25. 2007
  6. ncbi Signalling and phagocytosis in the orchestration of host defence
    J Magarian Blander
    Center for Immunobiology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Cell Microbiol 9:290-9. 2007
  7. ncbi Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors
    J Magarian Blander
    Department of Medicine, Mount Sinai School of Medicine, Immunology Institute, New York, USA
    Ann Rheum Dis 67:iii44-9. 2008
  8. ncbi Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction
    Arevik Mosoian
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:10178-83. 2010
  9. ncbi Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    Leif E Sander
    Department of Medicine III, RWTH University Hospital, 52074 Aachen, Germany
    J Exp Med 207:1453-64. 2010
  10. ncbi Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation
    Miriam Beer Torchinsky
    Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 458:78-82. 2009

Research Grants

  1. The Regulatory Control Mechanisms of Cross-presentation by Toll-like Receptors
    JULIE MAGARIAN BLANDER; Fiscal Year: 2010
  2. The Regulatory Control Mechanisms of Cross-presentation by Toll-like Receptors
    JULIE MAGARIAN BLANDER; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. ncbi Designing a type I interferon signaling phagosome
    J Magarian Blander
    The Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 37:947-9. 2012
    ..In this issue of Immunity, Henault et al. (2012) show that Fcγ-receptor, Toll-like receptor 9, and LC3 conspire to mold phagosomes into type I interferon signaling platforms...
  2. ncbi Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells
    J Magarian Blander
    Department of Medicine, Mount Sinai School of Medicine, Immunology Institute, 1425 Madison Avenue, New York, NY 10029, USA
    Immunol Res 54:50-68. 2012
    ..We speculate on how the intricate relationships among commensal, pathogen, and the host might ultimately determine susceptibility to autoimmune disease...
  3. ncbi Beyond pattern recognition: five immune checkpoints for scaling the microbial threat
    J Magarian Blander
    Mount Sinai School of Medicine, Immunology Institute, Department of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nat Rev Immunol 12:215-25. 2012
    ..Here, we propose five immune checkpoints that, as defined here, collectively determine the gravity of microbial encounters...
  4. ncbi On regulation of phagosome maturation and antigen presentation
    J Magarian Blander
    Center for Immunobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:1029-35. 2006
    ..An inducible mode of phagosome maturation triggered by these receptors ensures the selection of microbial antigens for presentation by major histocompatibility class II molecules during the simultaneous phagocytosis of self and non-self...
  5. ncbi Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation
    J Magarian Blander
    Center for Immunobiology, Mount Sinai School of Medicine, NY 10029, USA
    Trends Immunol 28:19-25. 2007
    ....
  6. ncbi Signalling and phagocytosis in the orchestration of host defence
    J Magarian Blander
    Center for Immunobiology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Cell Microbiol 9:290-9. 2007
    ..This mechanism prevents the potential presentation of peptides derived from self within the context of TLR-induced co-stimulatory signals...
  7. ncbi Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors
    J Magarian Blander
    Department of Medicine, Mount Sinai School of Medicine, Immunology Institute, New York, USA
    Ann Rheum Dis 67:iii44-9. 2008
    ..This current work aims to identify whether TLRs exert similar control on the presentation of phagocytosed antigens within MHC class I molecules, a process referred to as cross-presentation...
  8. ncbi Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction
    Arevik Mosoian
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:10178-83. 2010
    ..Understanding the mechanism of IFN induction by ProTalpha may provide therapeutic leads for IFN-sensitive viruses...
  9. ncbi Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    Leif E Sander
    Department of Medicine III, RWTH University Hospital, 52074 Aachen, Germany
    J Exp Med 207:1453-64. 2010
    ..Thus, gp130-dependent communication between the liver and MDSCs through APPs controls inflammatory responses during infection...
  10. ncbi Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation
    Miriam Beer Torchinsky
    Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 458:78-82. 2009
    ..Because T(H)17 cells have been correlated with autoimmune diseases, investigation of the pathways of innate recognition of infected apoptotic cells might lead to improved understanding of the causative defects in autoimmunity...
  11. ncbi T helper 17 cells: discovery, function, and physiological trigger
    Miriam Beer Torchinsky
    Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Cell Mol Life Sci 67:1407-21. 2010
    ..As our knowledge of T(H)17 and T regulatory cells grows, we are building on a new framework for the understanding of effector T cell differentiation and the biology of CD4(+) T cell adaptive immune responses...
  12. ncbi The unexpected link between infection-induced apoptosis and a TH17 immune response
    Corinna F Brereton
    Mount Sinai School of Medicine, Immunology Institute, Department of Medicine, 1425 Madison Ave, 12 20D, New York, NY 10029, USA
    J Leukoc Biol 89:565-76. 2011
    ..We also consider types of cell death other than apoptosis that can be triggered by microbial infection, and we highlight how little we know about the impact of various forms of cell death on the ensuing adaptive immune response...
  13. ncbi Responding to infection and apoptosis--a task for TH17 cells
    Corinna F Brereton
    Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1209:56-67. 2010
    ....
  14. ncbi Analysis of the TLR/NF-kappaB pathway in antigen-presenting cells in malignancies promoted by inflammation
    J Magarian Blander
    Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 512:99-117. 2009
    ..Understanding the details of these pathways will aid in the development of new diagnostic and therapeutic applications...
  15. ncbi Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR
    Tao Dao
    Laboratory of T Cell Immunobiology, Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 170:48-54. 2003
    ..Therefore, the recognition of self that promotes positive selection of the D10 TCR is highly peptide-specific...

Research Grants4

  1. The Regulatory Control Mechanisms of Cross-presentation by Toll-like Receptors
    JULIE MAGARIAN BLANDER; Fiscal Year: 2010
    ..The new knowledge we gain will further the design of therapeutic anti-viral and anti-tumor vaccines, and broaden our understanding of autoimmunity. ..
  2. The Regulatory Control Mechanisms of Cross-presentation by Toll-like Receptors
    JULIE MAGARIAN BLANDER; Fiscal Year: 2007
    ..The new knowledge we gain will further the design of therapeutic anti-viral and anti-tumor vaccines, and broaden our understanding of autoimmunity ..